Overexpression of FERM Domain Containing Kindlin 2 (FERMT2) in Fibroblasts Correlates with EMT and Immunosuppression in Gastric Cancer by Sheng-yan Yin, Yuan-jie Liu, Jie-pin Li, Jian Liu

“…In gastric cancer (GC), the fermitin family homolog-2 (FERMT2) is involved in macrophage signaling, promoting migration and invasion. …”
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Magnetic Resonance Imaging Visualization of Vulnerable Atherosclerotic Plaques at the Brachiocephalic Artery of Apolipoprotein E Knockout Mice by the Blood-Pool Contrast Agent B229... by Cinzia Parolini, Marco Busnelli, Giulia S. Ganzetti, Federica Dellera, Stefano Manzini, Eugenio Scanziani, Jason L. Johnson, Cesare R. Sirtori, Giulia Chiesa

“…A linear correlation between signal enhancement and macrophage content was found 10 minutes after B22956/1 injection ( p < .01). …”
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Attenuation of Apoptosis by Telmisartan in Atherosclerotic Plaques of Apolipoprotein E Mice: Evaluation Using Technetium 99m–Annexin A5 by Yan Zhao, Songji Zhao, Yuji Kuge, H. William Strauss, Francis G. Blankenberg, Nagara Tamaki

“…Telmisartan treatment significantly decreased the plaque size (0.05 ± 0.05 vs 0.11 ± 0.08, mm 2 ), macrophage infiltration level (0.02 ± 0.02 vs 0.03 ± 0.02, mm 2 ), lipid deposition level (0.01 ± 0.01 vs 0.02 ± 0.02, mm 2 ), and 99m Tc–annexin A5 accumulation level (1.30 ± 1.09 vs 2.15 ± 1.91, × 10 −6 /g). 99m Tc–annexin A5 accumulation levels in the plaques positively correlated with macrophage infiltration ( r = .69, p < .05) and lipid deposition ( r = .66, p < .05) levels. …”
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Induced Inflammatory and Oxidative Markers in Cerebral Microvasculature by Mentally Depressive Stress by Yuequan Zhu, Yazeed Haddad, Ho Jun Yun, Xiaokun Geng, Yuchuan Ding

“…On day 29, open field tests (OFT) and sucrose preference tests (SPT) were performed to assess depressive-like behaviors for the two groups (n=10/group). Macrophage infiltration into the brain tissue upon stress was analyzed by measuring expression of macrophage marker (CD68) with immunofluorescence in both the CRS and control groups (n=10/group). …”
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Understanding the Activation of Platelets in Diabetes and Its Modulation by Allyl Methyl Sulfide, an Active Metabolite of Garlic by Navya Malladi, Ebin Johny, Shravan K. Uppulapu, Vikas Tiwari, Md Jahangir Alam, Ramu Adela, Sanjay K. Banerjee

“…We observed an inhibitory effect of allyl methyl sulfide on platelet aggregation, platelet activation, platelet macrophage interaction, and increased ROS levels in type 1 diabetes. …”
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Pulmonary Alveolar Proteinosis by Sandeep M Patel, Hiroshi Sekiguchi, Jordan P Reynolds, Michael J Krowka

“…Recent advances in the understanding of the pathophysiology of PAP demonstrate that the idiopathic form is due to antigranulocyte macrophage-colony stimulating factor antibodies. Therapeutic targets that replace granulocyte macrophage colony stimulating factor or remove these antibodies are being actively developed. …”
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A pan-immune panorama of bacterial pneumonia revealed by a large-scale single-cell transcriptome atlas by Kun Xiao, Yan Cao, Zhihai Han, Yuxiang Zhang, Laurence Don Wai Luu, Liang Chen, Peng Yan, Wei Chen, Jiaxing Wang, Ying Liang, Xin Shi, Xiuli Wang, Fan Wang, Ye Hu, Zhengjun Wen, Yong Chen, Yuwei Yang, Haotian Yu, Lixin Xie, Yi Wang

“…Dysregulated neutrophil and macrophage responses contributed significantly to the pathogenesis of severe disease. …”
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Irbesartan Attenuates Atherosclerosis in Watanabe Heritable Hyperlipidemic Rabbits: Noninvasive Imaging of Inflammation by F-Fluorodeoxyglucose Positron Emission Tomography by Yan Zhao, Keita Fukao, Songji Zhao, Ayahisa Watanabe, Tadateru Hamada, Kazuaki Yamasaki, Yoichi Shimizu, Naoki Kubo, Naoyuki Ukon, Toru Nakano, Nagara Tamaki, Yuji Kuge

“…Irbesartan treatment significantly reduced the plaque size (43.1% of controls) and intraplaque macrophage infiltration level (48.1% of controls). The 18 F-FDG uptake level in plaques positively correlated with the plaque size ( r = .65, p < .05) and macrophage infiltration level ( r = .57, p < .05). …”
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Superoxide Dismutase 3 Limits Collagen-Induced Arthritis in the Absence of Phagocyte Oxidative Burst by Tiina Kelkka, Juha Petteri Laurila, Outi Sareila, Peter Olofsson, Mikko Olavi Laukkanen, Rikard Holmdahl

“…The NOX2 complex independent anti-inflammatory effect of SOD3 was further characterized in peritonitis, and SOD3 was found to reduce macrophage infiltration independently of NOX2 complex functionality. …”
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Negative Effects of SIGIRR on TRAF6 Ubiquitination in Acute Lung Injury In Vitro by Feng Tian, Qiang Lu, Jie Lei, Yunfeng Ni, Nianlin Xie, Daixing Zhong, Guang Yang, Shaokui Si, Tao Jiang

“…In this study, the effects of single immunoglobin IL-1 receptor-related protein (SIGIRR) on tumor necrosis factor- (TNF-) receptor-associated factor 6 (TRAF6) ubiquitination in acute lung injury (ALI) were evaluated in both alveolar epithelial cells and alveolar macrophage cells in vitro. Our results found that SIGIRR negatively regulated TRAF6 ubiquitination and such SIGIRR inhibition could enhance the TRAF6 expression in both alveolar epithelial cells (AECs) and alveolar macrophage cells (AMCs). …”
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Targeting NLRP3 Inflammasome Alleviates Synovitis by Reducing Pyroptosis in Rats with Experimental Temporomandibular Joint Osteoarthritis by Yinzi Xin, Wei Wang, Enyu Mao, Hefeng Yang, Song Li

“…Macrophage somehow promoted FLS pyroptosis in this study. …”
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Essential Role of Zinc and Zinc Transporters in Myeloid Cell Function and Host Defense against Infection by Muna Sapkota, Daren L. Knoell

“…In particular, zinc impacts macrophage function, a critical front-line cell in host defense, in addition to other immune cells. …”
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Reliea® combination of Codonopsis lanceolata and Chaenomeles sinensis extract alleviates airway inflammation on particulate matter 10 plus diesel exhaust particles (PM10D) ‑induced... by Yoon-Young Sung, Won-Kyung Yang, Jong Hoon Kim, Dongseok Shin, Seok June Son, Seung-Hyung Kim

“…RelA decreased the expression of interleukin (IL)-17, chemokine (C-X-C motif) ligand (CXCL)-1, thymus and activation-regulated chemokine, macrophage inflammatory protein-2, IL-1α, TNF-α, mucin 5AC, cyclooxygenase-2, and transient receptor potential cation channel subfamily A or V member 1 in BALF and lung, and inhibited IL-1α and macrophage marker F4/80 localization in lung of PM10D-induced mice. …”
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Cordyceps militaris solid medium extract alleviates lipopolysaccharide-induced acute lung injury via regulating gut microbiota and metabolism by Xiaoya Wang, Kang Zhang, Jingyan Zhang, Guowei Xu, Zhiting Guo, Xiaorong Lu, Chunhua Liang, Xueyan Gu, Liping Huang, Shuqi Liu, Lei Wang, Jianxi Li

“…We assessed pulmonary changes, inflammation, oxidative stress, and macrophage and neutrophil activation levels, then we analyzed the gut microbiota through 16S rRNA and analyzed metabolomics profile by UPLC-QTOF/MS. …”
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The Molecular Mechanism of FABP4 Inhibition Effects of GAS and 4-HBA in Gastrodia elata Blume Was Discussed Based on NMR and Molecular Docking by Yuyu Yang, Shihan Liu, Wenfang Jin, Zengyi Qu, Baolei Fan

“…Moreover, 3-phenoxy-2-phenylbenzoic acid (PPA) is a possible inhibitor of FABP4, reducing macrophage-related inflammation and endoplasmic reticulum stress. …”
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Palmitoylethanolamide Is a Disease-Modifying Agent in Peripheral Neuropathy: Pain Relief and Neuroprotection Share a PPAR-Alpha-Mediated Mechanism by L. Di Cesare Mannelli, G. D'Agostino, A. Pacini, R. Russo, M. Zanardelli, C. Ghelardini, A. Calignano

“…Repeated treatments with PEA reduced the presence of oedema and macrophage infiltrate, and a significant higher myelin sheath, axonal diameter, and a number of fibers were observable. …”
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Exercise Training Effects on Inflammatory Gene Expression in White Adipose Tissue of Young Mice by Tracy Baynard, Victoria J. Vieira-Potter, Rudy J. Valentine, Jeffrey A. Woods

“…Exercise training while on the HF diet protected against hepatic steatosis and possibly macrophage infiltration within white adipose tissue. …”
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Chronic Ethanol Feeding Modulates Inflammatory Mediators, Activation of Nuclear Factor-κB, and Responsiveness to Endotoxin in Murine Kupffer Cells and Circulating Leukocytes by Miriam Maraslioglu, Elsie Oppermann, Carolin Blattner, Roxane Weber, Dirk Henrich, Christian Jobin, Elke Schleucher, Ingo Marzi, Mark Lehnert

“…Chronic ethanol abuse is known to increase susceptibility to infections after injury, in part, by modification of macrophage function. Several intracellular signalling mechanisms are involved in the initiation of inflammatory responses, including the nuclear factor-κB (NF-κB) pathway. …”
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Effects of the Glutamine Administration on T Helper Cell Regulation and Inflammatory Response in Obese Mice Complicated with Polymicrobial Sepsis by Chiu-Li Yeh, Li-Han Su, Jin-Ming Wu, Po-Jen Yang, Po-Chu Lee, Po-Da Chen, Chun-Chieh Huang, Der-Yirng Hsieh, Hsueh-Ju Wang, Sung-Ling Yeh, Ming-Tsan Lin

“…Also, expressions of inflammatory cytokines and macrophage infiltration markers in adipose tissues and lungs were elevated. …”
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Enhanced hydrogel loading of quercetin-loaded hollow mesoporous cerium dioxide nanoparticles for skin flap survival by Xiangjun Liu, Yikun Ju, Pu Yang, Naisi Shen, Yunyuan Shao, Anqi Yang, Rui Wu, Lanjie Lei, Bairong Fang

“…In this study, we utilized hollow mesoporous cerium dioxide nanoparticles loaded with quercetin, which were later loaded into a light-cured double cross-linked hydrogel (HQu@BC) and injected into the flap site to activate macrophage reprogramming to maintain local ROS homeostasis and reduce inflammation. …”
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