High-level biosynthesis and purification of the antimicrobial peptide Kiadin based on non-chromatographic purification and acid cleavage methods by Liangjun Zheng, Fengyi Yang, Chen Wang, Muhammad Zafir, Zishuo Gao, Pilong Liu, Fatma A. El-Gohary, Xin Zhao, Huping Xue

“…Notably, Kiadin demonstrated significant post-antibiotic effects by disrupting bacterial membrane integrity, inducing cytoplasmic leakage, and inhibiting biofilm formation in E. coli K88 and S. aureus Mu50, without cytotoxicity towards mouse macrophages. In vivo studies further confirmed Kiadin's exceptional therapeutic efficacy against abdominal infections caused by E. coli K88. …”
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A Novel Adjuvant “Sublancin” Enhances Immune Response in Specific Pathogen-Free Broiler Chickens Inoculated with Newcastle Disease Vaccine by Yangke Liu, Jiang Zhang, Shuai Wang, Yong Guo, Tao He, Rui Zhou

“…On 7 and 21 dpv, pinocytosis of peritoneal macrophages, B lymphocyte proliferation assay, measurement of CD4+ and CD8+ T cells, and serum cytokine quantitation were carried out. …”
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Sublethal effects of copper nanoparticles on the histology of gill, liver and kidney of the Caspian roach, Rutilus rutilus caspicus by Sh. Aghamirkarimi, A. Mashinchian Moradi, I. Sharifpour, Sh. Jamili, P. Ghavam Mostafavi

“…Histological changes in kidneys included glomerular shrinkage, severe degeneration in the tubules cells, interstitial tissue and glomerulus, increase in interstitial tissue cells and macrophages aggregation. The degree of damages was more intensive at higher copper nanoparticles concentrations. …”
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HMOX1 as a potential drug target for upper and lower airway diseases: insights from multi-omics analysis by Enhao Wang, Shazhou Li, Yang Li, Tao Zhou

“…TwoSampleMR analysis indicated a negative causal relationship between HMOX1 exposure and the occurrence of upper and lower airway diseases (CRSwNP [(odds ratio (OR)/95% confidence interval (CI): 0.945/(0.893–0.999), P = 0.044], AR [OR/95% CI: 0.997/(0.994–0.999), P = 0.007], and AS [OR/95% CI: 0.935/(0.895–0.977), P = 0.003]). scRNA-seq data revealed HMOX1 localization in M2 macrophages. Molecular docking identified 15 antioxidants, including Acetylcysteine and Quercetin, that can upregulate HMOX1 expression. …”
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The Immunosuppressant Fingolimod (FTY720) for the Treatment of Mechanical Force-Induced Abnormal Scars by Masayo Aoki, Akatsuki Kondo, Noriko Matsunaga, Azusa Honda, Yuri Okubo, Kazuaki Takabe, Rei Ogawa

“…Flow cytometry showed that FTY720 decreased the frequencies of macrophages with M2 predominance in the scars but had no effect on total, CD4+, or CD8a+ T cell frequencies. …”
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SLC7A11 is a potential therapeutic target and prognostic biomarker correlated with immune cell infiltration in cervical cancer by Mutangala Muloye Guy, Tingting Bian, Longyun Sun, Yiping Hao, Xinlin Jiao, Wenjing Zhang, Teng Zhang, Baoxia Cui

“…The SLC7A11 high expression group showed greater enrichment of resting NK cells, neutrophils, M0 macrophages, and activated mast cells, whereas the SLC7A11 low expression group had higher levels of resting dendritic cells, resting mast cells, and follicular helper T cells. …”
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MCP5, a methyl-accepting chemotaxis protein regulated by both the Hk1-Rrp1 and Rrp2-RpoN-RpoS pathways, is required for the immune evasion of Borrelia burgdorferi. by Sajith Raghunandanan, Kai Zhang, Yan Zhang, Raj Priya, Ching Wooen Sze, Yongliang Lou, Michael J Lynch, Brian R Crane, Mark H Kaplan, Chunhao Li, X Frank Yang

“…Co-culture assays with NK cells and macrophages revealed that the mcp5 mutant enhanced interferon-gamma production by NK cells. …”
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Investigation of Scutellaria Barbata’s immunological mechanism against thyroid cancer using network pharmacology and experimental validation by Gen Ouyang, Yuangui Zhu, Zhehao Ouyang

“…Additionally, SPP1 expression correlated with the infiltration of 24 types of immune cells, with the highest correlation observed with macrophages. Molecular docking demonstrated that SPP1 has high binding stability with quercetin, Rhamnazin, and Salvigenin, with binding energies of -8.117, -7.494, and − 7.202 kJ∙mol − 1, respectively. …”
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Prediction of Immune Infiltration Diagnostic Gene Biomarkers in Kawasaki Disease by Hongjun Ba, Yao Wang, Lili Zhang, Huishen Wang, Zhan-Peng Huang, Youzhen Qin

“…Analyses of immune cell infiltration demonstrated that ALPL, EDEM2, and HIST2H2BE were linked to CD4 memory resting T cells, monocytes, M0 macrophages, CD8 T cells, neutrophils, and memory CD4 T cells. …”
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Contribution of Arginine Catabolic Mobile Element and Copper and Mercury Resistance Element in Methicillin-Resistant Staphylococcus aureus: A Vantage Point by Parya Shokrollahi, Alka Hasani, Mohammad Aghazadeh, Mohammad Yousef Memar, Akbar Hasani, Maryam Zaree, Mohammad Ahangarzadeh Rezaee, Javid Sadeghi

“…The presence of ACME increases fitness, thereby allowing bacteria to colonize the skin and mucous membrane while COMER contributes to genetic stability by knocking over the copper-mediated killing in macrophages. Evidence suggests that ACME and COMER have a more prominent role in enhancing biofilm capacity and ultimately persistent infections. …”
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Elucidating the role of pyrimidine metabolism in prostate cancer and its therapeutic implications by Liang Huang, Yu Xie, Shusuan Jiang, Kan Liu, Zhihao Ming, Hong Shan

“…Tumors in the P2 subgroup, characterized by higher pyrimidine metabolism, exhibited greater infiltration of activated CD4 + T cells and M2 macrophages, indicating a potential link between metabolic reprogramming and the immune response in prostate cancer. …”
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The Result of Timely Therapy for Whipple's Disease: a Clinical Case by S. N. Mekhtiev, O. A. Mekhtieva, E. Yu. Kalinina, V. E. Karev, A. V. Vanyan, O. M. Berko

“…The identified changes were represented by thickening of the villi and accumulations in the stroma of large macrophages (CD68+) with wide light cytoplasm containing abundant accumulations of PAS-positive, negative when stained with carbol fuchsin according to Ziehl — Nielsen and auramine-rhodamine (under microscopy in luminescence mode) short rods, as well as numerous optically empty small and larger cavities. …”
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Single Nucleotide Polymorphisms in PPARD Associated with Systemic Lupus Erythematosus in Chinese Populations by Yuan-yuan Qi, Ya-ling Zhai, Xin-ran Liu, Xiao-xue Zhang, Ya-fei Zhao, Xiang-hui Ning, Zhan-Zheng Zhao

“…PPAR-δ, encoded by the PPARD gene, was induced in macrophages promoting the timely disposal of apoptotic cells. …”
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Ferrostatin-1 inhibits osteoclast differentiation and prevents osteoporosis by suppressing lipid peroxidation by Wenbo Xu, Shiyan Lv, Xiaoyan Wang, Chengchao Song, Chunyang Xi, Jinglong Yan

“…Methods Bone marrow macrophages (BMMs) were extracted from C57BL/6J mice and induced to differentiate into osteoclasts, which were observed via TRAP staining, Phalloidin staining and bone pit assays. …”
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NT5E (CD73) as a prognostic biomarker and therapeutic target associated with immune infiltration in lung adenocarcinoma by Leyan Chen, Tuoya Qi, Bishu Zhang, Xuelong Wang, Mingfeng Zheng

“…A strong positive correlation was observed between NT5E expression and the presence of immune cells, including dendritic cells, macrophages, and CD4+ T cells, as well as the expression of various immune cell markers, suggesting that NT5E may influence the prognosis of LUAD patients by regulating immune cell infiltration. …”
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Novel insights into immunopathogenesis and crucial biomarkers between primary open‐angle glaucoma and systemic lupus erythematosus by Yixian Liu, Mengling You, Zhou Zeng, Jing Wang, Rong Rong, Xiaobo Xia

“…Immune infiltration analysis indicated an elevated presence of immune cells, including macrophages, T cells, and B cells, in both conditions. …”
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Correlation between MDA Level and Chitotriosidase-1 Activity in Seminal Fluid of Iraqi Infertile Males by Ali S. Abdul Aziz, Hedef D. Elyaseen, Hussain K. Kadhem

“…Chitotriosidase is a chitinase enzyme released by activated macrophages and is highly conserved and controlled. …”
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Enhanced effect of the immunosuppressive soluble HLA-G2 homodimer by site-specific PEGylation by Chisato Yamada, Kimiko Kuroki, Naoyoshi Maeda, Hiroshi Watanabe, Ami Takahashi, Katsumi Maenaka

“…One of the other isoforms, HLA-G2, lacks a α2 domain or β2m to form a nondisulfide-linked homodimer, and its ectodomain specifically binds to LILRB2 expressed in human monocytes, macrophages, and dendritic cells. The administration of the ectodomain of HLA-G2, designated the soluble HLA-G2 homodimer, showed significant immunosuppressive effects in mouse models of rheumatoid arthritis and systemic lupus erythematosus, presumably by binding to a mouse ortholog of LILRB2, paired immunoglobulin-like receptor B. …”
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Lnc-EST885 promotes hepatocellular carcinoma metastasis through PI3K / AKT pathway by interaction with TRAF4 by Shaoliang Zhu, Gang Wang, Yuxuan Zhang, Mengjie Zou, Zhi Li, Shenhong Qu, Xiaosu Zou, Wenqian Nong, Weiwei Miao, Qicong Chen, Juanmei Mo, Huibing Chen, Lequn Li, Xiaofeng Dong, Honglin Luo

“…Results: lnc-EST885 is one of the lncRNAs with the highest expression levels in M2-type macrophages. The expression of lnc-EST885 in HCC tissues is significantly higher than in normal tissues, and high expression is associated with poor prognosis. …”
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Lipid nanoparticles deliver DNA-encoded biologics and induce potent protective immunity by Dafei Chai, Junhao Wang, Jing Ming Lim, Xiaohui Xie, Xinfang Yu, Dan Zhao, Perry Ayn Mayson Maza, Yifei Wang, Dana Cyril-Remirez, Ken H. Young, Yong Li

“…Single-cell RNA sequencing (scRNA-seq) analysis revealed that the LNP-M/pSpike vaccine enhanced CD80 activation signaling in CD8+ T cells, NK cells, macrophages, and DCs, while reducing the immunosuppressive signals. …”
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