The endocannabinoid system and ophthalmic pathologies: a review of molecular mechanisms and its implications for clinical practice by Tomasz Charytoniuk, Stanisław Półjanowski, Mateusz Michalak, Karolina Kaźmierczak, Bartłomiej Kałużny

“…Furthermore, various research indicated the involvement of ECS in the molecular basis of various pathologies, mostly glaucoma, diabetic retinopathy, and age-related macular degeneration (AMD). Therefore, the researchers believe that this biological system, its receptors, pathways, and ligands might be considered as an auxiliary compound to reduce the number of patients suffering from ophthalmic diseases. …”
Get full text

Cell Therapy for Retinal Dystrophies: From Cell Suspension Formulation to Complex Retinal Tissue Bioengineering by Karim Ben M’Barek, Christelle Monville

“…Retinal degeneration is an irreversible phenomenon caused by various disease conditions including age-related macular degeneration (AMD) and retinitis pigmentosa (RP). …”
Get full text

Topical Nonsteroidal Anti-Inflammatory Drugs for Macular Edema by Andrea Russo, Ciro Costagliola, Luisa Delcassi, Francesco Parmeggiani, Mario R. Romano, Roberto dell'Omo, Francesco Semeraro

“…Hence, new therapeutic effects can be achieved, such as reduction of exudation secondary to age-related macular degeneration or diabetic maculopathy. We provide an updated review on the clinical use of NSAIDs for retinal diseases, with a focus on the potential future applications.…”
Get full text

Development of Anti-VEGF Therapies for Intraocular Use: A Guide for Clinicians by Pearse A. Keane, Srinivas R. Sadda

“…Around this time, it also became clear that increased intraocular VEGF production was not limited to ischemic retinal diseases but was also a feature of choroidal vascular diseases such as neovascular age-related macular degeneration (AMD). Thus, a new therapeutic era emerged, utilizing VEGF blockade for the management of chorioretinal diseases characterized by vascular hyperpermeability and/or neovascularization. …”
Get full text

Significance of Hyperreflective Foci as an Optical Coherence Tomography Biomarker in Retinal Diseases: Characterization and Clinical Implications by Serena Fragiotta, Solmaz Abdolrahimzadeh, Rosa Dolz-Marco, Yoichi Sakurada, Orly Gal-Or, Gianluca Scuderi

“…Despite this, HRF can be considered OCT biomarkers for disease progression, treatment response, and prognosis in several retinal diseases, including diabetic macular edema, age-related macular degeneration (AMD), retinal vascular occlusions, and inherited retinal dystrophies. …”
Get full text

"Energetics of the outer retina II: Calculation of a spatio-temporal energy budget in retinal pigment epithelium and photoreceptor cells based on quantification of cellular process... by Christina Kiel, Stella Prins, Alexander J E Foss, Philip J Luthert

“…Impaired energy metabolism combined with high demands are expected to cause energy insufficiencies that make the OR susceptible to complex blinding diseases such as age-related macular degeneration (AMD). Here, anatomical, physiological and quantitative molecular data were used to calculate the ATP expenditure of the main energy-consuming processes in three cell types of the OR for the night and two different periods during the day. …”
Get full text

Posterior Chamber Hemorrhage during Fluorescein Angiography by Manuel A. P. Vilela

“…A 76-year-old male was referred for angiographic control of age-related macular degeneration. He was pseudophakic OU, BCVA 20/40 OU. …”
Get full text

Anti-Vascular Endothelial Growth Factors as a Potential Risk for Implant Failure: A Clinical Report by Elham Emami, Pierre de Grandmont, Mélanie Menassa, Nicholas Audy, Robert Durand

“…This clinical report presents a rare case of implant failure in a patient who received intravitreal injections of a vascular endothelial growth factor (VEGF) inhibitor for the treatment of age-related macular degeneration. Following CARE guidelines, the report presents a case rehabilitated with a mandibular 2-implant overdenture using the immediate-loading protocol and standard procedures. …”
Get full text

Dry eye disease treatment improves subjective quality-of-life responses in patients with AMD, independent of disease stage. by Nehal Nailesh Mehta, Ines D Nagel, Akshay Agnihotri, Anna Heinke, Lingyun Cheng, Dirk-Uwe Bartsch, William R Freeman, Maria-Laura Gomez

“…<h4>Purpose</h4>To determine the impact of severity of age-related macular degeneration (AMD) on subjective treatment response in patients treated for dry eye disease.…”
Get full text

Contribution of Microglia-Mediated Neuroinflammation to Retinal Degenerative Diseases by Maria H. Madeira, Raquel Boia, Paulo F. Santos, António F. Ambrósio, Ana R. Santiago

“…This review aims at giving an overview of the roles of microglia-mediated neuroinflammation in major retinal degenerative diseases like glaucoma, age-related macular degeneration, and diabetic retinopathy.…”
Get full text

Lutein, Zeaxanthin, and meso-Zeaxanthin in the Clinical Management of Eye Disease by Nicole K. Scripsema, Dan-Ning Hu, Richard B. Rosen

“…Observational studies have reported that increased dietary intake and higher serum levels of lutein and zeaxanthin are associated with lower risk of age-related macular degeneration (AMD), especially late AMD. Randomized, placebo-controlled clinical trials have demonstrated that xanthophyll supplementation increases macular pigment levels, improves visual function, and decreases the risk of progression to late AMD, especially neovascular AMD. …”
Get full text

Management of Ocular Diseases Using Lutein and Zeaxanthin: What Have We Learned from Experimental Animal Studies? by Chunyan Xue, Richard Rosen, Adrienne Jordan, Dan-Ning Hu

“…The effects of lutein and zeaxanthin on the prevention and treatment of various eye diseases, including age-related macular degeneration, diabetic retinopathy and cataract, ischemic/hypoxia induced retinopathy, light damage of the retina, retinitis pigmentosa, retinal detachment, and uveitis, have been studied in different experimental animal models. …”
Get full text

Predictive Factors in OCT Analysis for Visual Outcome in Exudative AMD by Maria-Andreea Gamulescu, Georgios Panagakis, Carmen Theek, Horst Helbig

“…This is a retrospective analysis of 87 patients with exudative age-related macular degeneration who received three monthly intravitreal ranibizumab injections. …”
Get full text

Inflammatory Mediators and Angiogenic Factors in Choroidal Neovascularization: Pathogenetic Interactions and Therapeutic Implications by Claudio Campa, Ciro Costagliola, Carlo Incorvaia, Carl Sheridan, Francesco Semeraro, Katia De Nadai, Adolfo Sebastiani, Francesco Parmeggiani

“…Choroidal neovascularization (CNV) is a common and severe complication in heterogeneous diseases affecting the posterior segment of the eye, the most frequent being represented by age-related macular degeneration. Although the term may suggest just a vascular pathological condition, CNV is more properly definable as an aberrant tissue invasion of endothelial and inflammatory cells, in which both angiogenesis and inflammation are involved. …”
Get full text

Targeting Inflammation in Emerging Therapies for Genetic Retinal Disease by Ishaq A. Viringipurampeer, Abu E. Bashar, Cheryl Y. Gregory-Evans, Orson L. Moritz, Kevin Gregory-Evans

“…Genetic retinal diseases such as age-related macular degeneration and monogenic diseases such as retinitis pigmentosa account for some of the commonest causes of blindness in the developed world. …”
Get full text

The Efficacy of Conbercept in Polypoidal Choroidal Vasculopathy: A Systematic Review by Yimin Wang, Mengxi Shen, Jinwei Cheng, Xiaodong Sun, Peter K. Kaiser

“…The use of antivascular endothelial growth factor (VEGF) therapy in polypoidal choroidal vasculopathy (PCV), a subtype of neovascular age-related macular degeneration (nAMD), has been well established in randomized clinical trials. …”
Get full text

RatDNA: DATABASE ON MICROARRAY STUDIES OF RATS BEARING GENES ASSOCIATED WITH AGE-RELATED DISEASES by O. S. Kozhevnikova, M. K. Martyschenko, M. A. Genaev, E. E. Korbolina, N. A. Muraleva, N. G. Kolosova, Y. L. Orlov

“…People do not die of «healthy» aging: at any age conditions whose probability increases with age become the cause of their death. Age-related macular degeneration (AMD) becomes the main cause of vision problems and sight loss in people aged above 50. …”
Get full text

Visual, Musculoskeletal, and Balance Complaints in AMD: A Follow-Up Study by Christina Zetterlund, Hans Olof Richter, Lars-Olov Lundqvist

“…To investigate whether patients with age-related macular degeneration (AMD) run a potentially higher risk of developing visual, musculoskeletal, and balance complaints than age-matched controls with normal vision. …”
Get full text

Systems Biology Profiling of AMD on the Basis of Gene Expression by Mones S. Abu-Asab, Jose Salazar, Jingsheng Tuo, Chi-Chao Chan

“…Genetic pathways underlying the initiation and progression of age-related macular degeneration (AMD) have not been yet sufficiently revealed, and the correlations of AMD’s genotypes, phenotypes, and disease spectrum are still awaiting resolution. …”
Get full text

Lutein Leads to a Decrease of Factor D Secretion by Cultured Mature Human Adipocytes by Yuan Tian, Aize Kijlstra, Johan Renes, Martin Wabitsch, Carroll A. B. Webers, Tos T. J. M. Berendschot

“…Complement plays an important role in the pathogenesis of age related macular degeneration (AMD) and trials are currently being conducted to investigate the effect of complement inhibition on AMD progression. …”
Get full text