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1021
Response to Hydralazine-Valproate in a Patient with Mycosis Fungoides
Published 2010-01-01“…Histone deacetylase (HDAC) inhibitors have shown significant activity in the treatment of cutaneous T-cell lymphomas (CTCL). The epigenetic alterations of CTCL not only are limited to altered histone acetylation but also include aberrant DNA gene methylation hence, the combination of an HDAC inhibitor with a DNA demethylating agent is a promising therapy to be tested. …”
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1022
Uncommon Presentation of a Benign Nasopharyngeal Mass in an Adolescent: Comprehensive Review of Pediatric Nasopharyngeal Masses
Published 2013-01-01“…When malignant, the most common lesions encountered are rhabdomyosarcomas, carcinomas, and lymphomas. We report a single case from a tertiary care institution of an adolescent male with an unusual presentation of a benign nasopharyngeal mass and provide a comprehensive review of pediatric nasopharyngeal masses. …”
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1023
CAR-T therapy toxicities: the importance of macrophages in their development and possible targets for their management
Published 2025-01-01“…Abstract CAR-T cell therapies have risen to prominence over the last decade, and their indications are increasing with several products approved as early as second line in Large B Cell non-Hodgkin Lymphomas. Their major toxicities are the cytokine release syndrome (CRS) and the Immune-effector Cell Associated Neurotoxicity Syndrome (ICANS). …”
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1024
Childhood Hypopigmented Mycosis Fungoides: A Rare Diagnosis
Published 2016-01-01“…Primary cutaneous lymphomas (PCL) are rare in pediatrics. Mycosis fungoides (MF) is the most frequent PCL diagnosed in childhood. …”
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1025
Host Epithelial Interactions with Helicobacter Pylori: A Role for Disrupted Gastric Barrier Function in the Clinical Outcome of Infection?
Published 2005-01-01“…Infection of the human stomach with Helicobacter pylori may develop into gastritis, ulceration, adenocarcinoma and mucosal lymphomas. The pathogenic mechanisms that determine the clinical outcome from this microbial-epithelial interaction remain poorly understood. …”
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1026
CAR-T Therapy Beyond B-Cell Hematological Malignancies
Published 2025-01-01“…Despite the advances of CAR-T cells in certain hematological malignancies, mostly from B-cell derivations such as non-Hodgkin lymphomas, acute lymphoblastic leukemia and multiple myeloma, a significant portion of other hematological and non-hematological pathologies can benefit from this innovative treatment, as the results of clinical studies are demonstrating. …”
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1027
Crystal Structures of Tcl1 Family Oncoproteins and Their Conserved Surface Features
Published 2002-01-01“…Members of the TCL1 family of oncogenes are abnormally expressed in mature T-cell leukemias and B-cell lymphomas. The proteins are involved in the coactivation of protein kinase B (Akt/PKB), a key intracellular kinase. …”
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1028
Epstein-Barr Virus Infection in an Elderly Nonimmunocompromised Adult Successfully Treated with Rituximab
Published 2014-01-01“…In addition to causing a viral illness, it is also associated with various malignancies in particular B cell lymphomas and lymphoproliferative disorders. Differentiating between the two processes can be a diagnostic challenge. …”
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1029
Benign and non-neoplastic tumours of the duodenum
Published 2019-12-01“…Among tumours the following should be mentioned – benign: adenomas, lipomas, haemangiomas, and leiomyomas; and malignant: malignant tumours of epithelial origin, primary gastrointestinal stromal tumours, neuroendocrine tumours and carcinoids, lymphomas, sarcomas, teratomas, and secondary metastases. …”
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1030
Structure-guided engineering of immunotherapies targeting TRBC1 and TRBC2 in T cell malignancies
Published 2024-02-01“…Abstract Peripheral T cell lymphomas are typically aggressive with a poor prognosis. …”
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1031
DNA replication initiation drives focal mutagenesis and rearrangements in human cancers
Published 2024-12-01“…Sites of replication initiation impede nucleotide excision repair in melanoma and are off-targets for activation-induced deaminase (AICDA) activity in lymphomas. Using ductal pancreatic adenocarcinoma as a cancer model, we demonstrate that the initiation of DNA synthesis is error-prone at G-quadruplex-forming sequences in tumours displaying markers of replication stress, resulting in a previously recognised but uncharacterised mutational signature. …”
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1032
Gastric Collision Tumors: An Insight into Their Origin and Clinical Significance
Published 2015-01-01“…Tumors encountered are gastric adenocarcinomas colliding with lymphomas, gastrointestinal stromal tumors, squamous cell carcinomas, and neuroendocrine tumors. …”
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1033
Morphologic Features of Extrahepatic Manifestations of Hepatitis C Virus Infection
Published 2012-01-01“…Other HCV-associated entities include porphyria cutanea tarda, lichen planus, necrolytic acral erythema, membranous glomerulonephritis, diabetic nephropathy, B-cell non-Hodgkin lymphomas, insulin resistance, sialadenitis, sicca syndrome, and autoimmune thyroiditis. …”
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1034
HCV and Lymphoproliferation
Published 2012-01-01“…These latter range from benign, but prelymphomatous conditions, like mixed cryoglobulinemia, to frank lymphomas. Analogously with Helicobacter pylori related lymphomagenesis, the study of the effects of viral eradication confirmed the etiopathogenetic role of HCV and showed it is an ideal model for better understanding of the molecular mechanisms involved. …”
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1035
CAR-T CELLS IN CHRONIC LYMPHOCYTIC LEUKEMIA
Published 2024-04-01“…Among these new treatments, a potentially curative approach consists of the use of chimeric antigen receptor T (CAR-T) cell therapy, which achieved remarkable success in various B-cell malignancies, including B-cell Non-Hodgkin Lymphomas (NHLs) and B-acute lymphoblastic Leukemia (ALL). …”
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1036
Histopathological Spectrum and Immunohistochemistry Expression of Pediatric Solid Malignant Tumors: An Observational Study
Published 2025-01-01“…Results: The top five categories of tumors were retinoblastomas, lymphomas, neuroblastomas, bone and soft tissue tumors, and renal and reproductive system tumors. …”
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1037
MicroRNAs as Haematopoiesis Regulators
Published 2013-01-01“…Aberrant expression of miRNAs was observed in hematological malignancies including chronic myelogenous leukemia, chronic lymphocytic leukemia, multiple myelomas, and B cell lymphomas. In this review we have focused on discussing the role of miRNA in haematopoiesis.…”
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1038
Oncolytic Virotherapy for Hematological Malignancies
Published 2012-01-01“…Hematological malignancies such as leukemias, lymphomas, multiple myeloma (MM), and the myelodysplastic syndromes (MDSs) primarily affect adults and are difficult to treat. …”
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1039
ANCA-Associated Vasculitides and Hematologic Malignancies: Lessons from the Past and Future Perspectives
Published 2019-01-01“…The purpose of this paper is to collect and summarize all evidences relating to an association between ANCA-associated vasculitides (AAVs) and hematologic malignancies, in the form of either a paraneoplastic vasculitis or leukemias and lymphomas developing on a preexisting vasculitis. Additionally, the role of cyclophosphamide in vasculitis treatment has been assessed and compared to rituximab. …”
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1040
The investigation of marek disease, lenfoid leucosis and reticuloendotheliosis by elisa and histopathologic methods in chickens in konya province
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