Emerging carbapenem-resistant Klebsiella pneumoniae in a tertiary care hospital in Lima, Peru by Fiorella Krapp, Diego Cuicapuza, Guillermo Salvatierra, Jean P. Buteau, Catherine Amaro, Lizeth Astocondor, Noemí Hinostroza, Jan Jacobs, Coralith García, Pablo Tsukayama

“…ABSTRACT The emergence of carbapenem-resistant Klebsiella pneumoniae (CRKP) poses a significant public health threat, particularly in low- and middle-income countries (LMICs) with limited surveillance and treatment options. …”
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Policy brief: Optimising antimicrobial usage in paediatric inpatient hospital settings by J Cloete, M Karsas, T Chetty, A Pillay, M Archary, D Moore, T Reddy, Y Balakrishna, F Nakwa, R Lancaster, A Goga, P Jeena

“…Paediatric inpatients are particularly vulnerable to infections, leading to high antimicrobial consumption. In low-to-middle income countries (LMICs) like South Africa, research on antimicrobial usage for neonatal and paediatric healthcare-associated infections (HAI) is limited. …”
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Neurological syndromes associated with COVID-19: a multicenter study in Brazil by Aline de Moura Brasil Matos, Andre Borges Ferreira Gomes, Fernanda Martins Maia Carvalho, Francisco Tomaz Meneses de Oliveira, Lohana Santana Almeida da Silva, Flavia Esper Dahy, Joao Victor Luisi de Moura, Marcela Vieira Freire, Jose Ernesto Vidal, Rosa Maria Nascimento Marcusso, Jerusa Smid, Victor Rebelo Procaci, Rodrigo Meireles Massaud, Felipe Von Glehn, Jorge Casseb, Camila Malta Romano, Augusto Cesar Penalva de Oliveira, on behalf of NeurocovBR study group

“…Abstract Background Neurological manifestations associated with COVID-19 remain partially described, mainly in low- and middle-income countries where diagnostic tools are limited. …”
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Prevalence and determinants of HIV testing-seeking behaviors among women of reproductive age in Tanzania: analysis of the 2022 Demographic and health survey by Jackson Micheal Asingwire, Isaac isiko, Kuli Faith Rombe, Aaron Mwesigwa, Emmanuel Asher Ikwara, Haron Olot, Lenz Nwachinemere Okoro, Manankong Jane Precious Izunwanne, Blessing Onyinyechi Agunwa, Abdul Aziiz Bwana, William Yiga Kalemba, Ebuka Louis Anyamene

“…Abstract Aim HIV remains one of the major epidemics and public health concerns within low and middle-income countries such as Tanzania. This study aimed to assess the prevalence and the factors associated with HIV testing-seeking behaviors among women of childbearing age in Tanzania. …”
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Effectiveness of ICS/LABA and LAMA/LABA in COPD due to biomass by Alejandra Ramírez-Venegas, Francisco Montiel-Lopez, Robinson E. Robles-Hernández, Bartolome R. Celli, Raúl H. Sansores, Maricruz Cassou-Martínez, José L. Pérez Lara-Albisua, Claudia González-González, María E. Mayar-Maya, Aloisa P. Hernández-Morales, Rafael J. Hernández-Zenteno, Ramcés Falfán-Valencia, Ireri Thirión-Romero, Oliver Pérez-Bautista, Rogelio Pérez-Padilla

“…Background COPD due to biomass exposure (COPD-B) is highly prevalent in low- and middle-income countries, and there are no clinical trials designed to evaluate the effectiveness of the treatments currently recommended for patients with COPD due to cigarette smoking (COPD-C). …”
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Deployment and uptake of COVID-19 vaccines for refugees and migrants in regular and irregular situations: a mixed-method multicountry study by Biraj Man Karmacharya, Karl Blanchet, Jai K Das, Laetitia Nyirazinyoye, Maria Midea M Kabamalan, Nguyen Toan Tran, Zahra A Padhani, Anjali Joshi, Seyed-Moeen Hosseinalipour, Enrique Teran, Pierina Benavente, Vinay N Kampalath, Moussa Lonkila Zan, Elżbieta Anna Czapka, Cheryl Martens, Vicente B Jurlano

“…This study aimed to identify barriers and facilitators and estimate vaccination coverage among refugees and migrants in low- and middle-income countries, emphasising inclusive policies for effective rollout.Methods A mixed-method study was conducted in two phases in Ecuador, Nepal, Pakistan, the Philippines and Rwanda. …”
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Anti-phenolic glycolipid antibodies in Mycobacterium bovis infected cattle by Zijie Zhou, Anouk van Hooij, J. Hessel M. van Dijk, Nina Musch, Louise Pierneef, Hamza Khalid, Kees Franken, Thomas Holder, Neil Watt, Anita L. Michel, Jeroen D.C. Codée, Martin Vordermeier, Paul L.A.M. Corstjens, Elisabeth M.D.L. van der Heijden, Jayne C. Hope, Annemieke Geluk

“…Additionally, M. bovis transmission from animals to humans can result in zoonotic TB, especially in low- and middle-income countries (LMICs), highlighting the need to enhance One Health surveillance to mitigate this threat.Antibodies directed against a major mycobacterial cell wall component of M. leprae, phenolic glycolipid-I (PGL-I), have shown excellent performance in identifying M. leprae infection in humans and animals. …”
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Is there a mental health diagnostic crisis in primary care? Current research practices in global mental health cannot answer that question by Brandon A. Kohrt, Dristy Gurung, Ritika Singh, Sauharda Rai, Mani Neupane, Elizabeth L. Turner, Alyssa Platt, Shifeng Sun, Kamal Gautam, Nagendra P. Luitel, Mark J.D. Jordans

“…In low- and middle-income countries, fewer than 1 in 10 people with mental health conditions are estimated to be accurately diagnosed in primary care. …”
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Resistome phylodynamics of multidrug-resistant Shigella isolated from diarrheal patients by Asaduzzaman Asad, Md. Abu Jaher Nayeem, Md. Golam Mostafa, Ruma Begum, Shah Nayeem Faruque, Suraia Nusrin, Israt Jahan, Shoma Hayat, Zhahirul Islam

“…Healthcare providers in low- and middle-income countries (LMICs) often face trouble finding effective drugs among the many antibiotics introduced in diarrheal treatment. …”
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Combining genomics and epidemiology to investigate a zoonotic outbreak of rabies in Romblon Province, Philippines by Mirava Yuson, Criselda T. Bautista, Eleanor M. Rees, Carlijn Bogaardt, Van Denn D. Cruz, Rowan Durrant, Anna Formstone, Daria L. Manalo, Duane R. Manzanilla, Mikolaj Kundergorski, Leilanie Nacion, Hannaniah Aloyon, Jude Karlo Bolivar, Jeromir Bondoc, Christina Cobbold, Efraim Panganiban, Shynie Vee. M. Telmo, Jobin Maestro, Mary Elizabeth G. Miranda, Nai Rui Chng, Kirstyn Brunker, Katie Hampson

“…Abstract Rabies is a viral zoonosis that kills thousands of people annually in low- and middle-income countries across Africa and Asia where domestic dogs are the reservoir. …”
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Diversity in the medical research ecosystem: a descriptive scientometric analysis of over 49 000 studies and 150 000 authors published in high-impact medical journals between 2007... by Leo Anthony Celi, Jonathan Shaffer, Marie-Laure Charpignon, Liam G McCoy, Luis Filipe Nakayama, Jack Gallifant, Urvish Jain, Joao Matos, Pia Gabrielle I Alfonso, Marisa Cobanaj, Amelia Morel Fiske, Alexander J Gates, Frances Dominique V Ho, Mohammad Kashkooli, Naira Link

“…However, researchers identifying as women and those affiliated with institutions in low- and middle-income countries (LMICs) have been largely under-represented in high-IF journals across multiple fields of medicine. …”
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Global, regional, and national burdens of heart failure in adolescents and young adults aged 10–24 years from 1990 to 2021: an analysis of data from the Global Burden of Disease St... by Chengzhi Yang, Yuhe Jia, Changlin Zhang, Zening Jin, Yue Ma, Xuanye Bi, Aiju Tian

“…According to different underlying causes of HF, both high-income countries and low- and middle-income countries need to better prevent HF in adolescents and young adults. …”
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Clinicogenetic characterization and response to disease-modifying therapies in spinal muscular atrophy: real-world experience from a reference center in Southern Brazil by Ana Letícia Amorim de Albuquerque, Júlia Kersting Chadanowicz, Isabela Possebon Bevilacqua, Ana Lucia Portella Staub, Pablo Brea Winckler, Patricia Zambone da Silva, Simone Chaves Fagondes, Renata Salatti Ferrari, Claudia Denise de Oliveira Trojahn, Viviane Zechlinski Sacharuk, Thayne Woycinck Kowalski, Karina Carvalho Donis, Michele Michelin Becker, Jonas Alex Morales Saute

“…Conclusion: This real-world study reinforces the effectiveness of disease-modifying therapies for SMA in Brazil within the context of low- and middle-income countries, which is greater the earlier and the better the patient's functional status.…”
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Prognostic Modeling for Bone Sarcomas Based on a Large Prospective Cohort From a Tertiary Care Cancer Center in India by Jyoti Bajpai, Laboni Sarkar, Sushmita Rath, Akash Pawar, Arun Chandrashekharan, Goutam Panda, Dharmpal Jakar, Jaya Ghosh, Siddhartha Laskar, Bharat Rekhi, Nehal Khanna, Jifmi Jose, Mukta Ramdawar, Nilendu Purandare, Prabhat Bhargava, Nivedita Chakrabarty, Kunal Gala, Yogesh Kembhavi, Venkatesh Rangarajan, Shripad Banavali, Sudeep Gupta

“…For 38 (43.6%) of 82 AYA with metastatic extremity ES, significant factors were failure to complete protocol (HR, 3.88) and metastases not amenable to local treatment (HR, 10.6).CONCLUSIONWe developed simple, effective prognostic models for AYA with bone sarcomas with specific potential relevance for low- and middle-income countries.…”
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Experience on postmortem minimally invasive tissue sampling to ascertain the cause of death determination in South African children: A case for implementing as standard of care by J du Toit, K Storath, I Dunn, P Makekeng, M Moosa, K Mothibi, N Umuneza, C A Rees, D Blau, S Lala, Y Adam, S Velaphi, M Hale, P Swart, J Wadula, L Mothibi, A Wise, V Baba, P Jaglal, S Mahtab, S Madhi, Z Dangor

“…MITS proves a valid alternative to full diagnostic autopsies, especially in low- and middle-income countries. In Soweto, South Africa (SA), the Child Health and Mortality Prevention Surveillance (CHAMPS) programme has delineated over 1 000 child and stillbirth deaths since 2017. …”
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The development of a nurse-led preoperative anaesthesia screening tool by Delphi consensus by M B Nejthardt, P Alexandris, S Bechan, M F A Bijli, S Chetty, J M Dippenaar, M Gibbs, M Johnson, H Kluyts, R Llewellyn, M Motiang, P Mogane, P Motshabi, B Mrara, F Roodt, U Singh, S Spijkerman, E Turton, J van der Westhuizen, B Biccard

“… Background. Low- and middle-income countries have a critical shortage of specialist anaesthetists. …”
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Direct maternal morbidity and the risk of pregnancy-related deaths, stillbirths, and neonatal deaths in South Asia and sub-Saharan Africa: A population-based prospective cohort stu... by Fahad Aftab, Imran Ahmed, Salahuddin Ahmed, Said Mohammed Ali, Seeba Amenga-Etego, Shabina Ariff, Rajiv Bahl, Abdullah H Baqui, Nazma Begum, Zulfiqar A Bhutta, Godfrey Biemba, Simon Cousens, Vinita Das, Saikat Deb, Usha Dhingra, Arup Dutta, Karen Edmond, Fabian Esamai, Amit Kumar Ghosh, Peter Gisore, Caroline Grogan, Davidson H Hamer, Julie Herlihy, Lisa Hurt, Muhammad Ilyas, Fyezah Jehan, Mohammed Hamad Juma, Michel Kalonji, Rasheda Khanam, Betty R Kirkwood, Aarti Kumar, Alok Kumar, Vishwajeet Kumar, Alexander Manu, Irene Marete, Usma Mehmood, Nicole Minckas, Shambhavi Mishra, Dipak K Mitra, Mamun Ibne Moin, Karim Muhammad, Sam Newton, Serge Ngaima, Andre Nguwo, Muhammad Imran Nisar, John Otomba, Mohammad Abdul Quaiyum, Sophie Sarrassat, Sunil Sazawal, Katherine E Semrau, Caitlin Shannon, Vinay Pratap Singh, Sajid Soofi, Seyi Soremekun, Atifa Mohammed Suleiman, Venantius Sunday, Thandassery R Dilip, Antoinette Tshefu, Yaqub Wasan, Kojo Yeboah-Antwi, Sachiyo Yoshida, Anita K Zaidi, Alliance for Maternal and Newborn Health Improvement (AMANHI) maternal morbidity study group

“…<h4>Background</h4>Maternal morbidity occurs several times more frequently than mortality, yet data on morbidity burden and its effect on maternal, foetal, and newborn outcomes are limited in low- and middle-income countries. We aimed to generate prospective, reliable population-based data on the burden of major direct maternal morbidities in the antenatal, intrapartum, and postnatal periods and its association with maternal, foetal, and neonatal death in South Asia and sub-Saharan Africa.…”
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Implementation of in utero laparotomy-assisted fetoscopic spina bifida repair in two centers in Latin America: rationale for this approach in this regionAJOG Global Reports at a Gl... by Jezid Miranda, PhD, Miguel A. Parra-Saavedra, PhD, William O. Contreras-Lopez, PhD, Cristóbal Abello, MD, Guido Parra, MD, Juan Hernandez, MD, Amanda Barrero, MD, Isabela Leones, MD, Adriana Nieto-Sanjuanero, MD, Gerardo Sepúlveda-Gonzalez, MD, Magdalena Sanz-Cortes, PhD

“…Background: Spina bifida (SB) is a severe congenital malformation that affects approximately 150,000 infants annually, predominantly in low- and middle-income countries, leading to significant morbidity and lifelong disabilities. …”
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Association between gestational weight gain and adverse pregnancy outcomes: cohort analysis from South Asia and Sub-Saharan Africa by Anisur Rahman, Fyezah Jehan, Gary M Shaw, Sunil Sazawal, Salahuddin Ahmed, Abdullah H Baqui, David K Stevenson, Monjur Rahman, Jesmin Pervin, Shaki Aktar, Rasheda Khanam, Sayedur Rahman, Nitya Wadhwa, Ge Zhang, Huan Xu, Usma Mehmood, Shinjini Bhatnagar, Jeffrey S A Stringer, Bellington Vwalika, Waqasuddin Khan, Nabidul Haque Chowdhury, Imran Nisar, Javairia Khalid, Nima Aghaeepour, U Tin Nu, Yuri V Sebastião, Ramachandran Thiruvengadam, Ayushi, Bapu Koundinya Desiraju, Fatma Kabole, Muhammad Farrukh Qazi, Margaret Kasaro, Bihila Abdalla Bakari

“…Introduction Studies of gestational weight gain (GWG) and adverse pregnancy outcomes seldom focus on low-to-middle-income countries (LMICs), despite their high burden of morbidity and mortality. …”
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Prevalence and determinants of faecal carriage of carbapenem- and third-generation cephalosporin-resistant Enterobacterales: a cross-sectional household survey in northern VietnamR... by Max van Wijk, Hoang Huy Tran, Bich Ngoc Thi Vu, Costanza Tacoli, Tu Cam Thi Nguyen, Quynh Dieu Pham, Thương Hong Thi Nguyen, Trang Thu Nguyen, Hien Anh Thi Nguyen, Tung Son Trinh, Thai Duy Pham, Huong Kieu Thi Tran, Dung Tien Viet Vu, Duc Anh Dang, Tien Dac Tran, Duong Thanh Nguyen, H. Rogier van Doorn, Thomas Kesteman, Sonia Lewycka

“…Summary: Background: Antimicrobial resistance (AMR) is a silent pandemic causing 1.27 million deaths in 2019, disproportionately affecting low- and middle-income countries, but resistance among commensal microbiota and the determinants of carriage have not been widely reported. …”
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