Successful Tocilizumab Therapy for Macrophage Activation Syndrome Associated with Adult-Onset Still’s Disease: A Case-Based Review by Eri Watanabe, Hitoshi Sugawara, Takeshi Yamashita, Akira Ishii, Aya Oda, Chihiro Terai

“…We report the case of a 71-year-old Japanese woman with adult-onset Still’s disease (AOSD) in whom macrophage activation syndrome (MAS) developed despite therapy with oral high-dose prednisolone and intravenous methylprednisolone pulse therapy twice. …”
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Cathepsin C Is Involved in Macrophage M1 Polarization via p38/MAPK Pathway in Sudden Cardiac Death by Jialin Dai, Jiangjin Liu, Qiong Zhang, Yang An, Bing Xia, Changwu Wan, Yuanyuan Zhang, Yanni Yu, Jie Wang

“…Besides, CTSC regulated macrophage polarization to M1 through the FAK-induced p38/MAPK signaling pathway. …”
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Analysis of the effect of ALA-PDT on macrophages in footpad model of mice infected with Fonsecaea monophora based on single-cell sequencing by Chen Wenyi, Wu Xuelin, Yaqoob Muhammad Danish, Liu Kangxing, Hu Yanqing, Ke Xiuling, Hu Yongxuan

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Knockdown of PTEN promotes colon cancer progression and induces M2 macrophage polarization in the colon cancer cell environment by Xu Han, Ting Yan, Lina Wang, Bin He, Huaxu Yu

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M2-like macrophage-derived exosomes inhibit osteoclastogenesis via releasing miR-1227-5p by Shan Chen, Jian Liu, Lilei Zhu

Subjects: “…M2 macrophage…”
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Pancreatic Acinar Cells Employ miRNAs as Mediators of Intercellular Communication to Participate in the Regulation of Pancreatitis-Associated Macrophage Activation by Yong Zhao, Hao Wang, Ming Lu, Xin Qiao, Bei Sun, Weihui Zhang, Dongbo Xue

“…Macrophage activation plays an important role in the inflammatory response in acute pancreatitis. …”
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IgG4-mediated M2 macrophage polarization in tertiary lymphoid structures of esophageal cancer: implications for immunosuppression by Hui Wang, Hui Wang, Jirui Li, Yinghai Wang, Yang Chen, Yang Chen, Weifeng Zhang, Xinyan Pan, Xinyan Pan, Chanjuan Su, Ziteng Li, Li Wang, Li Wang, Jiang Gu, Jiang Gu

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Troglitazone and Δ2Troglitazone Enhance Adiponectin Expression in Monocytes/Macrophages through the AMP-Activated Protein Kinase Pathway by Jaw-Shiun Tsai, Lee-Ming Chuang, Ching-Shih Chen, Chan-Jung Liang, Yuh-Lien Chen, Ching-Yu Chen

“…Here, we tested the effect of troglitazone (TG) and its newly synthesized derivative, 5-[4-(6-hydroxy-2,5,7,8-tetramethyl-chroman-2-yl-methoxy)-benzylidene]-2,4-thiazolidinedione (Δ2troglitazone, (Δ2TG)), on the adiponectin expression in monocytes/macrophages and the relative mechanisms. The expression of adiponectin was located in macrophages of atherosclerotic lesions from patients and cholesterol-fed rabbits. …”
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Anti-Inflammatory and Antioxidant Effects of Carpesium cernuum L. Methanolic Extract in LPS-Stimulated RAW 264.7 Macrophages by Yea-Jin Park, Se-Yun Cheon, Dong-Sung Lee, Divina C. Cominguez, Zhiyun Zhang, Sangwoo Lee, Hyo-Jin An

“…The aim of this study was to examine the effects of a methanolic extract of C. cernuum (CLME) on lipopolysaccharide- (LPS-) induced RAW 264.7 mouse macrophages and a sepsis mouse model. The data presented in this study indicated that CLME inhibited LPS-induced production of proinflammatory mediators such as nitric oxide (NO) and prostaglandin E2 (PGE2) in RAW 264.7 cells. …”
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Urinary Macrophage Migration Inhibitory Factor Serves as a Potential Biomarker for Acute Kidney Injury in Patients with Acute Pyelonephritis by Ming-Yuan Hong, Chin-Chung Tseng, Chia-Chang Chuang, Chia-Ling Chen, Sheng-Hsiang Lin, Chiou-Feng Lin

“…Conventional markers of kidney function that are familiar to clinicians, including the serum creatinine and blood urea nitrogen levels, are unable to reveal genuine injury to the kidney, and their use may delay treatment. Macrophage migration inhibitory factor (MIF) is a proinflammatory cytokine, and the predictive role and pathogenic mechanism of MIF deregulation during kidney infections involving acute kidney injury (AKI) are not currently known. …”
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The Role of Monocyte/Macrophage and CXCR3 in Differentiation between Recurrent Hepatitis C and Acute Cellular Rejection Postliver Transplantation by Asmaa Ibrahim Gomaa, Nermine Ahmed Ehsan, Ahmed A. Elrefaei, Mervat Mohamed Sultan, Maha Mohamed Elsabaawy

“…The expression of CD 68 (macrophage marker), CD11b (BDM marker), and CxCR3 in the postliver transplant biopsy using immunohistochemistry was determined. …”
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Administration of PDE4 Inhibitors Suppressed the Pannus-Like Inflammation by Inhibition of Cytokine Production by Macrophages and Synovial Fibroblast Proliferation by Katsuya Kobayashi, Toshio Suda, Haruhiko Manabe, Ichiro Miki

“…PDE4 inhibitors could have therapeutic effects on pannus formation in RA by inhibition of cytokine production by macrophages and synovial fibroblast proliferation.…”
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Macropinocytosis enhances foamy macrophage formation and cholesterol crystallization to activate NLRP3 inflammasome after spinal cord injury by Chenxi Zhang, Shujie Zhao, Zhenfei Huang, Ao Xue, Hao Liu, Siming Dai, Ziyang Zheng, Yin Li, Xiaodong Guo, Jun Gu, Feng Zhang, Fubing Wang, Yongxiang Wang, Xiaohua Zhou, Shujun Zhang, Hanwen Zhang, Jun Shen, Jian Chen, Guoyong Yin

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Taenia crassiceps-Excreted/Secreted Products Induce a Defined MicroRNA Profile that Modulates Inflammatory Properties of Macrophages by Diana Martínez-Saucedo, Juan de Dios Ruíz-Rosado, César Terrazas, Blanca E. Callejas, Abhay R. Satoskar, Santiago Partida-Sánchez, Luis I. Terrazas

“…Our previous studies indicate that Taenia crassiceps-excreted/secreted antigens (TcES) downregulate inflammatory responses in rodent models of autoimmune diseases, by promoting the generation of alternatively activated-like macrophages (M2) in vivo. However, the molecular mechanisms triggered by TcES that modulate macrophage polarization and inflammatory response remain unclear. …”
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<i>In vitro</i> assay of biological activity of a national preparation of macrophage activating factor (GcMAF-RF) by E. V. Levites, S. S. Kirikovich, E. V. Dolgova, A. S. Proskurina, G. S. Ritter, А. A. Ostanin, E. R. Chernykh, S. S. Bogachev

Subjects: “…gc protein-derived macrophage activating factor (gcmaf)…”
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Peripheral Blood-Derived Mesenchymal Stem Cells Modulate Macrophage Plasticity through the IL-10/STAT3 Pathway by Qi-Ming Pang, Rui Yang, Meng Zhang, Wang-Hui Zou, Nan-Nan Qian, Qi-Jing Xu, Hui Chen, Jia-Chen Peng, Xiao-Ping Luo, Qian Zhang, Tao Zhang

“…Mesenchymal stem cells (MSCs) are multipotent cells that can skew the balance of M1/M2 macrophage polarization towards the M2 phenotype via their paracrine effects, thereby promoting anatomical and functional recovery after many inflammatory diseases induced by macrophages. …”
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Genotype-driven sensitivity of mice to tick-borne encephalitis virus correlates with differential host responses in peripheral macrophages and brain by Michaela Berankova, Jiri Holoubek, Vaclav Hönig, Zuzana Matusova, Martin Palus, Jiri Salat, Imtissal Krayem, Jarmila Vojtiskova, Pavel Svoboda, Veronika Pranclova, Lukas Valihrach, Peter Demant, Marie Lipoldova, Daniel Ruzek

“…Results Virus production in BALB/c and CcS-11 macrophages exhibited similar kinetics 24 and 48 h post-infection (hpi), but CcS-11 macrophages yielded significantly higher titers 72 hpi. …”
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The Antiviral Effect of High-Molecular Weight Poly-Gamma-Glutamate against Newcastle Disease Virus on Murine Macrophage Cells by Melbourne Talactac, Jong-Soo Lee, Hojin Moon, Mohammed Y. E. Chowdhury, Chul Joong Kim

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Engineered GM-CSF polarizes protumorigenic tumor-associated macrophages to an antitumorigenic phenotype and potently synergizes with IL-12 immunotherapy by Yue Wang, Kevin Chang, Aslan Mansurov, Jun Ishihara, Seounghun Kang, Trevin Kurtanich, Hye Rin Chun, Anna J Slezak, Lisa R Volpatti, Thomas Wang, Aaron T Alpar, Kirsten C Refvik, O Isabella Hansen, Gustavo J Borjas, Brendan T K Berg, Ha-Na Shim, Kevin T Hultgren, Suzana Gomes, Ani Solanki, Melody A Swartz, Jeffrey A Hubbell

“…Background The use of immune checkpoint inhibitors (CPIs) has become a dominant regimen in modern cancer therapy, however immune resistance induced by tumor-associated macrophages (TAMs) with immune suppressive and evasion properties limits responses. …”
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Luteolin Regulates the Differentiation of Regulatory T Cells and Activates IL-10-Dependent Macrophage Polarization against Acute Lung Injury by Ke Xie, Yu-sen Chai, Shi-hui Lin, Fang Xu, Chuan-jiang Wang

“…Luteolin treatment decreased the proportion of M1 macrophages and increased the proportion of M2 macrophages in lungs of CLP-induced mouse models. …”
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