Hemosiderin-Laden Macrophages in Bronchoalveolar Lavage: Predictive Role for Acute Exacerbation of Idiopathic Interstitial Pneumonias by Toru Arai, Tomoko Kagawa, Yumiko Sasaki, Reiko Sugawara, Chikatoshi Sugimoto, Kazunobu Tachibana, Yoshiki Fujita, Seiji Hayashi, Yoshikazu Inoue

“…Background. Hemosiderin-laden macrophages (HLMs) have been identified in the bronchoalveolar lavage fluid (BALF) of patients with idiopathic pulmonary fibrosis (IPF). …”
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Modulation of Leishmania (L.) amazonensis Growth in Cultured Mouse Macrophages by Prostaglandins and Platelet Activating Factor by M. V. C. Lonardoni, C. L. Barbieri, M. Russo, S. Jancar

“…It was found that pretreatment of macrophages with 10−5 M of the PAF antagonists, BN-52021 or WEB-2086, increased macrophage infection by 17 and 59%, respectively. …”
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Cryopreserved human alternatively activated macrophages promote resolution of acetaminophen-induced liver injury in mouse by Maria Elena Candela, Melisande Addison, Rhona Aird, Tak-Yung Man, Jennifer A. Cartwright, Candice Ashmore-Harris, Alastair M. Kilpatrick, Philip J. Starkey Lewis, Anna Drape, Mark Barnett, Donna Mitchell, Colin McLean, Neil McGowan, Marc Turner, James W. Dear, Stuart J. Forbes

“…We have previously demonstrated that alternatively, activated macrophages are a potential therapeutic option to reverse acute liver injury in pre-clinical models. …”
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Gender Differences in Pulmonary Function, Respiratory Symptoms, and Macrophage Proteomics among HIV-Infected Smokers by Shiva D. Rahmanian, Karen L. Wood, Shili Lin, Mark A. King, April Horne, Shangbin Yang, Haifeng M. Wu, Philip T. Diaz

“…In a subset bronchoalveolar lavage was performed with proteomic analysis of their alveolar macrophages. Results. The majority of the participants were male 213 (87.6%). …”
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HDL-free cholesterol influx into macrophages and transfer to LDL correlate with HDL-free cholesterol content by Dedipya Yelamanchili, Baiba K. Gillard, Antonio M. Gotto, Jr., Miguel Caínzos Achirica, Khurram Nasir, Alan T. Remaley, Corina Rosales, Henry J. Pownall

“…The influx of HDL-FC into macrophages and transfer to LDL increase linearly with HDL-FC. …”
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Evolution of the Macrophage CD163 Phenotype and Cytokine Profiles in a Human Model of Resolving Inflammation by Betsy J. Evans, Dorian O. Haskard, Gregory Sempowksi, R. Clive Landis

“…There was a significant increase in leukocyte infiltrate at 40 h with appearance of a “resolving macrophage” phenotype CD14+CD163+ by flow cytometry. …”
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Biopsy location and tumor-associated macrophages in predicting malignant glioma recurrence using an in-silico model by Pejman Shojaee, Edwin Weinholtz, Nadine S. Schaadt, Friedrich Feuerhake, Haralampos Hatzikirou

“…Our findings reveal that macrophage density at the tumor edge contributed to a high predictive value of feature importance for the selected regression model. …”
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Restriction of mitochondrial oxidation of glutamine or fatty acids enhances intracellular growth of Mycobacterium abscessus in macrophages by Ho Won Kim, Ji Won Lee, Hoe Sun Yoon, Hwan-Woo Park, Young Ik Lee, Sung Ki Lee, Jake Whang, Jong-Seok Kim

“…However, how Mab rewires macrophage energy metabolism to facilitate its survival is poorly understood. …”
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Multifunctional nanoparticles confers both multiple inflammatory mediators scavenging and macrophage polarization for sepsis therapy by Wenjie Xi, Weijie Wu, Lili Zhou, Qi Zhang, Shushu Yang, Lihong Huang, Yijun Lu, Jing Wang, Xinjin Chi, Yang Kang

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Oxidative stress promotes lipid-laden macrophage formation via CYP1B1 by Yin Zhu, Saugata Dutta, Yohan Han, Dooyoung Choi, Francesca Polverino, Caroline A. Owen, Payaningal R. Somanath, Xiaoyun Wang, Duo Zhang

“…Emerging evidence suggests that lipid-laden macrophages (LLM) participate in lung damage in various clinical conditions. …”
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Autologous precision-cut lung slice co-culture models for studying macrophage-driven fibrosis by So-Yi Chang, So-Yi Chang, Wen-Hsin Chang, Wen-Hsin Chang, David C. Yang, Qi-Sheng Hong, Qi-Sheng Hong, Ssu-Wei Hsu, Ssu-Wei Hsu, Reen Wu, Ching-Hsien Chen, Ching-Hsien Chen

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Recent advances in adipose-derived mesenchymal stem cell-derived exosomes for regulating macrophage polarization by Zhewei Dong, Yingli Fu, Zhongming Cai, Hao Dai, Yucang He

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Stryphnodendron adstringens have a modulatory effect on inflammatory cytokines markers of in vitro activated macrophages by Ivana Beatrice Mânica da Cruz, Cibele Ferreira Teixeira, Neida Luiza Pellenz, Moisés Henrique Mastella, Verônica Farina Azzolin, Euler Esteves Ribeiro, Fernanda Barbisan

“…This will be achieved using an in vitro protocol with the commercial macrophage cell line RAW 264.7. Methods: The macrophage inflammatory response was induced by the natural antigen phytohemagglutinin (PHA), with and without supplementation of different concentrations of S. adstringens extract. …”
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Role of β2 Integrins in the Binding of Thymocytes to RatThymic Macrophages by Miodrag Čolić, Vesna Ilić, Takuya Tamatani, Masayuki Miyasaka, Miloš D. Pavlović

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Sulforaphane ameliorates non-alcoholic steatohepatitis by KLF4-mediated macrophage M2 polarization by Xianghui Huang, Jia Xu, Ye Xu, Bingxin Huangfu, Feng Zhang, Yanzhou Hu, Ruxin Gao, Xinxin Ren, Boyang Zhang, Kunlun Huang, Xiaoyun He

“…We found that SFN attenuates the inflammatory injury in a macrophage cell line and the liver of NASH mice, owing to the promotion of M1-type macrophage polarization toward the M2-type and the regulation of inflammatory mediators. …”
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Transplantable Subcutaneous Hepatoma 22a Affects Functional Activity of Resident Tissue Macrophages in Periphery by Ekaterina P. Kisseleva, Andrei V. Krylov, Olga I. Stepanova, Victoria I. Lioudyno

“…We hypothesized that macrophage tumor-dependent reactions can be mediated differentially by factors released from live or dead tumor cells. …”
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The Role of Dectin-1-Mediated M1 Macrophage Polarization in Cerebral Ischemia-Reperfusion Injury by Chen Zongyun, Lin Bixia, Ding Fadian, Hong Xiaoping, Chen Hongbin, Deng Yu, Liu Qicai, Ye Xiaoyi, Zeng Kai

“…The high expression level of dectin-1 may affect M1 macrophage polarization and brain cell apoptosis in cerebral ischemia-reperfusion injury.…”
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Mycobacteria Exploit Host GPR84 to Dampen Pro-Inflammatory Responses and Promote Infection in Macrophages by Reziya Wumaier, Ke Zhang, Jing Zhou, Zilu Wen, Zihan Chen, Geyang Luo, Hao Wang, Juliang Qin, Bing Du, Hua Ren, Yanzheng Song, Qian Gao, Bo Yan

“…G-protein-coupled receptor 84 (GPR84), a member of the G-protein-coupled receptor family, contributes to the regulation of pro-inflammatory reactions and the migration of innate immune cells, such as macrophages. Its role in mycobacterial infection, however, has not yet been explored. …”
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Possible Involvement of Liver Resident Macrophages (Kupffer Cells) in the Pathogenesis of Both Intrahepatic and Extrahepatic Inflammation by Yuki Kakinuma, Takuya Kimura, Yoshifumi Watanabe

“…Liver resident macrophages designated Kupffer cells (KCs) form the largest subpopulation of tissue macrophages. …”
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Smad4 deficiency in hepatocytes attenuates NAFLD progression via inhibition of lipogenesis and macrophage polarization by Wei Yang, Xuanxuan Yan, Rui Chen, Xin Xin, Shuang Ge, Yongxiang Zhao, Xinlong Yan, Jinhua Zhang

“…Furthermore, targeting CXCL1 using CXCR2 inhibitors diminished hepatocyte lipogenesis and inhibited the polarization of M1-type macrophages. Collectively, these results suggested that Smad4 plays a vital role in exacerbating NAFLD and may be a promising candidate for anti-NAFLD therapy.…”
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