Characterizing the regulatory effects of H2A.Z and SWR1-C on gene expression during hydroxyurea exposure in Saccharomyces cerevisiae. by Hilary T Brewis, Peter C Stirling, Michael S Kobor

“…To explore this possibility, we generated mRNA transcript profiles for wild-type, htz1Δ, swr1Δ, and htz1Δswr1Δ mutants before and after exposure to hydroxyurea (HU), which induces DNA replication stress. …”
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Effects of brain renin- angiotensin system inhibition in ISIAH rats with inherited stress-induced arterial hypertension by L. O. Klimov, M. A. Ryazanova, L. A. Fedoseeva, A. L. Markel

“…It was shown that prolonged inhibition of the central RAS, AT1 receptors in particular, can lead to a decrease in blood pressure and significant changes in the level of expression of brain RAS genes in ISIAH rats. The mRNA level of RAS genes in the kidney does not significantly change due to this inhibition. …”
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Stromal Derived Factor-1/CXCR4 Axis Involved in Bone Marrow Mesenchymal Stem Cells Recruitment to Injured Liver by Kuai Xiao Ling, Li Peng, Zhang Jian Feng, Cao Wei, Yuan Wei Yan, Shao Nan, Guan Cheng Qi, Wang Zhi Wei

“…The expression of CXCR4 in BMSCs at mRNA level and protein level was confirmed by RT-PCR, flow cytometry, and immunocytochemistry. …”
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Dietary Supplemental Glutamine Enhances the Percentage of Circulating Endothelial Progenitor Cells in Mice with High-Fat Diet-Induced Obesity Subjected to Hind Limb Ischemia by Chi-Hsuan Ko, Sung-Ling Yeh, Chiu-Li Yeh

“…The superoxide dismutase activity and reduced glutathione content in affected muscles were higher, whereas mRNA expressions of interleukin-6 and tumor necrosis factor-α were lower in the HG than those in the HI group. …”
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Veronicastrum axillare Alleviates Lipopolysaccharide-Induced Acute Lung Injury via Suppression of Proinflammatory Mediators and Downregulation of the NF-κB Signaling Pathway by Quanxin Ma, Kai Wang, Qinqin Yang, Shun Ping, Weichun Zhao, Qiyang Shou, Weimin Zhou, Minli Chen

“…We observed that V. axillare suppressed the mRNA expression of interleukin-1β (IL-1β), IL-6, monocyte chemotactic protein-1 (MCP-1), cyclooxygenase-2 (COX-2), and tumor necrosis factor-α (TNF-α) in RAW264.7 cells challenged with LPS. …”
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Single nucleotide polymorphism and expression of genes for immune competent cell proliferation and differentiation in radiation-exposed individuals by E. A. Blinova, V. S. Nikiforov, M. A. Yanishevskaya, A. A. Akleyev

“…The objective of the current study was to analyze the influence of ionizing radiation on the transcription activity of the STAT3, GATA3, NFkB1, PADI4 genes, which regulate proliferation and differentiation of immune competent human cells; and to assess the potential influence of single nucleotide polymorphisms located in regulatory regions of the genes on the amount of mRNA. The study involved people who had been chronically exposed due to releases of radioactive waste into the Techa River. …”
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Hippocampal glucocorticoid receptor and microRNA gene expression and serum cortisol concentration in foxes selected for behavior toward humans by V. Yu. Ovchinnikov, E. V. Antonov, G. V. Vasilyev, S. G. Shihevich, D. V. Shepeleva, Yu. E. Herbeck

“…The same applies to NR3C1 mRNA as well. That is why we performed a miRNA-seq analysis on a portion of the fox dorsal hippocampus. …”
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Chitooligosaccharides suppress airway inflammation, fibrosis, and mucus hypersecretion in a house dust mite-induced allergy model by Yun-Ho Kim, Chan-Ho Park, Ju Myung Kim, Yeo Cho Yoon

“…In the HDM-induced allergic respiratory model, COS suppressed the infiltration of inflammatory cells around the airways and inhibited the mRNA expression of Th1 immune cytokines in lung tissues, while also reducing the expression of nuclear factor kappa B (NF-κB)-related proteins. …”
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Protection of Corneal Limbus from Riboflavin Prevents Epithelial Stem Cell Loss after Collagen Cross-Linking by Hyo Kyung Lee, Jin Suk Ryu, Hyun Jeong Jeong, Mee Kum Kim, Joo Youn Oh

“…Robust expression of CK3/12 was observed in the limbal epithelium in the group with a ring. The mRNA levels of ABCG2, FGF2, IL-1β, and IL-6 were significantly increased in the corneas with a ring. …”
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Sonic Hedgehog Signaling Drives Proliferation of Synoviocytes in Rheumatoid Arthritis: A Possible Novel Therapeutic Target by Mingxia Wang, Shangling Zhu, Weixiang Peng, Qiuxia Li, Zhaoxia Li, Minqi Luo, Xiaoxue Feng, Zhuofeng Lin, Jianlin Huang

“…Cyclopamine (a specific inhibitor of Shh signaling) decreased mRNA expression of Shh, Ptch1, Smo, and Gli1 in cultured RA FLS, Shh, and Smo protein expression, and significantly decreased FLS proliferation. …”
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Effects of Glutamate and Aspartate on Serum Antioxidative Enzyme, Sex Hormones, and Genital Inflammation in Boars Challenged with Hydrogen Peroxide by Hengjia Ni, Lu Lu, Jinpin Deng, Wenjun Fan, Tiejun Li, Jiming Yao

“…Both glutamate and aspartate promoted genital mRNA expressions of anti-inflammatory factors after oxidative stress. …”
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Immunoinformatic strategy for developing multi-epitope subunit vaccine against Helicobacter pylori. by Md Nahian, Md Rasel Khan, Fabiha Rahman, Hossain Mohammed Reza, Imren Bayil, Tanjum Ahmed Nodee, Tabassum Basher, Mostafizur Rahaman Sany, Rabeya Najnin Munmun, S M Ariful Habib, Lincon Mazumder, Mrityunjoy Acharjee

“…The proposed vaccine candidates were evaluated based on population coverage, molecular docking, immune simulations, codon adaptation, secondary mRNA structure, and in silico cloning. The vaccine candidates exhibited antigenic scores of 1.19 and 1.01, with 93.5% and 90.4% of the most rama-favored regions, respectively. …”
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Gene Regulatory Network of Human GM-CSF-Secreting T Helper Cells by Szabolcs Éliás, Angelika Schmidt, David Gomez-Cabrero, Jesper Tegnér

“…By combining information about mRNA expression, DNA accessibility, and predicted transcription factor binding, we reconstructed directed gene regulatory networks connecting transcription factors to their targets, which comprise putative key regulators of human GM-CSF-positive CD4 T cells as well as memory CD4 T cells. …”
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The ERK1/2 Inhibitor U0126 Attenuates Diabetes-Induced Upregulation of MMP-9 and Biomarkers of Inflammation in the Retina by Ghulam Mohammad, Mohammad Mairaj Siddiquei, Mohammad Imtiaz Nawaz, Ahmed M. Abu El-Asrar

“…The expression of MMP-9 was quantified by zymography, and the mRNA level of MMP-9 and TIMP-1 was quantified by RT-PCR. …”
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T Cell Repertoire and Inflammatory Bowel Disease by Kenneth Croitoru, David KH Wong, Maria E Baca-Estrada

“…Using monoclonal antibodies to T cell receptor variable-gene products or polymerase chain reaction analysis of variable-gene mRNA expression, the mucosal T cell repertoire has been examined in humans. …”
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Role of Peroxisome Proliferator-Activated Receptor β/δ and B-Cell Lymphoma-6 in Regulation of Genes Involved in Metastasis and Migration in Pancreatic Cancer Cells by Jeffrey D. Coleman, Jerry T. Thompson, Russell W. Smith, Bogdan Prokopczyk, John P. Vanden Heuvel

“…In human pancreatic cancer tissue there was significantly higher expression of MMP-9 and PPARβ/δ, and lower levels of BCL-6 mRNA. PPARβ/δ activation reduced the TNFα-induced expression of various genes implicated in metastasis and reduced the invasion through a basement membrane in cell culture models. …”
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Spontaneously Diabetic Torii (SDT) Fatty Rat, a Novel Animal Model of Type 2 Diabetes Mellitus, Shows Blunted Circadian Rhythms and Melatonin Secretion by Katsuya Sakimura, Tatsuya Maekawa, Shin-ichi Kume, Takeshi Ohta

“…To get an insight into the mechanism underlying the impaired melatonin secretion in SDT fatty rats, the expression of arylalkylamine N-acetyltransferase (Aanat) and acetylserotonin O-methyltransferase (Asmt) mRNA, which encode the rate-limiting enzymes for melatonin synthesis, was investigated in the pineal gland. …”
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miR-24-3p/KLF8 Signaling Axis Contributes to LUAD Metastasis by Regulating EMT by Pengyu Jing, Nianlin Xie, Nan Zhao, Ximing Zhu, Pei Li, Guizhou Gao, Haizhou Dang, Zhongping Gu

“…The interaction of miR-24-3p and KLF8 was demonstrated by luciferase reporter activity assay, in vitro migration and invasion studies, and in vivo metastatic studies. miR-24-3p level was downregulated in LUAD and negatively associated with KLF8 mRNA expression. miR-24-3p controls LUAD metastasis by directly targeting KLF8 and inducing Snail and E-cadherin expressions. …”
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Inducible Lentivirus-Mediated siRNA against TLR4 Reduces Nociception in a Rat Model of Bone Cancer Pain by Ruirui Pan, Huiting Di, Jinming Zhang, Zhangxiang Huang, Yuming Sun, Weifeng Yu, Feixiang Wu

“…Results showed that LvOn-siTLR4 intrathecal injection with doxycycline (Dox) oral administration effectively reduced the nociception induced by Walker 256 cells while inhibiting the mRNA and protein expression of TLR4. Proinflammatory cytokines as TNF-α and IL-1β in spinal cord were also decreased. …”
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Hepatocyte Growth Factor Effects on Mesenchymal Stem Cells Derived from Human Arteries: A Novel Strategy to Accelerate Vascular Ulcer Wound Healing by Sabrina Valente, Carmen Ciavarella, Emanuela Pasanisi, Francesca Ricci, Andrea Stella, Gianandrea Pasquinelli

“…This study was aimed at verifying whether HGF/SF influences proliferation, migration, and angiogenesis on mesenchymal stem cells isolated from human arteries (hVW-MSCs). hVW-MSCs were exposed to NIBSC HGF/SF (2.5, 5, 10, and 70 ng/mL) from 6 hrs to 7 days. HGF and c-MET mRNA and protein expression, cell proliferation (Alamar Blue and Ki–67 assay), migration (scratch and transwell assays), and angiogenesis (Matrigel) were investigated. hVW-MSCs displayed stemness features and expressed HGF and c-MET. …”
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