Proinflammatory Responses of Heme in Alveolar Macrophages: Repercussion in Lung Hemorrhagic Episodes by Rafael L. Simões, Maria Augusta Arruda, Cláudio Canetti, Carlos H. Serezani, Iolanda M. Fierro, Christina Barja-Fidalgo

“…Clinical and experimental observations have supported the notion that free heme released during hemorrhagic and hemolytic episodes may have a major role in lung inflammation. With alveolar macrophages (AM) being the main line of defense in lung environments, the influence of free heme on AM activity and function was investigated. …”
Get full text

The Response of Macrophages and Neutrophils to Hypoxia in the Context of Cancer and Other Inflammatory Diseases by Antje Egners, Merve Erdem, Thorsten Cramer

“…Members of the hypoxia-inducible transcription factor (HIF) family emerged as pivotal molecular regulators of macrophages and neutrophils. In this review, we will summarize the molecular responses of macrophages and neutrophils to hypoxia in the context of cancer and other chronic inflammatory diseases and discuss the potential avenues for therapeutic intervention that arise from this knowledge.…”
Get full text

Hyperuricemia-induced complications: dysfunctional macrophages serve as a potential bridge by Wenyi Gu, Wenyi Gu, Jiajing Zhao, Yu Xu, Yu Xu, Yu Xu

Subjects: Get full text

Ethanol Disrupts the Protective Crosstalk Between Macrophages and HBV-Infected Hepatocytes by Murali Ganesan, Anup S. Pathania, Grace Bybee, Kusum K. Kharbanda, Larisa Y. Poluektova, Natalia A. Osna

Subjects: Get full text

Ventral Prostate Fibrosis in the Akita Mouse Is Associated with Macrophage and Fibrocyte Infiltration by Sanghee Lee, Guang Yang, William Mulligan, Jerry Gipp, Wade Bushman

“…We performed hematoxylin and eosin staining to score tissue injury and inflammation, picrosirius red staining to quantitate collagen content, and immunostaining to identify monocytes/macrophages and infiltrating fibrocytes. We observed significantly greater numbers of monocytes/macrophages and fibrocytes specifically in the ventral prostate of the Akita mice and found that this was associated with significant greater collagen content specifically in the ventral prostate of the Akita mice. …”
Get full text

CAR-T therapy toxicities: the importance of macrophages in their development and possible targets for their management by Joseph Norton, Patrick Stiff

Get full text

Macrophage to neuron communication via extracellular vesicles in neuropathic pain conditions by Francesca Picco, Lynda Zeboudj, Silvia Oggero, Vincenzo Prato, Thomas Burgoyne, Nikita Gamper, Marzia Malcangio

Subjects: Get full text

Spatial transcriptomic analysis identifies epithelium-macrophage crosstalk in endometriotic lesions by Gregory W. Burns, Zhen Fu, Erin L. Vegter, Zachary B. Madaj, Erin Greaves, Idhaliz Flores, Asgerally T. Fazleabas

“…Spatial transcriptomics highlighted increased signaling between the lesion epithelium and macrophages, emphasizing the role of the epithelium in driving lesion inflammation. …”
Get full text

Tigulixostat Alleviates Hyperuricemic Nephropathy by Promoting M2 Macrophage Polarization by Xue L, Tao Q, Chang H, Yan S, Wang L, Zhao Z, Tu C

Subjects: Get full text

Inhibition of Synovial Macrophage Pyroptosis Alleviates Synovitis and Fibrosis in Knee Osteoarthritis by Li Zhang, Runlin Xing, Zhengquan Huang, Nongshan Zhang, Li Zhang, Xiaochen Li, Peimin Wang

“…Increasing evidence has shown that macrophage pyroptosis in different tissues participates in chronic aseptic inflammation and is related to tissue fibrosis. …”
Get full text

lncRNA-Triggered Macrophage Inflammaging Deteriorates Age-Related Diseases by Lulingxiao Nie, Peng Zhang, Qian Wang, Xinyi Zhou, Qi Wang

“…This review discusses the involvement of macrophage inflammaging in various ARDs and its regulation via lncRNA. …”
Get full text

Targeting lipid metabolism of macrophages: A new strategy for tumor therapy by Nan Shao, Hui Qiu, Jing Liu, Daimin Xiao, Juanjuan Zhao, Chao Chen, Jiajia Wan, Mengmeng Guo, Guiyou Liang, Xu Zhao, Lin Xu

Subjects: “…Tumor-associated macrophage…”
Get full text

Decreased Apoptotic Rate of Alveolar Macrophages of Patients with Idiopathic Pulmonary Fibrosis by Fotios Drakopanagiotakis, Areti Xifteri, Evaggelos Tsiambas, Andreas Karameris, Konstantina Tsakanika, Napoleon Karagiannidis, Demetrios Mermigkis, Vlasis Polychronopoulos, Demosthenes Bouros

“…The apoptotic profile of alveolar macrophages (AMs) in IPF is unclear. Aim. To investigate whether AMs of patients with IPF exhibit a different apoptotic profile compared to normal subjects. …”
Get full text

Injectable double network hydrogel with adjustable stiffness for modulation of macrophage polarization by Jinxin Wu, Bing Han, Shili Ai, Aijing Wang, Yilin Song, Moran Jin, Xiaozhong Qu, Xiaoyan Wang

Subjects: Get full text

Induction of macrophage migration inhibitory factor precedes the onset of acute tonsillitis by Takeji Nishikawa, Riichiro Abe, Hiroshi Shimizu, Kunihiko Kobayashi, Yukihiro Kusunoki, Nobuko Inamoto, Yuichiro Yamasaki, Osamu Takeuchi, Hironori Niizeki, Tadamichi Shimizu, Kazuhiro Hashiguchi, Jun Nishihira

Get full text

Distinct Redox Signalling following Macrophage Activation Influences Profibrotic Activity by Caitlin V. Lewis, Antony Vinh, Henry Diep, Chrishan S. Samuel, Grant R. Drummond, Barbara K. Kemp-Harper

“…To date, the ROS-generating capacities of macrophages in different activation states have not been thoroughly compared. …”
Get full text

Haptoglobin Genotype-Dependent Anti-Inflammatory Signaling in CD163+ Macrophages by R. Clive Landis, Pandelis Philippidis, Jan Domin, Joseph J. Boyle, Dorian O. Haskard

“…Intraplaque hemorrhage causes adaptive remodelling of macrophages towards a protective phenotype specialized towards handling iron and lipid overload, denoted Mhem. …”
Get full text

Macrophage Infiltration and ITGB2 Expression in ESCC: A Novel Correlation by Tao Huang, Longqian Wei, Huafu Zhou, Jun Liu

Subjects: Get full text

Macrophage-related inflammatory responses to degradation products of biodegradable molybdenum implants by Danyang Liu, Jiahao Chen, Jiannan Zhou, Jingtao Dai, Haotian Qin, Guojiang Wan, Junyu Qian, Ping Li, Jiang Li

Subjects: Get full text

Cigarette smoke compromises macrophage innate sensing in response to pneumococcal infection by Wei-Chih Liao, Chia-Huei Chou, Mao-Wang Ho, Jo-Tsen Chen, Shu-Ling Chou, Yu-Tsen Huang, Ngoc-Niem Bui, Hui-Yu Wu, Chi-Fan Lee, Wei-Chien Huang, Chih-Ho Lai

Subjects: Get full text