Impairments of Antigen-Presenting Cells in Pulmonary Tuberculosis by Ludmila V. Sakhno, Ekaterina Ya. Shevela, Marina A. Tikhonova, Sergey D. Nikonov, Alexandr A. Ostanin, Elena R. Chernykh

“…The phenotype and functional properties of antigen-presenting cells (APC), that is, circulating monocytes and generated in vitro macrophages and dendritic cells, were investigated in the patients with pulmonary tuberculosis (TB) differing in lymphocyte reactivity to M. tuberculosis antigens (PPD-reactive versus PPD-anergic patients). …”
Get full text

Changes in IL-16 Expression in the Ovary during Aging and Its Potential Consequences to Ovarian Pathology by Jessica Ramirez, Pincas Bitterman, Sanjib Basu, Animesh Barua

“…Similar patterns were also observed for macrophages. Expression of miR-125a-5p decreased significantly (P<0.001) with the increase in IL-16 expression during aging. …”
Get full text

Skin Cell and Tissue Responses to Cross-Linked Hyaluronic Acid in Low-Grade Inflammatory Conditions by Benjamin Sanchez, Sandra Ferraro, Audrey Josset-Lamaugarny, Aurélie Pagnon, Charlie K. Hee, Lauren Nakab, Dominique Sigaudo-Roussel, Bérengère Fromy

“…Endothelial cells and fibroblasts were preconditioned using inflammatory medium produced by M1 macrophages. 24 h after LMW-HA fragments and HA stimulation, no cytokine was released in these preconditioned cells. …”
Get full text

CD24 is expressed in HNSCC and is correlated with a dampened immune response by Deborah C. Schubert, Marvin Hürter, Dimo Dietrich, Sebastian Strieth, Peter Brossart, Peter Altevogt, Christine Sanders, Glen Kristiansen

“…Purpose:: Recently, CD24 on tumor cells was identified as a phagocytic inhibitor contributing to an immunosuppressive tumor microenvironment via binding to Siglec-10 on macrophages. Head and neck squamous cell carcinoma (HNSCC) are highly immunogenic tumors, but little is known about the expression of CD24 in HNSCC. …”
Get full text

The SGLT-2 Inhibitor Dapagliflozin Has a Therapeutic Effect on Atherosclerosis in Diabetic ApoE−/− Mice by Weiling Leng, Xinshou Ouyang, Xiaotian Lei, Mingxia Wu, Liu Chen, Qinan Wu, Wuquan Deng, Ziwen Liang

“…The effects of dapagliflozin on the IL-1β production in culturing primary macrophages of wild type and NLRP3−/− knockout mice were investigated for mechanism analyses. …”
Get full text

Role of autophagy defects and significance of adherent-invasive <i>Escherichia coli</i> in Crohn's disease development by I. V. Mayev, D. N. Andreev, D. V. Rakitina, Yu. P. Baykova

“…This phenotype of microorganisms has capacity of adhesion to mucosal epithelial cells, invasion, and active replication inside macrophages. In patients with genetic predisposition AIEC replication in macrophages at reduced clearance of microorganisms due to alteration of autophagy process can induce the unsound immune response with development inflammatory changes characteristic for CD.Conclusion. …”
Get full text

The Role of Oxidized Low-Density Lipoproteins in Atherosclerosis: The Myths and the Facts by Giuseppe Maiolino, Giacomo Rossitto, Paola Caielli, Valeria Bisogni, Gian Paolo Rossi, Lorenzo A. Calò

“…Experimental data carried out in cellular lines and animal models of atherosclerosis support the proatherogenic role of oxidized LDLs: (a) through chemotactic and proliferating actions on monocytes/macrophages, inciting their transformation into foam cells; (b) through stimulation of smooth muscle cells (SMCs) recruitment and proliferation in the tunica intima; (c) through eliciting endothelial cells, SMCs, and macrophages apoptosis with ensuing necrotic core development. …”
Get full text

Induced sputum is a reproducible method to assess airway inflammation in asthma by Elena Bacci, Silvana Cianchetti, Stefano Carnevali, Maria Laura Bartoli, Federico L. Dente, Antonella Di Franco, Daniele Giannini, Barbara Vagaggini, Pier Luigi Paggiaro

“…Detectable differences were 5.5% for macrophages, 0.6% for lymphocytes, 5.2% for neutrophils, and 3.0% for eosinophils. …”
Get full text

Antimicrobial, Anti-Inflammatory, Antiparasitic, and Cytotoxic Activities of Laennecia confusa by María G. Martínez Ruiz, Melissa Richard-Greenblatt, Zaida N. Juárez, Yossef Av-Gay, Horacio Bach, Luis R. Hernández

“…All bioactive extracts and fractions assayed were also found to be cytotoxic to macrophages. In addition, the hexane and methane extracts show anti-inflammatory activity by suppressing the secretion of interleukine-6.…”
Get full text

Loss of PKM2 dysregulates inflammatory signaling in the infarcted murine heart by Katie C. Y. Lee, Allison L. Williams, Akitoshi Hara, Vedbar S. Khadka, Jeffrey Hayashi, Ralph V. Shohet

“…Immunohistochemistry revealed greater abundance of macrophages in PKM2−/− hearts prior to MI, with a small increase in CD86+ macrophages in PKM2−/− infarcted hearts. …”
Get full text

Study of the effect of azithromycin on airway remodeling in asthma via the SAPK/JNK pathway by Dannv Ma, Huaqing Du, Yi Huang, Aiwu Pan, Lu Gan

“…The numbers of inflammatory cells, macrophages, eosinophils, neutrophils and lymphocytes in bronchoalveolar lavage fluid (BALF) were detected by Diff-Quik staining. …”
Get full text

Siglec-E augments adipose tissue inflammation by modulating TRAF3 signaling and monocytic myeloid-derived suppressor cells during obesity by Ahmed Rakib, Mousumi Mandal, Md Abdullah Al Mamun, Sonia Kiran, Nelufar Yasmen, Lexiao Li, Daniel M. Collier, Jianxiong Jiang, Frank Park, Udai P. Singh

“…Immune cells, including macrophages, T cells, and neutrophils, infiltrate the AT and secrete proinflammatory cytokines to exacerbate the AT inflammation. …”
Get full text

Overcoming immunosuppression in cancer: how ketogenic diets boost immune checkpoint blockade by Victoria E. Stefan, Daniela D. Weber, Roland Lang, Barbara Kofler

“…In contrast, immune-suppressive cells such as regulatory CD4+ T lymphocytes, M2 macrophages, and myeloid-derived suppressor cells were reported to be decreased or largely unaffected in tumors of KD-fed mice. …”
Get full text

Generalized actinobacillosis in a cow by Enver Beytut, Mehmet Tuzcu

“…Microscopical examination revealed that the granulomas were characterized by colonies of bacteria surrounded by radially arranged projections in the center of neutrophil leucocyles which were again surrounded by macrophages and giant cells of Langhans type with outer fibrous capsule including lymphocyte and plasma cells. …”
Get full text

Comprehensive analysis of scRNA-seq and bulk RNA-seq reveals the non-cardiomyocytes heterogeneity and novel cell populations in dilated cardiomyopathy by Siyu He, Chunyu Li, Mingxin Lu, Fang Lin, Sangyu Hu, Junfang Zhang, Luying Peng, Li Li

“…Additionally, two subpopulations of M2 macrophages, M2-like1 and M2-like2, were identified with distinct features. …”
Get full text

STING agonism overcomes STAT3-mediated immunosuppression and adaptive resistance to PARP inhibition in ovarian cancer by Changli Qian, Gordon J Freeman, Tao Jiang, Ursula Matulonis, Ziying Lin, Hye-Jung Kim, Anniina Färkkilä, Hua Yu, Xin Cheng, Panagiotis A Konstantinopoulos, Antons Martincuks, Joyce F Liu, Qiwei Wang, Liya Ding, Michael J Kearns, Shaozhen Xie, Inga-Maria Launonen, Thomas M Roberts, Jean J Zhao

“…STAT3 ablation in tumor cells mitigates polarization of protumor macrophages and increases tumor-infiltrating T cells on PARP inhibition. …”
Get full text

Plateau hypoxia improves tumor immune microenvironment and inhibits subcutaneous tumor growth of colorectal cancer by ZHAO Sijie, WANG Meng, GAO Yuan

“…Flow cytometry was used to determine the percentages of macrophages， T lymphocytes， IFN-γ+ T lymphocytes， and myeloid-derived suppressor cells （MDSC）. …”
Get full text

A detoxified TLR4 agonist inhibits tumour growth and lung metastasis of osteosarcoma by promoting CD8+ cytotoxic lymphocyte infiltration by Ryunosuke Oyama, Akira Nabeshima, Makoto Endo, Alexey Novikov, Toshifumi Fujiwara, Capucine Phelip, Nobuhiko Yokoyama, Yoshinao Oda, Martine Caroff, Yoshihiro Matsumoto, Jerome Kerzerho, Yasuharu Nakashima

“…Lipo-MP-LPS promoted CD8+ T cells and M1 macrophages infiltration in primary tumours and CD8+ T cells in metastases, with an M1-phenotype macrophage shift. …”
Get full text

Hepatoprotective Role of 4-Octyl Itaconate in Concanavalin A-Induced Autoimmune Hepatitis by Wenchang Yang, Yaxin Wang, Peng Zhang, Tao Wang, Chengguo Li, Xin Tong, Xiangyu Zeng, Yuping Yin, Kaixiong Tao, Ruidong Li

“…In addition, OI inhibited Con A-induced activation of nuclear factor-kappa B (NF-𝜅B) and the expression of proinflammatory cytokines in macrophages. Therefore, OI protected mice from Con A-induced liver damage and may be associated with Nrf2 activation and NF-𝜅B inhibition. …”
Get full text

The immune-related gene CD5 is a prognostic biomarker associated with the tumor microenvironment of breast cancer by Yi Zhao, Hengheng Zhang, Wenwen Wang, Guoshuang Shen, Miaozhou Wang, Zhen Liu, Jiuda Zhao, Jinming Li

“…TIC analysis showed that CD5 expression was positively correlated with the infiltration of CD8+ T cells, activated memory CD4+ T cells, gamma delta T cells, and M1 macrophages and negatively correlated with the infiltration of M2 macrophages. …”
Get full text