Adipose Tissue-Specific Deletion of 12/15-Lipoxygenase Protects Mice from the Consequences of a High-Fat Diet by Banumathi K. Cole, Margaret A. Morris, Wojciech J. Grzesik, Kendall A. Leone, Jerry L. Nadler

“…High-fat diet-fed ad-12/15-LO exhibited improved fasting glucose levels and glucose metabolism, and epididymal adipose tissue from these mice exhibited reduced inflammation and macrophage infiltration compared to wild-type mice. …”
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Neuroprotective Effects of Collagen-Glycosaminoglycan Matrix Implantation following Surgical Brain Injury by Jia-Hui Chen, Wei-Cherng Hsu, Kuo-Feng Huang, Chih-Huang Hung

“…Proinflammatory (tumor necrosis factor-alpha (TNF-α), interleukin-6 (IL-6), and NF-κB (nuclear factor kappa-light-chain-enhancer of activated B cells)) and anti-inflammatory (IL-10 and granulocyte-macrophage colony-stimulating factor (GMCSF)) cytokine expression was evaluated by enzyme-linked immunosorbent assays. …”
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Possible Roles of Proinflammatory and Chemoattractive Cytokines Produced by Human Fetal Membrane Cells in the Pathology of Adverse Pregnancy Outcomes Associated with Influenza Viru... by Noboru Uchide, Kunio Ohyama, Toshio Bessho, Makoto Takeichi, Hiroo Toyoda

“…Influenza virus infection induced the mRNA expression of not only the proinflammatory cytokines but also chemoattractive cytokines, such as monocyte chemoattractant protein (MCP)-1, regulated on activation, normal T-cell expressed and secreted (RANTES), macrophage inflammatory protein (MIP)-1β, IL-8, growth-regulated oncogene (GRO)-α, GRO-β, epithelial cell-derived neutrophil-activating protein (ENA)-78, and interferon inducible protein (IP)-10 in cultured chorion cells. …”
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Integrated Single-Cell and RNA Sequencing Analysis Identifies Key Immune Cell and Dendritic Cells Associated Genes Participated in Myocarditis by Qiang Gong, Jianfeng Huang, Qicai Wu

“…Monocytes annotated 3 subclusters including DC, macrophage, and monocytes. Hub genes of Ctss, Mpeg1, Cybb, H2-Ab1, Ly86, CD74, and Lgals3 were highly expressed in monocytes cluster. …”
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Comprehensive Analysis of N6-Methyladenosine RNA Methylation Regulators in the Diagnosis and Subtype Classification of Acute Myocardial Infarction by Xianpei Wang, Ying Wu, Ruoyao Guo, Linwei Zhao, Juanjuan Yan, Chuanyu Gao

“…Importantly, we found that patients with high METTL3 expressions had an increased level of Activated.CD4.T.cell and Type.2.T.helper.cell, while having a decreased level of CD56bright.natural.killer.cell, Macrophage, Monocyte, Natural.killer.cell, and Type.17.T.helper.cell. …”
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Myeloid cell-derived apCAFs promote HNSCC progression by regulating proportion of CD4+ and CD8+ T cells by Feilong Ren, Lin Meng, Shize Zheng, Jiasen Cui, Shaoyi Song, Xing Li, Dandan Wang, Xing Li, Qilin Liu, Wenhuan Bu, Hongchen Sun

“…This transdifferentiation was propelled by the macrophage migration inhibitory factor (MIF), which was secreted by tumor cells and activated the JAK/STAT3 signaling pathway. …”
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A Mutation in IL4RA Is Associated with the Degree of Pathology in Human TB Patients by Christoph Hölscher, Lisa Heitmann, Ellis Owusu-Dabo, Rolf D. Horstmann, Christian G. Meyer, Stefan Ehlers, Thorsten Thye

“…In these mice, the IL-13-mediated increased susceptibility, human-like pathology of collagen deposition around centrally necrotizing granulomas, and alternative macrophage activation were abolished. Together, our genetic association study in human TB patients further supports the assumption that IL-13/IL-4Rα-dependent mechanisms are involved in mediating tissue pathology of human TB.…”
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Additive Effects of Glutathione in Improving Antibiotic Efficacy in HIV–<i>M.tb</i> Co-Infection in the Central Nervous System: A Systematic Review by Leena Nabipur, Michael Mouawad, Vishwanath Venketaraman

“…Results: Preclinical studies showed that GSH improves macrophage antimicrobial function, reduces oxidative stress, and limits <i>Mycobacterium tuberculosis</i> (<i>M.tb</i>) growth. …”
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CpG Oligodeoxynucleotides Inhibit RANKL-Induced Osteoclast Formation by Upregulating A20 Deubiquitinase in RAW 264.7 Cells by Seong-Kyu Kim, Jung-Yoon Choe, Ki-Yeun Park

“…RAW 264.7 cells, a murine monocyte-macrophage cell line, were incubated with or without CpG-ODN in the presence of RANKL. …”
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Dengue Infection and Its Relationship with Evans Syndrome: A Pediatric Case by Ivan Jose Ardila Gomez, Pilar Pérez López, Mónika Rocío Hernández Carreño, Juan Camilo Barrios Torres

“…Dengue is not an exception, and it is able to explain different autoimmune phenomena including macrophage activation. Mechanisms have been described by which an exacerbated response of the disease is triggered through the increase of infected cells, formation of immune complexes, and complement pathway activation, which lead to a cross-reaction of viral antigens with epithelial cells with platelets with subsequent endothelial dysfunction and bleeds. …”
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Investigation of the association between circulating inflammatory proteins and encephalitis risk in Europeans by two-sample Mendelian randomization analysis by Yanwei Liu, Xilong Wang, Qiang Zhao, Jun Wei, Shiqiang Yang

“…Inflammatory factors potentially causally associated with autoimmune encephalitis are C-C motif chemokine 28 levels and Macrophage inflammatory protein 1a levels.ConclusionThis study identifies potential causal effects of certain circulating inflammatory factors on susceptibility to three types of encephalitis. …”
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Promising Therapeutic Functions of Bone Marrow Mesenchymal Stem Cells Derived-Exosome in Asthma by Jia-Ying Yuan, Xiang-Yun Wang, Zhi-Ying Tong, Yu-Chao Dong, Jia-Yi Zhao, Yi Zhang, Yan Shang

“…Points also hold that BMMSC-Exo could interfere with airway inflammation and airway remolding in asthma via modulating the immune response, regulating gene expression, adjusting the phenotype of macrophage, etc. However, BMMSC-Exo still lacked more clinical trials for evaluating the effects on asthma, and the technology of extraction and purification still needs to be improved for wide use. …”
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Effects of growth factors during in vitro culture of mouse and rat embryos by E. Yu. Brusentsev, T. N. Igonina, I. N. Rozhkova, D. S. Ragaeva, S. Ya. Amstislavsky

“…In vitro culture of preimplantation embryos of ICR, HT1AN/Icgn, HT1AC/Icgn and C57BL/6J-Ay mouse strains as well as in OXYS/Icgn rat strain in media containing granulocyte-macrophage colony stimulating factor (GM-CSF) or epidermal growth factor (EGF) has been studied. …”
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Magnetic Resonance Imaging of Contrast-Induced Acute Renal Injury and Related Pathological Alterations In Vivo by Yanfei Li, Dafa Shi, Haoran Zhang, Xiang Yao, Ke Ren

“…Strong correlation may exist between MRI densitometry (T2WI, DTI, and BOLD) and pathology. Neutrophil and macrophage chemotaxis occurred in CI-AKI, and we observed that Ly6G was the strongest at 48 h (P<0.0001). …”
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Nanoparticles containing intracellular proteins modulate neutrophil functional and phenotypic heterogeneity by Leonore Raudszus, Farbod Bahreini, Susanne Allan, Kai-Uwe Kalies, Charles C. Caldwell, Kathrin Kalies

“…For example, neutrophils regulate ongoing inflammation by modulating macrophage function through efferocytosis, T cell responses by antigen presentation and the release of cytokines. …”
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Immunogenicity and vaccine efficacy of Actinobacillus pleuropneumoniae-derived extracellular vesicles as a novel vaccine candidate by Su Hyun Park, Yun Hye Kim, Hyeon Jin Lee, Jeong Moo Han, Byoung-Joo Seo, Gyeong-Seo Park, Chonghan Kim, Young Bae Ryu, Woo Sik Kim

“…Notably, APP-EV immunization enhanced macrophage phagocytosis and improved survival rates in mice challenged with APP infection compared to those treated with Coglapix. …”
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Invariant Natural Killer T Cells as Key Players in Host Resistance against Paracoccidioides brasiliensis by Joes Nogueira-Neto, Flavio V. Loures, Alessandra S. Schanoski, David A. G. Andrade, Michelangelo B. Gonzatti, Tania A. Costa, Bruno C. Vivanco, Patrícia Xander, Daniela S. Rosa, Vera L. G. Calich, Alexandre C. Keller

“…Using splenocytes from CD1d (CD1d-/-) and iNKT-deficient (Jα18-/-) mice, we found that iNKT cells are the innate source of IFN-γ after P. brasiliensis infection and are required to potentiate macrophage oxidative burst and control fungal growth. …”
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Adipocytes from New Zealand Obese Mice Exhibit Aberrant Proinflammatory Reactivity to the Stress Signal Heat Shock Protein 60 by Tina Märker, Jennifer Kriebel, Ulrike Wohlrab, Volker Burkart, Christiane Habich

“…Preadipocytes and mature adipocytes from nonobese diabetic (NOD), New Zealand obese (NZO), and C57BL/6J mice were analyzed for Hsp60 binding, Hsp60-activated signaling pathways, and Hsp60-induced release of the chemokine CXCL-1 (KC), interleukin 6 (IL-6), and macrophage chemoattractant protein-1 (MCP-1). Hsp60 showed specific binding to (pre-)adipocytes of NOD, NZO, and C57BL/6J mice. …”
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The role of lactylation in tumor growth and cancer progression by Khulood Al-Malsi, Khulood Al-Malsi, Khulood Al-Malsi, Sinan Xie, Sinan Xie, Sinan Xie, Yunshi Cai, Yunshi Cai, Yunshi Cai, Nader Mohammed, Kunlin Xie, Kunlin Xie, Kunlin Xie, Tian Lan, Tian Lan, Tian Lan, Hong Wu, Hong Wu, Hong Wu

“…Lactylation, for example, activates genes such as Arg1, which is a hallmark of the M2 macrophage phenotype implicated in immunosuppression and tumor growth. …”
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A Cornflower Extract Containing N-Feruloylserotonin Reduces Inflammation in Human Skin by Neutralizing CCL17 and CCL22 and Inhibiting COX-2 and 5-LOX by Christophe Carola, Andrew Salazar, Christin Rakers, Franck Himbert, Quoc-Tuan Do, Philippe Bernard, Joerg von Hagen

“…Thymus and Activation-Regulated Chemokine (TARC/CCL17) and Macrophage-Derived Chemokine (MDC/CCL22) are two key chemokines exerting their biological effect via binding and activating a common receptor CCR4, expressed at the surface of type 2 helper T (Th2) cells. …”
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