Hepatitis D virus infection triggers CXCL9-11 upregulation in hepatocytes and liver infiltration of CXCR3+ CD4 T cells by Jan-Hendrik Bockmann, Lena Allweiss, Annika Volmari, David da Fonseca Araújo, Matin Kohsar, Anastasia Hyrina, Janine Kah, Zhijuan Song, Josolyn Chan, Katja Giersch, Tassilo Volz, Marc Lütgehetmann, Jeffrey J. Wallin, Dmitry Manuilov, Meghan M. Holdorf, Simon P. Fletcher, Ansgar W. Lohse, Antonio Bertoletti, Julian Schulze zur Wiesch, Maura Dandri

“…Because recruitment of Th1-polarised CD4 T cells to the liver has been also described for other severe liver diseases, such as autoimmune hepatitis, it may represent an important mechanism of aggravating liver diseases. …”
Get full text

Genetic polymorphism of hepatitis C virus and risk of hepatocellular carcinoma by S. N. Mammayev, A. M. Karimova

“…Hepatocellular carcinoma is one of the most dreadful outcomes of chronic liver diseases, in particular — chronic hepatitis C (CHC). …”
Get full text

Staffing at Ambulatory Endoscopy Centers in the United States: Practice, Trends, and Rationale by Deepak Agrawal, Rajeev Jain

Get full text

Effect of Chronic Hepatitis B Virus (HBV) Infection on Lipid Profile in Iraqi Patients by Amnah Raad Ibrahim, Athraa Zaidan Hassan, Raghad Hassan Hussein, Redhwan Abdul Kareem Alameer

“… Hepatitis B Virus (HBV) is known to target the liver, potentially leading to liver diseases. There's a notable link between dyslipidemia, an anomaly in lipid levels, and HBV infection. …”
Get full text

Efficacy of TIPS plus extrahepatic collateral embolisation in real-world data: a validation study by Chao Chen, Feng Zhang, Hao Wu, Wei Wu, Hui Xue, Yuzheng Zhuge, Chunqing Zhang, Guangchuan Wang, Zhengjie Li, Qiong Wu, Bo Wei, Jun Tie, Xiubin Sun, Lianhui Zhao, Yifu Xia, Jiao Xu, Peijie Li

Get full text

Fagonia indica Repairs Hepatic Damage through Expression Regulation of Toll-Like Receptors in a Liver Injury Model by Fareeha Azam, Nadeem Sheikh, Gibran Ali, Asima Tayyeb

“…In conclusion, the current study not only proposes Fagonia indica, a strong hepatoprotective candidate, but also recommends an immune regulatory toll-like receptor pathway as an important therapeutic target in liver diseases.…”
Get full text

Solid Pseudopapillary Neoplasms Are Rare, Indolent Pancreatic Tumors in Young Women by Amin Dalili, Mohsen Aliakbarian, Mehdi Karimi-Shahri, Alireza Samadi, Sara Raji

Get full text

The effect of economic crisis and austerity measures on deaths of despair in Brazil: An interrupted time series analysis. by Raphael Mendonça Guimarães, Karina Cardoso Meira, Cristiane Teixeira da Silva Vicente, Silvania Suely de Araújo Caribé, Luise Bernardes da Silva Neves, Nicole Almeida Vardiero

“…Some recent analyses have described that, in the context of the instability of social protection institutions and economic crisis, there is an increase in mortality rates selectively from drug overdoses, suicides and alcohol-related liver diseases. This group of causes was named "Deaths of Despair. …”
Get full text

Osmotic myelinolysis: literature review and case report by G. Rutkauskaitė, A. Klimašauskienė

“…Hyponatremia is commonly found in patients with chronic alcoholism and malnutrition and can be caused by liver diseases, the syndrome of inappropriate antidiuretic hormone secretion, as well as adrenal insufficiency and iatrogenic disorders. …”
Get full text

Guanidine‐Derived Polymeric Nanoinhibitors Target the Lysosomal V‐ATPase and Activate AMPK Pathway to Ameliorate Liver Lipid Accumulation by Yunfei Zhao, Ke Hu, Fangliang Wang, Lulu Zhao, Yu Su, Jun Chen, Gang Zou, Liming Yang, Li Wei, Mengjiao Deng, Yunyu He, Ping Wang, Xiong Z Ruan, Yaxi Chen, Chao Yu

“…Long‐term and anomalous lipid accumulation in the liver is a highly relevant factor contributing to liver diseases. However, the development of the reliable medications and their pharmacological mechanisms remain insufficient. …”
Get full text

An Efficient Protocol for Deriving Liver Stem Cells from Neonatal Mice: Validating Its Differentiation Potential by Sugapriya Dhanasekaran, Devilakshmi Sithambaram, Kavitha Govarthanan, Bijesh Kumar Biswal, Rama S. Verma

“…Thus, the unlimited availability of cell type favors setting up the functional recovery of the damaged liver, ensuring ahead success towards treating liver diseases. We attempted to isolate liver stem derived cells (LDSCs) from mouse neonatal liver using single step minimal exposure to enzyme followed by in vitro culturing. …”
Get full text

Association of Alanine Aminotransferase and Periodontitis: A Cross-Sectional Analysis—NHANES 2009–2012 by R. Constance Wiener, Usha Sambamoorthi, Richard J. Jurevic

“…Alanine Aminotransferase is an enzyme associated with not only liver diseases, liver conditions, and metabolic syndrome, but also inflammation. …”
Get full text

The role of endoscopic ultrasound in the diagnosis and characterization of focal liver lesions by Ahmed Morad Hashim, Gamal Eldin Mansour Mohamed Gamal, Abeer Abdellatef, Hany Hagag Ahmed

“…Several established diagnostic tools such as magnetic resonance imaging (MRI), transabdominal ultrasound (US), and computed tomography (CT) are well-studied for assessing liver diseases. Endoscopic ultrasound (EUS), traditionally used for evaluating the mediastinum, biliary tract, esophagus, stomach, and pancreas, is increasingly complementing these traditional diagnostic methods in hepatology. …”
Get full text

Construction and Evaluation of a Subcutaneous Splenic Injection Port for Serial Intraportal Vein Cell Delivery in Murine Disease Models by Toshio Miki, Chika Takano, Irving M. Garcia, Brendan H. Grubbs

“…Liver-directed cell transplantation is, therefore, an attractive therapeutic option to treat various metabolic disorders as well as liver diseases. Although clinical liver-directed cell transplantation requires multiple cell injections into the portal venous system, a mouse model is lacking which allows us to perform repetitive cell injections into the portal venous system. …”
Get full text

Pathological Microenvironment‐Remodeling Nanoparticles to Alleviate Liver Fibrosis: Reversing Hepatocytes‐Hepatic Stellate Cells Malignant Crosstalk by Ling‐Feng Zhang, Wen‐Qi Deng, Xing‐Huan Wang, Qing‐Wen Huang, Su‐Qing Liang, Ze‐Quan Ding, Liang Qi, Yi Wang, Tian‐Jiao Zhou, Lei Xing, Jai‐Woo Lee, Yu‐Kyoung Oh, Hu‐Lin Jiang

“…This study presents an innovative strategy to modulate cellular interactions for enhanced anti‐fibrotic therapy and suggests a promising approach for treating other chronic liver diseases.…”
Get full text

Hepatitis C Worldwide and in Brazil: Silent Epidemic—Data on Disease including Incidence, Transmission, Prevention, and Treatment by Iara Fabricia Kretzer, Andrea do Livramento, Joel da Cunha, Sabrina Gonçalves, Iraci Tosin, Celso Spada, Aricio Treitinger

“…The infection is a leading cause of liver diseases like cirrhosis and hepatocellular carcinoma (HCC); thus, HCV infection constitutes a critical public health problem. …”
Get full text

Conditioned medium derived from mesenchymal stem cells and spinal cord injury: A review of the current therapeutic capacities by Gholam Reza Kaka, Farrokh Modarresi

Get full text

Application of dynamic enhanced scanning with GD-EOB-DTPA MRI based on deep learning algorithm for lesion diagnosis in liver cancer patients by Bo Liu, Jinhua Yang, Yifei Wu, Xi Chen, Xueru Wu

“…Gd-EOB-DTPA-enhanced magnetic resonance imaging (MRI) technology is in high demand.ObjectivesThe purpose of the study is to segment the liver using an enhanced multi-gradient deep convolution neural network (EMGDCNN) and to identify and categorize a localized liver lesion using a Gd-EOB-DTPA-enhanced MRI.MethodsWe provided the classifier images of the liver in five states (unenhanced, arterial, portal venous, equilibrium, and hepatobiliary) and labeled them with localized liver diseases (hepatocellular carcinoma, metastasis, hemangiomas, cysts, and scarring). …”
Get full text

Issues occult hepatitis B virus infection by I. A. Morozov, L. Yu. Ilchenko, N. I. Gromova, I. G. Fyedorov, I. V. Gordeychuk, A. K. Knyazhentseva, E. V. Zverkova, M. I. Mikhaylov

“…With the help of up-to-date molecular-biological and morphological methods to determine frequency of the occult form of chronic hepatitis B (CHB) among HBsAg-negative patients with chronic liver diseases (CLD) of various etiology and to present clinical and morphological characteristic.Material and methods. …”
Get full text

Intestinal microbiota dysbiosis contributes to the liver damage in subchronic arsenic-exposed mice by Dong Ling, Luo Peng, Zhang Aihua

“…There is an extensive amount of evidence that links changes in the intestinal microbiota structure to the progression and pathophysiology of many liver diseases. However, comprehensive analysis of gut flora dysbiosis in arsenic-induced hepatotoxicity is lacking. …”
Get full text