Odevixibat treatment in a child with hypoplastic left heart syndrome and severe cholestatic pruritus: a case report by Rainer Ganschow, Christof Maucksch, Peter Rauschkolb, Martin B. E. Schneider

“…Odevixibat is an ileal bile acid transporter inhibitor under investigation for the treatment of cholestatic liver diseases. Here, we describe the effects of odevixibat treatment in a pediatric patient with congenital heart disease and severe cholestatic pruritus. …”
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Hyponatremia In Ischemic Stroke Patients And Its Relationship To Clinical Outcomes In Such Patients by Maria Zafar, Aneza Jalil, Amber Ghaffer, Mahnoor Yousaf, Sadia Batool

“…All patients with hemorrhagic stroke, having previous history of stroke, recent head injury, CNS infection, already using sodium lowering diuretics, or with end-stage diseases like Heart failure, chronic kidney disease and decompensated liver diseases were excluded from the study. Primary outcome measures were in-hospital mortality and duration of hospital stay (LOS). …”
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Outer Membrane Vesicles Derived from Adherent-Invasive Escherichia coli Induce Inflammatory Response and Alter the Gene Expression of Junction-Associated Proteins in Human Intestin... by Bahareh Nadalian, Banafsheh Nadalian, Mohammad Reza Zali, Abbas Yadegar

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Rheumatoid Arthritis Effects on Kidney and Liver and their Correlations with CDAI by Tamara Salman Mohammed, Raya Ezat Maroof, Ali Hussein Al-Hafidh

“…Persistent usage of anti-rheumatic drugs has several side effects, which may cause heart, kidney, or liver diseases. This study aims to assess the influence of RA duration on kidney and liver enzymes and study the correlation between these enzyme levels and RA disease activity (CDAI). …”
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Sex Differences Associated with Primary Biliary Cirrhosis by Daniel S. Smyk, Eirini I. Rigopoulou, Albert Pares, Charalambos Billinis, Andrew K. Burroughs, Luigi Muratori, Pietro Invernizzi, Dimitrios P. Bogdanos

“…Primary biliary cirrhosis (PBC) is a cholestatic liver disease of autoimmune origin, characterised by the destruction of small intrahepatic bile ducts. …”
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Hepatic encephalopathy: pathogenesis, clinical presentation, diagnostics, treatment by Ch. S. Pavlov, I. V. Damulin, V. T. Ivashkin

“…HE is a complex of neurological and psychiatric disorders that develop on a background of severe liver diseases due to portal blood shunting and impaired liver detoxication function. …”
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Enhancing the efficacy of low doses of N-acetyl-L-cysteine in mitigating CCl4-induced hepatotoxicity in animal model using physical cold plasma by Masume Farhadi, Farshad Sohbatzadeh, Akbar Hajizadeh Moghaddam, Yasaman Firouzjaei, Cheng Cheng

“…Liver diseases have become widespread especially due to various factors of modern life. …”
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Gene therapy by hepatocyte growth factor results in regression of experimental liver fibrosis by N. A. Dzhoyashvili, N. I. Kalinina, I. B. Beloglazova, Z. I. Tsokolayeva, P. I. Makarevich, Yu. L. Perov, Ye. V. Parfenova, V. A. Tkachuk

“…Obtained results allow to consider gene therapy by hepatocyte growth factor in composition of non-viral vectors as one of perspective methods of treatment of chronic liver diseases.…”
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An atypical presentation of autoimmune hepatitis with delayed menarche in a Nigerian adolescent: a case report by Promise Udoka Asogwa, Bruno Basil, Winifred Njideka Adiri, Nelson Ugwu, Gideon Ekene Anigbo, Evaristus Offia, Casmir Orjioke

“…Abstract Background Autoimmune hepatitis is a chronic liver disease marked by immune-mediated inflammation, necrosis, and the potential to progress to cirrhosis if not treated. …”
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Evaluation of the Acute Hepatoprotective Potential of Hydroethanolic Extract of Duranta erecta L. Parts by Shadrack Donkor, Christopher Larbie, Gustav Komlaga, Benjamin Obukowho Emikpe

“…Liver disease is a major health problem and its treatment is costly in most developing countries with attendant adverse effects. …”
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Antifibrotic Effect of Combination of Nilotinib and Stem Cell-Conditioned Media on CCl4-Induced Liver Fibrosis by Gamal Shiha, Ahmed Nabil, Ahmed Lotfy, Reham Soliman, Ayman A. Hassan, Islam S. Ali, Doaa F. Gad, Faten Zahran

“…Liver fibrosis is the excessive extracellular matrix accumulation of proteins, such as collagen, which follows the chronic liver diseases. Advanced liver fibrosis leads to cirrhosis and liver failure. …”
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Factors associated with pulmonary complications after hepatectomy and establishment of nomogram: A real-world retrospective study by Kunyu Han, Hui Liu, Ruiping Bai, Jiarui Li, Linjuan Zhang, Rui An, Di Peng, Jiamin Zhao, Mengwen Xue, Xin Shen

“…Background and Aims: Hepatectomy is currently the most effective way to treat liver diseases, and its safety has observably improved. …”
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Application of ursodeoxycholic acid at non-alcoholic and alcohol-induced steatohepatitis by Ye. A. Fedos’ina, M. V. Mayevskaya

“…Prevalence of liver steatosis as pathomorphologic substrate of various liver diseases is quite high, however the special attention is given to patients with signs of inflammation and fibrosis, i.e. with confirmed alcohol-induced and non-alcoholic steatohepatitis. …”
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An Efficient Protocol for Deriving Liver Stem Cells from Neonatal Mice: Validating Its Differentiation Potential by Sugapriya Dhanasekaran, Devilakshmi Sithambaram, Kavitha Govarthanan, Bijesh Kumar Biswal, Rama S. Verma

“…Thus, the unlimited availability of cell type favors setting up the functional recovery of the damaged liver, ensuring ahead success towards treating liver diseases. We attempted to isolate liver stem derived cells (LDSCs) from mouse neonatal liver using single step minimal exposure to enzyme followed by in vitro culturing. …”
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Liver macrophage-derived exosomal miRNA-342-3p promotes liver fibrosis by inhibiting HPCAL1 in stellate cells by Wenshuai Li, Lirong Chen, Qi Zhou, Tiansheng Huang, Wanwei Zheng, Feifei Luo, Zhong Guang Luo, Jun Zhang, Jie Liu

“…Conclusion This study reveals a previously unidentified profibrotic mechanism of crosstalk between macrophages and HSCs in the liver and suggests an attractive novel therapeutic strategy for treating fibroproliferative liver diseases. Graphical Abstract…”
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Mesenchymal stem cells-derived exosomes attenuate mouse non-heart-beating liver transplantation through Mir-17-5p-regulated Kupffer cell pyroptosis by Yang Tian, Ming Jin, Nanwei Ye, Zhenzhen Gao, Yuancong Jiang, Sheng Yan

“…Abstract Background Liver transplantation is the most effective treatment for end-stage liver disease. However, the shortage of donor livers has become a significant obstacle to the advancement of liver transplantation. …”
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Reversal of Experimental Liver Damage after Transplantation of Stem-Derived Cells Detected by FTIR Spectroscopy by Danna Ye, Philip Heraud, Rangsun Parnpai, Tong Li

“…The transplantation of autologous BM-MSCs holds great potential for treating end-stage liver diseases. The aim of this study was to compare the efficiency of transplanted rBM-MSCs and rBM-MSC-derived differentiated stem cells (rBM-MSC-DSCs) for suppression of dimethylnitrosamine-injured liver damage in rat model. …”
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Hepatitis C Worldwide and in Brazil: Silent Epidemic—Data on Disease including Incidence, Transmission, Prevention, and Treatment by Iara Fabricia Kretzer, Andrea do Livramento, Joel da Cunha, Sabrina Gonçalves, Iraci Tosin, Celso Spada, Aricio Treitinger

“…The infection is a leading cause of liver diseases like cirrhosis and hepatocellular carcinoma (HCC); thus, HCV infection constitutes a critical public health problem. …”
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Tenascin C-Guided Nanosystem for Precision Delivery of Obeticholic Acid in Liver Fibrosis Therapy by Yawen Wang, Lei Yang, Qing Xu, Taiyu Liu, Hongliang He, Lisha Liu, Lifang Yin

“…<b>Objective:</b> Liver fibrosis, a hallmark of chronic liver diseases, is characterized by excessive extracellular matrix (ECM) deposition and scar tissue formation. …”
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Hepatitis D virus infection triggers CXCL9-11 upregulation in hepatocytes and liver infiltration of CXCR3+ CD4 T cells by Jan-Hendrik Bockmann, Lena Allweiss, Annika Volmari, David da Fonseca Araújo, Matin Kohsar, Anastasia Hyrina, Janine Kah, Zhijuan Song, Josolyn Chan, Katja Giersch, Tassilo Volz, Marc Lütgehetmann, Jeffrey J. Wallin, Dmitry Manuilov, Meghan M. Holdorf, Simon P. Fletcher, Ansgar W. Lohse, Antonio Bertoletti, Julian Schulze zur Wiesch, Maura Dandri

“…Because recruitment of Th1-polarised CD4 T cells to the liver has been also described for other severe liver diseases, such as autoimmune hepatitis, it may represent an important mechanism of aggravating liver diseases. …”
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