Comprehensive analysis of endoscopic ultrasound (EUS) in mediastinal lesions: patient characteristics, diagnostic outcomes, safety, and efficacy: a multi-country study by Hussein Okasha, Eyad Gadour, Ghias Un Nabi Tayyab, Andrada Seicean, Elbacha Hicham, Emad Emad, Turki Alamri, Nadeem Tehami, Heero Ismael Faraj, Ahmed Alzamzamy, Hiwa Hussein, Mohammed Tag-Adeen, Mohamed Elbasiony, Abed Al-Lehibi, Shereen Saleh, Zaher Houmani, Mohamed Abdelghani, Khaled Ragab, Zahi Ismaili, Othmane Drir, Elsayed Ghoneem, Omar Abdallah, Souad Rebiai, Nonthalee Pausawasdi, Fedoua Rouibaa, Mohamed Borahma, Hassan Atalla, Mahmoud Farouk, Ahmed Altonbary

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Aetiology of chronic liver disease is a valuable factor for stratifying adverse outcomes of acute decompensation: prospective observational study by Jung Hee Kim, Sung-Eun Kim, Do Seon Song, Hee Yeon Kim, Eileen L. Yoon, Ji Won Park, Tae Hyung Kim, Young-Kul Jung, Ki Tae Suk, Hyung Joon Yim, Jung Hyun Kwon, Sung Won Lee, Seong Hee Kang, Moon Young Kim, Soung Won Jeong, Jae-Young Jang, Jeong Ju Yoo, Sang Gyune Kim, Young-Joo Jin, Gab Jin Cheon, Byung Seok Kim, Yeon Seok Seo, Hyoungsu Kim, Dong Hyun Sinn, Woo Jin Chung, Hwi Young Kim, Han Ah Lee, Seung Woo Nam, In Hee Kim, Ji Hoon Kim, Hee Bok Chae, Joo Hyun Sohn, Ju Yeon Cho, Yoon Jun Kim, Jin Mo Yang, Jung Gil Park, Won Kim, Hyun Chin Cho, Dong Joon Kim

“…Viral hepatitis with alcohol-related CLD showed a poor liver function profile and a high frequency of acute-on-chronic liver failure (ACLF) [22.1% vs. 19.6% (alcohol CLD), 8.1% (viral CLD), 5.6% (autoimmune related CLD and 16.0% (cryptogenic CLD)] with worse adverse outcomes (mortality or liver transplantation) than other aetiologies. The difference in aetiology was a significant factor for 28-day adverse outcomes in multivariate analysis even in a high MELD score (≥15), which indicated poor baseline liver function and prognosis (p < 0.001).Conclusion The aetiology of CLD constitutes a pivotal determinant influencing both short- and long-term adverse outcomes of AD in CLD, even among individuals presenting with elevated MELD scores. …”
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Placental growth factor modulates endothelial NO production and exacerbates experimental hepatopulmonary syndrome by Fabien Robert, Feriel Benchenouf, My Ngoc Ha, Alessandra Cuomo, Mina Ottaviani, Maxime Surbier, Raphaël Thuillet, Corinne Normand, Florent Dumont, Céline Verstuyft, Frederic Fiore, Frederic Guinut, Marc Humbert, Audrey Coilly, Emmanuel Gonzales, Olivier Sitbon, Ly Tu, Christophe Guignabert, Laurent Savale

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Contextual Vulnerability Should Guide Fair Subject Selection in Xenotransplantation Clinical Trials by Gianna Strand

“…[xvii] Large cohort studies of both pediatric kidney and liver transplant recipients found no correlation between intellectual disability and graft or patient survival.…”
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Pancreatic Anastomosis Disruption Seven Years Postpancreaticoduodenectomy by Walid Faraj, Zaki Abou Zahr, Deborah Mukherji, Ahmad Zaghal, Mohamed Khalife

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The role of lactylation in tumor growth and cancer progression by Khulood Al-Malsi, Khulood Al-Malsi, Khulood Al-Malsi, Sinan Xie, Sinan Xie, Sinan Xie, Yunshi Cai, Yunshi Cai, Yunshi Cai, Nader Mohammed, Kunlin Xie, Kunlin Xie, Kunlin Xie, Tian Lan, Tian Lan, Tian Lan, Hong Wu, Hong Wu, Hong Wu

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Primary Hepatic Neuroendocrine Tumor with Unusual Thyroid Follicular-Like Morphologic Characteristics by Mohd Elmugtaba Ibrahim, Kerolos Abadeer, Qihui (Jim) Zhai, Aziza Nassar

“…In 2008, the patient’s liver transplant failed because of ischemic cholangiopathy, and she underwent a second liver transplant. …”
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The Relationship Between Hepatopulmonary Syndrome and Altitude by Morgan A Valley, James F Trotter, Deborah Thomas, Adit A Ginde, Steven R Lowenstein, Benjamin Honigman

“…BACKGROUND: In a previous small retrospective study, the authors reported that hepatopulmonary syndrome was less common among liver transplant candidates at high-altitude centres compared with low-altitude centres.…”
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Chronic Hepatitis C with Cyanosis by Mahmood Alawainati, Jawad Khamis, Muneer Abdulla, Saeed Alsaeed

“…Screening for this complication is appropriate in liver transplant candidates, and diagnosed patients should be evaluated extensively for liver transplant.…”
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Improving 1-year liver allograft survival hazard ratios by Resham­ Ramkissoon, Ashley Rosier, Savitha Iyengar, Timucin Taner, William Sanchez

“…Our balance measure was maintaining similar liver transplant volumes and avoiding limiting access to transplant. …”
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Posttransplant Metabolic Syndrome by M. Shadab Siddiqui, Richard K. Sterling

“…Until then, early recognition, prevention, and treatment of its components are vital in improving outcomes in liver transplant recipients.…”
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A Practical Review of Cytomegalovirus in Gastroenterology and Hepatology by Ali Y. Fakhreddine, Catherine T. Frenette, Gauree G. Konijeti

“…This review will focus on the pathophysiology, diagnosis, and management of CMV in patient populations relevant to the practice of gastroenterology and hepatology—liver transplant recipients, inflammatory bowel disease patients, and otherwise immunocompetent patients.…”
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Clinical Recommendations for the Use of Recombinant Human Erythropoietin in Patients with Hepatitis C Virus Being Treated with Ribavirin by Morris Sherman, Lawrence Cohen, Mary Anne Cooper, Magdy Elkashab, Victor Feinman, David Fletcher, Nigel Girgrah, Jenny Heathcote, Mark Levstik, William B McNaull, David Wong, Florence Wong, Colina Yim

“…Data also support the clinical benefit of combination antiviral therapy in patients coinfected with HCV and HIV, and in patients who have received a liver transplant.…”
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Nontoxigenic Vibrio cholerae Septicemia in an Immunocompromised Patient by Kamran Kadkhoda, Heather Adam, Matthew W. Gilmour, Gregory W. Hammond

“…We report a recent case of non-O1, non-O139, nontoxigenic Vibrio cholerae septicemia in a post-liver-transplant immunocompromised patient associated with prior seafood consumption. …”
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Acute Liver Rejection in a Multiple Myeloma Patient Treated with Lenalidomide by Iuliana Vaxman, John Eaton, Hee Eun Lee, Morie A. Gertz

“…Herein we present a patient that underwent a liver transplant due to primary biliary cholangitis (PBC) and after 9 years developed multiple myeloma. …”
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Expression of Maspin and Ezrin Proteins in Periocular Basal Cell Carcinoma by Mansooreh Bagheri, Masoomeh Eghtedari, Mandana Bagheri, Bita Geramizadeh, Mohammadreza Talebnejad

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Acute Fatty Liver Disease of Pregnancy in the Second Trimester by Faraz Afridi, Michael Feely, Raju Reddy

“…She was diagnosed with AFLP as per the Swansea criteria. An orthotopic liver transplant was attempted but was unsuccessful. AFLP usually presents between the 30th to 38th weeks of gestation. …”
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Pharmacometabolomics Enables Real-World Drug Metabolism Sciences by Fleur B. Nijdam, Marieke A. J. Hof, Hans Blokzijl, Stephan J. L. Bakker, Eelko Hak, Gérard Hopfgartner, Frank Klont, on behalf of the TransplantLines Investigators

“…Lastly, the observed metabolic patterns showed no notable differences between kidney and liver transplant recipients. <b>Conclusions</b>: Our findings demonstrate the potential of PMx to enhance the understanding of drug metabolism, even for well-studied compounds such as CsA. …”
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The Emerging Role of Nanomedicine in the Management of Nonalcoholic Fatty Liver Disease: A State-of-the-Art Review by Seyedeh Alia Moosavian, Thozhukat Sathyapalan, Tannaz Jamialahmadi, Amirhossein Sahebkar

“…Nonalcoholic fatty liver disease (NAFLD) is a common chronic liver disease that can lead to end-stage liver disease needing a liver transplant. Many pharmacological approaches are used to reduce the disease progression in NAFLD. …”
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Intermittent Boluses of Local Anesthetic Through Quadratus Lumborum Catheters for Analgesia in a Living Donor Hepatectomy by Shelly B. Borden, Molly K. Groose, Eric R. Simon, Aaron S. Hess, Kristopher M. Schroeder

“…The demand for liver transplants in the United States far exceeds the supply of organs. …”
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