Tracheobronchial Manifestations of Aspergillus Infections by Rafal Krenke, Elzbieta M. Grabczak

“…Thus, invasive or potentially invasive Aspergillus airway diseases are discussed separately in three groups of patients: (1) lung transplant recipients, (2) highly immunocompromised patients with hematologic malignancies and/or patients undergoing hematopoietic stem cell transplantation, and (3) the remaining, less severely immunocompromised patients or even immunocompetent subjects.…”
Get full text

Low CD4/CD8 Ratio in Bronchus-Associated Lymphoid Tissue Is Associated with Lung Allograft Rejection by K. V. Shenoy, C. Solomides, F. Cordova, T. J. Rogers, D. Ciccolella, G. J. Criner

“…Patients were grouped by frequency and severity of acute rejection based on International Society of Heart Lung Transplant (ISHLT) criteria. Transbronchial biopsies were reviewed for BALT by a blinded pathologist. …”
Get full text

BPI-ANCA Provides Additional Clinical Information to Anti-Pseudomonas Serology: Results from a Cohort of 117 Swedish Cystic Fibrosis Patients by Ulrika Lindberg, Malin Carlsson, Thomas Hellmark, Mårten Segelmark

“…Lung function and patient outcome, alive, lung transplanted, or dead, were registered. BPI-ANCA showed the highest correlation with lung function impairment with an r-value of 0.44. …”
Get full text

The Burden of Cost in Bronchiolitis Obliterans Syndrome: Predictions for the Next Decade by Christopher A. Jones, David G. Chapman, Peter Weimersheimer, Luca Fernandez, Oscar Alejandro Mesa, Christian Peters, Bart M. Vanaudenaerde, Mitchell C. Norotsky, Robin Vos

“…BOS affects half of all lung transplant patients within the first 5 years post-transplant, rising to the majority of patients (~80%) within the first decade following transplant. …”
Get full text

EBV-Negative Monomorphic B-Cell Posttransplant Lymphoproliferative Disorder with Marked Morphologic Pleomorphism and Pathogenic Mutations in ASXL1, BCOR, CDKN2A, NF1, and TP53 by Agata M. Bogusz

“…This report describes an unusual case of a 33-year-old woman that developed a monomorphic EBV-negative PTLD consistent with diffuse large B-cell lymphoma (DLBCL) 13 years after heart-lung transplant. Histological examination revealed marked pleomorphism of the malignant cells including nodular areas reminiscent of classical Hodgkin lymphoma (cHL) with abundant large, bizarre Hodgkin-like cells. …”
Get full text

Targeting TCMR-associated cytokine genes for drug screening identifies PPARγ agonists as novel immunomodulatory agents in transplantation by Lu Hu, Lu Hu, Xiaohan Zhang, Xiaohan Zhang, Weiqi Zhang, Weiqi Zhang, Shuai Jin, Shuai Jin, Jie Zhao, Jianming Zheng, Wenli Song, Zhongyang Shen, Zhongyang Shen, Zhongyang Shen

“…This study aimed to define a TCMR-associated cytokine gene set and identify drugs to prevent TCMR through drug repurposing.MethodsGene expression profiles from kidney, heart, and lung transplant biopsies were obtained from the Gene Expression Omnibus (GEO) database. …”
Get full text

Genetic characterization of a rare case of pheochromocytoma in a pulmonary transplant patient by Stéfanie Parisien-La Salle, Florence Perreault, Gilles Corbeil, Julie Morisset, Charles Poirier, Catherine Beauregard, Agnès Räkel, Marjorie Labrecque, Martine Tétreault, Martine Tétreault, Christian Cohade, Pasquale Ferraro, Isabelle Bourdeau

“…Chronic hypoxia can lead to gain of function somatic variants in the EPAS1 gene that encodes for hypoxia-inducible factor 2-alpha (HIF-2α), involved in PPGL tumorigenesis.ObjectiveTo describe a rare case of PCC in a pulmonary transplant patient and characterize the tumour’s genetic background.Clinical CaseA 47 year-old man underwent a lung transplant for chronic obstructive pulmonary disease associated with alpha-1 antitrypsin deficiency. …”
Get full text

Pulmonary hypertension in Finland 2008-2020: A descriptive real-world cohort study (FINPAH) by Markku Pentikäinen, Piia Simonen, Helena Tuunanen, Pauliina Leskelä, Terttu Harju, Pertti Jääskeläinen, Christian Asseburg, Minna Oksanen, Erkki Soini, Christina Wennerström, Airi Puhakka, Terttu Harju, Elina Heliövaara, Pertti Jääskeläinen, Katriina Kahlos, Pentti Korhonen, Tiina Kyllönen, Pauliina Leskelä, Kirsi Majamaa-Voltti, Piia Simonen, Anu Turpeinen, Helena Tuunanen, Ville Vepsäläinen, Tapani Vihinen

“…Ten PAH patients had a lung transplant. PAH subtype, cardiac output, and the presence of ischemic heart disease or type 2 diabetes predicted survival.CTEPH patients (n = 189) were 63 years (mean) at diagnosis and 49% were women. …”
Get full text

Efficacy and Safety of Low-Dose Cyclosporine with Everolimus and Steroids in de novo Heart Transplant Patients: A Multicentre, Randomized Trial by Andreas Zuckermann, Shoei-Shen Wang, Heather Ross, Maria Frigerio, Howard J. Eisen, Christoph Bara, Daniel Hoefer, Maurizio Cotrufo, Gaohong Dong, Guido Junge, Anne M. Keogh

Get full text

Derivation of a simple risk calculator for predicting clinical worsening in patients with pulmonary hypertension due to interstitial lung disease by K. El-Kersh, R. Bag, N. Bhatt, C. King, A. Waxman, F. Rischard, H. Kim, D. Cella, E. Shen, SD Nathan

“…The risk calculators may also find utility as part of the composite allocation score of ILD-PH patients listed for lung transplant. Future research in this area could include incorporating longer-term outcomes as well as validating the risk models in a separate patient population.…”
Get full text

Nomogram model using serum Club cell secretory protein 16 to predict prognosis and acute exacerbation in patients with idiopathic pulmonary fibrosis by Yaqiong Tian, Xuan Zhou, Mi Tian, Lijun Ren, Ruyi Zou, Hanyi Jiang, Miaomiao Xie, Mei Huang, Jingjing Ding, Yin Liu, Jingyu Chen, Min Cao, Hourong Cai

Get full text

Longitudinal immunogenicity cohort study of SARS-CoV-2 mRNA vaccines across individuals with different immunocompromising conditions: heterogeneity in the immune response and cruci... by Annalisa Ciabattini, Elena Pettini, Fabio Fiorino, Jacopo Polvere, Simone Lucchesi, Chiara Coppola, Simone Costagli, Gabiria Pastore, Anna Sicuranza, Monica Tozzi, Arianna Lippi, Francesca Panza, Monica Bocchia, Alessandro Bucalossi, Guido Garosi, David Bennett, Sonia Bernazzali, Massimiliano Fabbiani, Francesca Montagnani, Donata Medaglini

Get full text