Mechanistic insights into 5-aminolevulinic acid photodynamic therapy for acne vulgaris: targeting lipogenesis via the OLR1-Wnt/β-catenin pathway by Jia Yan, Linglin Zhang, Qingyu Zeng, Yitao Qian, Ke Li, Xiaojing Liu, Yun Wu, Yu Yan, Haiyan Zhang, Szeman Cheung, Jia Liu, Ronald Sroka, Xiuli Wang, Lei Shi

“…We employed transcriptomic analysis, lipid staining, and gene silencing techniques to dissect the molecular interactions induced by ALA-PDT. …”
Get full text

Fatty liver syndrome associated with some post parturation period diseases by Veysi Aslan, Reşat Aştı, Mehmet Nizamlıoğlu, Tevfik Tekeli, Abdullah Başoğlu, Ülker Demirci

“…Glucose, GOT', FFA and total lipid values of blood samples and liver fat were measured. …”
Get full text

The Effect of Aerobic Exercise on the Oxidative Capacity of Skeletal Muscle Mitochondria in Mice with Impaired Glucose Tolerance by Dan Wang, Dong-Mou Jiang, Rong-Rong Yu, Lin-Lin Zhang, Yan-Zhong Liu, Jia-Xin Chen, Hai-Chun Chen, Yi-Ping Liu

“…Results. (1) Mice with high-fat diet for 30 weeks showed impaired glucose tolerance, insulin resistance, and lipid metabolism disorders. The level of LDH, PDH, SDH, and CCO in the gastrocnemius homogenate of mice was reduced. …”
Get full text

PPARα Is Required for PPARδ Action in Regulation of Body Weight and Hepatic Steatosis in Mice by Wojciech G. Garbacz, Jeffrey T. J. Huang, Larry G. Higgins, Walter Wahli, Colin N. A. Palmer

“…PPARα is a target of well established lipid-lowering drugs. PPARδ (also known as PPARβ/δ) has been investigated as a promising antidiabetic drug target; however, the evidence in the literature on PPARδ effect on hepatic lipid metabolism is inconsistent. …”
Get full text

Insulin Resistance Predicts Atherogenic Lipoprotein Profile in Nondiabetic Subjects by Flávia De C. Cartolano, Gabriela D. Dias, Maria C. P. de Freitas, Antônio M. Figueiredo Neto, Nágila R. T. Damasceno

“…For that, we evaluated the capacity of IR to predict an atherogenic lipid subfraction profile. Methods. Complete clinical evaluation and biochemical analysis (lipid, glucose profile, LDL, and HDL subfractions and LDL phenotype and size) were performed in 181 patients. …”
Get full text

JTT-130, a Novel Intestine-Specific Inhibitor of Microsomal Triglyceride Transfer Protein, Improves Hyperglycemia and Dyslipidemia Independent of Suppression of Food Intake in Diab... by Shohei Sakata, Makoto Ito, Yasuko Mera, Tomohiko Sasase, Hiromi Yamamoto, Makoto Kakutani, Takeshi Ohta

“…We investigated the effects of JTT-130 on glucose and lipid metabolism independent of the suppression of feeding by comparing with pair-fed animals. …”
Get full text

Assessment of effectiveness of oral supplementation of isolated fiber of carrot on metabolic parameters in mature rats by Maria Rosana Ramirez, Debora Manuale, Juan Carlos Yori

“…With the exception of total high-density lipoprotein cholesterol, the other lipid fractions decrease significantly in rats supplemented. …”
Get full text

Cellular Composition Changes and Nitrogen Uptake under Extra-Limited Nitrogen Conditions by Thermosynechococcus sp. CL-1 Carbon Biofixation by Tseng Chi-Ming, Ko Tzu-Hsing, Hsueh Hsin-Ta, Chen Hsing-Hui, Ray Dah-Tong, Shen Yun-Hwei, Chu Hsin

“…CL-1 (TCL-1) at 50°C. The lipid, carbohydrate, and protein cellular components which can be used as bioenergy precursors along with their content as a function of various C/N ratios are quantified. …”
Get full text

Hypertriglyceridemia Is Associated with Reduced Leukoaraiosis Severity in Patients with a Small Vessel Stroke by Daqiang Ke, Feng Zhou, Hui Liang, Yang Xu, Haiyan Lou

“…PVH and SWMLs were accessed on MRI with the Fazekas scale, and lipid levels were measured. Univariate and multivariable regression analyses were used to assess the relation between different lipid profiles and severity of PVH and SWMLs. …”
Get full text

Anti-Glycemic and Anti-Hepatotoxic Effects of Mangosteen Vinegar Rind from Garcinia mangostana Against HFD/STZ-Induced Type II Diabetes in Mice by Karim Naymul, Jeenduang Nutjaree, Tangpong Jitbanjong

“…MVR and glibenclamide treatment to HFD/STZ-induced diabetic mice significantly reduced their plasma glucose, plasma lipid profile, and hepatic lipid profile (P<0.05). …”
Get full text

Not Only Glycaemic But Also Other Metabolic Factors Affect T Regulatory Cell Counts and Proinflammatory Cytokine Levels in Women with Type 1 Diabetes by Katerina Stechova, Jana Sklenarova-Labikova, Tereza Kratzerova, Pavlina Pithova, Dominik Filipp

“…Regulatory T cell counts correlated with HbA1c, diabetic neuropathy, lipid spectra parameters, and IL-6 levels. Total T-helper cell count was interconnected with BMI and glycaemia variability correlated with lipid spectra parameters, insulin dose, and vitamin D levels. …”
Get full text

Role of gut microbiota and fecal metabolites in the protective effect of soybean pulp-rich diet against estrogen-induced cholestasis in rats by Jiawei Wang, Qichao Hu, Jianying Wang, Liwei Lang, Shizhang Wei, Haotian Li, Manyi Jing, Xiao Ma, Yanling Zhao, Xuelin Zhou

“…Moreover, the soybean pulp-rich diet could modulate the abundances of Prevotella spp. and Tyzzerella, reducing EIC by regulating lipid metabolism and short-chain fatty acids synthesis. …”
Get full text

Niacin Inhibits Vascular Inflammation via Downregulating Nuclear Transcription Factor-κB Signaling Pathway by Yanhong Si, Ying Zhang, Jilong Zhao, Shoudong Guo, Lei Zhai, Shutong Yao, Hui Sang, Nana Yang, Guohua Song, Jue Gu, Shucun Qin

“…Furthermore, niacin also modulates plasma lipid by upregulating the expression of factors involved in the process of reverse cholesterol transport.…”
Get full text

Modulating p56Lck in T-Cells by a Chimeric Peptide Comprising Two Functionally Different Motifs of Tip from Herpesvirus saimiri by Jean-Paul Vernot, Ana María Perdomo-Arciniegas, Luis Alberto Pérez-Quintero, Diego Fernando Martínez

“…These results provide the basis for the development of new compounds capable of modulating therapeutic targets present in lipid rafts.…”
Get full text

The Association of Adipokines and Myokines in the Blood of Obese Children and Adolescents with Lipoprotein Lipase rs328 Gene Variants by Alexander V. Shestopalov, Vadim V. Davydov, Genrik T. Tumanyan, Elena D. Teplyakova, Tatiana P. Shkurat, Elena V. Mashkina, Mikhail A. Shkurat, Andrey M. Gaponov, Anastasia A. Sadova, Olga V. Borisenko, Sergey A. Roumiantsev

“…Obesity develops largely due to genetic factors, with the genetic polymorphism of lipid metabolism enzymes being of particular importance. …”
Get full text

The Association between Adiponectin Single Nucleotide Polymorphisms and Side Effects of Isotretinoin in Acne Patients by Munir Garba, Omar F. Khabour, Karem H. Alzoubi, Ahmed Abu-Siniyeh, Firas Al-Qarqaz

“…Results. Alterations in lipid profile with a significant increase of ALT (P=0.007) were detected after isotretinoin treatment. …”
Get full text

Tuftelin 1 Facilitates Hepatocellular Carcinoma Progression through Regulation of Lipogenesis and Focal Adhesion Maturation by Lei Zhu, Kai X. Zhou, Ming Z. Ma, Lin L. Yao, Yan L. Zhang, Hui Li, Chang Du, Xiao M. Yang

“…Emerging evidences demonstrated critical roles of lipid de novo synthesis in HCC progression, yet its regulatory mechanisms are not fully understood. …”
Get full text

Potential Role of ANGPTL4 in the Cross Talk between Metabolism and Cancer through PPAR Signaling Pathway by Laura La Paglia, Angela Listì, Stefano Caruso, Valeria Amodeo, Francesco Passiglia, Viviana Bazan, Daniele Fanale

“…At first, ANGPTL4 has been identified as an adipokine exclusively involved in lipid metabolism, because of its prevalent expression in liver and adipose tissue. …”
Get full text

Yindanxinnaotong, a Chinese compound medicine, synergistically attenuatesatherosclerosis progress by Long Cheng, Guo-feng Pan, Xiao-dong Zhang, Jian-lu Wang, Wan-dan Wang, Jian-yong Zhang, Hui Wang, Ri-xin Liang, Xiao-bo Sun

“…We initiallyperformed a computational prediction based on a network pharmacology simulation,which clued YD exerted synergistically anti-atherosclerosis properties by vascularendothelium protection, lipid-lowering, anti-inflammation and anti-oxidation. …”
Get full text

Lipidomic Signature of Pregnant and Postpartum Females by Longitudinal and Transversal Evaluation: Putative Biomarkers Determined by UHPLC-QTOF-ESI⁺-MS by Alexandra Traila, Marius Craina, Carmen Socaciu, Andreea Iulia Socaciu, Diana Nitusca, Catalin Marian

“…Lipidomics was prioritized, and a solvent mixture was employed to enhance lipid extraction, using UHPLC-QTOF-ESI⁺-MS. …”
Get full text