A cross-tissue transcriptome-wide association study identified susceptibility genes for age-related macular degeneration by Hongfan Yang, Haofei Huang, Kunlin Pu

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Gene Therapy with Endogenous Inhibitors of Angiogenesis for Neovascular Age-Related Macular Degeneration: Beyond Anti-VEGF Therapy by Selwyn M. Prea, Elsa C. Chan, Gregory J. Dusting, Algis J. Vingrys, Bang V. Bui, Guei-Sheung Liu

“…Age-related macular degeneration (AMD) is the leading cause of substantial and irreversible vision loss amongst elderly populations in industrialized countries. …”
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Efficacy and safety of faricimab for neovascular age-related macular degeneration: a systematic review and network meta-analysis by Francisco Rodríguez, Daniel Samacá-Samacá, Claudia Hernández-Castillo, Laura Prieto-Pinto, Carolina Sardi, Hugo Ocampo, Joshua Kock, Fabián Hernández

“…Objective To evaluate the efficacy and safety of faricimab compared with other anti-vascular endothelial growth factor (anti-VEGF) agents in treating neovascular age-related macular degeneration (nAMD) patients.Methods and analysis A systematic review (SR) was conducted up to January 2023. …”
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Zoledronic acid as adjuvant therapy in neovascular age-related macular degeneration: a randomised controlled pilot study by Øystein Kalsnes Jørstad, Morten Carstens Moe, Morten Wang Fagerland, Yngvil Solheim Husum, Erik Fink Eriksen

“…Aims To assess the feasibility of a study protocol for a randomised controlled trial of zoledronic acid (ZA) as adjuvant therapy for neovascular age-related macular degeneration (nAMD).Methods In this 1-year, randomised, double-blinded, placebo-controlled pilot study, nAMD patients were allocated 1:1 to receive intravenous ZA 5 mg or placebo at baseline and after 6 months in addition to intravitreal anti-vascular endothelial growth factor (anti-VEGF) therapy following a treat-and-extend regimen. …”
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A Novel Smartphone-Based Color Test for Detection of Color Vision Defects in Age Related Macular Degeneration by Vassilios Karampatakis, Diamantis Almaliotis, Leonidas Karamitopoulos, George Kalliris, Stavroula Almpanidou

“…To evaluate the efficacy of the smartphone-based K-color test to detect color defects in patients with Age-related Macular Degeneration (AMD). Methods. 88 patients (n = 135 eyes) with AMD and 28 controls (n = 53 eyes) underwent color testing with the Hardy–Rand–Rittler (H-R-R), the K-color test, and the Ishihara test. …”
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The Diagnostic Capability of Swept Source OCT Angiography in Treatment-Naive Exudative Neovascular Age-Related Macular Degeneration by Daniel Ahmed, Martin Stattin, Anna-Maria Haas, Stefan Kickinger, Maximilian Gabriel, Alexandra Graf, Katharina Krepler, Siamak Ansari-Shahrezaei

“…To evaluate the capability of swept source-optical coherence tomography angiography (SS-OCTA) in the detection and localization of treatment-naive macular neovascularization (MNV) secondary to exudative neovascular age-related macular degeneration (nAMD). …”
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Association between Metformin and a Lower Risk of Age-Related Macular Degeneration in Patients with Type 2 Diabetes by Yu-Yen Chen, Ying-Cheng Shen, Yun-Ju Lai, Chun-Yuan Wang, Keng-Hung Lin, Shih-Chao Feng, Chiao-Ying Liang, Li-Chen Wei, Pesus Chou

“…This population-based, retrospective cohort study was to investigate whether metformin is associated with a lower risk of subsequent age-related macular degeneration (AMD) in patients with type 2 diabetes. …”
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Short-Term Results of Switch from Conbercept to Bevacizumab or Ranibizumab in Eyes with Persistent Neovascular Age-Related Macular Degeneration by Zongyi Wang, Mengyang Li, Yuou Yao, Jie Hu, Jiyang Tang, Ran Tang, Zhenyu Piao, Jinfeng Qu

“…To study the short-term anatomical and functional outcomes in patients with neovascular age-related macular degeneration (nAMD) who were previously treated with conbercept and switched to ranibizumab or bevacizumab due to persistent activity. …”
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Joint Effect of CFH and ARMS2/HTRA1 Polymorphisms on Neovascular Age-Related Macular Degeneration in Chinese Population by Kai Fang, Pei Gao, Jun Tian, Xueying Qin, Wenzhen Yu, Juan Li, Qing Chen, Lvzhen Huang, Dafang Chen, Yonghua Hu, Xiaoxin Li

“…The etiology of neovascular age-related macular degeneration (nAMD) cannot be completely explained by identified environmental risk factors or single-locus gene variants. …”
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QTL mapping of human retina DNA methylation identifies 87 gene-epigenome interactions in age-related macular degeneration by Jayshree Advani, Puja A. Mehta, Andrew R. Hamel, Sudeep Mehrotra, Christina Kiel, Tobias Strunz, Ximena Corso-Díaz, Madeline Kwicklis, Freekje van Asten, Rinki Ratnapriya, Emily Y. Chew, Dena G. Hernandez, Sandra R. Montezuma, Deborah A. Ferrington, Bernhard H. F. Weber, Ayellet V. Segrè, Anand Swaroop

“…Our study thus defines key roles of genetic variations driving methylation changes, prioritizes epigenetic control of gene expression, and suggests frameworks for regulation of macular degeneration pathology by genotype–environment interaction in retina.…”
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A comprehensive review on early detection of drusen patterns in age-related macular degeneration using deep learning models by Kiruthika M, Malathi G

Subjects: “…Age-related Macular Degeneration (AMD)…”
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Intravitreal Dexamethasone in Patients with Wet Age-Related Macular Degeneration Resistant to Anti-VEGF: A Prospective Pilot Study by Ermete Giancipoli, Antonio Pinna, Francesco Boscia, Gianluigi Zasa, Giovanni Sotgiu, Simone Dore, Giuseppe D’Amico Ricci

“…To evaluate the efficacy and safety of a single intravitreal dexamethasone implant (DXI) combined with intravitreal antivascular endothelial growth factor (anti-VEGF) therapy, in patients with neovascular age-related macular degeneration (wet-AMD) resistant to conventional treatment. …”
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Treatment of Neovascular Age-Related Macular Degeneration with Anti-VEGF Agents: Predictive Factors of Long-Term Visual Outcomes by Ana Catarina Pedrosa, Tiago Sousa, João Pinheiro-Costa, João Beato, Manuel S. Falcão, Fernando Falcão-Reis, Angela Carneiro

“…To evaluate the predictive factors of long-term visual outcomes in neovascular age-related macular degeneration (nAMD) treated with antivascular endothelial growth factor (anti-VEGF) agents. …”
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Predictive value of different baseline optical coherence tomography biomarkers for visual acuity changes in neovascular age-related macular degeneration by Hamid Riazi-Esfahani, Hooshang Faghihi, Fatemeh Bazvand, Mohammadreza Mehrabi Bahar, Hassan Khojasteh, Ahmed Husein Ahmed, Shahin Faghihi, Ali Fakhraie, Mohammad Hossein Zamani, Samin Ghasemi, Esmaeil Asadi Khameneh, Elias Khalili Pour

Subjects: “…Age-related macular degeneration…”
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Comparison of Progression Rate of Retinal Pigment Epithelium Loss in Patients with Neovascular Age-Related Macular Degeneration Treated with Ranibizumab and Aflibercept by Juliana Wons, Magdalena A. Wirth, Nicole Graf, Matthias D. Becker, Stephan Michels

“…Retinal pigment epithelium (RPE) loss in neovascular age-related macular degeneration (nAMD) seem to have a linear progression but might be influenced by the treatment. …”
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Emotional and physical experiences of people with neovascular age-related macular degeneration during the injection process in Germany: a qualitative study by Oliver Zeitz, Martina Breuning, Christine Holmberg, Christian Wolfram, Anne Thier

“…Experiencing neovascular macular degeneration was dominated by the injection experience. …”
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Mesenchymal stem cell‐derived exosomes mitigate amyloid β‐induced retinal toxicity: Insights from rat model and cellular studies by Amanda Qarawani, Efrat Naaman, Rony Ben‐Zvi Elimelech, Michal Harel, Shahaf Sigal‐Dror, Tali Ben‐Zur, Tamar Ziv, Daniel Offen, Shiri Zayit‐Soudry

Subjects: “…age‐related macular degeneration…”
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Neovascular age-related macular degeneration: disease pathogenesis and current state of molecular biomarkers predicting treatment response—a scoping review by Nikolaos Dervenis, Eleftherios Agorogiannis, Panagiotis Dervenis

“…Age-related macular degeneration is a major cause of blindness, and the development of anti-vascular endothelial growth factor (VEGF) intravitreal treatments has revolutionised the management of the disease. …”
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Use of Imaging Modalities in Real Life: Impact on Visual Acuity Outcomes of Ranibizumab Treatment for Neovascular Age-Related Macular Degeneration in Germany by Joachim Wachtlin, Georg Spital, Steffen Schmitz-Valckenberg, Sandra Liakopoulos, Jessica Vögeler, Bettina Müller, Focke Ziemssen, Ocean study group

“…To date, there are limited prospective real-world data on the impact of optical coherence tomography (OCT) diagnostics on treatment outcomes in neovascular age-related macular degeneration (nAMD). Therefore, the prospective, noninterventional OCEAN study (NCT02194803) evaluated the use of OCT imaging and its impact on functional outcomes in Germany. …”
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Three-Year Outcomes of Patients with Neovascular Age-Related Macular Degeneration Treated with Aflibercept under the National Health Insurance Program in Taiwan by Kang-Jung Lo, Jin-Yu Chang, Hsin-Yi Chang, Shih-Hwa Chiou, De-Kuang Hwang, Shih-Jen Chen

“…To observe and analyze the long-term outcomes of patients with neovascular age-related macular degeneration (nAMD) treated with aflibercept monotherapy under the National Health Insurance (NHI) program in Taiwan. …”
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