Genomics costing tool: considerations for improving cost-efficiencies through cross scenario comparison by Marco Marklewitz, Alexandr Jaguparov, Aude Wilhelm, Oluwatosin Wuraola Akande, Biran Musul, Angela Lee Poates, Babak Afrough, Ashley Norberg, Noah Clayton Hull, Soudeh Ehsani, Group members of GCT pilot working group, Joanna Salvi Le Garrec, Toni Whistler

“…In response to the need for a systematic cost estimation approach for sustainable genomic surveillance, particularly in low- and middle-income countries, five institutions collaborated to develop the genomics costing tool (GCT). …”
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Exome sequencing in Nigerian children with early‐onset epilepsy syndromes by Ibitayo Abigail Ademuwagun, Yagoub Adam, Solomon Oladapo Rotimi, Steffen Syrbe, Maximilian Radtke, Julia Hentschel, Johannes R. Lemke, Ezekiel Adebiyi

“…Exome sequencing (ES) offers a diagnostic yield of 24%–62%, but these figures primarily reflect data from high‐income countries (HICs) and may not be applicable to low‐ and middle‐income countries (LMICs). In this study, we employed ES to investigate the genetic basis of early‐onset epilepsy in 22 affected children from Nigeria. …”
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Clinical spectrum of disease and outcomes in children with Omicron SARS-COV-2 infection in Cape Town, South Africa by C. Bekker, I. Dewandel, A. Redfern, C. McKenzie, J. Lishman, L. M. Verhagen, M. Claassen, S. Wilson, R. Dunbar, C. Bosch, G. van Zyl, W. Preiser, P. Goussard, H. Rabie, M. M. van der Zalm

“…INTRODUCTION: Children with underlying comorbidities and infants are most severely affected by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection, including in low- and middle-income countries with a high prevalence of HIV and TB. …”
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The pattern of antibiotic utilisation among intensive care unit patients hospitalised in a Gauteng (South African) provincial tertiary hospital: Comparing findings before and durin... by L Spinickum, Z Booth, S Leigh-de Rapper

“…Furthermore, the public health system has issues that make it difficult to routinely monitor, quantify antibiotic consumption, and offer evaluation, feedback and intervention, particularly in low- and middle- income countries such as South Africa (SA). Therefore, this study aimed to determine antibiotic utilisation before and during the COVID-19 pandemic in a Gauteng provincial tertiary hospital (GPTH) in SA. …”
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The use of emergency medical services for palliative situations in Western Cape Province, South Africa: A retrospective, descriptive analysis of patient records by C Gage, B Spies, K Crombie, L Gwyther, W Stassen

“…This imbalance is particularly acute in low-to middle-income countries (LMICs), where up to 80% of patients requiring palliative care reside. …”
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Folic acid supplementation during preconception period in sub-Saharan African countries: A systematic review and meta-analysis. by Mekuriaw Nibret Aweke, Elsa Awoke Fentie, Muluken Chanie Agimas, Lemlem Daniel Baffa, Ever Siyoum Shewarega, Aysheshim Kassahun Belew, Esmael Ali Muhammad, Berhanu Mengistu

“…The prevalence is about twice as common in low- and middle-income countries and more prevalent in sub-Saharan Africa. …”
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Substantial Impact of Later-Life Depression Among Community Older Adults on the Family Caregivers’ Burden in the Home Care Setting of Chiang Mai, Northern Thailand by Keisuke Shimizu, Myo Nyein Aung, Saiyud Moolphate, Thin Nyein Nyein Aung, Yuka Koyanagi, Siripen Supakankunti, Motoyuki Yuasa

“…It is particularly burdensome in low- and middle-income countries, where care for older people mainly relies on the family in the absence of long-term care facilities. …”
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Pathways to care for psychosis in rural Uganda: Mixed-methods study of individuals with psychosis, family members, and local leaders by Yang Jae Lee, Kayera Sumaya Nakaziba, Sophie Waimon, Grace Agwang, Kailash Menon, Sam Samuel, Aaron Damon Dyas, Travor Nkolo, Haba Ingabire, Jason Wykoff, Olivia Hobbs, Rauben Kazungu, Job Basiimwa, Robert Rosenheck, Scholastic Ashaba, Alexander C. Tsai

“… Abstract Background Low- and middle-income countries (LMICs) bear a disproportionate burden of mental illness, with limited access to biomedical care. …”
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Effect of tropical climates on the quality of commonly used antibiotics: the protocol for a systematic review and meta-analysis by Johnstone Thitiri, Moses Ngari, Christina W Obiero, James A Berkley, Tsegaye Melaku, Sultan Suleman, Gemmechu Hasen, Sileshi Belew, Jimmy Shangala

“…Introduction Medicine quality can be influenced by environmental factors. In low- and middle-income countries (LMICs) with tropical climates, storage facilities of medicines in healthcare settings and homes may be suboptimal. …”
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Missed opportunity for nasal continuous positive airway pressure in preterm neonates admitted at a tertiary-level hospital newborn unit in Kenya: a mixed method study by Florence Murila, Peace Kakibibi, Diana Marangu-Boore

“…However, NCPAP is not easily accessible to every preterm neonate in low- and middle-income countries, and this is the case in Kenya.Objectives To determine the proportion of preterm neonates admitted to the newborn unit (NBU) at Kenyatta National Hospital (KNH), a tertiary referral hospital in Kenya, with a missed opportunity for NCPAP and to determine the barriers and facilitators of NCPAP utilisation.Design and setting We conducted a hospital-based cross-sectional study that employed interactive explanatory concurrent mixed methods. …”
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Attitudes of nurses toward telenursing and influencing factors in resource-limited settings: Northwest Ethiopia 2022 by Fikadu Wake Butta, Biniyam Chaklu Tilahun, Berhanu Fikadie Endehabtu, Adamu Ambachew Shibabaw, Alex Ayenew Chereka, Ayenew Sisay Gebeyew, Mekides Molla Reda, Gemeda Wakgari Kitil, Teshome Demis Nimani

“…Notably, 89% of this shortage is expected to impact low- and middle-income countries. To address the growing demand for nursing professionals, the concept of telenursing care is being considered. …”
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Cost-effectiveness and budget impact of covering Burkitt lymphoma in children under Ghana’s National Health Insurance Scheme by Richmond Owusu, Dakota Pritchard, Lieke Fleur Heupink, Godwin Gulbi, Brian Asare, Ivy Amankwah, Joycelyn Azeez, Martha Gyansa-Lutterodt, Lydia Dsane-Selby, Ruby Aileen Mensah, William Omane-Adjekum, Francis Ruiz, Mohamed Gad, Justice Nonvignon, Lumbwe Chola, Ghana Health Technology Assessment Technical Working Group

“…Delayed care seeking and treatment abandonment, often due to the financial burden of care seeking to families, are common reasons for a relatively low overall survival (OS) in low-and middle-income countries. In this study, we analyzed the cost-effectiveness of extending health insurance coverage to children with Burkitt lymphoma (BL) in Ghana. …”
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Impacts of National Reimbursement Drug Price Negotiation on drug accessibility, utilization, and cost in China: a systematic review by Zheng Zhu, Jiawei Zhang, Zhihu Xu, Quan Wang, Yu Qi, Li Yang

“…It provides useful experience and lessons in improving access to innovative medicines for other low-and middle-income countries.…”
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Assessing the financial burden of multimorbidity among patients aged 30 and above in India by Sudheer Kumar Shukla, Pratheeba John, Sakshi Khemani, Ankur Shaji Nair, Nishikant Singh, Rajeev Sadanandan

“…Abstract Background Multimorbidity is associated with significant out-of-pocket expenditures (OOPE) and catastrophic health expenditure (CHE), especially in low- and middle-income countries like India. Despite this, there is limited research on the financial burden of multimorbidity in outpatient and inpatient care, and cross-state comparisons of CHE are underexplored. …”
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Knowledge, attitude, and reasons for non-uptake of human papilloma virus vaccination among nursing students by Soni Chauhan, Surya Kant Tiwari, Vishal Dubey, Pragya Tripathi, Priyanka Pandey, Anuj Singh, Narendra Pal Singh Choudhary

“…Abstract Background Cervical cancer is a significant health issue, especially in low- and middle-income countries like India, where it ranks fourth among women. …”
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Unexplored avenues: a narrative review of cognition and mood in postmenopausal African women with female genital circumcision/mutilation/cutting by Rohina Kumar, Noelia Calvo, Gillian Einstein, Gillian Einstein, Gillian Einstein, Gillian Einstein, Gillian Einstein, Gillian Einstein

“…Recent ageing research has projected the lifespan and proportion of postmenopausal women living in low- and middle-income countries to substantially increase over the years, especially on the African continent. …”
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Bacteraemia in a Nigerian hospital: Implementing antimicrobial resistance surveillance by Adewale A. Amupitan, Adeyemi T. Adeyemo, Adefunke O. Amupitan, Temitope O. Obadare, Aaron O. Aboderin

“…Implementing surveillance in low- and middle-income countries (LMICs) is challenging. Aim: To investigate bacteraemia and describe AMR surveillance. …”
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How prepared is Nigeria digital payment for health workers? A landscape analysis by Folashayo Peter Adeniji, David Ayobami Adewole, Segun Bello, Elizabeth Ekirapa, Juliet Aweko, Vincent Michael Kiberu, Charles Opio, Peter Waiswa, Olufunmilayo Ibitola Fawole

“…Abstract Introduction Stakeholders in the health sector have advocated for the optimization of digital payment channels in low-and-middle-income countries in order to improve program outcomes. …”
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Rural-urban disparity in uptaking skilled antenatal care visits by pregnant women in Bangladesh: Zero and One Inflated Poisson regression model. by Lubana Tanvia, M Ershadul Haque, Wasimul Bari

“…<h4>Background</h4>Utilization of maternal health care services, specifically, antenatal care services from skilled health providers have been given utmost priority in low- and middle-income countries over years with a view of mitigating complications during pregnancy as well as safeguarding the health and survival of both mother and newborn. …”
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Prevalence of mortality caused by injuries at Livingstone University Hospital, Zambia. A retrospective cross-sectional study. by Lukundo Siame, Malan Malumani, Chiyeñu O R Kaseya, Sergiy Ivashchenko, Leah Nombwende, Sepiso K Masenga, Benson M Hamooya, Michelo Haluuma Miyoba

“…<h4>Background</h4>Trauma is a major global public health issue, with an annual death toll of approximately 5 million, disproportionately affecting low- and middle-income countries. Zambia bears a significant burden of trauma-related mortalities, contributing to 7% of all annual deaths and 1 in 5 premature deaths in the country. …”
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