Investigation of CD47 Expression in Renal Cell Tumors and Evaluation of Its Relationship with Prognostic Parameters by Ömer Faruk Dizibüyük, Zehra Bozdağ, Metin Karakök

“…The interaction of CD47 with SIRPα triggers a “don’t eat me” signal to the macrophages, inhibiting phagocytosis. Much progress has been made in targeting CD47 for cancer immunotherapy in solid tumors (STs) and hematological malignancies. …”
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Maternal Hypertension and Early Atherosclerotic Lesions in Aortas of Deceased Fetuses and Neonates by Janet María Capote-Santa Cruz Pacheco, Carmen Teresa Peraza Méndez, Marlene Ferrer Arrocha, Lisandra Álvarez de la Nuez, Belkis Ortega de la Campa, Mirian Castro Ortega

“…<br /><strong>Results:</strong> of the total number of deceased studied, 70.6 % presented early atherosclerotic lesions, characterized by thickening of the intima as a cushion, presence of lymphocytes in the intima or in the arterial wall close to it and/or macrophages. In some cases, one of these histological variants was observed and in others a combination of two or three. …”
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Microvesicles Derived from Human Umbilical Cord Mesenchymal Stem Cells Enhance Alveolar Type II Cell Proliferation and Attenuate Lung Inflammation in a Rat Model of Bronchopulmonar... by Ou Zhou, Jingyi You, Xiaochuan Xu, Jiang Liu, Huijun Qiu, Chang Hao, Wenjing Zou, Wenjie Wu, Zhou Fu, Daiyin Tian, Lin Zou

“…Furthermore, MVs were large vesicles with a diameter of 100-900 nanometers and mostly uptaken by alveolar epithelial type II cells (AT2) and macrophages. Compared with the LPS-exposed group, MVs restored the AT2 cell number and SP-C expression in vivo and promoted the proliferation of AT2 cells in vitro. …”
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Rac1-dependent regulation of osteoclast and osteoblast differentiation by developmentally regulated GTP-binding 2 by Jung Ha Kim, Semun Seong, Kabsun Kim, Inyoung Kim, Jeong Woo Park, Jeong-Tae Koh, Nacksung Kim

“…Downregulation of Drg2 using siRNA in bone marrow-derived macrophages inhibited osteoclast differentiation and function and Rac1 activation in vitro. …”
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Functional analysis of the type II toxin-antitoxin system ParDE in Streptococcus suis serotype 2 by Qibing Gu, Xiayu Zhu, Jiale Ma, Tao Jiang, Zihao Pan, Huochun Yao

“…ΔparDE also exhibited a reduced anti-oxidative stress ability, and ΔparDE was more susceptible to phagocytosis and killing by macrophages. Moreover, the biofilm formation ability of the ΔparDE strain was significantly enhanced compared to ZY05719. …”
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Hemophagocytic Lymphohistiocytosis in a Patient with Classical Hodgkin Lymphoma by G. Hyun, K. J. Robbins, N. Wilgus, L. Grosso, S. D. Goyal

“…Though the pathogenesis is not fully known, HLH is understood to be a reactive process in the setting of uncontrolled activation of macrophages, CD8+ cytotoxic lymphocytes, and other immune cells. …”
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How to Translate Basic Knowledge into Clinical Application of Biologic Therapy in Spondyloarthritis by Chung-Tei Chou

“…Any drug including anti-TNFα blocker which can downregulate the TCR, infiltrated neutrophils, or CD163+ macrophages in the synovial tissue is the rationale for the management of SpA. …”
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Structural Brain Changes Associated with Overweight and Obesity by Erick Gómez-Apo, Alejandra Mondragón-Maya, Martina Ferrari-Díaz, Juan Silva-Pereyra

“…Mechanisms of volume reduction are unknown, and neuroinflammation caused by obesity is likely to induce neuronal loss. Adipocytes, macrophages of the adipose tissue, and gut dysbiosis in overweight and obese individuals result in the secretion of the cytokines and chemokines that cross the blood-brain barrier and may stimulate microglia, which in turn also release proinflammatory cytokines. …”
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Fluid flow impacts endothelial-monocyte interactions in a model of vascular inflammatory fibrosis by Isabelle Linares, Kaihua Chen, Ava Saffren, Mehran Mansouri, Vinay V. Abhyankar, Benjamin L. Miller, Stefano Begolo, Hani A. Awad, James L. McGrath

“…The addition of tissue macrophages to the tendon compartment further increased the degree of circulating monocyte infiltration into the tissue matrix. …”
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Chronic exposure to diesel engine exhaust and alteration of the airway bacteriome by Menghui Jiang, Yongwei Yan, Tao Wang, Bojia Wang, Yanting Li, Jinglong Tang, Yuxin Zheng

“…Furthermore, the Spearman analysis indicated notable correlations of specific species with carbon content in airway macrophages (CCAM), club cell protein (CC16), FVC and FEV1. …”
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Implementation Nutrigenomic of Vitamin D in Periodontitis by Hervina Hervina, I Dewa Made Sukrama, I Made Jawi

“…The anti-microbial effect of vitamin D results from the binding of 1,25(OH)2D3 with VDR which then induces cAMP, b-def-2 and b-def-3 peptides by macrophages, monocytes, gingival epithelium and periodontal ligament epithelium. …”
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LysR-Type Transcriptional Regulator VirR Responds to Temperature and pH and Directly Activates the Transcription of virS-Containing Operon in Rhodococcus equi by Tsutomu Kakuda, Takashi Sato, Mari Takuhara, Hirofumi Hagiuda, Yasunori Suzuki

“…Rhodococcus equi—a facultative intracellular pathogen of macrophages—causes bronchopneumonia in foals and patients who are immunocompromised. …”
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Markers of Inflammation and Fibrosis in the Orbital Fat/Connective Tissue of Patients with Graves’ Orbitopathy: Clinical Implications by Przemyslaw Pawlowski, Joanna Reszec, Anja Eckstein, Kristian Johnson, Andrzej Grzybowski, Lech Chyczewski, Janusz Mysliwiec

“…No expression of COX2 was found in patients with GO. Conclusions. Macrophages and CD4 T lymphocytes are both engaged in the active/severe and long stage of inflammation in the orbital tissue. …”
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Impaired Healing of a Cutaneous Wound in an Inducible Nitric Oxide Synthase-Knockout Mouse by Takashi Kitano, Hiroshi Yamada, Maki Kida, Yuka Okada, Shizuya Saika, Munehito Yoshida

“…Population of granulation tissue-related cell types, that is, myofibroblasts and macrophages, growth factor expression, and reepithelialization were evaluated. …”
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Effects of Repeated Cisplatin and Monosodium Glutamate on Visceral Sensitivity in Rats by Yolanda López-Tofiño, Laura López-Gómez, Marta Martín-Ruíz, Jose Antonio Uranga, Kulmira Nurgali, Gema Vera, Raquel Abalo

“…On week 6, compared with the control, cisplatin (with or without MSG) did not modify the colonic infiltration of eosinophils, macrophages, neutrophils, or mast cells. Although MSG seems to be useful in ameliorating some of the adverse effects of cisplatin, such as gastrointestinal motility disturbances or neuropathic pain, it does not alleviate visceral pain.…”
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Targeting fucosyltransferase FUT8 as a prospective therapeutic approach for DLBCL by Hao Xu, Qi Li, Yuchen Zhang, Chuan He, Xinyun Zhang, Zhiming Wang, Meifang Zhao, Yali Chai, Wenzhuo Zhuang, Bingzong Li

“…Additionally, morusinol’s ability to hinder M2-like polarization of tumor-associated macrophages suggested its potential in immune response modulation within DLBCL. …”
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Patient with Jaundice, Dyspnea and Hyperferritinemia after COVID-19 by V. R. Grechishnikova, P. E. Tkachenko, M. S. Zharkova, T. P. Nekrasova, V. T. Ivashkin

“…Liver biopsy was performed, morphological study revealed signs of “vanishing bile duct” syndrome, excessive activation of macrophages and hemosiderosis of sinusoidal cells. Identified lesions can be found in hemophagocytic lymphohistiocytosis (HLH), a life-threatening complication of coronavirus infection. …”
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Dulaglutide Protects Mice against Diabetic Sarcopenia-Mediated Muscle Injury by Inhibiting Inflammation and Regulating the Differentiation of Myoblasts by Fengyi Deng, Wenyan Wu, Xingyu Fan, Xing Zhong, Nuojin Wang, Yue Wang, Tianrong Pan, Yijun Du

“…Mouse muscle tissues were then pathologically evaluated and stained with F4/80 or MPO to detect macrophages and neutrophils, respectively. In addition, inflammatory factors and FNDC5 in the muscle tissues were detected using qRT-PCR. …”
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Sodium butyrate attenuate hyperglycemia-induced inflammatory response and renal injury in diabetic mice by Yan Man, Zhang Yan-Yan, Xi Yue, Ding Long-Kun, Sun Chang, Qu Li-Juan, Qian Xin, Xu Jing-Wen, Sun Wen, Wu Liang

“…The activation of the monocyte-macrophage system and the damage to the renal and pancreatic tissue are common complications in patients with diabetes induced by hyper-glycemia. …”
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The Antimalarial Chloroquine Suppresses LPS-Induced NLRP3 Inflammasome Activation and Confers Protection against Murine Endotoxic Shock by Xiaoli Chen, Ning Wang, Yuanfeng Zhu, Yongling Lu, Xin Liu, Jiang Zheng

“…CQ attenuated NF-κB and MAPK activation and prohibited expression of IL-1β, IL-18, and Nlrp3 in LPS treated murine bone marrow-derived macrophages (BMDMs), demonstrating its inhibitory effect on the priming signal of NLRP3 activation. …”
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