The Effects of Dexmedetomidine on Secondary Acute Lung and Kidney Injuries in the Rat Model of Intra-Abdominal Sepsis by Uğur Koca, Çimen Gülben Olguner, Bekir Uğur Ergür, Emel Altekin, Aydın Taşdöğen, Seden Duru, Pelin Girgin, Kerim Gündüz, Serap Cilaker Mıcılı, Seda Güzeldağ, Muhammed Akkuş

“…In order to evaluate tissue injury we determined kidney tissue mononuclear cell infiltration score, alveolar macrophage count, histological kidney and lung injury scores and kidney and lung tissue immunoreactivity scores. …”
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Preliminary screening of new biomarkers for sepsis using bioinformatics and experimental validation. by Hao Wang, Wei Xiong, Wu Zhong, Yingchun Hu

“…S100A11 and QPCT were widely distributed in all immune cells, and QPCT was mainly localized in the macrophage cell lineage. In the sepsis group, the qPCR results showed that S100A11, QPCT, and IFITM2 expression levels were significantly higher in the sepsis group(P < 0.05).…”
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Understanding Delayed T-Cell Priming, Lung Recruitment, and Airway Luminal T-Cell Responses in Host Defense against Pulmonary Tuberculosis by Christopher R. Shaler, Carly Horvath, Rocky Lai, Zhou Xing

“…Customarily, the alveolar macrophage (AM) acts as a sentinel, detecting and alerting surrounding cells to the presence of an invader. …”
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巨噬细胞移动抑制因子在原发性肝癌中的临床意义 by 林曲, 黄明声, 温景芸, 董敏, 汪清铭, 吴祥元

“…【目的】探讨肝癌患者血清巨噬细胞移动抑制因子（macrophage migration inhibitory factor,MIF）水平与其临床特征及预后的关系。…”
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Boosting the human antiviral response in conjunction with natural plant products by Rashmi Srivastava, Neeraj Kumar Dubey, Megha Sharma, Harsha Kharkwal, Rajesh Bajpai, Rakesh Srivastava

“…PNPs control compounds such as alkaloids, flavonoids, terpenoids, and polyphenols to promote antiviral cytokine synthesis, increase T-cell and macrophage activity, and activate antiviral genes. Studies have investigated the molecular interactions between PNPs, viruses, and host cells, exploring the potential of combining PNPs with conventional antiviral drugs to enhance efficacy. …”
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Genetic Deletion of Soluble Epoxide Hydrolase Attenuates Inflammation and Fibrosis in Experimental Obstructive Nephropathy by Chin-Wei Chiang, Hsueh-Te Lee, Der-Cherng Tarng, Ko-Lin Kuo, Li-Ching Cheng, Tzong-Shyuan Lee

“…Moreover, sEH−/− mice with UUO showed lower levels of inflammation-related and fibrosis-related protein such as monocyte chemoattractant protein-1, macrophage inflammatory protein-2, interleukin-1β (IL-1β), IL-6, inducible nitric oxide synthase, collagen 1A1, and α-actin. …”
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Mesenchymal Stem Cells in Renal Fibrosis: The Flame of Cytotherapy by Quan Zhuang, Ruoyu Ma, Yanshuang Yin, Tianhao Lan, Meng Yu, Yingzi Ming

“…Renal fibrosis, as the fundamental pathological process of chronic kidney disease (CKD), is a pathologic extension of the normal wound healing process characterized by endothelium injury, myofibroblast activation, macrophage migration, inflammatory signaling stimulation, matrix deposition, and remodelling. …”
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Augmenter of Liver Regeneration (ALR) Protects Kidney from Ischemia/Reperfusion (I/R) Injury via Regulation of TLR4/MAPK Signaling Pathway by Ying Li, Yanying Xiong, Huihui Li, Yan Luo, Ling Zhang, Qin Zhang, Weijian Xiong, Haitao Tu

“…Meanwhile, tubular epithelial cell apoptosis, neutrophil (24 h) and macrophage (72 h) infiltration to tubulointerstitium, and levels of inflammatory cytokines were decreased considerably in the rhALR-treated rats as compared to control. …”
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Effects of B-Blockers on the Sympathetic and Cytokines Storms in Covid-19. by Al-kuraishy, Hayder M., Al-Gareeb, Ali Ismail, Mostafa-Hedeab, Gomaa, Keneth Iceland, Kasozi, Zirintunda, Gerald, Aslam, Akhmed, Allahyani, Mamdouh, Welburn, Susan Christina, Batiha, Gaber El-Saber

“…The potential mechanisms of SS in Covid-19 are through different pathways such as hypoxia, which activate the central sympathetic center through carotid bodies chemosensory input and induced proinflammatory cytokines, which cross the blood-brain barrier and activation of the sympathetic center. b2-receptors signaling pathway play a crucial role in the production of pro-inflammatory cytokines, macrophage activation, and B-cells for the production of antibodies with inflammation exacerbation. b-blockers have anti-inflammatory effects through reduction release of pro-inflammatory cytokines with inhibition of NF-kB. …”
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Proteomic analysis of murine norovirus-infected Raw 264.7 cells reveals the induction of Ras GTPases by Sung Ho Yun, Md Arif-Ur Rahman, Soo-Bin Nam, Soo Hyeon Kim, Gyuri Kim, Kun Cho, Jong-Soon Choi

“…In the current study, the host response to MNV was examined using the macrophage Raw 264.7 in terms of the altered host proteomes. …”
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Sodium butyrate attenuate hyperglycemia-induced inflammatory response and renal injury in diabetic mice by Yan Man, Zhang Yan-Yan, Xi Yue, Ding Long-Kun, Sun Chang, Qu Li-Juan, Qian Xin, Xu Jing-Wen, Sun Wen, Wu Liang

“…The activation of the monocyte-macrophage system and the damage to the renal and pancreatic tissue are common complications in patients with diabetes induced by hyper-glycemia. …”
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MCL Plays an Anti-Inflammatory Role in Mycobacterium tuberculosis-Induced Immune Response by Inhibiting NF-κB and NLRP3 Inflammasome Activation by Qingwen Zhang, Xinru Jiang, Weigang He, Kailin Wei, Jinxia Sun, Xiangyang Qin, Yuejuan Zheng, Xin Jiang

“…In this experiment, we examined the inhibitory effect of MCL on Mtb-induced inflammatory response in mouse macrophage-like cell line Raw264.7 by downregulating the activation of nuclear factor kappa B (NF-κB) and NLRP3 inflammasome. …”
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CD109, a master regulator of inflammatory responses by Adel Batal, Adel Batal, Setareh Garousi, Setareh Garousi, Kenneth W. Finnson, Kenneth W. Finnson, Anie Philip, Anie Philip

“…CD109 exerts its effects by modulating processes such as cytokine secretion, immune cell recruitment, macrophage polarization, T helper cell function and cancer cell phenotype and function. …”
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Multi-Walled Carbon Nanotubes Accelerate Leukaemia Development in a Mouse Model by Qingqing Wang, Jingdan Han, Mujia Wei, Huikai Miao, Min Zhang, Biao Wu, Yao Chen, Yanwen Zheng, Robert Peter Gale, Bin Yin

“…Additionally, similar exposures elevated pro-inflammatory cytokines such as interleukin (IL)-1β, IL-6, and tumor necrosis factor (TNF)-α and induced reactive oxygen species (ROS) in a murine macrophage cell line. These effects were significantly reduced in immunodeficient mice and when mice were treated with methoxypolyethylene glycol amine (PEG)-modified MWCNTs. …”
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PDK1/mTOR Signaling in Myeloid Cells Differentially Regulates the Early and Late Stages of Sepsis by Juan Du, Guoli Li, Mingxi Hua, Junyan Han, Yu Hao, Hui Zeng, Ang Li, Yaxian Kong

“…The phenotypes and the activation state of the macrophage and neutrophil correlate with their metabolism. …”
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Enhanced glycolysis-derived lactate promotes microglial activation in Parkinson’s disease via histone lactylation by Qixiong Qin, Danlei Wang, Yi Qu, Jiangting Li, Ke An, Zhijuan Mao, Jingyi Li, Yongjie Xiong, Zhe Min, Zheng Xue

“…Recent studies highlight that histone lactylation promotes macrophage homeostatic gene expression via transcriptional regulation, but its role in microglia activation in Parkinson’s disease (PD) remains unclear. …”
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Suppression of In Vivo Neovascularization by the Loss of TRPV1 in Mouse Cornea by Katsuo Tomoyose, Yuka Okada, Takayoshi Sumioka, Masayasu Miyajima, Kathleen C. Flanders, Kumi Shirai, Tomoya Morii, Peter S. Reinach, Osamu Yamanaka, Shizuya Saika

“…TRPV1 gene ablation did not affect invasion of neutrophils and macrophage in a cauterized mouse cornea. Blocking TRPV1 signal does not affect angiogenic effects by HUVECs in vitro. …”
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Interleukin-34 as a Robust Predictor of No-Reflow Phenomenon in ST-Elevation Myocardial Infarction: Insights into Inflammatory Mechanisms and Clinical Implications by Mehdi Karasu, Hasan Ata Bolayır, İbrahim Aktaş

“…Conclusion: IL-34 emerges as a robust predictor of no-reflow in STEMI, potentially reflecting its role in macrophage activation and the inflammatory response. …”
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Adipose Tissue-Specific Deletion of 12/15-Lipoxygenase Protects Mice from the Consequences of a High-Fat Diet by Banumathi K. Cole, Margaret A. Morris, Wojciech J. Grzesik, Kendall A. Leone, Jerry L. Nadler

“…High-fat diet-fed ad-12/15-LO exhibited improved fasting glucose levels and glucose metabolism, and epididymal adipose tissue from these mice exhibited reduced inflammation and macrophage infiltration compared to wild-type mice. …”
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Regulatory Role of GSK-3β on NF-κB, Nitric Oxide, and TNF-α in Group A Streptococcal Infection by Yu-Tzu Chang, Chia-Ling Chen, Chiou-Feng Lin, Shiou-Ling Lu, Miao-Huei Cheng, Chih-Feng Kuo, Yee-Shin Lin

“…The results revealed that GAS could activate NF-κB, followed by an increased expression of inducible nitric oxide synthase (iNOS) and NO production in a murine macrophage cell line. Activation of GSK-3β occurred after GAS infection, and inhibition of GSK-3β reduced iNOS expression and NO production. …”
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