High-Titer Rheumatoid Factor is Associated with Worse Clinical Outcomes and Higher Needs for Advanced Therapies in Rheumatoid Arthritis Under Real-Life Conditions by Victor Davi R. S. Oliveira, Ana Paula M. G. Reis, Claiton V. Brenol, Ivânio A. Pereira, Karina R. Bonfiglioli, Letícia R. Pereira, Manoel B. Bértolo, Maria de Fátima L. C. Sauma, Maria Fernanda B. R. Guimarães, Paulo Louzada-Júnior, Rina D. N. Giorgi, Sebastião C. Radominski, Licia Maria H. Mota, Cleandro P. Albuquerque, Geraldo R. Castelar-Pinheiro

“…Bivariate (Student’s t and chi-squared tests) tests and multiple logistic and linear regression analyses were conducted. …”
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Risk factors associated with mortality and pathogen characteristics of bloodstream infection-induced severe sepsis in the pediatric intensive care unit: a retrospective cohort stud... by Jian Chen, Jian Chen, Haixin Huang, Ruichen Zhang, Yueqiang Fu, Chunmei Jing

“…Clinical and laboratory indicators along with pathogen characteristics were summarized. Logistic regression analysis was employed to identify independent risk factors associated with 28-day mortality.ResultsA total of 192 patients with bloodstream infection (BSI)-induced severe sepsis were identified, with a 28-day in-hospital mortality rate of 36.98% (71/192). …”
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Serum neuritin as a predictive biomarker of early neurological deterioration and poor prognosis after spontaneous intracerebral hemorrhage: a prospective cohort study by Yanwen Xu, Hanyu Zhu, Yuqi Su, Zhizhi Chen, Chuanliu Wang, Ming Yang, Feifei Jiang, Yunping Li, Yongming Xu

“…END was defined as a decrease of ≥2 points in the GCS score within 24 h of admission. A multivariate logistic regression model was used to assess the independent relationships between serum neuritin levels, END, and poor prognosis.ResultsSerum neuritin levels were significantly increased at the time of patient admission, continued to rise on day 1, peaked on day 3, and then gradually diminished from day 5 until day 10. …”
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The impact of pre-transplant ventricular assist device support in pediatric patients with end-stage heart failure on the outcomes of heart transplantation—“a single center experien... by L. Lily Rosenthal, L. Lily Rosenthal, L. Lily Rosenthal, Carola Grinninger, Sarah Marie Ulrich, Robert Dalla Pozza, Nikolaus A. Haas, Paolo Brenner, Michael Schmoeckel, Sebastian Michel, Sebastian Michel, Sebastian Michel, Christian Hagl, Christian Hagl, Jürgen Hörer, Jürgen Hörer, Jürgen Hörer

“…Secondary outcome was examined by mean of univariable and multivariable logistic regression, severity of cardiac disease based on ECMO-support pre VAD-support, mean waiting time for transplantation, mean OR time and mean length of hospital stay before and after transplantation.Results144 patients could be included in the final analysis. …”
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Prevalence and clinical profile of comorbidity among newly diagnosed pulmonary tuberculosis patients: a multi-center observational study in eastern China by Wei Wang, Wei Wang, Xiaomeng Wang, Xiaomeng Wang, Songhua Chen, Jun Li, Qinglin Cheng, Yu Zhang, Qian Wu, Qian Wu, Kui Liu, Kui Liu, Xuli Jiang, Bin Chen, Bin Chen

“…Univariate and multivariate logistic regression analyzes were performed to identify the effects of comorbidities on the clinical features of the participants.ResultsOf the 8,421 total participants, 27.6% reported cavities in the chest radiography results, 41.9% were Mycobacterium tuberculosis-positive in the etiology test results, and 38.7% (3,258/8,421) had at least one type of comorbidity. …”
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Association between Loa loa microfilaremia and anatomical hyposplenia in a rural area of the Republic of Congo: a population-based cross-sectional study by Charlotte Boullé, Elodie Lebredonchel, Jérémy T. Campillo, Valentin Dupasquier, Marlhand C. Hemilembolo, Sébastien D. S. Pion, Jean Claude Djontu, Ludovic Rancé, Philippe Souteyrand, François Missamou, Michel Boussinesq, Francine Ntoumi, Cédric B. Chesnais

“…Blood samples were analyzed for L. loa MFD, Plasmodium-PCR, Anti-Plasmodium falciparum-IgG, total IgM, sickle-cell disease status, and hematological abnormalities. Linear and logistic regressions were used to assess these associations. …”
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Metabolic syndrome in type 1 diabetes: higher time above range and glycemic variability revealed by continuous glucose monitoring (CGM) by Yayu Fang, Wei Liu, Xiaoling Cai, Yu Zhu, Mingxia Zhang, Siqian Gong, Xiangqing Wang, Chu Lin, Rui Zhang, Sai Yin, Juan Li, Yongran Huo, Xiaodan Hu, Xiaoqi Xie, Linong Ji

“…The comparison of CGM metrics suggested significantly higher time above range (TAR, 48.9%, IQR 35.3–59.5 vs. 32.8%, IQR 16.1–47.6; P < 0.001), standard deviation (SD, 3.6 ± 0.9 mmol/L vs. 3.2 ± 1.0 mmol/L; P = 0.022) and interquartile range (IQR, 4.2 mmol/L, IQR 3.2–4.8 vs. 3.7 mmol/L, IQR 3.0-4.5; P = 0.046) in those with metabolic syndrome. And the Logistic regression analysis showed that TAR (OR 1.53, 95% CI 1.02–2.23, per 20% increase), SD ( OR 1.75, 95% CI 1.07–2.84, P = 0.025) and IQR (OR 1.50, 95% CI 1.03–2.19, P = 0.036) were positively associated with metabolic syndrome after adjusting for age, sex, diabetes duration, BMI and complication status. …”
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Sex-related association between smoke exposure and gallstones in a US population: a cross-sectional study by Xingyong Huang, Xuanyu Hao, Tingting Wang, Xiaoyue Zhang, Peng Wu, Lufan Shen, Yuanyuan Yang, Wanchuan Zhang, Kai Zhang

“…Results Of the 6,982 participants, a total of 6.2% (212) men and 14.5% (512) women reported having gallstones. Logistic regression analysis showed smoking and high serum cotinine level were risk factors associated with gallstones among women, both in the model 1 (current smoker: odds ratio [OR] = 1.563, 95% confidence interval [CI] = 1.044–2.339, p = 0.032; former smoker: OR = 1.434, 95% CI = 1.116–1.842, p = 0.007; cotinine ≥ 3 ng/mL: OR = 1.800, 95% CI = 1.247–2.596, p = 0.005; and cotinine 0.05–2.99 ng/mL: OR = 1.640, 95% CI = 1.188–2.263, p = 0.005) and model 2 (current smoker: OR = 1.588, 95% CI = 1.015–2.483, p = 0.044; cotinine ≥ 3 ng/mL: OR = 1.825; 95% CI = 1.181–2.821, p = 0.011; and cotinine 0.05–2.99 ng/mL: OR = 1.509, 95% CI = 1.075–2.126, p = 0.022). …”
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Anticholinergic burden and behavioral and psychological symptoms in older patients with cognitive impairment by Sabrina Pistorio, Gianluca Scotto di Tella, Vittoria Canzanella, Raffaella Merenda, Gianluigi Cuomo, Paola Iacotucci, Vincenzo Carnovale, Leonardo Bencivenga, Maria Vargas, Annalaura Manes, Mauro Cataldi, Giuseppe Rengo, Giuseppe Rengo, Michela Zanetti, Grazia Daniela Femminella, Grazia Daniela Femminella

“…A multiple linear regression was performed to identify factors associated with higher NPI score and a logistic regression model was built to identify drug classes associated with ACB ≥ 3.ResultA total of 173 patients (mean age 74 ± 7, 74 men) were included in the study; 132 patients with ACB &lt; 3 (low risk) versus 41 patients with ACB ≥3 (high risk) were compared. …”
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Prevalence and determinants of unintended pregnancy among rural reproductive age women in Ethiopia by Melak Jejaw, Kaleb Assegid Demissie, Misganaw Guadie Tiruneh, Kaleab Mesfin Abera, Yawkal Tsega, Abel Endawkie, Wubshet D. Negash, Amare Mesfin Workie, Lamrot Yohannes, Mihret Getnet, Nigusu Worku, Adina Yeshambel Belay, Lakew Asmare, Hiwot Tadesse Alemu, Demiss Mulatu Geberu, Asebe Hagos

“…A total weighted samples of 974 reproductive-aged rural women were included in this analysis. Multilevel mixed logistic regression analysis was employed to consider the effect of hierarchal nature of EDHS data using Stata version 14 to determine individual and community level factors. …”
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Detection of cervical precancerous lesions and cancer by small-scale RT-qPCR analysis of oppositely deregulated mRNAs pairs in cytological smears by Anastasia A. Artyukh, Mikhail K. Ivanov, Mikhail K. Ivanov, Sergei E. Titov, Sergei E. Titov, Victoria V. Dzyubenko, Sergey E. Krasilnikov, Sergey E. Krasilnikov, Anastasia O. Shumeikina, Anastasia O. Shumeikina, Anastasia O. Shumeikina, Nikita A. Afanasev, Anastasia V. Malek, Sergei A. Glushkov, Eduard F. Agletdinov

“…Our aim was to devise an assay detecting severe cervical lesions (≥HSIL) via analysis of cellular mRNA expression in cytological smears.MethodsThrough logistic regression analysis of a reverse-transcription quantitative PCR (RT-qPCR) dataset generated from analysis of six mRNAs in 167 cervical smears with various cytological diagnoses, we generated a family of linear classifiers based on paired mRNA concentration ratios. …”
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Hypertension moderates the relationship between plasma beta-amyloid and cognitive impairment: a cross-sectional study in Xi’an, China by Ziyu Liu, Yaoli He, Simeng Cui, Liangjun Dang, Binyan Zhang, Jin Wang, Wenhui Lu, Kang Huo, Yu Jiang, Chen Chen, Ling Gao, Shan Wei, Yi Zhao, Ningwei Hu, Jingyi Wang, Hong Lv, Hong Lv, Qiumin Qu, Qiumin Qu, Suhang Shang

“…Decreased plasma Aβ40 was defined as &lt; 25th percentile. Multivariate logistic regression examined the relationship between plasma Aβ and CI in total population, the hypertension subgroup and the non-hypertension subgroup.Results737 participants (49.5%) had hypertension and 189 participants (12.7%) had CI. …”
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Interaction study of the effects of environmental exposure and gene polymorphisms of inflammatory and immune-active factors on chronic obstructive pulmonary disease by Rui Wang, Yuanyuan Li, Yuting Jiang, Xiaona Liu, Hongqi Feng, Zhe Jiao, Bingyun Li, Chang Liu, Yuncheng Shen, Fang Chu, Chenpeng Zhu, Dianjun Sun, Wei Zhang

“…Face-to-face interviews, lung function tests, and multiplex polymerase chain reaction were used to obtain data. Logistic regression model, generalized multifactor dimensionality reduction and crossover analysis were used to analyse the effects of SNPs, gene–gene interactions, and gene-environment interactions on COPD. …”
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The impact of war on people with type 2 diabetes in Ukraine: a survey studyResearch in context by Oksana Sulaieva, Viktoriia Yerokhovych, Sergii Zemskov, Iuliia Komisarenko, Vitalii Gurianov, Volodymyr Pankiv, Oleksandr Tovkai, Tetyana Yuzvenko, Violetta Yuzvenko, Andrii Tovkai, Zlatoslava Shaienko, Tetyana Falalyeyeva, Nadiya Skrypnyk, Taras Romaniv, Nadiya Pasyechko, Taras Krytskyy, Solomiia Danyliuk, Andrii Klantsa, Dmytro Krasnienkov, Oleksandr Gurbych, Nazarii Kobyliak

“…Next, the impact of intrinsic and war-related factors on T2D progression was assessed via logistic regression analysis and machine learning tools. …”
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A systematic analysis of the contribution of genetics to multimorbidity and comparisons with primary care dataResearch in context by Olivia Murrin, Ninon Mounier, Bethany Voller, Linus Tata, Carlos Gallego-Moll, Albert Roso-Llorach, Lucía A. Carrasco-Ribelles, Chris Fox, Louise M. Allan, Ruby M. Woodward, Xiaoran Liang, Jose M. Valderas, Sara M. Khalid, Frank Dudbridge, Sally E. Lamb, Mary Mancini, Leon Farmer, Kate Boddy, Jack Bowden, David Melzer, Timothy M. Frayling, Jane A.H. Masoli, Luke C. Pilling, Concepción Violán, João Delgado

“…Methods: We defined chronic, common, and heritable conditions in individuals aged ≥65 years, using two large primary-care databases [CPRD (UK) N = 2,425,014 and SIDIAP (Spain) N = 1,053,640], and estimated heritability using the same definitions in UK Biobank (N = 451,197). We used logistic regression to estimate the co-occurrence of pairs of conditions in the primary care data. …”
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Parsing the heterogeneity of depression: a data-driven subgroup derived from cognitive function by Chenyang Xu, Yanbao Tao, Yunhan Lin, Jiahui Zhu, Zhuoran Li, Jiayi Li, Mingqia Wang, Tao Huang, Chuan Shi

“…A linear mixed-effects model, incorporating time and group (with interaction term: time × group) as fixed effects, was used to assess cognitive changes over time. Stepwise logistic regression analysis was conducted to identify risk factors associated with these subgroups.ResultsTwo distinct neurocognitive subgroups were identified: (1) a cognitive-impaired subgroup with global impairment across all domains assessed by the C-BCT, and (2) a cognitive-preserved subgroup, exhibited intact cognitive function, with performance well within the healthy range. …”
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Clonal hematopoiesis of indeterminate potential is a risk factor of gastric cancer: A Prospective Cohort in UK Biobank study by Zhihui Xi, Huolun Feng, Kunling Chen, Xin Guo, Dandan Zhu, Jiabin Zheng, Yong Li

“…Main outcomes and measures: Odds ratio (OR) of CHIP with gastric cancer risk was estimated using multivariable logistic regression models. Participants were grouped based on age and CHIP status to examine if there are differences in the cumulative incidence of gastric cancer. …”
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Tobacco control environment: cross-sectional survey of policy implementation, social unacceptability, knowledge of tobacco health harms and relationship to quit ratio in 17 low-inc... by Annika Rosengren, Li Wei, Khalid Yusoff, Martin McKee, Clara K Chow, Rajeev Gupta, Koon Teo, Sumathy Rangarajan, Patricio Lopez-Jaramillo, Rafael Diaz, Alvaro Avezum, Fernando Lanas, Noorhassim Ismail, Romaina Iqbal, Jephat Chifamba, Gilles Dagenais, Salim Yusuf, Anna B Gilmore, Scott Lear, Wang Yang, Omar Rahman, Katarzyna Zatonska, Prem Mony, Rajesh Kumar, Afzalhussein Yusufali, Daniel J Corsi, Ehimario Igumbor, V Mohan, Annamarie Kruger, Krishnapillai Vijayakumar, Yuksel Altuntas, Ahmad Bahonar

“…Objectives This study examines in a cross-sectional study ‘the tobacco control environment’ including tobacco policy implementation and its association with quit ratio.Setting 545 communities from 17 high-income, upper-middle, low-middle and low-income countries (HIC, UMIC, LMIC, LIC) involved in the Environmental Profile of a Community's Health (EPOCH) study from 2009 to 2014.Participants Community audits and surveys of adults (35–70 years, n=12 953).Primary and secondary outcome measures Summary scores of tobacco policy implementation (cost and availability of cigarettes, tobacco advertising, antismoking signage), social unacceptability and knowledge were associated with quit ratios (former vs ever smokers) using multilevel logistic regression models.Results Average tobacco control policy score was greater in communities from HIC. …”
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Association Between Urinary Metal Levels and Chronic Kidney Dysfunction in Rural China: A Study on Sex-Specific Differences by Kaisheng Teng, Qinyi Guan, Qiumei Liu, Xiaoting Mo, Lei Luo, Jiahui Rong, Tiantian Zhang, Wenjia Jin, Linhai Zhao, Songju Wu, Zhiyong Zhang, Jian Qin

“…Then, we used binary logistic regression, along with restricted cubic spline (RCS) models, to assess the individual exposure effects of specific metals on CKD. …”
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Postpartum depression and associated factors among childbearing women from the recent Demographic and Health Survey data of Mozambique: Multilevel analysis by Mamaru Melkam, Bezawit Melak Fente, Yohannes Mekuria Negussie, Zufan Alamrie Asmare, Hiwot Altaye Asebe, Beminate Lemma Seifu, Alemayehu Kasu Gebrehana, Sintayehu Simie Tsega, Meklit Melaku Bezie, Angwach Abrham Asnake

“…Depression during childbirth can have several detrimental effects, including increased risk of complication and decreased satisfaction with birth, decreased trust in medical facilities, and decreased women's participation in maternity and newborn healthcare units.Therefore, this study amid to reveal the prevalence of postpartum depression and associated factors at individual and community levels among women who give birth in Mozambique's recent data Demographic and Health Survey (DHS). Method: Multilevel logistic regression analysis was carried out from the recent Demographic and Health Survey data. …”
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