Induction of Apoptosis Coupled to Endoplasmic Reticulum Stress through Regulation of CHOP and JNK in Bone Marrow Mesenchymal Stem Cells from Patients with Systemic Lupus Erythemato... by Genkai Guo, Yan Meng, Wei Tan, Yunfei Xia, Chun Cheng, Xiaolan Chen, Zhifeng Gu

“…Furthermore, blockage of PERK signaling expression by siRNA not only significantly reduced the expression of CHOP, but also activated the anti-apoptotic regulator B-cell lymphoma-2 (Bcl-2). Blockage of IRE-1 or JNK1/2 by siRNA resulted in the decreased expression of JNK1/2 and proapoptosis protein Bcl-2 associated protein X (BAX). …”
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Chlormethine Gel for Treatment of Patients with Mycosis Fungoides: Best Practices and Guidance to Clinicians by Larisa Geskin, Christiane Querfeld, Emmilia Hodak, Neda Nikbakht, Evangelia Papadavid, Marco Ardigò, Ulrike Wehkamp, Martine Bagot

“…Abstract Background Mycosis fungoides (MF) is the most common form of cutaneous T cell lymphoma. While multiple guidelines provide treatment recommendations, there are currently no clear treatment algorithms for MF. …”
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Investigating orbital foreign device-associated malignancies: a scoping review by Jeong Hyun Ha, Jagmeet S. Arora, Jamasb J. Sayadi, Nada R. Khattab, Shannon D. Francis, Thomas M. Johnstone, Yeonji Jang, Gordon K. Lee

“…Other malignancies observed were pleomorphic sarcoma, synovial sarcoma, marginal zone B-cell lymphoma, sebaceous carcinoma, malignant melanoma, adenocarcinoma, and metastatic lung adenocarcinoma. …”
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Alternative Expression Pattern of MALT1-A20-NF-κB in Patients with Rheumatoid Arthritis by Xu Wang, Lihua Zhu, Ziwei Liao, Fan Zhang, Ling Xu, Yan Xu, Shaohua Chen, Lijian Yang, Yi Zhou, Yangqiu Li

“…In this study, we analyzed the expression level of A20, NF-κB, and A20 regulatory factor mucosa-associated lymphoid tissue lymphoma translocation gene 1 (MALT1) in patients with RA. …”
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Sjögren Syndrome Complicated with Cystic Lung Disease and Pulmonary Amyloidosis by Koichiro Takahashi, Hironori Sadamatsu, Shinsuke Ogusu, Kazutoshi Komiya, Tomomi Nakamura, Shinya Kimura, Naoko Sueoka-Aragane

“…After 6 years, the cystic lung lesions on CT gradually enlarged and increased in number, but she remained to have no respiratory symptoms and no manifestations of lymphoma. Here, we report a rare case of Sjögren syndrome complicated with cystic lung disease and pulmonary amyloidosis.…”
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Subcutaneous Granulomatous Inflammation due to Basidiobolomycosis: Case Reports of 3 Patients in Buruli Ulcer Endemic Areas in Benin by Luc V. C. Brun, Jean Jacques Roux, Ghislain E. Sopoh, Julia Aguiar, Miriam Eddyani, Wayne M. Meyers, Dirk Stubbe, Marie T. Akele Akpo, Françoise Portaels, Bouke C. de Jong

“…Basidiobolomycosis is a rare subcutaneous mycosis, which can be mistaken for several other diseases, such as soft tissue tumors, lymphoma, or Buruli ulcer in the preulcerative stage. …”
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Aberrant c-AMP signalling in richter syndrome revealed by single-cell transcriptome and 3D chromatin analysis by Heng Li, Cheng Xing, Ji Li, Yihao Zhan, Ming Luo, Peilong Wang, Yue Sheng, Hongling Peng

“…Abstract Richter syndrome (RS), characterized by aggressive lymphoma arising from chronic lymphocytic leukaemia (CLL), presents a poor response to treatment and grim prognosis. …”
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Improved ChIP Sequencing for H3K27ac Profiling and Super-Enhancer Analysis Assisted by Fluorescence-Activated Sorting of Formalin-Fixed Paraffin-Embedded Tissues by Nenggang Jiang, Zhihao Wen, Huan Tao, Hongyan Liao

“…In this study, the protocol of ChIP-seq with purified cells from FFPE lymphoid tissue of nodal T follicular helper cell lymphoma, angioimmunoblastic type (nTFHL-AI) after fluorescence-activated cell sorting (FACS) was established and optimized. …”
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Regulation of S100A8/A9 (Calprotectin) Binding to Tumor Cells by Zinc Ion and Its Implication for Apoptosis-Inducing Activity by Yuichi Nakatani, Masatoshi Yamazaki, Walter J. Chazin, Satoru Yui

“…We previously reported that S100A8/A9 induces apoptosis of EL-4 lymphoma cells via the uptake of extracellular zinc in a manner similar to DTPA, a membrane-impermeable zinc chelator. …”
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Laboratory diagnosis of H. pylori among dyspeptic patients using Culture and Rapid urease test by Hogir Mohammed Shukri Saadi, Ali Yahya Saeed

“…Knowledge of the epidemic and the Routes of transmission of this pathogen are important points to avoid from spreading and may be useful in identifying high-risk populations, especially in areas that have high rates of gastric lymphoma, gastric cancer, and gastric ulcer. The current study concludes (RUT) was superlative than culture for the detection of Helicobacter pylori. …”
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Cutaneous pseudolymphoma: a case series of three patients by Yue Yao, Yue Yao, Yue Yao, Yijia He, Yijia He, Yijia He, Zhuochen Wu, Zhuochen Wu, Zhuochen Wu, Jinfang Zhang, Jinfang Zhang, Jinfang Zhang, Guoqiang Zhang, Guoqiang Zhang, Guoqiang Zhang

“…Cutaneous pseudolymphoma is a type of reactive lymphoid hyperplasia that pathologically and/or clinically mimics cutaneous lymphoma. It has a variety of pathogenic factors. However, in many cases, no etiology can be identified. …”
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Rare Site of an Inflammatory Myofibroblastic Tumor at the Epididymis: A Case Report by Lange A, Dominiak N, Petros FG

“…Histology confirmed a 2.4 cm inflammatory myofibroblastic tumors with scattered positivity for smooth muscle actin, negative pancytokeratin, and negative anaplastic lymphoma kinase. Patient recovered well with no reoccurrence at this time.Conclusion: Inflammatory myofibroblastic tumors recurrence rate is < 2%; however, some literature suggests higher depending on location and immunohistochemical profile. …”
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In Vitro Evaluation of a Stable Monomeric Gold(II) Complex with Hematoporphyrin IX: Cytotoxicity against Tumor and Kidney Cells, Cellular Accumulation, and Induction of Apoptosis by Georgi Momekov, Dilyan Ferdinandov, Spiro Konstantinov, Sonja Arpadjan, Daniela Tsekova, Galina Gencheva, Panayot R. Bontchev, Margarita Karaivanova

“…The complex exhibits strong cytotoxicity, whereby the leukaemia- and lymphoma-derived cell lines are more sensitive, with IC50 values comparable to those of the reference anticancer drug cisplatin. …”
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Pediatric and adolescent cancer disparities in the Middle East and North Africa (MENA) region: incidence, mortality, and survival across socioeconomic strata by Ankita Shukla, Rouba Karen Zeidan, Basema Saddik

“…MIR was higher in low-income countries, particularly for males and specific cancer types such as liver, colon and rectum, brain and central nervous system (CNS) cancers, and non-Hodgkin lymphoma among others. A negative correlation was observed between a country’s SDI and MIR (-0.797) and SDI and mortality rates (-0.547) indicating that higher SDI corresponds to lower MIR and lower mortality rates. …”
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Alveolar Rhabdomyosarcoma of Nasopharynx and Paranasal Sinuses in Children Diagnosis and Treatment—Review of the Literature and Case Report by Cristian Mârțu, Ștefan Dragoș Tîrnovanu, Ioana Mârțu, Dan Ferariu, Dan Mârțu, Alexandra Jităreanu, Luminița Rădulescu

“…Rhabdomyosarcoma is the second most common ENT neoplasm in children, following lymphoma, with an incidence of approximately 6 cases per 1,000,000 annually. …”
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Occupational disparities in survival in Korean women with cancer: a nationwide registry linkage study by Ichiro Kawachi, Hye-Eun Lee, Eun-A KIM, Masayoshi Zaitsu

“…HRs for mortality adjusting for age and year of diagnosis were calculated in the study sample and subgroups with 10 specific cancer sites including thyroid, breast, stomach, cervix, colon or lung cancer using managers, professionals and technical workers as the reference.Results Women in service/sales (HR 1.25, 95% CI 1.15 to 1.35) and blue-collar occupations (HR 1.34, 95% CI 1.25 to 1.44) had poorer survival for all cancer sites combined, while blue-collar workers showed poorer survival for lung (HR 1.41, 95% CI 1.14 to 1.77), breast (HR 1.28, 95% CI 1.06 to 1.54), cervical cancer (HR 1.42, 95% CI 1.02 to 2.06) and non-Hodgkin’s lymphoma (HR 1.69, 95% CI 1.09 to 2.77) compared with women in professional and managerial positions.Conclusion We found substantial and significant inequalities in overall survival by the occupational group among Korean women with cancer, even in the context of universal access to cancer screening and treatment.…”
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Comparative Approach to Define Increased Regulatory T Cells in Different Cancer Subtypes by Combined Assessment of CD127 and FOXP3 by Marc Beyer, Sabine Classen, Elmar Endl, Matthias Kochanek, Martin R. Weihrauch, Svenja Debey-Pascher, Percy A. Knolle, Joachim L. Schultze

“…Here, we demonstrate that the expanded FOXP3+ T-cell population in patients with colorectal cancer, CLL, MGUS, MM, follicular lymphoma, and Hodgkin's disease are exclusively CD127low Treg cells and were strongly suppressive. …”
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Inhibition of the anti-apoptotic protein BCL2 in EML4-ALK cell models as a second proposed therapeutic target for non-small cell lung cancer. by Richard Junior Zapata Dongo, Diletta Fontana, Luca Mologni, Juan Enrique Faya Castillo, Stefany Fiorella Infante Varillas

“…The anaplastic lymphoma kinase (ALK) oncoprotein plays a crucial role in non-small cell lung cancer (NSCLC) by activating signaling pathways involved in cell proliferation and survival through constitutive phosphorylation. …”
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Molecular Signature of miR-34a/NEAT-1/p53 Axis in Mycosis Fungoides by Reham Fares, Shimaa M. Elasmer, Abeer Khalefa A., Olfat G. Shaker, Samar M. El-Tahlawi, Ahmed Sabri, Sara M. Yaseen

“…Mycosis fungoides (MF) is a type of cutaneous T-cell lymphoma where red rash exists on the skin. Understanding the role of miRNAs and ncRNAs in p53-response has become an open discussion, as they can regulate p53 or its downstream targets, and ncRNAs themselves. …”
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An Unusual Case of Systemic Inflammatory Myofibroblastic Tumor with Successful Treatment with ALK-Inhibitor by Sanjivini V. Jacob, John D. Reith, Angerika Y. Kojima, William D. Williams, Chen Liu, Lizette Vila Duckworth

“…Tumor cells showed immunoreactivity for smooth muscle actin and anaplastic lymphoma kinase 1 (ALK1). Tissue from the L5 vertebra showed a process histologically identical to that seen in the liver. …”
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