Cytokine-armed oncolytic herpes simplex viruses: a game-changer in cancer immunotherapy? by Howard L Kaufman, Hongbin Wang, Dipongkor Saha, Samuel D Rabkin, Mia Borlongan, Uyen Le, Hans J Nauwynck

“…Talimogene laherparepvec is an oncolytic herpes simplex virus type 1 (oHSV), approved for the treatment of recurrent melanoma, and the virus encodes the human cytokine, granulocyte-macrophage colony-stimulating factor (GM-CSF). A significant advantage of oncolytic viruses is the ability to deliver therapeutic payloads to the tumor site that can help drive antitumor immunity. …”
Get full text

Naringenin, a Food Bioactive Compound, Reduces Oncostatin M Through Blockade of PI3K/Akt/NF-κB Signal Pathway in Neutrophil-like Differentiated HL-60 Cells by Na-Ra Han, Hi-Joon Park, Seong-Gyu Ko, Phil-Dong Moon

“…While exposure to granulocyte-macrophage colony-stimulating factor (GM-CSF) induced elevated OSM release and mRNA expression, the elevated OSM release and mRNA expression were diminished by the addition of NAR in dHL-60 cells. …”
Get full text

Soy polysaccharide maintains colonic homeostasis to protect from dextran sulphate sodium-induced colitis by modulating gut microbiota and intestinal epithelial regeneration by Nana Zhang, Jianlin Liu, Weiyue Zhang, Xinxin Guo, Shuying Li, Hongtai Zhang, Minjie Wang, Bei Fan, Fengzhong Wang

“…SP suppressed DSS-induced inflammatory response and enhanced M1 to M2 macrophage polarization. Further investigation showed that SP significantly promoted the regeneration of crypt and the expansion of goblet cell production. …”
Get full text

Different Pathological Roles of Toll-Like Receptor 9 on Mucosal B Cells and Dendritic Cells in Murine IgA Nephropathy by Tadahiro Kajiyama, Yusuke Suzuki, Masao Kihara, Hitoshi Suzuki, Satoshi Horikoshi, Yasuhiko Tomino

“…However, CpG-A-group showed clear extension of mesangial proliferative lesions with increase of serum IgA-IgG2a IC and its glomerular depositions, while CpG-B-group showed extent of glomerular sclerotic lesions with increase of serum and glomerular IgA and M2 macrophage infiltration. Present results indicate that mucosal TLR9 on B cells and DC may differently contribute to the progression of this disease via induction of nephritogenic IgA or IgA-IgG IC, respectively. …”
Get full text

Spatially mapping the tumour immune microenvironments of non-small cell lung cancer by Lysanne Desharnais, Mark Sorin, Morteza Rezanejad, Bridget Liu, Elham Karimi, Aline Atallah, Anikka M. Swaby, Miranda W. Yu, Samuel Doré, Saskia Hartner, Benoit Fiset, Yuhong Wei, Baharak Kadang, Roni Rayes, Philippe Joubert, Sophie Camilleri-Broët, Pierre-Olivier Fiset, Daniela F. Quail, Jonathan D. Spicer, Logan A. Walsh

“…This spatial analysis revealed distinct patterns of immune cell aggregation, particularly among macrophage populations, that correlated with patient prognosis differentially in adenocarcinoma and squamous cell carcinoma, suggesting potential new strategies for therapeutic intervention. …”
Get full text

Boosting the human antiviral response in conjunction with natural plant products by Rashmi Srivastava, Neeraj Kumar Dubey, Megha Sharma, Harsha Kharkwal, Rajesh Bajpai, Rakesh Srivastava

“…PNPs control compounds such as alkaloids, flavonoids, terpenoids, and polyphenols to promote antiviral cytokine synthesis, increase T-cell and macrophage activity, and activate antiviral genes. Studies have investigated the molecular interactions between PNPs, viruses, and host cells, exploring the potential of combining PNPs with conventional antiviral drugs to enhance efficacy. …”
Get full text

Genetic Deletion of Soluble Epoxide Hydrolase Attenuates Inflammation and Fibrosis in Experimental Obstructive Nephropathy by Chin-Wei Chiang, Hsueh-Te Lee, Der-Cherng Tarng, Ko-Lin Kuo, Li-Ching Cheng, Tzong-Shyuan Lee

“…Moreover, sEH−/− mice with UUO showed lower levels of inflammation-related and fibrosis-related protein such as monocyte chemoattractant protein-1, macrophage inflammatory protein-2, interleukin-1β (IL-1β), IL-6, inducible nitric oxide synthase, collagen 1A1, and α-actin. …”
Get full text

Integrated multi-omics analysis reveals clinical significance of hepatocyte nuclear factor-1β in tumor immune microenvironment, immunotherapy and prognostic prediction for colon ad... by Fushan Gao, Wenlin Gong, Haihua He, Zhen Zhang, Hongcai Yang, Fei Shao, Yibo Gao, Jie He

“…CIBERSORT, TIME, and GSVA analyses revealed that HNF1B was associated with macrophage infiltration, immune checkpoints, and signaling pathways. …”
Get full text

Building an Immune-Related Genes Model to Predict Treatment, Extracellular Matrix, and Prognosis of Head and Neck Squamous Cell Carcinoma by Yushi Yang, Yang Feng, Qin Liu, Ji Yin, Chenglong Cheng, Cheng Fan, Chenhui Xuan, Jun Yang

“…The low-risk group was associated with immune-related pathways, a low incidence of gene mutation, a high level of M1 macrophage infiltration, regulatory T cells, CD8 T cells, and B cells, active immunity, and larger benefits from immune checkpoint inhibitors (ICIs) therapy. …”
Get full text

Serum Cytokines in Young Pediatric Patients with Congenital Cardiac Shunts and Altered Pulmonary Hemodynamics by Leína Zorzanelli, Nair Yukie Maeda, Mariana Meira Clavé, Vera Demarchi Aiello, Marlene Rabinovitch, Antonio Augusto Lopes

“…Cytokines were measured by chemiluminescence. Macrophage migration inhibitory factor (MIF) was found to be inversely related to pulmonary blood flow (r=-0.33, p=0.026) and was higher in group II (high pulmonary vascular resistance) compared to group I (high pulmonary blood flow) (p=0.017). …”
Get full text

Achyranthes bidentata Polysaccharide along with Anti-IL-5 Antibody Inhibits Allergic Lung Inflammation and Airway Hyperresponsiveness Mice Induced by House Dust Mites by Jian Sun, Shiwei Sheng, Gang Zhao

“…ABPS can induce production of TNF-α in macrophage, enhance the killing ability of NK cells, and promote the proliferation of B cells. …”
Get full text

Radioiodine Labeled Anti-MIF McAb: A Potential Agent for Inflammation Imaging by Chao Zhang, Gui-hua Hou, Jian-kui Han, Jing Song, Ting Liang

“…Macrophage migration inhibitory factor (MIF) is a proinflammatory cytokine that may play a role in the pathogenesis of inflammation. …”
Get full text

Metabolomic profiling of amines in sepsis predicts changes in NOS canonical pathways. by Abel Tesfai, Niall MacCallum, Nicholas S Kirkby, Hime Gashaw, Nicola Gray, Elizabeth Want, Gregory J Quinlan, Sharon Mumby, James M Leiper, Mark Paul-Clark, Blerina Ahmetaj-Shala, Jane A Mitchell

“…The iNOS supporting capacity of plasma was determined using a mouse macrophage cell-based bioassay.<h4>Main results</h4>Of all the amines measured 22, including L-arginine and ADMA, displayed significant differences in samples from patients with sepsis. …”
Get full text

Transplanted Adult Neural Stem Cells Express Sonic Hedgehog In Vivo and Suppress White Matter Neuroinflammation after Experimental Traumatic Brain Injury by Genevieve M. Sullivan, Regina C. Armstrong

“…Importantly, NSC transplantation significantly reduced reactive astrogliosis and microglial/macrophage activation in the corpus callosum after TBI. …”
Get full text

Hepatitis B e Antigen Seroconversion Is Related with the Function of Dendritic Cells in Chronic Hepatitis B Virus Infection by Chunjing Lin, Hai Zou, Shumin Wang

“…The peripheral blood mononuclear cells (PBMC) from 21 chronic HBV patients in immune tolerance state, 23 patients in inactive HBsAg carrier state, and 10 healthy HBV-naive blood donors were incubated and induced into DC in presence of granulocyte-macrophage colony stimulating factor (GM-CSF) and interleukin-4 (IL-4), respectively. …”
Get full text

Phase I Study of Anti-CD3 x Anti-Her2 Bispecific Antibody in Metastatic Castrate Resistant Prostate Cancer Patients by Ulka Vaishampayan, Archana Thakur, Ritesh Rathore, Nicola Kouttab, Lawrence G. Lum

“…The men received 2.5, 5 or 10 × 109 aATC per infusion with low dose interleukin-2 and granulocyte-macrophage colony stimulating factor. Results. There were no dose limiting toxicities, and there was 1 partial responder and 3 of 7 patients had significant decreases in their PSA levels and pain scores. …”
Get full text

The Physiological Role of GABA in Fine-Tuning Control of Blood Glucose and Diabetes Treatment by Mohsen Davari, Shahla Sohrabipour, Atefeh Golkari

“…These substances encompass insulin-like growth factors, macrophage migration inhibitory factors, pituitary adenylate cyclase-activating polypeptide, preptin, and gamma-aminobutyric acid (GABA). …”
Get full text

Wedelolactone Mitigates Alcoholic Steatohepatitis via Modulating the TLR4/MyD88/NF-κB Pathway by Tao Jiang, Bingde Hu, Yongxia Li, Shuihong Yu

“…Histopathological evaluations revealed that WEL mitigated liver injury, lipid accumulation, and macrophage infiltration provoked by alcohol consumption and a high-fat diet in mice. …”
Get full text

Neuroprotective potential of isofraxidin: Alleviating parkinsonian symptoms, inflammation and microglial activation by Tin-An Wang, Shiao-Yun Li, Li-Yun Fann, I-Hsun Li, Tsung-Ta Liu, Hao-Yuan Hung, Chieh-Wen Chang, Chih-Chien Cheng, Ying-Che Huang, Pei-Yeh Yu, Jui-Hu Shih

“…Previous research has confirmed that isofraxidin can reduce macrophage expression and inhibit peripheral inflammation. …”
Get full text

P2X7 Receptor Activation Induces Reactive Oxygen Species Formation and Cell Death in Murine EOC13 Microglia by Rachael Bartlett, Justin J. Yerbury, Ronald Sluyter

“…This study aimed to determine if P2X7 activation induces the uptake of organic cations, reactive oxygen species (ROS) formation, and death in the murine microglial EOC13 cell line. Using the murine macrophage J774 cell line as a positive control, RT-PCR, immunoblotting, and immunolabelling established the presence of P2X7 in EOC13 cells. …”
Get full text