Down-Regulation of Tristetraprolin Expression Results in Enhanced IL-12 and MIP-2 Production and Reduced MIP-3α Synthesis in Activated Macrophages by Ulla Jalonen, Riina Nieminen, Katriina Vuolteenaho, Hannu Kankaanranta, Eeva Moilanen

“…The present data provide IL-12, MIP-2, and MIP-3α as novel inflammatory cytokine targets for TTP-mediated mRNA decay and stress the role of TTP in the regulation of the inflammatory process.…”
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Signaling Crosstalk between PPARγ and BMP2 in Mesenchymal Stem Cells by Ichiro Takada, Yoshiko Yogiashi, Shigeaki Kato

“…Although BMP2 did not interfere with PPARγ-mediated adipogenesis, BMP2 increased mRNA expression levels of PPARγ target genes (such as Fabp4 and Nr1h3) when cells were first treated with troglitazone (TRO). …”
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BNT162b2 Vaccination during Pregnancy Protects Both the Mother and Infant: Anti-SARS-CoV-2 S Antibodies Persistently Positive in an Infant at 6 Months of Age by Chetna Mangat, Natasa Milosavljevic

“…Vaccinations are the most important intervention for controlling the ongoing coronavirus disease (COVID-19) pandemic, caused by the SARS-CoV-2 virus. BNT162b2 is an mRNA-based vaccine, which is promising and safe for use during pregnancy, as it could help prevent SARS-CoV-2 infection and its complications during pregnancy. …”
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CUZD1 and Anti-CUZD1 Antibodies as Markers of Cancer and Inflammatory Bowel Diseases by Christos Liaskos, Eirini I. Rigopoulou, Timoklia Orfanidou, Dimitrios P. Bogdanos, Christos N. Papandreou

“…Human CUZD1 is mapped at chromosome 10q26.13 and the loss of this region is a frequent event in various malignant tumours. mRNA overexpression of CUZD1 has been noted in ovarian cancer and serum levels of CUZD1 are elevated in women with ovarian cancer and patients suffering from pancreatic cancer. …”
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CTGF Attenuates Tendon-Derived Stem/Progenitor Cell Aging by Yun-feng Rui, Min-hao Chen, Ying-juan Li, Long-fei Xiao, Peng Geng, Pei Wang, Zheng-yuan Xu, Xuan-pu Zhang, Guang-chun Dai

“…Here, we investigated the role of connective tissue growth factor (CTGF) in TSPC aging. CTGF protein and mRNA levels were markedly decreased in the aged TSPCs. …”
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In Vitro Study of Combined Application of Bevacizumab and 5-Fluorouracil or Bevacizumab and Mitomycin C to Inhibit Scar Formation in Glaucoma Filtration Surgery by Yuanyuan Zhang, Shaopin Zhu, Xun Xu, Lei Zuo

“…In addition, the effects of combined drugs on VEGF(R) mRNA in HTFs were detected to explore the possible underlying drug mechanisms. …”
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Sequential Treatment with Activin and Hepatocyte Growth Factor Induces FOXM1 to Promote Colorectal Cancer Liver Metastasis by Hong Peng, Ting Ye, Lei Deng, Xiaofang Yang, Zheng Jiang, Jinjun Guo

“…Activin alone increased the mRNA and protein expression of FOXM1. In contrast, HGF alone enhanced the phosphorylation of FOXM1, without altering the total protein level of FOXM1. …”
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Comparison of saliva and blood derived cell free RNAs for detecting oral squamous cell carcinoma by Yuan Hu, Manbin Xu, Muyuan Liu, Hanwei Peng

“…In our study to enhance OSCC detection, we analyzed cell-free RNA (cfRNA) transcriptomes (mRNA, lncRNA) from blood (plasma) and saliva samples of individuals in three groups: OSCC group, oral benign tumor group, and a normal control group. …”
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SNHG5/miR-299-5p/ATF2 Axis as a Biomarker in Immune Microenvironment of Intervertebral Disc Degeneration by Yu Shi, Rong Guo, Yanyan Zeng, Qian Fang, Xianglong Wang, Wei Liu, Guozhi Huang, Wen Wu

“…After multimodel screening and verification, key gene marker was found, namely, ATF2. The lncRNA/miRNA/mRNA axis closely related to ATF2 have also been found, namely, SNHG5/miR-299-5p/ATF2. …”
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Protective Effect of Uric Acid on ox-LDL-Induced HUVECs Injury via Keap1-Nrf2-ARE Pathway by Yajuan Lin, Yunpeng Xie, Zhujing Hao, Hailian Bi, Yang Liu, Xiaolei Yang, Yunlong Xia

“…A microfluidic device was used to mimic the vascular environment in the body, and the level of mRNA levels of inflammatory factors was determined by RT-PCR. …”
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Astragaloside IV Inhibits NF-κB Activation and Inflammatory Gene Expression in LPS-Treated Mice by Wei-Jian Zhang, Balz Frei

“…AS-IV also inhibited LPS-induced upregulation of inflammatory gene expression in different organs. Lung mRNA levels of cellular adhesion molecules, MCP-1, TNFα, IL-6, and TLR4 were significantly attenuated, and lung neutrophil infiltration and activation were strongly inhibited, as reflected by decreased myeloperoxidase content, when the mice were pretreated with AS-IV. …”
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Neurally Derived Tissues in Xenopus laevis Embryos Exhibit a Consistent Bioelectrical Left-Right Asymmetry by Vaibhav P. Pai, Laura N. Vandenberg, Douglas Blackiston, Michael Levin

“…Bilateral misexpression of a depolarizing channel mRNA affects primarily the right eye, revealing an additional functional asymmetry in the control of eye patterning by Vmem. …”
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Ethyl Caffeate Ameliorates Collagen-Induced Arthritis by Suppressing Th1 Immune Response by Shikui Xu, Aixue Zuo, Zengjun Guo, Chunping Wan

“…Th1 cell differentiation assay was performed, and mRNA expression in interferon-γ-related signaling was examined by q-PCR analysis. …”
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Myricetin exposure reduces PC differentiation in vitro in primary human B cells by Shabirul Haque, Betty Diamond

“…Quantification of PCs (CD27 + + , CD38 +) was obtained by flow cytometry. The expression of mRNA was measured by qPCR. Ig secretion in culture supernatant was measured by ELISA. …”
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Trigonelline exerts its neuroprotective effects in experimental spinal cord injury through modulation of inflammation, apoptosis, and neurotrophic factors by Zhi-Lan Ye, Yuan Cao

“…It notably (P<0.05) downregulated apoptotic (Bax and caspase-3) and inflammatory (COX-II) markers, while upregulating Bcl-2 and BDNF mRNA expression in the spinal cord (P<0.05). Furthermore, trigonelline effectively alleviated (P<0.05) SCI-induced alterations in mitochondrial complex levels, resulting in enhanced nicotinamide adenine dinucleotide dehydrogenase, succinate dehydrogenase, redox activity, and cytochrome-C levels. …”
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Anti-oxidation enhancement, inflammation alleviation, and microbial composition optimization of using tussah (Antheraea pernyi) silk fibroin peptides for hyperglycaemia remission. by Rui Mi, Xuejun Li, Yajie Li, Xingfan Du

“…<h4>Results</h4>The results indicated that TSFP could significantly reduce the fasting blood glucose (FBG) levels and suppress the mRNA expression of glycometabolism genes of diabetic mice. …”
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Small-Molecule Hormones: Molecular Mechanisms of Action by Monika Puzianowska-Kuznicka, Eliza Pawlik-Pachucka, Magdalena Owczarz, Monika Budzińska, Jacek Polosak

“…A direct interaction of small-molecule hormones with membrane phospholipids and with mRNA is also postulated. In these mechanisms, the reaction to hormonal stimulus appears within seconds or minutes.…”
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Distinct plasmablast developmental intermediates produce graded expression of IgM secretory transcripts by Evelyn P. Sievert, Marissa C. Franke, Kayla B. Thomas, Yoseop Yoon, Yongsheng Shi, Roger Sciammas

“…This extraordinary capacity requires the upregulation of PC transcriptional determinants that specify PC fate, increase immunoglobulin mRNA synthesis, coordinate alternative 3′ end processing of the heavy chain transcript from the distal to proximal polyadenylation site (PAS), and remodel the secretory pathway. …”
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Clopidogrel Protects Endothelium by Hindering TNFα-Induced VCAM-1 Expression through CaMKKβ/AMPK/Nrf2 Pathway by Huabing Yang, Pengjun Zhao, Shiliu Tian

“…Additionally, TNFα dramatically augmented VCAM-1 expression at protein and mRNA levels. INN treatment strikingly repressed TNFα-induced expression of VCAM-1 and HL-60 cell adhesion. …”
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Targeting T-Cell Activation for Malaria Immunotherapy: Scoping Review by Balsa Nobility Gustifante, Shafia Khairani, Nisa Fauziah, Silvita Fitri Riswari, Afiat Berbudi

“…The findings underscore the potential of T cells, particularly CD8+ T cells, in liver-stage defense and advocate for the exploration of advanced vaccine platforms and novel therapies, such as mRNA-based vectors and monoclonal antibodies.…”
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