Role of tRNA-Derived Fragments in Protozoan Parasite Biology by Manu Sharma, Upinder Singh

“…tRNA molecules are among the most fundamental and evolutionarily conserved RNA types, primarily facilitating the translation of genetic information from mRNA into proteins. Beyond their canonical role as adaptor molecules during protein synthesis, tRNAs have evolved to perform additional functions. …”
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Modulation of miRNAs in Pulmonary Hypertension by Sudhiranjan Gupta, Li Li

“…They are a class of small, noncoding RNAs that contributes crucial roles typically through binding of the 3′-untranslated region of mRNA. A single miRNA may influence several signaling pathways associated with cardiac remodeling by targeting multiple genes. …”
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Annexin A2 Coordinates STAT3 to Regulate the Invasion and Migration of Colorectal Cancer Cells In Vitro by Dianhui Xiu, Lin Liu, Fengli Qiao, Haishan Yang, Lu Cui, Guifeng Liu

“…Results demonstrated that both Anxa 2 and STAT3 were highly expressed in CRC specimens in both mRNA and protein levels, with or without phosphorylation (Tyrosine 23 in Anxa 2 and Tyrosine 705 in STAT3). …”
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COVID-19: Understanding the New Variants of Concern by Ke-Yan Loo, Vengadesh Letchumanan

“…Fortunately, early evidence shows that the mRNA vaccines are still effective against the current circulating Omicron sublineages of the coronavirus. …”
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The Role of Methylation in Chronic Lymphocytic Leukemia and Its Prognostic and Therapeutic Impacts in the Disease: A Systematic Review by Sevastianos Chatzidavid, Christina-Nefeli Kontandreopoulou, Nefeli Giannakopoulou, Panagiotis T. Diamantopoulos, Christos Stafylidis, Marie-Christine Kyrtsonis, Maria Dimou, Panayiotis Panayiotidis, Nora-Athina Viniou

“…The following is a review focusing on the present knowledge about single gene/gene promoter methylation or mRNA expression in CLL cases as well as records of older data that have been published in past papers.…”
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The Survivin −31 Snp in Human Colorectal Cancer Correlates with Survivin Splice Variant Expression and Improved Overall Survival by Anna G. Antonacopoulou, Konstantina Floratou, Vasiliki Bravou, Anastasia Kottorou, Fotinos-Ioannis Dimitrakopoulos, Stella Marousi, Michalis Stavropoulos, Agelos K. Koutras, Chrisoula D. Scopa, Haralabos P. Kalofonos

“…In the present study, the mRNA levels of the five known isoforms of survivin as well as survivin protein were assessed in matched normal and neoplastic colorectal tissue. …”
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Ultra-sensitive fluorescence-activated droplet single-cell sorting based on Tetramer-HCR-EvaGreen amplification by Long Chen, Yi Xu, Lele Zhou, Ding Ma, Rong Zhang, Yifan Liu, Xianqiang Mi

“…The sorted MCF-7 cells showed similar proliferation together with CK19 and EGFR mRNA expression compared with the control cells. …”
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Effect of Hemin on Brain Alterations and Neuroglobin Expression in Water Immersion Restraint Stressed Rats by Merhan Ragy, Fatma Ali, Maggie M. Ramzy

“…Stress hormones, oxidative stress markers, malondialdehyde (MDA), and total antioxidant capacity (TAC) were measured and expressions of neuroglobin and S100B mRNA in brain tissue were assayed. Our results revealed that hemin significantly affects brain alterations induced by acute stress and this may be through increased expression of neuroglobin and through antioxidant effect. …”
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Effect of dietary Cucurbita pepo extract on performance, hemato-immunological parameters, immune-related gene expression and bacterial resistance in rainbow trout, Oncorhynchus myk... by Kaveh Vakili, Amir Eghbal Khajehrahimi, Behnam Salimi, Shapour Kakoolaki, Arman Ghorbanzadeh

“…Furthermore, the highest mRNA level of tumor necrosis factor (TNF-α) was observed in 4 % CPE diet. …”
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Development of RNA interference-based therapy for rare genetic diseases by Milya Urfa Ahmad, Syarifah Dewi

“…RNAi employs small RNA molecules, such as small interfering RNA (siRNA) and microRNA (miRNA), to bind specific mRNA molecules and prevent their translation into proteins. …”
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Pharmaceutical approaches for COVID-19: An update on current therapeutic opportunities by Fan Sijia, Wang Hongling, Wu Dean, Liu Lu

“…Various natural compounds such as sarsapogenin, lycorine, biscoclaurine, vitamin B12, glycyrrhizic acid, riboflavin, resveratrol and kaempferol, various vaccines and drugs such as AZD1222, mRNA-1273, BNT162b2, Sputnik V, and remdesivir, lopinavir, favipiravir, darunavir, oseltamivir, and umifenovir, resp., have been discussed comprehensively. …”
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The Expression of MMP-2 Following Immobilization and High-Intensity Running in Plantaris Muscle Fiber in Rats by Eli Carmeli, Tal Gal Haimovitch

“…High-intensity running and immobilization increased both mRNA and protein levels of matrix metalloproteinase type 2 (MMP-2) in plantaris. …”
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Leptin Induces an Inflammatory Phenotype in Lean Wistar Rats by Monique Allman, Mathew Wallace, Latausha Gaskin, Chantal A. Rivera

“…Compared to vehicle controls, leptin enhanced mRNA levels of IL-6 (8-fold) and MCP-1 (5-fold) in mesenteric adipose tissue (MAT). …”
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Rosa moschata ameliorates haloperidol-induced Parkinson's disease via reduction of neurodegeneration and oxidative stress by Badriyah S. Alotaibi, Uzma Saleem, Maryam Farrukh, Zunera Chaudhary, Nabia Anwar, Ifat Alsharif, Abdullah R. Alanzi, Tasahil S. Albishi, Fatima A. Jaber, Wedad Saeed Al-Qahtani, Muhammad Ajmal Shah

“…The extract also markedly downregulated the mRNA expressions of IL-1β, α-synuclein, IL-1α, and TNF-α in brain tissue. …”
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Substance P Increases Cell-Surface Expression of CD74 (Receptor for Macrophage Migration Inhibitory Factor): In Vivo Biotinylation of Urothelial Cell-Surface Proteins by Katherine L. Meyer-Siegler, Shen-Ling Xia, Pedro L. Vera

“…SP treatment increased MIF and CD74 mRNA in urothelial cells. Our data indicate that intraluminal MIF, released from urothelial cells as a consequence of SP treatment, interacts with urothelial cell-surface CD74. …”
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Morphological and functional convergence of visual projection neurons from diverse neurogenic origins in Drosophila by Rana Naja El-Danaf, Katarina Kapuralin, Raghuvanshi Rajesh, Félix Simon, Nizar Drou, Filipe Pinto-Teixeira, Mehmet Neset Özel, Claude Desplan

“…To address their origin, we used single-cell mRNA sequencing to define the transcriptome of LCN subtypes and identified lines that are expressed throughout their development. …”
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Anti-inflammatory activity of Alpinia officinarum hance on rat colon inflammation and tissue damage in DSS induced acute and chronic colitis models by Vijayabharathi Rajendiran, Vidhya Natarajan, Sivasithamparam Niranjali Devaraj

“…In addition, the in-vitro study showed that HEAO treatment inhibited the proliferation of HT-29 cells and down regulated the mRNA expression of NF-κB and COX-2. Taken together, these results suggest that HEAO is a promising anti-oxidant and anti-inflammatory agent that support its possible therapeutic role in the treatment of colitis. …”
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M6A Modification and Transcription Analysis of LncRNA in Cerebral Ischemia/Reperfusion Injury by Jierong Mo, Zhiquan Li, Zhengfei Yang, Zuhua Huang, Pengpeng Guo, Jianfeng Gao, Haiqiong xiao, Ping Ye, Haini Qin, Tianen Zhou, Jun Jiang

“…Finally, a LncRNA-miRNA-mRNA network was constructed. Therefore, this study explored the potential key LncRNAs and regulatory mechanisms of CIRI.…”
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AHNAK2: a potential diagnostic biomarker for pancreatic cancer related to cellular motility by Mohamed Zardab, Barts Pancreas Tissue Bank, Richard P. Grose, Hemant M. Kocher

“…In gene panels developed for early diagnosis of pancreatic cancer, high AHNAK2 mRNA expression was one possible biomarker. In silico analysis of published human sample datasets (n = 177) and ex vivo analysis of human plasma samples (n = 30 PDAC with matched 30 healthy control) suggested AHNAK2 could be a diagnostic biomarker. …”
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Evolution of tick vaccinology by José de la Fuente, Srikant Ghosh, Ala Tabor

“…Future directions will advance in these areas together with other novel technologies such as multiomics, AI and Big Data, mRNA vaccines, microbiota-driven probiotics and vaccines, and combination of vaccines with other interventions in collaboration with regions with high incidence of tick infestations and tick-borne diseases for a personalized medicine approach.…”
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