Alström’s Syndrome, Leber’s Hereditary Optic Neuropathy, or Retinitis Pigmentosa? A Case of Misdiagnosis by Palaiologos Alexopoulos, Chrysanthos Symeonidis, Tryfon Rotsos

“…AS affects metabolism, and symptomatology includes type 2 diabetes mellitus (T2DM), obesity, hypogonadism and gynecomastia in males, progressive bilateral sensorineural hearing loss, cardiomyopathy, nonalcoholic fatty liver disease (NAFLD), cirrhosis, and chronic progressive kidney disease. …”
Get full text

Autoimmune Hepatitis: Clinical Manifestations and Diagnostic Criteria by Ian G Mcfarlane

“…This review (published in 1999) noted that the original descriptive criteria appeared to be quite robust and required only relatively minor modifications to bring them up to date with developments and experience in diagnostic modalities for liver disease in general. Analysis of published data on the application of the original criteria in nearly 1000 patients revealed that the diagnostic scoring system had an overall diagnostic accuracy of 89.8%, with a sensitivity of 98.0%. …”
Get full text

Modeling challenges of hepatitis D virus kinetics during bulevirtide-based therapy by Adquate Mhlanga, Ori Wasserman, Pietro Lampertico, Scott J. Cotler, Harel Dahari

Get full text

Algorithm of management of patients with acute cholestatic hepatitis (Clinical case presentation) by T. A. Deyeva, Ye. N. German, M. V. Mayevskaya, V. T. Ivashkin

“…In the submitted case a main role in recognition of an etiology of liver disease have played by careful taking of past history and analysis of all possible causes of disease, that can be the key point in diagnostic search and choice of patient management tactics.…”
Get full text

Model for hepatitis C virus transmissions by Elamin H. Elbasha

“…Hepatitis C virus (HCV) is a leading cause of chronic liver disease. Thispaper presents a deterministic model for HCV infection transmission and usesthe model to assess the potential impact of antiviral therapy. …”
Get full text

Update on a Pharmacokinetic-Centric Alternative Tier II Program for MMT—Part II: Physiologically Based Pharmacokinetic Modeling and Manganese Risk Assessment by Michael D. Taylor, Harvey J. Clewell, Melvin E. Andersen, Jeffry D. Schroeter, Miyoung Yoon, Athena M. Keene, David C. Dorman

“…We also present novel PBPK simulations to predict manganese tissue concentrations in fetal, neonatal, pregnant, or aged individuals, as well as individuals with liver disease or chronic manganese inhalation. The results of these simulations could help guide risk assessors in the application of uncertainty factors as they establish exposure guidelines for the general public or workers.…”
Get full text

Characterization of liver, adipose, and fecal microbiome in obese patients with MASLD: links with disease severity and metabolic dysfunction parameters by Katherine J. P. Schwenger, Julia K. Copeland, Yasaman Ghorbani, Lina Chen, Elena M. Comelli, David S. Guttman, Sandra E. Fischer, Timothy D. Jackson, Allan Okrainec, Johane P. Allard

“…Abstract Background Metabolic dysfunction-associated steatotic liver disease (MASLD) encompasses a range of histological findings from the generally benign simple steatosis to steatohepatitis (MASH) which can progress to fibrosis and cirrhosis. …”
Get full text

Imaging the Abdominal Manifestations of Cystic Fibrosis by C. D. Gillespie, M. K. O’Reilly, G. N. Allen, S. McDermott, V. O. Chan, C. A. Ridge

“…Liver cirrhosis is the most important extrapulmonary cause of death in CF, yet significant challenges remain in the diagnosis of CF related liver disease. The capacity to predict those patients at risk of developing cirrhosis remains a significant challenge. …”
Get full text

Polymorphism of genes and drug-induced liver injury by P. Ye. Tkachenko, M. V. Mayevskaya, V. T. Ivashkin

“…Data of investigations allow to expand the concept of pathogenetic mechanisms of drug-induced liver disease, that, in turn, promotes development of the test systems providing diagnostics at molecular genetic level.…”
Get full text

Intestinal Permeability Assays: a Review by A. A. Iakupova, S. R. Abdulkhakov, R. K. Zalyalov, A. G. Safin, R. A. Abdulkhakov

“…The assay and result standardisation will facilitate practice in functional and organic intestinal diseases, as well as allergies, diabetes mellitus, non-alcoholic fatty liver disease and some other illnesses.…”
Get full text

Targeting ion homeostasis in metabolic diseases: Molecular mechanisms and targeted therapies by Yanjiao Zhang, Kaile Ma, Xinyi Fang, Yuxin Zhang, Runyu Miao, Huifang Guan, Jiaxing Tian

“…The incidence of metabolic diseases—hypertension, diabetes, obesity, metabolic dysfunction-associated steatotic liver disease (MASLD), and atherosclerosis—is increasing annually, imposing a significant burden on both human health and the social economy. …”
Get full text

Use of Idarucizumab to Revert the Anticoagulant Effect of Dabigatran in Heart Transplant Surgery: An Institutional Experience by Álvaro Herrera-Escandón, Orlando Castaño-Cifuentes, Carlos A. Plata-Mosquera

“…Heart transplant is a surgical procedure with a high risk of perioperative bleeding in patients with a previous history of sternotomy, congestive liver disease, and/or use of oral anticoagulants. Anticoagulation is usually done with coumarin agents (warfarin, acenocoumarol), while on the waiting list, vitamin K is available allowing for partial reversal of the anticoagulant effect, although with variable INR and risk of uncontrolled bleeding. …”
Get full text

Efficacy of nucleoside analogues for hepatitis B virus-related liver failure: A network meta-analysis by Wu Jian, Yin Fang, Zhou Xinmin

“…The highest two- and three-month survival rate was recorded for patients using tenofovir. The end-stage liver disease (MELD) score and mortality in patients undergoing tenofovir treatment were the lowest. …”
Get full text

Differential Impacts of Soybean and Fish Oils on Hepatocyte Lipid Droplet Accumulation and Endoplasmic Reticulum Stress in Primary Rabbit Hepatocytes by Xueping Zhu, Zhihui Xiao, Yumin Xu, Xingli Zhao, Ping Cheng, Ningxun Cui, Mingling Cui, Jie Li, Xiaoli Zhu

“…Parenteral nutrition-associated liver disease (PNALD) is a severe ailment associated with long-term parenteral nutrition. …”
Get full text

Liver Injury with Features Mimicking Autoimmune Hepatitis following the Use of Black Cohosh by Grace Guzman, Eric R. Kallwitz, Christina Wojewoda, Rohini Chennuri, Jamie Berkes, Thomas J. Layden, Scott J. Cotler

“…Both patients reported black cohosh use for at least six months and had no evidence of another cause of liver disease. Their liver biopsies showed a component of centrilobular necrosis consistent with severe drug-induced liver injury. …”
Get full text

Selecting Candidates for Liver Transplantation: A Medical Ethics Perspective on the Microallocation of a Scarce and Rationed Resource by Eric M Yoshida

“…Following the success and acceptance of transplantation in the treatment of end-stage liver disease, there has been a progressive increase in the number of patients seeking a limited supply of donor organs. …”
Get full text

Fibrolamellar Carcinoma: 2012 Update by Michael Torbenson

“…Their etiology remains a mystery, as they are not associated with chronic liver disease. Fibrolamellar carcinomas are not indolent tumors, but have an overall better prognosis than typical hepatocellular carcinomas, in part because of the younger age at presentation and the lack of cirrhosis. …”
Get full text

Primary biliary cirrhosis: clinical and laboratory criteria of diagnostics and up-to-date treatment by L. Yu. Il’chenko, V. I. Reshetn’yak

“…PBC is organ-specific autoimmune liver disease affecting predominantly women that is characterized by chronic progressing destruction of intrahepatic bile ducts with portal inflammation, resulting in development of liver cirrhosis (LC). …”
Get full text

miR-559 Inhibits Proliferation, Autophagy, and Angiogenesis of Hepatocellular Carcinoma Cells by Targeting PARD3 by Chunjing Wang, Chengcheng Li, Rui Hao

Get full text

Putative Factors That May Modulate the Effect of Exercise on Liver Fat: Insights from Animal Studies by Faidon Magkos

“…An increase in intrahepatic triglyceride (IHTG) content is the hallmark of nonalcoholic fatty liver disease (NAFLD) and is strongly associated with insulin resistance and dyslipidemia. …”
Get full text