Ex vivo delivery of recombinant IL-10 to human donor lungs by Jonathan C. Yeung, Terumoto Koike, Dirk Wagnetz, Tiago N. Machuca, Riccardo Bonato, Mingyao Liu, Stephen Juvet, Marcelo Cypel, Shaf Keshavjee

“…Conclusions: Gene therapy remains superior as it allows for continued production of IL-10 within the alveoli where it has the potential to continuously act on alveolar macrophages and epithelial cells in a paracrine fashion.…”
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Recovery and Biodistribution of Ex Vivo Expanded Human Erythroblasts Injected into NOD/SCID/IL2Rγnull mice by Barbara Ghinassi, Leda Ferro, Francesca Masiello, Valentina Tirelli, Massimo Sanchez, Giovanni Migliaccio, Carolyn Whitsett, Stefan Kachala, Isabelle Riviere, Michel Sadelain, Anna Rita Migliaccio

“…Ex vivo expanded erythroblasts (EBs) may serve as advanced transfusion products provided that lodgment occurs in the macrophage-niche of the marrow permitting maturation. …”
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Phenazine biosynthesis-like domain-containing protein (PBLD) and Cedrelone promote antiviral immune response by activating NF-ĸB by Peili Hou, Hongchao Zhu, Fengyun Chu, Yan Gao, Xiaonan Sun, Fuzhen Zhang, Xiaomeng Wang, Yueyue Feng, Xingyu Li, Yu Liu, Jun Wang, Xiaoyun Wang, Daniel Chang He, Hongmei Wang, Hongbin He

“…Furthermore, the therapeutic potential of Cedrelone lies in its ability to enhance antiviral immunity in primary macrophages and to promote survival and reduce lung tissue damage in HSV-1-infected mice in a PBLD-dependent manner. …”
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A Peptide Analogue of Selectin Ligands Attenuated Atherosclerosis by Inhibiting Monocyte Activation by Zhishuai Ye, Shanfeng Zhang, Yubo Liu, Shujing Wang, Jianing Zhang, Rongchong Huang

“…In the WTD- and PLCA-induced atherosclerosis models, atherosclerotic plaque formation and monocyte/macrophage infiltration of the arterial wall both decreased in ApoE-/- mice treated with the IELLQAR peptide. …”
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Integrative analysis of 5-methylcytosine associated signature in papillary thyroid cancer by Ying Ding, Xinying Li, Wenlong Wang, Lei Cai

“…CIBERSORT analysis showed Tregs, M0 macrophages, dendritic cells resting, and eosinophils were positively correlated to the risk score. …”
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Capsular polysaccarides of probiotics and their immunomodulatory roles by Jing Li, Saisai Feng, Leilei Yu, Jianxin Zhao, Fengwei Tian, Wei Chen, Qixiao Zhai

“…In turn, they also exhibit immunomodulatory activities, such as strengthening the functions of macrophages, promoting the maturation of antigen-presenting cells, and inducing regulatory T cells. …”
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TLR2 Expression in Relation to IL-6 and IL-1<mml:math alttext="$eta$"> <mml:mi>&#x03B2;</mml:mi> </mml:math> and their Natural Regulators Production by PMN and...

“…<p>Recently, it has been reported that TLR2 on macrophages plays a unique role in the inflammatory response and host defense to infection with <emph>Borrelia burgdorferi</emph> (<emph>Bb</emph>) which is an etiologic agent of Lyme disease. …”
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ROS-Mediated NLRP3 Inflammasome Activity Is Essential for Burn-Induced Acute Lung Injury by Shichao Han, Weixia Cai, Xuekang Yang, Yanhui Jia, Zhao Zheng, Hongtao Wang, Jun Li, Yan Li, Jianxin Gao, Lei Fan, Dahai Hu

“…In the in vitro experiments, we used AMs (alveolar macrophages) challenged with burn serum to mimic the postburn microenvironment and noted that the serum significantly upregulated NLRP3 inflammasome signaling and reactive oxygen species (ROS) production. …”
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Passive infusion of an S2-Stem broadly neutralizing antibody protects against SARS-CoV-2 infection and lower airway inflammation in rhesus macaques. by Christopher T Edwards, Kirti A Karunakaran, Elijah Garcia, Nathan Beutler, Matthew Gagne, Nadia Golden, Hadj Aoued, Kathryn L Pellegrini, Matthew R Burnett, Christopher Cole Honeycutt, Stacey A Lapp, Thang Ton, Mark C Lin, Amanda Metz, Andrei Bombin, Kelly Goff, Sarah E Scheuermann, Amelia Wilkes, Jennifer S Wood, Stephanie Ehnert, Stacey Weissman, Elizabeth H Curran, Melissa Roy, Evan Dessasau, Mirko Paiardini, Amit A Upadhyay, Ian N Moore, Nicholas J Maness, Daniel C Douek, Anne Piantadosi, Raiees Andrabi, Thomas R Rogers, Dennis R Burton, Steven E Bosinger

“…We observed a significant reduction in inflammatory cytokines and macrophages within the lower airway of animals infused with 10mg/kg and 1mg/kg doses of CC40.8. …”
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The Microbiota Determines Susceptibility to Experimental Autoimmune Uveoretinitis by Jarmila Heissigerova, Petra Seidler Stangova, Aneta Klimova, Petra Svozilkova, Tomas Hrncir, Renata Stepankova, Miloslav Kverka, Helena Tlaskalova-Hogenova, John V. Forrester

“…GF mice had lower numbers of infiltrating macrophages and significantly less T cell infiltration in the retina than CV mice with EAU. …”
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Potential Toxicity of the Essential Oil from Minthostachys mollis: A Medicinal Plant Commonly Used in the Traditional Andean Medicine in Peru by Juan Pedro Rojas-Armas, Jorge Luis Arroyo-Acevedo, José Manuel Ortiz-Sánchez, Miriam Palomino-Pacheco, Hugo Jesus Hilario-Vargas, Oscar Herrera-Calderón, Julio Hilario-Vargas

“…In the lung, inflammatory infiltrate was observed, predominantly lymphocytic with severe hemorrhage and presence of macrophages with hemosiderin. In the repeated dose study, male rats (5/5) and female rats (2/5) died at the dose of 500 mg/kg/day. …”
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The Toxoplasma rhoptry protein ROP55 is a major virulence factor that prevents lytic host cell death by Margarida T. Grilo Ruivo, Ji-hun Shin, Todd Lenz, Stephanie Y. Matsuno, Katherine Olivia Yanes, Arnault Graindorge, Maguy Hamie, Laurence Berry-Sterkers, Mathieu Gissot, Hiba El Hajj, Karine G. Le Roch, Melissa B. Lodoen, Maryse Lebrun, Diana Marcela Penarete-Vargas

“…ΔROP55 infection also induced RIPK3-dependent necroptosis in human and mouse primary macrophages. Moreover, ΔROP55 parasites were significantly impaired in virulence in female mice and prevented NF-κB activation and parasite clearance in mBMDM. …”
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“Lung-on-a-chip” as an instrument for studying the pathophysiology of human respiration by Oksana A. Zhukova, Iuliia V. Ozerskaya, Dmitry V. Basmanov, Vsevolod Yu. Stolyarov, Vladimir G. Bogush, Vladimir V. Kolesov, Kirill A. Zykov, Gaukhar M. Yusubalieva, Vladimir P. Baklaushev

“…Depending on the type of LoC (single-, double- and three-channel), the membrane may contain only alveolocytes or alveolocytes combined with other cells — endotheliocytes, fibroblasts, alveolar macrophages or tumor cells. Some LoC models also include proteinic or hydrogel stroma, imitating the pulmonary interstitium. …”
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ISCOM-type matrix from beta-escin and glycyrrhizin saponins by V. Petkov, S. Tsibranska, I. Manoylov, L. Kechidzhieva, K. Ilieva, S. Bradyanova, N. Ralchev, N. Mihaylova, N. Denkov, A. Tchorbanov, S. Tcholakova

“…These particles are successful included into isolated mouse macrophages. Conclusions: Among the variety of generated nanoparticles, the E3-M2 particles demonstrated properties of safe and efficient devices for future vaccine design and antigen targeting to immune system.…”
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An ultrasound-driven PLGA/Zn-KNN hybrid piezoelectric scaffold with direct and immunoregulatory antibacterial activity for bone infection by Yuhao Zheng, Shu Wang, Wenhe Jin, Zhuoxuan Li, Guoju Yang, Xiaoxu Li, Ning Li, Yue Wang, Fan Sheng, Zhiming Song

“…Mechanistic investigation suggested that extracellular matrix ligands and complement and coagulation cascades may have a moderate effect on macrophage phagocytosis. This work highlights potential application methods for fabricating novel antibacterial hybrid piezoelectric scaffolds and engineering macrophages with immunoregulatory antibacterial activity.…”
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Acute and Subchronic Airway Inflammation after Intratracheal Instillation of Quartz and Titanium Dioxide Agglomerates in Mice by Martin Roursgaard, Keld A. Jensen, Steen S. Poulsen, Niels-Erik V. Jensen, Lars K. Poulsen, Maria Hammer, Gunnar D. Nielsen, Søren T. Larsen

“…At the nano-size rutile and amorphous TiO2, subchronic lung inflammation was apparent from a dose-dependent increase in BALF macrophages. Histology showed little inflammation overall. …”
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Interleukin-18 Expression Increases in the Aorta and Plasma of Patients with Acute Aortic Dissection by Haiying Hu, Guangtai Zhang, Huanli Hu, Wenjing Liu, Jixiang Liu, Shuanli Xin, Xiufeng Zhao, Liying Han, Liping Duan, Xinshun Huang, Chao Chang

“…IL-18 may participate in AD by regulating macrophage differentiation and macrophage-induced SMC apoptosis.…”
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Anti-Neuroinflammatory Effects of Prenylated Indole Alkaloids from the Antarctic Fungus <i>Aspergillus</i> sp. Strain SF-7367 by Zhiming Liu, Chi-Su Yoon, Thao Quyen Cao, Hwan Lee, Il-Chan Kim, Joung Han Yim, Jae Hak Sohn, Dong-Sung Lee, Hyuncheol Oh

“…Secondary metabolites of SF-7367 were isolated using high-performance liquid chromatography followed by validation of their anti-inflammatory effects in lipopolysaccharide-stimulated BV2 microglia and RAW264.7 macrophages. Chemical analysis of metabolites from the fungal strain revealed five known compounds: epideoxybrevianamide E (<b>1</b>), brevianamide V/W (<b>2</b>), brevianamide K (<b>3</b>), brevianamide Q (<b>4</b>), and brevianamide R (<b>5</b>). …”
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High-Affinity Anti-VISTA Antibody Protects against Sepsis by Inhibition of T Lymphocyte Apoptosis and Suppression of the Inflammatory Response by Tianzhu Tao, Lulong Bo, Teng Li, Longbao Shi, Hui Zhang, Bo Ye, Yuhai Xu, Qingqing Ma, Xiaoming Deng, Guorong Zhang

“…Expression profiles of VISTA on T lymphocytes and macrophage were examined at 24 and 72 h postsurgery. …”
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CCR2 signaling regulates anti-chlamydia T cell immune responses in the airway. by Shuaini Yang, Jinxi Yu, Xue Dong, Jiajia Zeng, Lu Tan, Hong Zhang, Ruoyuan Sun, Yuqing Tuo, Jing Yang, Chunxiao Wan, Hong Bai

“…CCR2, a member of the G protein-coupled receptor (GPCR) superfamily, is widely expressed on monocytes, macrophages, activated T cells, and other cell types, and plays a critical role in coordinating the immune response to various infections. …”
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