An Update on Less Invasive and Endoscopic Techniques Mimicking the Effect of Bariatric Surgery by Froukje J. Verdam, Ruben Schouten, Jan Willem Greve, Ger H. Koek, Nicole D. Bouvy

“…Obesity (BMI 30–35 kg/m2) and its associated disorders such as type 2 diabetes, nonalcoholic fatty liver disease, and cardiovascular disease have reached pandemic proportions worldwide. …”
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Asymptomatic Intestinal Malrotation Progressing to Midgut Volvulus in a Decompensated Alcoholic Cirrhotic Adult: A Rare Scenario Requiring Special Considerations by Vatche Melkonian, Pablo Quadri, Chintalapati R. Varma, Mustafa Nazzal, Henry B. Randall, Minh-Tri J. P. Nguyen

“…Observation continued as his liver disease improved with alcohol cessation (Child-Pugh class A, MELD score 8). …”
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Vaccinating Adult Patients with Cirrhosis: Trends over a Decade in the United States by Abhijeet Waghray, Nisheet Waghray, Hicham Khallafi, K. V. Narayanan Menon

“…The progression of chronic liver disease to cirrhosis involves both innate and adaptive immune system dysfunction resulting in increased risk of infectious complications. …”
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Deciphering Platelet Kinetics in Diagnostic and Prognostic Evaluation of Hepatocellular Carcinoma by Bibek Aryal, Munekazu Yamakuchi, Toshiaki Shimizu, Jun Kadono, Akira Furoi, Kentaro Gejima, Teruo Komokata, Teruto Hashiguchi, Yutaka Imoto

“…Platelet contribution to the liver pathophysiology is typically facilitated by the platelet-derived growth factors that are sequestered in different subsets of alpha and dense granules, and the release of these growth factors is synchronized according to the stage and type of liver disease or injury. Thus, platelets harbor clinically relevant information with potential diagnostic and prognostic implications in liver diseases. …”
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Targeting ion homeostasis in metabolic diseases: Molecular mechanisms and targeted therapies by Yanjiao Zhang, Kaile Ma, Xinyi Fang, Yuxin Zhang, Runyu Miao, Huifang Guan, Jiaxing Tian

“…The incidence of metabolic diseases—hypertension, diabetes, obesity, metabolic dysfunction-associated steatotic liver disease (MASLD), and atherosclerosis—is increasing annually, imposing a significant burden on both human health and the social economy. …”
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Rules for investigation of patients with asymptomatic elevation of serum aminotransferase activity by M. V. Mayevskaya, V. T. Ivashkin, Ye. N. German

“…States at which in absence of primary liver disease levels of ALT and AST can raise are described.…”
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Holotranscobalamin Is a Useful Marker of Vitamin B12 Deficiency in Alcoholics by Alberto Fragasso, Clara Mannarella, Angela Ciancio, Oronzo Scarciolla, Nicoletta Nuzzolese, Rocco Clemente, Eustachio Vitullo, Andrea Sacco

“…Falsely increased values of Cbl can be caused by alcoholic liver disease. Measurement of total vitamin B12 serum levels might be misleading in alcoholics, because a tissue metabolic deficiency is possible even with normal serum Cbl levels. …”
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Fungal Bezoar: A Rare Cause of Ureteral Obstruction by Nabil Zeineddine, Wissam Mansour, Sandy El Bitar, Marco Campitelli, Neville Mobarakai

“…A 52-year-old male, with diabetes mellitus and alcoholic liver disease, presented to the Emergency Room for right flank pain of 3 days’ duration, associated with dysuria. …”
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Psychometric Validation of the Hepatitis C Symptom and Impact Questionnaire (HCV-SIQv4) in a Diverse Sample of Adults with Chronic Hepatitis C Virus Infection Treated with an Inter... by Andrew Trigg, Eric Chan, Helen Kitchen, Tom Willgoss, Kai Fai Ho, Renee Pierson, Jane Scott

“…**Results:** Data from 437 patients were analyzed. Stage of liver disease was associated with symptom severity and functioning at baseline. …”
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Effectively Screening for Coronary Artery Disease in Patients Undergoing Orthotopic Liver Transplant Evaluation by Bryan C. Lee, Feng Li, Adam J. Hanje, Khalid Mumtaz, Konstantinos D. Boudoulas, Scott M. Lilly

“…Coronary artery disease (CAD) is prevalent in patients with end-stage liver disease and associated with poor outcomes when undergoing orthotopic liver transplantation (OLT); however, noninvasive screening for CAD in this population is less sensitive. …”
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The Role of Monocyte/Macrophage and CXCR3 in Differentiation between Recurrent Hepatitis C and Acute Cellular Rejection Postliver Transplantation by Asmaa Ibrahim Gomaa, Nermine Ahmed Ehsan, Ahmed A. Elrefaei, Mervat Mohamed Sultan, Maha Mohamed Elsabaawy

“…Liver transplantation (LT) is the recommended treatment for patients with advanced liver disease and cirrhosis in all guidelines, mostly as a complication of HCV. …”
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The Role of Genetic and Immune Factors for the Pathogenesis of Primary Sclerosing Cholangitis in Childhood by Priscila Menezes Ferri, Ana Cristina Simões e Silva, Soraya Luiza Campos Silva, Diego Junior Queiroga de Aquino, Eleonora Druve Tavares Fagundes, Débora Marques de Miranda, Alexandre Rodrigues Ferreira

“…Primary sclerosing cholangitis (PSC) is a rare cholestatic liver disease characterized by chronic inflammation of the biliary tree resulting in liver fibrosis. …”
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Estrogen-dependent activation of TRX2 reverses oxidative stress and metabolic dysfunction associated with steatotic disease by Alfredo Smiriglia, Nicla Lorito, Marina Bacci, Angela Subbiani, Francesca Bonechi, Giuseppina Comito, Marta Anna Kowalik, Andrea Perra, Andrea Morandi

“…Abstract Metabolic dysfunction-associated steatotic liver disease (MASLD) encompasses a spectrum of hepatic disorders, ranging from simple steatosis to steatohepatitis, with the most severe outcomes including cirrhosis, liver failure, and hepatocellular carcinoma. …”
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MFG-E8 Knockout Aggravated Nonalcoholic Steatohepatitis by Promoting the Activation of TLR4/NF-κB Signaling in Mice by Jun Hu, Hui Du, Yinglin Yuan, Peipei Guo, Junxia Yang, Xinru Yin, Jin Liu, Shengwang Wu, Jingyuan Wan, Xia Gong

“…Nonalcoholic steatohepatitis (NASH) is the common liver disease characterized by hepatic steatosis, inflammation, and fibrosis; there are no approved drugs to treat this disease because of incomplete understanding of pathophysiological mechanisms of NASH. …”
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Platelet Counts and Liver Enzymes after Bariatric Surgery by Hans-Erik Johansson, Arvo Haenni, Björn Zethelius

“…Obesity is characterized by liver steatosis, chronic inflammation, and increased liver enzymes, that is, gamma-glutamyltransferase (GGT) and alanine aminotransferase (ALT), markers for nonalcoholic fatty liver disease (NAFLD) and liver fat content. Increased platelet counts (PCs) are associated with inflammatory conditions and are a valuable biomarker of the degree of fibrosis in NAFLD. …”
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Role of HNF6 in liver homeostasis and pathophysiology by Miaomiao Tian, Weizhen Gao, Shujun Ma, Huiling Cao, Yu Zhang, Fuxiang An, Jianni Qi, Zhen Yang

“…We also highlight gaps in liver disease research and provide future research directions for the application of HNF6 and its downstream molecules as attractive targets in the treatment of liver diseases.…”
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Presence of Serum Antinuclear Antibodies Does Not Impact Outcomes in HBV-Related Acute-on-Chronic Liver Failure by Lin Lin, Bin Lin, Qing Lan, Longgen Liu, Jianchun Lu, Xiujun Zhang, Shuqin Zheng, Yuan Xue

“…Patients with negative ANA had a higher international normalized ratio, model for end-stage liver disease (MELD), and MELD-sodium scores than those with positive ANA (all P<0.05). …”
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Point of Care Perioperative Coagulation Management in Liver Transplantation and Complete Portal Vein Thrombosis by Cristiano Piangatelli, Lucia Faloia, Claudia Cristiani, Ilaria Valentini, Marco Vivarelli

“…We report the successful application of a point-of-care (POC) rotational viscoelastic thromboelastometry-guided (TEM) testing system (ROTEM) which allowed management of coagulation during LT in a 64-year-old cirrhotic patient with a model for end-stage liver disease (MELD) score of 16. Perioperatively, the patient showed complete PVT, hepatomegaly, splenomegaly, recanalization of the umbilical vein, and portosystemic shunt. …”
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Comparative Analysis of Clinical Characteristics and Antimicrobial Resistance Between <i>Acinetobacter baumannii</i> and Other <i>Acinetobacter</i> Species by Si-Ho Kim, Seok Jun Mun

“…In a multivariable analysis of 30-day mortality, factors associated with higher mortality included moderate to severe liver disease, chronic kidney disease, carbapenem resistance, septic shock, and higher Pitt Bacteremia Scores. …”
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Sindrom Hepatorenal pada Anak by Yusri Dianne Jurnalis, Yorva Sayoeti, Julinar .

“…HRS is diagnosis by exclusion and all other cause of acute renal injury in patient advanced liver disease. Management requires combined use of splanchnic and peripheral vasoconstrictor in combination with intravenous albumin may improve renal function in HRS. …”
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