Metformin and Probiotics Interplay in Amelioration of Ethanol-Induced Oxidative Stress and Inflammatory Response in an In Vitro and In Vivo Model of Hepatic Injury by Farhin Patel, Kirti Parwani, Dhara Patel, Palash Mandal

“…Despite rigorous research, there is still no Food and Drug Administration (FDA) approved therapies for any stage of alcoholic liver disease (ALD). Interestingly, metformin (Met) and several probiotic strains possess the potential of inhibiting alcoholic liver injury. …”
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Assessment of liver fibrosis by acoustic radiation force impulse elastography in rheumatic disease patients on long-term methotrexate treatment by Arindam Nandy Roy, Gayatri Senapathy, Vijay Kumar Bongu, Yarram Ashok Kumar, Syeda Sana Fatima, Regina Lata Thadigiri

“…Pre-defined cut-off ARFI values were used to assess the stage of liver disease. Results: The mean ARFI value in the patient group was 1.14. …”
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High-density lipoprotein cholesterol as a prognostic marker for 90-day transplant-free mortality in hepatitis B virus-related acute-on-chronic liver failure by Ke Shi, Yi Zhang, Yanqiu Li, Xiaojing Wang, Ying Feng, Xianbo Wang

“…The prognostic value of HDL-C (AUC at day 90: 0.732) was comparable to the model for end-stage liver disease score of 0.729. Additionally, HDL-C levels were inversely correlated with interleukin (IL)-4, IL-6, and tumor necrosis factor-α (all P<0.05). …”
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Comparing Mortality Risk Predictive Ability of Different Scoring Systems in Cirrhotic Patients with Bacteremia by Chi-Chieh Hung, Yin-Chou Hsu, Kuo-Hsuan Lin

“…The Pitt bacteremia score (PBS), model for end-stage liver disease (MELD) score, Child–Pugh score, and quick sequential Organ Failure Assessment (qSOFA) score were calculated and compared using the area under the receiver operating characteristic (AUROC) curves. …”
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Mesenchymal Stem Cell Transplantation for Liver Cell Failure: A New Direction and Option by Yantian Cao, Bangjie Zhang, Rong Lin, Qingzhi Wang, Jie Wang, Fangfang Shen

“…Notably, the decreased value (D value) of Model for End-Stage Liver Disease score (MELD) of acute-on-chronic liver failure (ACLF) group was higher than that of chronic liver failure (CLF) group (14.93 ± 1.24 versus 4.6 ± 5.66, P<0.05). …”
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Achieving Complete Remission of Hepatocellular Carcinoma: A Significant Predictor for Recurrence-Free Survival after Liver Transplantation by Christin Bürger, Miriam Maschmeier, Anna Hüsing-Kabar, Christian Wilms, Michael Köhler, Martina Schmidt, Hartmut H. Schmidt, Iyad Kabar

“…Liver transplantation (LT) is a curative treatment for hepatocellular carcinoma (HCC) and the underlying primary liver disease; however, tumor recurrence is still a major issue. …”
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Hepatocellular Carcinoma with Both Fibrolamellar and Classical Components: An Unusual Morphological Pattern by Diana Castro-Villabón, Luis E. Barrera-Herrera, Paula A. Rodríguez-Urrego, Rachel Hudacko, Alonso Vera, Johanna Álvarez, Rafael Andrade, Rocío López

“…It is usually seen in young adults without underlying liver disease. Histologically, it shows large cells with abundant eosinophilic cytoplasm, large vesicular nuclei, prominent nucleoli, and lamellar type fibrosis. …”
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Comparative analysis of the DCNN and HFCNN Based Computerized detection of liver cancer by Sandeep Dwarkanth Pande, Pala Kalyani, S Nagendram, Ala Saleh Alluhaidan, G Harish Babu, Sk Hasane Ahammad, Vivek Kumar Pandey, G Sridevi, Abhinav Kumar, Ebenezer Bonyah

“…Researchers have explored numerous machine learning (ML) techniques and deep learning (DL) approaches aimed at the automated recognition of liver disease by analysing computed tomography (CT) images. …”
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Prevalence of Elevated Alanine Aminotransferase by Diagnostic Criterion, Age, and Gender among Adolescents by Jing Zhang, Zheng-Ying Wang, Jing-Ping Zhang, Hua Zhou, Zan Ding

“…Serum alanine aminotransferase (ALT) activity was measured not only to detect liver disease, but also to monitor overall health. The purpose of this study was to obtain the prevalence of elevated ALT levels among adolescents. …”
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MELD Score Is Not Related to Spontaneous Bacterial Peritonitis by Luciana Haddad, Tatiana Morgado Conte, Liliana Ducatti, Lucas Nacif, Luiz Augusto Carneiro D’Albuquerque, Wellington Andraus

“…Demographics data, etiology of liver disease, MELD score, and inscription on the waiting list for liver transplantation were analyzed. …”
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Respiratory syncytial virus vaccination in older adults and patients with chronic disorders: A position paper from the Portuguese Society of Pulmonology, the Portuguese Association... by Tiago Alfaro, Filipe Froes, Cláudia Vicente, Rui Costa, Cristina Gavina, Rui Baptista, António Maio, Saraiva da Cunha, João Sérgio Neves, Pedro Leuschner, Sofia Duque, Paula Pinto

“…Background Respiratory syncytial virus (RSV) is an important cause of lower respiratory tract infection, hospitalisation and death in adults.Methods Based on evidence regarding the impact of RSV on adult populations at risk for severe infection and the efficacy and safety of RSV vaccines, the Portuguese Society of Pulmonology, the Portuguese Association of General and Family Medicine, the Portuguese Society of Cardiology, the Portuguese Society of Infectious Diseases and Clinical Microbiology, the Portuguese Society of Endocrinology, Diabetes and Metabolism, and the Portuguese Society of Internal Medicine endorses this position paper with recommendations to prevent RSV-associated disease and its complications in adults through vaccination.Conclusion The RSV vaccine is recommended for people aged ≥50 years with risk factors (chronic obstructive pulmonary disease, asthma, heart failure, coronary artery disease, diabetes, chronic kidney disease, chronic liver disease, immunocompromise, frailty, dementia, and residence in a nursing home) and all persons aged ≥60 years. …”
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Ketosis Onset Type 2 Diabetes Had Better Islet β-Cell Function and More Serious Insulin Resistance by Hongyun Lu, Fang Hu, Yingjuan Zeng, Lingling Zou, Shunkui Luo, Ying Sun, Hong Liu, Liao Sun

“…Our results showed that ketosis onset group had higher prevalence of nonalcoholic fatty liver disease (NAFLD) than nonketotic group (P=0.04). …”
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Potential alternative and novel biomarkers for paediatric MAFLD: exploratory evidence from a Chinese cohort by Fan Yang, Mengyuan Hu, Lulian Xu, Xiaowei Zheng, Lihong Zhu, Le Zhang, Haoyang Zhang

“…Abstract Background While the associations between pediatric non-obese metabolic dysfunction-associated fatty liver disease (MAFLD) and multiple diagnostic biomarkers are well-established, the role of a broader range of blood-based, urine-based, and body composition-based biomarkers for monitoring MAFLD are needed. …”
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Impact of Chronic Statins Use on the Development of Esophagitis in Patients with Gastroesophageal Reflux Disease by Tawfik Khoury, Amir Mari, Hana Amara, Mohamed Jabaren, Abdulla Watad, Wiliam Nseir, Wisam Sbeit, Mahmud Mahamid

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Association between Interferon-Inducible Protein 6 () Polymorphisms and Hepatitis B Virus Clearance by Geun-Hee Park, Kyoung-Yeon Kim, Sung Won Cho, Jae Youn Cheong, Gyeong Im Yu, Dong Hoon Shin, Kyu Bum Kwack

“…However, these cells are killed through HBV-induced apoptosis during the antigen-presenting period in HBV-induced chronic liver disease (CLD) patients. Interferon-inducible protein 6 (IFI6) delays type I interferon-induced apoptosis in cells. …”
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U-shaped associations between body mass index and serum liver enzyme levels by Zixi Huang, Hualong Liu, Wen Zhuo, Yuliang Chen, Ying Huang, Xin Chen, Teng Lu, Zhenyan Xu

“…Specifically, in the higher BMI range, the positive associations between BMI and liver enzymes were more robust in men (AST and ALT), participants with fatty liver disease (AST and ALT), and participants with a history of smoking (AST, ALT, and GGT). …”
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Noninvasive Evaluation of Liver Function in Morbidly Obese Patients by Patrick H. Alizai, Isabella Lurje, Andreas Kroh, Sophia Schmitz, Tom Luedde, Julia Andruszkow, Ulf P. Neumann, Florian Ulmer

“…More than half of the obese patients develop nonalcoholic fatty liver disease (NAFLD), which may further progress to nonalcoholic steatohepatitis (NASH) and cirrhosis. …”
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Theoretical modeling of hepatitis C acute infection in liver-humanized mice support pre-clinical assessment of candidate viruses for controlled-human-infection studies by Zhenzhen Shi, Adquate Mhlanga, Yuji Ishida, Ari Josephson, Nicholson T. Collier, Hiromi Abe-Chayama, Chise Tateno-Mukaidani, Scott J. Cotler, Jonathan Ozik, Marian Major, Jordan J. Feld, Kazuaki Chayama, Harel Dahari

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RELATIONSHIPS BETWEEN LIPID PROFILE AND COMPLETE BLOOD CELL COUNT PARAMETERS by Yevhen Dzis, Oleksandra Tomashevska, Andriy Petrukh

“…The study is a fragment of the planned scientific research of the Department of Internal Medicine No. 2 of the Danylo Halytsky Lviv National Medical University: "Peculiarities and markers of the course of internal diseases under conditions of combination with metabolic syndrome and metabolically associated fatty liver disease", state registration number: 0122U000165.…”
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Analysis of Factors Related to Pulmonary Nodules in Patients With Fatty Liver: A Large-Scale Cohort Study Based on a Physical Examination Population by Qin Y, Huang X, Lin J, Pan L, Liang Q, Li W

“…Multifactorial logistic regression analysis showed that male gender, body weight, age, and diastolic blood pressure were significant factors influencing lung nodule development in fatty liver patients.Conclusion: Fatty liver disease is independently associated with an increased incidence of pulmonary nodules, highlighting its importance in lung cancer screening and prevention.Keywords: pulmonary nodules, fatty liver, health checkup, influencing factors, retrospective cohort study…”
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