Activation of PPAR𝛾 by Rosiglitazone Does Not Negatively Impact Male Sex Steroid Hormones in Diabetic Rats by Mahmoud Mansour, Elaine Coleman, John Dennis, Benson Akingbemi, Dean Schwartz, Tim Braden, Robert Judd, Eric Plaisance, Laura Ken Stewart, Edward Morrison

“…Treatment for eight weeks increased PPAR𝛾 mRNA and protein in the testis and elevated serum adiponectin, an adipokine marker for PPAR𝛾 activation. …”
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Apoptosis through Death Receptors in Temporal Lobe Epilepsy-Associated Hippocampal Sclerosis by Marcelo Ananias Teocchi, Lília D’Souza-Li

“…In addition, we evaluated the hippocampal relative mRNA expression of the two TNF receptors, TNFRSF1A and TNFRSF1B, in patients, being both upregulated (n=14; P<0.01 and P<0.04, resp.) when compared to the post mortem control group (n=4). …”
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VCAM-1 Promotes Angiogenesis of Bone Marrow Mesenchymal Stem Cells Derived from Patients with Trauma-Induced Osteonecrosis of the Femoral Head by Regulating the Apelin/CCN2 Pathway by Yiming Shao, Lei Sun, Baodong Ma, Ranran Jin, Yueyao Ban, Ruibo Li, Jianfa Wang, Hongkai Lian, Han Yue

“…VCAM-1 enhances the migration and angiogenesis of BMSCs. We further performed mRNA transcriptome sequencing to explore the mechanisms by which VCAM-1 promotes angiogenesis. …”
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Blood Transcriptional Signatures for Disease Progression in a Rat Model of Osteoarthritis by Michał Korostyński, Natalia Małek, Marcin Piechota, Katarzyna Starowicz

“…Functional links that connect expression of the gradually downregulated genes to the G13 signaling pathway were indicated. The mRNA abundance levels of the identified transcripts were further analyzed in publicly available gene expression dataset obtained from a GARP study cohort of OA patients. …”
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USING THE METHODS OF SYSTEMS BIOLOGY FOR PREDICTING PERSPECTIVE TARGET GENES TO SELECT C3 AND C4 CEREALS FOR OXIDATIVE STRESS RESISTANCE by A. V. Doroshkov, A. V. Bobrovskikh

“…Because these genes undergo the most conservative evolution and have the highest level of mRNA expression, we may assume that they contribute a lot to the antioxidant system functioning of the C3 and C4 cereal plants studied. …”
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FTO effects the proliferation, invasion, and glycolytic metabolism of colon cancer by regulating PKM2 by Kongyan Zhang, Fei Zhang, Jiahe Wang

“…In vitro experiments utilized five human colon cancer cell lines and a normal colon epithelial cell line, with Western blotting and RT-PCR for protein and mRNA quantification, respectively, and lentiviral transfection to modulate FTO expression. …”
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Analysis of ginseng rusty root symptoms transcriptome and its pathogenesis directed by reactive oxygen species theory by Pengcheng Yu, Xiaowen Song, Wei Zhang, Yao Yao, Junling Ren, Liyang Wang, Wenfei Liu, Zhaoping Meng, Xiangcai Meng

“…In this study, the phloem tissue of healthy Panax ginseng (AG), the nonred tissue of the phloem epidermis around the lesion (BG), and the red lesion site tissue of GRS (CG) were extracted for mRNA transcriptomic analysis; 35,958 differentially expressed genes (DEGs) were identified and were associated with multiple stress resistance pathways, reactive oxygen species (ROS), and iron ion binding. …”
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siRNA therapeutics for effective management of rheumatoid arthritis by Vishakha R. Chakole, Tathagata Dutta, Priyankar Sen

“…siRNA is a specialized type of RNA that precisely targets a mRNA, and effectively silences the respective genes. …”
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Negative Effects of SIGIRR on TRAF6 Ubiquitination in Acute Lung Injury In Vitro by Feng Tian, Qiang Lu, Jie Lei, Yunfeng Ni, Nianlin Xie, Daixing Zhong, Guang Yang, Shaokui Si, Tao Jiang

“…Such modulation between TRAF6 and SIGIRR could affect cytokine secretion and exacerbate the immune response; the IL-8, NFKB1, and NFKBIA mRNA levels were reduced after SIGIRR overexpression. …”
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Transmembrane and Ubiquitin-Like Domain-Containing 1 Promotes Glioma Growth and Indicates Unfavorable Prognosis by Yinggang Liu, Changcheng Cai, Ke Wu, Libo Hu

“…We conducted a comprehensive analysis using two cohorts: a retrospective glioma cohort from our hospital and The Cancer Genome Atlas (TCGA) cohort. The mRNA levels of TMUB1 were assessed through reverse transcription-quantitative polymerase chain reaction (RT-qPCR). …”
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Methyl-Arginine Profile of Brain from Aged PINK1-KO+A53T-SNCA Mice Suggests Altered Mitochondrial Biogenesis by Georg Auburger, Suzana Gispert, Nadine Brehm

“…The strongest effects were documented for the adhesion modulator CMAS, the mRNA decapping/deadenylation factor PATL1, and the synaptic plasticity mediator CRTC1/TORC1. …”
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circ_ZFR Is Linked to Paclitaxel Resistance in Cervical Cancer via miR-944 Sponging and IL-10 Upregulation by Xiaoqian Long, Meiyun Zheng, Youlin Yang, Yi Chen, Xiahui Zhang, Haiyan Zhang

“…Herein, two types of CC cells (SiHa/PTX and Hela/PTX) were utilized. The levels of IL-10 mRNA, miR-944, and circ_ZFR were measured using qRT-PCR analyses. …”
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Elevated Glucose and Interleukin-1β Differentially Affect Retinal Microglial Cell Proliferation by Filipa I. Baptista, Célia A. Aveleira, Áurea F. Castilho, António F. Ambrósio

“…Exposure of retinal neural cell cultures to high glucose upregulated both mRNA and protein levels of IL-1β. High glucose decreased microglial and macroglial cell proliferation, whereas IL-1β increased their proliferation. …”
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Caffeine Consumption Influences Lidocaine Action via Pain-Related Voltage-Gated Sodium Channels: An In Vivo Animal Study by Reham Alfaraj, Zainab Alabdulsalam, Zahrah Alfaraj, Hawraa Alsunni, Hussain Alhawaj, Omar Omar, Hatem Abuohashish

“…The molecular analysis of dorsal root ganglia suggested that CAF upregulated the mRNA expression of the Nav1.3, Nav1.7, and Nav1.8 sodium channel subtypes. …”
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The influence of follicular fluid on the regulation of apoptosis and related genes during IVM of camel oocytes by A.A. Ammari, AR. Alhimaidi, K.N. Yaseen, B.O. Almutairi, R.A. Amran, A. AL-juaimlan, A. Rady

“…Consequently, the follicular fluid from camels had a substantial effect on the mRNA transcript level of the BCL2 gene, which is related to apoptosis. …”
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Notch Signaling Mediates TNF-α-Induced IL-6 Production in Cultured Fibroblast-Like Synoviocytes from Rheumatoid Arthritis by Zhijun Jiao, Wenhong Wang, Jie Ma, Shengjun Wang, Zhaoliang Su, Huaxi Xu

“…Exposure of RA FLSs to TNF-α (10 ng/ml) led to increase of Hes-1, a target gene of Notch signaling, and a marked upregulation of Notch 2, Delta-like 1, and Delta-like 3 mRNA levels. Blockage of Notch signaling by a γ-secretase inhibitor (DAPT) inhibited IL-6 secretion of RA FLSs in response to TNF-α while treatment with recombinant fusion protein of Notch ligand Delta-like 1 promoted such response. …”
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TMEM100 Modulates TGF-β Signaling Pathway to Inhibit Colorectal Cancer Progression by Huixia Li, Chuan Cheng, Weibo You, Jiujian Zheng, Jie Xu, Peng Gao, Jianping Wang

“…This study investigated the functional mechanism of transmembrane protein 100 (TMEM100) as a tumor inhibitor gene in CRC cells and offered a reference for the treatment of CRC. Methods. The mRNA expression data of CRC were acquired from the TCGA database to mine differentially expressed mRNAs. …”
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Restoration of Genetic Code in Macular Mouse Fibroblasts via APOBEC1-Mediated RNA Editing by Sonali Bhakta, Hiroko Kodama, Masakazu Mimaki, Toshifumi Tsukahara

“…Identification of the core component of the apoB RNA editing holoenzyme, APOBEC, and investigation into new candidate genes encoding other elements of the complex could reveal further details regarding APOBEC-mediated mRNA editing. Menkes disease is a recessive X-chromosome-linked hereditary syndrome in humans, caused by defective copper metabolism due to mutations in the <i>ATP7A</i> gene, which encodes a copper transport protein. …”
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Influence of leptin administration to pregnant female mice on obesity development, taste preferences, and gene expression in the liver and muscles of their male and female offsprin... by E. I. Denisova, M. M. Savinkova, E. N. Makarova

“…It also increased the consumption of standard chow and the mRNA levels of genes for the insulin receptor and glucose transporter type 4 in the muscles of both male and female offspring. …”
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An XBB.1.5-based inactivated SARS-CoV-2 vaccine partially protects against XBB.1.5 and JN.1 strains in hamsters by Ryuta Uraki, Mutsumi Ito, Maki Kiso, Kiyoko Iwatsuki-Horimoto, Masafumi Endo, Seiya Yamayoshi, Yoshihiro Kawaoka

“…Vaccination is an essential primary preventative measure. While mRNA vaccines have been widely used worldwide, it is essential that we continue to prepare alternative vaccine modalities. …”
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