Management of Coagulopathy in Patients with Decompensated Liver Cirrhosis by Pooja D. Amarapurkar, Deepak N. Amarapurkar

“…As there is reduction in both anti and procoagulant factors, global tests of coagulation are normal in patients with acute and chronic liver disease indicating that coagulopathy in liver disease is more of a myth than a reality. …”
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Highlights of the Fourth Canadian Symposium on Hepatitis C: Moving towards a National Action Plan by Selena M. Sagan, Benoit Dupont, Jason Grebely, Mel Krajden, Sonya A. MacParland, Jennifer F. Raven, Sahar Saeed, Jordan J. Feld, D. Lorne Tyrrell, Joyce A. Wilson

“…The Canadian Institutes of Health Research (CIHR) and the Public Health Agency of Canada (PHAC) have identified HCV-related liver disease as a priority. In 2015, the release of well-tolerated, short course treatments (~12 weeks) able to cure the majority of treated HCV patients revolutionized HCV therapy. …”
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CALLY index, but not HALP score, is associated with mortality in cirrhosis patients by Yıldız Günay, Bedel Cihan, Zortuk Ökkeş, Selvi Fatih, Karanci Yusuf

“…Cirrhosis is a chronic liver disease that is characterized by inflammation and fibrosis, as well as liver dysfunction. …”
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Exploring the association between herbal medicine usage and drug-induced liver injury: insights from a nationwide population-based cohort study using SCCS in South Korea by Taehyun Yang, Juhee Ahn, Juhee Ahn, Sungho Won, Sungho Won, Sungho Won, Sanghun Lee

“…Patients with pre-existing liver disease exhibit increased susceptibility to DILI. …”
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CIHR Canadian HIV Trials Network Coinfection and Concurrent Diseases Core: Canadian Guidelines for Management and Treatment of HIV/Hepatitis C Coinfection in Adults by Mark Hull, Marina Klein, Stephen Shafran, Alice Tseng, Pierre Giguère, Pierre Côté, Marc Poliquin, Curtis Cooper, on behalf of The CIHR Canadian HIV Trials Network HIV/Hepatitis C Management and Treatment Guidelines Working Group

“…HIV-HCV management is more complex due to the accelerated progression of liver disease, the timing and nature of antiretroviral and HCV therapy, mental health and addictions management, socioeconomic obstacles and drug-drug interactions between new HCV direct-acting antiviral therapies and antiretroviral regimens.…”
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Pretransplant Evaluation and Liver Transplantation Outcome in PBC Patients by Maja Mijic, Ivona Saric, Bozena Delija, Milos Lalovac, Nikola Sobocan, Eva Radetic, Dora Martincevic, Tajana Filipec Kanizaj

“…Primary biliary cholangitis (PBC) is an autoimmune chronic cholestatic liver disease characterized by progressive cholangiocyte and bile duct destruction leading to fibrosis and finally to liver cirrhosis. …”
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Evaluating the Cause of Death in Obese Individuals: A Ten-Year Medical Autopsy Study by Jad Saab, Steven P. Salvatore

“…Increased death rates in the obese due to pulmonary embolism and liver disease should receive special clinical attention. …”
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TFCP2 Genetic Polymorphism Is Associated with Predisposition to and Transplant Prognosis of Hepatocellular Carcinoma by Zhikun Liu, Feng Gao, Zhou Shao, Haiyang Xie, Lin Zhou, Xiao Xu, Shusen Zheng

“…These findings indicate that rs7959378 is associated with the risk of HCC in patient with chronic liver disease and prognosis of HCC patients after liver transplantation.…”
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Barriers Preventing Liver Transplantation in Canadians with HIV Infection – Perceptions of HIV Specialists by Curtis L Cooper, Joanne DeForest, John Gill, Richard Lalonde, on behalf of the Canadian HIV Trials Network (CTN) Co-Infection Core Group

“…A median 20% of the nearly 12,700 HIV patients followed at these sites had concurrent liver disease (20% caused by hepatitis C virus, 5% caused by hepatitis B virus and 5% were alcohol-related). …”
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Urinary tract infections in patients with decompensated liver cirrhosis, listed for liver transplantation by P. D. Bessonov, I. V. Borzunov, E. N. Bessonova

“…To study the urinary infection rate in patients with liver cirrhosis (LC) and indications for liver transplantation with assessment of etiologic spectrum and features of the progression of liver disease at development of this complication. Material and methods. …”
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Herbicide Widespread: The Effects of Pethoxamid on Nonalcoholic Fatty Liver Steatosis In Vitro by Anna Virginia Adriana Pirozzi, Antonietta Stellavato, Chiara Schiraldi, Mariateresa Giuliano

“…Due to similarities to glyphosate, we did look at the effect of pethoxamid on impaired liver cells HepG2, using a nonalcoholic fatty liver disease (NAFLD) cell model in vitro. Pethoxamid was cytotoxic starting at 1 ppm. …”
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The changing demographics and severity in hospitalized patients across COVID-19 variants: A national cohort study by Priyanka Parajuli, Lara A.C. Phipps, Roy Sabo, Rasha Alsaadawi, Amanda Robinson, Evan French, Richard K. Sterling, N3C. consortium

“…Results: The severity of SARS-CoV-2 decreased in the omicron-subsequent wave with decreased utilization of mechanical ventilation and decreased 30-day mortality among patients with comorbidities like diabetes mellitus, obesity, and liver disease. Although with each subsequent wave, the sex distribution remained equal and constant, there was an increase in rates of diabetes, liver disease, and respiratory disease amongst patients hospitalized with COVID-19 over the COVID waves despite the decreasing 30-day mortality and mechanical ventilation. …”
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Evaluation of Adrenal Function in Nonhospitalized Patients with Cirrhosis by Maryam Moini, Mitra Yazdani Sarvestani, Mesbah Shams, Masood Nomovi

“…Categorization of liver disease severity was done according to model for end-stage liver disease (MELD) score. …”
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CIHR Canadian HIV Trials Network Co-Infection and Concurrent Diseases Core: Updated Canadian Guidelines for the Treatment of Hepatitis C Infection in HIV-hepatitis C Coinfected Adu... by Mark Hull, Stephen Shafran, Alice Tseng, Pierre Giguère, Marina B Klein, Curtis Cooper

“…Management of HIV-HCV coinfection is more complex due to the accelerated progression of liver disease, the timing and nature of antiretroviral and HCV therapy, mental health and addictions management, socioeconomic obstacles and drug-drug interactions between new HCV direct-acting antiviral therapies and antiretroviral regimens.…”
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Renal Impairment in Cirrhosis Unrelated to Hepatorenal Syndrome by Gavin Low, Graeme JM Alexander, David J Lomas

“…Renal impairment is common in liver disease and may occur as a consequence of the pathophysiological changes that underpin cirrhosis or secondary to a pre-existing unrelated insult. …”
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Panhypopituitarism due to Absence of the Pituitary Stalk: A Rare Aetiology of Liver Cirrhosis by Marta Gonzalez Rozas, Lidia Hernanz Roman, Diego Gonzalez Gonzalez, José Luis Pérez-Castrillón

“…Insulin resistance is the main pathophysiological axis of metabolic syndrome and is the causal factor in the development of nonalcoholic fatty liver disease (NAFLD). We present the case of a young patient with liver cirrhosis of unknown aetiology that was finally attributed to panhypopituitarism.…”
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A Cytokine That Is Involved in Immune Responses in Chronic Hepatitis B Virus Patients by Noor R. Abady, Zeana Shakir Al-Al Hindi

“…Abstract Background: The present research examines the part interleukin-17 (IL-17) plays in the progression of liver disease in people infected with the long-term hepatitis B virus. …”
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Liver Transplantation: Evolving Patient Selection Criteria by Andy S Yu, Aijaz Ahmed, Emmet B Keeffe

“…The development of minimal listing criteria for patients with chronic liver disease based on a specific definition for decompensation of cirrhosis has facilitated the more uniform listing of patients at individual centres across the United States. …”
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Impact of Weight Reduction on Thyroid Function and Nonalcoholic Fatty Liver among Egyptian Adolescents with Obesity by Mona Karem Amin, Ahmed Ibrahim Ali, Hesham Elsayed

“…This may explain the emergence of nonalcoholic fatty liver as the leading cause of liver disease. Several previous studies have addressed the association between thyroid function and nonalcoholic fatty liver disease. …”
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A Case of Prolonged Cholestatic Hepatitis Induced by Azithromycin in a Young Woman by Caterina Maggioli, Luca Santi, Giacomo Zaccherini, Vittoria Bevilacqua, Francesca Giunchi, Paolo Caraceni

“…We here report the case of a prolonged cholestatic hepatitis after administration of azithromycin in a young woman with no history of liver disease.…”
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