Genetic diversity leads to differential inflammatory responses to cigarette smoke in mice by Md Imam Faizan, Gagandeep Kaur, Sadiya Bi Shaikh, Felix Effah, Hoshang Unwalla, Irfan Rahman

“…The study involves a comprehensive approach, including BALF cytokine analysis, evaluation of lung tissue architecture, assessment of macrophages and its associated proteins (MMP9 & MMP12) abundance. …”
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Cysteinyl Leukotriene Receptor-1 Antagonists as Modulators of Innate Immune Cell Function by A. J. Theron, H. C. Steel, G. R. Tintinger, C. M. Gravett, R. Anderson, C. Feldman

“…Cysteinyl leukotrienes (cysLTs) are produced predominantly by cells of the innate immune system, especially basophils, eosinophils, mast cells, and monocytes/macrophages. Notwithstanding potent bronchoconstrictor activity, cysLTs are also proinflammatory consequent to their autocrine and paracrine interactions with G-protein-coupled receptors expressed not only on the aforementioned cell types, but also on Th2 lymphocytes, as well as structural cells, and to a lesser extent neutrophils and CD8+ cells. …”
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Active Ingredients and Potential Mechanism of Additive Sishen Decoction in Treating Rheumatoid Arthritis with Network Pharmacology and Molecular Dynamics Simulation and Experimenta... by Ren J, Liu Z, Qi X, Meng X, Guo L, Yu Y, Dong T, Li Q

“…Jinhong Ren, Ze Liu, Xiaoming Qi, Xiangda Meng, Linglin Guo, Yating Yu, Tao Dong, Qingshan Li Shanxi Key Laboratory of Innovative Drug for the Treatment of Serious Diseases Basing on the Chronic Inflammation, College of Traditional Chinese Medicine and Food Engineering, Shanxi University of Chinese Medicine, Jinzhong, People’s Republic of ChinaCorrespondence: Qingshan Li, Email sxlqs0501@sxtcm.edu.cnBackground: Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disease in which macrophages produce cytokines that enhance inflammation and contribute to the destruction of cartilage and bone. …”
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CD163, a novel receptor for TNF, was revealed in situ by proximity ligation assay by Alexandre Cousin, Myriam Oger, Aymar de Jenlis, Audrey Lejart, Laure Barbier, Diane Riccobono, Xavier Holy, Anne-Laure Favier, Krisztina Nikovics

“…Furthermore, the combination of immunolabeling and PLA offered additional insights, particularly, the internalization of TNF following its binding with CD163 in macrophages. Our work focused on in situ interactions of TNF with macrophages TNF receptors and suggested exciting perspectives for further understanding and application of cytokine-based therapies.…”
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The tryptophan-aspartate (WD) repeat domain of bovine Coronin-1A promotes mycobacterial survival by inhibiting calcium signaling-mediated phagosome-lysosome fusion by Jing Yang, Zhunan Li, Aicong Li, Yayi Liu, Xinyan Zhang, Yong Zhang, Yuanpeng Gao

“…Overall, our findings revealed that bCoronin-1A had a critical impact on mycobacterial survival in macrophages by inhibiting calcium-mediated phagosome-lysosome fusion. …”
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Oncolytic vaccinia virus armed with anti-CD47 nanobody elicit potent antitumor effects on multiple tumor models via enhancing innate and adoptive immunity by Jie Chen, Liu Yang, Mengyuan Li, Qian Ye, Shibing Wang, Zengpeng Li, Wenbin Qian

“…Furthermore, treatment with OVV-αCD47nb also remodeled the TME, as shown by increased T cell infiltration, CD8+ T cell activation and tumor-associated macrophages polarization, significantly enhancing innate and adoptive immunity. …”
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Role of TNF-Alpha, IFN-Gamma, and IL-10 in the Development of Pulmonary Tuberculosis by Yone Vila Nova Cavalcanti, Maria Carolina Accioly Brelaz, Juliana Kelle de Andrade Lemoine Neves, José Candido Ferraz, Valéria Rêgo Alves Pereira

“…IFN-gamma is the main cytokine involved in the immune response against mycobacteria, and its major function is the activation of macrophages, allowing them to exert its microbicidal role functions. …”
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Mechanistic insights into pachymic acid’s action on triple-negative breast Cancer through TOP2A targeting by Ming Liu, Li Zheng, Yang Zhang, Jinhui Tian

“…PA probably exert its therapeutic effects through the tumor immune microenvironment, involving elements such as Dendritic cells activated, Eosinophils, Macrophages M0, Macrophages M1, and T cells CD4 memory activated. …”
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Peptidoglycan-Like Components in Z-100, Extracted from Mycobacterium tuberculosis Strain Aoyama B, Increase IL-12p40 via NOD2 by Takayuki Horii, Yuki Orikawa, Yuta Ohira, Runa Eta, Uiko Tominaga, Takanori Sato, Takao Tanaka

“…Mouse bone marrow-derived cells and CD14+ cells were cultured in the presence of granulocyte-macrophage colony-stimulating factor, differentiated into macrophage-like cells, and then stimulated with Z-100. …”
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The impaired response of nasal epithelial cells to microplastic stimulation in asthma and COPD by Magdalena Paplińska-Goryca, Paulina Misiukiewicz-Stępień, Monika Wróbel, Katarzyna Mycroft-Rzeszotarska, Dorota Adamska, Julia Rachowka, Milena Królikowska, Krzysztof Goryca, Rafał Krenke

“…This study aimed to evaluate the biological effects of polyamide fibres on nasal epithelium co-cultivated with macrophages in control, asthma, and COPD groups. Nasal epithelial cells alone or in co-culture with monocyte-derived macrophages were exposed to polyamide fibres for 48 h. …”
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Expression and prognostic value of ferritinophagy-related NCOA4 gene in low-grade glioma: integration of bioinformatics and experimental validation by Guangtang Chen, Xueping Shi, Rukai Jiao, Jiacai Qian, Xiaolin Du, Jian Liu, Xi Zeng

“…Multivariate Cox regression identified NCOA4, age, CD8 T cells, and macrophages as LGG independent prognostic factors (all p < 0.05). …”
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Positive feedback loop involving AMPK and CLYBL acetylation links metabolic rewiring and inflammatory responses by Wenke Wang, Boquan Wu, Mingjun Hao, Sichong Chen, Ruiting Cong, Wenjie Wu, Pengbo Wang, Qiaoyi Zhang, Pengyu Jia, Yuequn Song, Bo Liu, Siyao Qu, Jian-Fei Pei, Da Li, Naijin Zhang

“…Abstract Metabolic rewiring underlies effective macrophages defense to respond disease microenvironment. …”
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Differential Proliferative Characteristics of Alveolar Fibroblasts in Interstitial Lung Diseases: Regulative Role of IL-1 and PGE2 by Elizabeth Fireman, Shlomo Ben Efraim, Joel Greif, Hava Peretz, Shmuel Kivity, Marcel Topilsky, Yosef Rodrig, A. Yellin, Ron N. Apte

“…Similarly, alveolar macrophages (AM) derived supernatant, obtained from CO, did not suppress the proliferation of SA and HP Fb. …”
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Downregulation of the Proinflammatory State of Circulating Mononuclear Cells by Short-Term Treatment with Pioglitazone in Patients with Type 2 Diabetes Mellitus and Coronary Artery... by Andreas Pfützner, Alexander Weise, Elisabeth Pfützner-Riehn, Georg Lübben, Michael Morcos, Efstrathios Karagiannis, Matthias Weber, Thomas Forst

“…Protein risk marker levels (hsCRP, MMP-9, MCP-1, etc.) and the expression of NFκB subunits and NFκB-modulated cytokines from isolated peripheral monocyte/macrophages were determined at baseline and endpoint. …”
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Nε-Carboxymethyl-Lysine Negatively Regulates Foam Cell Migration via the Vav1/Rac1 Pathway by Zhengyang Bao, Lili Zhang, Lihua Li, Jinchuan Yan, Qiwen Pang, Zhen Sun, Yue Geng, Lele Jing, Chen Shao, Zhongqun Wang

“…Background. Macrophage-derived foam cells play a central role in atherosclerosis, and their ultimate fate includes apoptosis, promotion of vascular inflammation, or migration to other tissues. …”
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It’s about TIME – Gal-9 as a potential immunotherapeutic target in pancreatic ductal adenocarcinoma by Christin Knickmeier, Gaetan Aime Noubissi Nzeteu, Bernhard F. Gibbs, Frederik J. H. Hoogwater, Maarten W. Nijkamp, Maximilian Bockhorn, N. Helge Meyer

“…Gal-9 significantly contributes to the immunosuppressive milieu of PDAC by interacting with various immune cells, such as T cells, macrophages, and myeloid-derived suppressor cells (MDSCs). …”
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Lunasin protease inhibitor concentrate decreases pro-inflammatory cytokines and improves histopathological markers in dextran sodium sulfate-induced ulcerative colitis by Andrea Nieto-Veloza, Zhihong Wang, Qixin Zhong, Doris D’Souza, Hari B. Krishnan, Vermont P. Dia

“…First, an in vitro test was performed in lipopolysaccharide (LPS)-activated RAW264.7 murine macrophages by measuring the production of nitric oxide (NO), interleukin-6 (IL-6), and tumor necrosis factor α (TNF-α) as inflammatory markers. …”
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Locally administered liposomal drug depot enhances rheumatoid arthritis treatment by inhibiting inflammation and promoting cartilage repair by Zongquan Zhang, Guan Wang, Zhuo Zhang, Xiaoya Liang, Guoshuang Wang, Maochang Xu, Xi Yang, Xiaolin Zhong, Chunhong Li, Meiling Zhou

“…Abstract Rheumatoid arthritis (RA) is a chronic autoimmune condition characterized by synovial hyperplasia, where inflammatory macrophages within the joint synovium produce multiple inflammatory cytokines, leading to cartilage damage. …”
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Prevention of Cyclophosphamide-Induced Immunosuppression in Mice with the Antimicrobial Peptide Sublancin by Shuai Wang, Shuo Huang, Qianhong Ye, Xiangfang Zeng, Haitao Yu, Desheng Qi, Shiyan Qiao

“…In normal mice, the phagocytic activity of mouse peritoneal macrophages was significantly enhanced by oral administration of sublancin (1.0 mg/kg body weight) to BALB/c mice for 7 days (P<0.01). …”
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Promiscuous Chemokine Antagonist (BKT130) Suppresses Laser-Induced Choroidal Neovascularization by Inhibition of Monocyte Recruitment by Shira Hagbi-Levi, Michal Abraham, Liran Tiosano, Batya Rinsky, Michelle Grunin, Orly Eizenberg, Amnon Peled, Itay Chowers

“…Mononuclear phagocytes, including monocytes and their tissue descendants, macrophages, have long been implicated in the pathogenesis of neovascular AMD (nvAMD). …”
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