Genetic mechanisms of the influence of light and phototransduction on Drosophila melanogaster lifespan by I. A. Solovev, M. V. Shaposhnikov, A. A. Moskalev

“…Over the long period of the evolution of light signal transduction systems, many mechanisms have emerged that allow to form an adequate response of the organism to illumination, modulating the highly conservative signaling cascades, including those associated with aging and lifespan (FOXO, SIRT1, NF-kB, mTOR/S6k, PPARa, etc). In this review, we consider the relationship between lifespan, photoregimens, and also the expression of the genes encoding the phototransduction cascade and the circadian oscillator elements of animal cells. …”
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CLOVES Syndrome: A Review of Clinical, Genetic, and Therapeutic Aspects by Julianna Podolec, Silvia Ciraolo, Joanna Wojda, Adam Sobiński, Zuzanna Kościuszko, Katarzyna Kurza, Agnieszka Kulczycka-Rowicka, Matylda Czerwonka, Katarzyna Lesiczka-Fedoryj, Anna Walczak

“…It focuses on the role of PIK3CA gene mutations, challenges in diagnosis, and treatment options, including PI3K/AKT/mTOR pathway inhibitors. Research Materials and Methods: This article is based on a review of the current literature and clinical reports from various sources. …”
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Mitochondrial Dysfunction: A Basic Mechanism in Inflammation-Related Non-Communicable Diseases and Therapeutic Opportunities by Anna Hernández-Aguilera, Anna Rull, Esther Rodríguez-Gallego, Marta Riera-Borrull, Fedra Luciano-Mateo, Jordi Camps, Javier A. Menéndez, Jorge Joven

“…Regulating mitochondrial function may require a multifaceted approach that includes drugs and plant-derived phenolic compounds with antioxidant and anti-inflammatory activities that improve mitochondrial biogenesis and act to modulate the AMPK/mTOR pathway.…”
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A Peptide Analogue of Selectin Ligands Attenuated Atherosclerosis by Inhibiting Monocyte Activation by Zhishuai Ye, Shanfeng Zhang, Yubo Liu, Shujing Wang, Jianing Zhang, Rongchong Huang

“…Our results also revealed that IELLQAR inhibited the differentiation of monocytes into macrophages through P-selectin-dependent activation of the nuclear factor- (NF-) κB and mammalian target of rapamycin (mTOR) pathways. Conclusion. Collectively, our results demonstrated that IELLQAR, a peptide analogue of selectin ligands, inhibited selectin binding to monocytes, which led to subsequent attenuation of atherosclerosis via inhibition of monocyte activation. …”
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Identification of natural phytochemicals as AKT2 inhibitors using molecular docking and dynamics simulations as potential cancer therapeutics by Jibon Kumar Paul, Mahir Azmal, Md Naimul Haque Shohan, Mohua Mrinmoy, ANM Shah Newaz Been Haque, Omar Faruk Talukder, Ajit Ghosh

“…The PI3K/AKT/mTOR pathway is central in regulating key cellular processes such as proliferation, survival, metabolism, and angiogenesis. …”
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Proteome differences of dental stem cells between permanent and deciduous teeth by data-independent acquisition proteomics by Zhang Suping, Liu Yuqing, Dong Jin, Jiao Min, Gu Yongchun, Chen Liling, Yuan Na, Wang Jianrong, Yang Dezhao, Meng Fanwen

“…These proteins are known to be involved in critical cellular processes such as mitochondrial energy metabolism, mTOR-related autophagy pathway, and innate immune response. …”
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Effects of Enterocytozoon hepatopenaei infection on intestinal immune defense and physiological processes of Penaeus vannamei by Zheng Cao, Chuanyu He, Zhipeng Yin, Caiyi Chen, Fan Li, Dongchun Yan, Ting Li, Linrui Chang, Lingjun Si

“…Moreover, the expression levels of key genes involved in nutrient absorption, transport and synthesis, such as glucose transporter 1, Na+-K+ATPase, fatty acid synthase, acetyl-CoA carboxylase, rapamycin kinase, mTOR regulation-related protein, eukaryotic translation initiation factor 4E binding protein, ribosomal protein S6 kinase, were significantly up-regulated. …”
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Vernolactone Promotes Apoptosis and Autophagy in Human Teratocarcinomal (NTERA-2) Cancer Stem-Like Cells by Nuwanka K. Abeysinghe, Ira Thabrew, Sameera R. Samarakoon, Meran K. Ediriweera, Kamani H. Tennekoon, Varuni P. C. Pathiranage, Anuka S. Mendis

“…Effects of vernolactone on the expression of autophagy-related genes (LC3, Beclin 1, PI3K, Akt, and mTOR) were evaluated using real-time PCR. 2,2-Diphenyl-1-2,2-diphenyl-picrylhydrazyl (DPPH) radical scavenging assay, 2,2′-azinobis-(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) radical scavenging, and ferric reducing antioxidant power (FRAP) assays were also carried out to evaluate the antioxidant activity of vernolactone. …”
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Autophagy-Enhancing Properties of <i>Hedyotis diffusa</i> Extracts in HaCaT Keratinocytes: Potential as an Anti-Photoaging Cosmetic Ingredient by Qiwen Zheng, Xiangji Jin, Trang Thi Minh Nguyen, Eun-Ji Yi, Se-Jig Park, Gyeong-Seon Yi, Su-Jin Yang, Tae-Hoo Yi

“…Our findings indicate that HD promotes autophagy by modulating the PI3K/AKT/mTOR and PINK/PARK2 pathways, which stabilizes mitochondrial quality, maintains MMP and Ca²⁺ balance, and reduces cytochrome c release. …”
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Apigenin, a natural flavonoid, promotes autophagy and ferroptosis in human endometrial carcinoma Ishikawa cells in vitro and in vivo by Yancui Liang, Qian Zhong, Runhui Ma, Zhijing Ni, Kiran Thakur, Jianguo Zhang, Zhaojun Wei

“…On the other hand, apigenin could promote autophagy via up-regulating Beclin 1, ULK1, ATG5, ATG13, and LC3B and down-regulating AMPK, mTOR, P70S6K, and ATG4. Furthermore, apigenin could inhibit tumor tissue proliferation and restrict tumor growth via ferroptosis in vivo.…”
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Arsenic toxicity in Antarctic krill oil and its impact on human intestinal cells by Haiyan Zhang, Yunyun Ji, Zhongquan Jiang, Guangxin Yang, Cong Kong, Zhemin Shen, Tao Yuan, Xiaosheng Shen

“…Arsenic exposure elevated ROS levels, disrupted mitochondrial membrane potential, upregulated apoptosis-related genes such as Caspase-3, Caspase-9, and Bax, and downregulated the PI3K/AKT/mTOR signaling pathway. This study elucidates the mechanisms underlying arsenic toxicity in AKO and underscores its implications for food safety assessments.…”
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MAPK4 inhibits the early aberrant activation of B cells in rheumatoid arthritis by promoting the IRF4-SHIP1 signaling pathway by Pei Huang, Guangli Yang, Pingping Zhang, Yin Zhu, Yaning Guan, Jian Sun, Qian Li, Yang An, Xiaoqi Shi, Juanjuan Zhao, Chaohong Liu, Zhixu He, Yan Chen, Zuochen Du

“…Loss of MAPK4 in KO mice enhances proximal BCR signaling and activates the PI3K-AKT-mTOR pathway, leading to heightened B cell proliferation. …”
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Palmitic Acid Methyl Ester Enhances Adipogenic Differentiation in Rat Adipose Tissue-Derived Mesenchymal Stem Cells through a G Protein-Coupled Receptor-Mediated Pathway by Jian-Hong Lin, Huan-Hsin Chang, Wen-Sen Lee, Pei-Ching Ting, Yu-Po Luo, Kun-Ta Yang

“…Moreover, PAME significantly increased phosphorylation of extracellular signal-regulated kinases (ERK), but not AKT and mTOR. Cotreatment with PAME and a GPR40/120 antagonist together inhibited the PAME-enhanced ERK phosphorylation and adipogenic differentiation. …”
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CD36 inhibition enhances the anti-proliferative effects of PI3K inhibitors in PTEN-loss anti-HER2 resistant breast cancer cells by You-Yu Liu, Wei-Lun Huang, Sin-Tian Wang, Hui-Ping Hsu, Tzu-Ching Kao, Wei-Pang Chung, Kung-Chia Young

“…Results The activated HER2/PI3K/AKT/mTOR signaling pathway positively correlated with SCD-1 and CD36 expression in PTEN-loss breast cancer cells. …”
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Feedback loop centered on MAF1 reduces blood–brain barrier damage in sepsis-associated encephalopathy by Xuebiao Wei, Wenqiang Jiang, Zhonghua Wang, Yichen Li, Yuanwen Jing, Yongli Han, Linqiang Huang, Shenglong Chen

“…Furthermore, it increased phosphatase and tensin homolog (PTEN) expression and inactivated the serine/threonine kinase (AKT)/mechanistic target of the rapamycin kinase (mTOR) signaling pathway. Interference with forkhead box O1 (FOXO1) inhibited MAF1 expression and activated the RIG-I/IRF3 signaling pathway, while MAF1 overexpression promoted PTEN expression, decreased cell apoptosis, and normalized autophagy. …”
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Mogroside ⅡE, an in vivo metabolite of sweet agent, alleviates acute lung injury via Pla2g2a-EGFR inhibition by Weichao Lü, Guoqing Ren, Kuniyoshi Shimizu, Renshi Li, Chaofeng Zhang

“…In addition, M2E protected ALI induced with LPS against inflammatory and damage which were significantly dependent upon the downregulation of AKT and mTOR via the inhibition of Pla2g2a-EGFR. Pla2g2a may represent a potential target for M2E in the improvement of LPS-induced lung injury, which may represent a promising strategy to treat ALI.…”
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Identification of Critical Signature in Post‐Traumatic Stress Disorder Using Bioinformatics Analysis and in Vitro Analyses by Lifen Liu, Yang Liu, Rui Li, Yue Teng, Shuyang Zhao, Jinhong Chen, Changjiang Li, Xinyu Hu, Lin Sun

“…Notably enriched pathways included neuroactive ligand‐receptor interaction, mechanistic target of rapamycin (mTOR) signaling pathway, nicotine addiction, and dopaminergic synapse. …”
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Fetal and neonatal cardiac tumor diagnosed as Tuberous Sclerosis associated rhabdomyomas resulting from novel pathogenic missense variant detected in TSC2 gene: A case report by Aya Kawasaki, MD, Hidefumi Tonoki, MD, PhD, Osamu Sasaki, MD, PhD, Yoko Matsushita, MD, PhD, Michiko Watari, MD, PhD, Nobuhiro Takahashi, MD, Satoko Fujieda, MD

“…This pathogenic variant is located on exon 10 of the TSC2 gene, which encodes the hamartin binding domain, leading to impair inhibitory function of the hamartin-tuberin complex, which activates mammalian target of rapamycin(mTOR) activity. The cardiac tumors were diagnosed as rhabdomyomas, a major clinical feature of TS, since the penetrance of this gene variants are thought to be 100%. …”
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GENI as an AMPK Activator Binds α and γ Subunits and Improves the Memory Dysfunction of Alzheimer’s Disease Mouse Models via Autophagy and Neuroprotection by Ying Wang, Lanjie Li, Danni Chen, Jiaheng Shan, Meijuan Yi, Hiroyuki Osada, Minoru Yoshida, Lan Xiang, Jianhua Qi

“…Meanwhile, the AMPK/unc-51-like autophagy-activating kinase 1 (ULK1)/microtubule-associated protein 1 light chain 3 beta (LC3B) and AMPK/mammalian target of rapamycin (mTOR) signaling pathways involved in anti-AD effects of GENI. …”
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Platycodin D inhibits tumor proliferation by modulating macrophage polarization through promoting JAK2 ubiquitination by Wei Wu, Jie Zhang, Zijiao Wang, Chuan Cheng, Dongdong Yuan, Li Peng, Le Li

“…Treatment with PD led to a significant reduction in melanoma tumor weight, inhibition of the mTOR pathway, and suppression of M2-polarized macrophages. …”
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