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1381
Mediator kinase inhibition suppresses hyperactive interferon signaling in Down syndrome
Published 2025-02-01“…A subset of these lipids (e.g. oleamide, desmosterol) serve as ligands for nuclear receptors PPAR and LXR, and activation of these receptors occurred specifically during hyperactive IFN signaling in CA-treated cells, revealing mechanistic links between Mediator kinases, lipid metabolism, and nuclear receptor function. …”
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1382
High-speed centrifugation reduces immune rejection by removing bone marrow elements from fresh osteochondral allografts
Published 2025-03-01“…In addition, OCAs using the HSC method exhibited reduced recognition by the host immune system compared with OCAs without HSC, thereby reducing immune rejection. Lipids were the most abundant and difficult-to-remove antigenic components and are the most likely to affect host macrophage polarisation, playing an important role in immune rejection. …”
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1383
Annexin A8 deficiency delays atherosclerosis progression
Published 2025-01-01“…Plaques of ApoE−/−AnxA8−/− were characterized by lower lipid and inflammatory content, smaller necrotic core, thicker fibrous cap and less apoptosis compared with those in ApoE−/−AnxA8+/+. …”
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1384
Novel type 2 diabetes prediction score based on traditional risk factors and circulating metabolites: model derivation and validation in two large cohort studiesResearch in context
Published 2025-01-01“…Findings: 11 metabolomic biomarkers, including glycolysis related metabolites, ketone bodies, amino acids, and lipids, were selected. In internal validation within the UKB, adding these metabolites significantly increased the C-index (95% confidence interval (95% CI)) of the clinical CDRS from 0.815 (0.800, 0.829) to 0.834 (0.820, 0.847) and the continuous net reclassification index (NRI) with 95% CI was 39.8% (34.6%, 45.0%). …”
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1385
Risk factors affecting polygenic score performance across diverse cohorts
Published 2025-01-01“…Covariates with the largest differences included age, sex, blood lipids, physical activity, and alcohol consumption, with R2 being nearly double between best- and worst-performing quintiles for certain covariates. …”
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1386
Relevance of superoxide dismutase type 1 to lipoid pneumonia: the first retrospective case-control study
Published 2025-01-01“…Abstract Background Lipoid pneumonia (LP) is a rare disease caused by the accumulation of lipids and lipid-laden macrophages in the alveoli inducing damage. …”
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1387
γ-亚麻酸对α-亚麻酸转化为DHA的影响 Effect of γ-linolenic acid on the conversion of α-linolenic acid to DHA
Published 2025-01-01“…After 24 h of gavage, the lipids in the serum, liver, small intestine wall and brain of mice in each group were extracted. …”
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1388
Determination of the physicochemical and microbiological quality of buffalo milk in the south of lake Maracaibo
Published 2023-11-01“…In Venezuela, the standards for raw materials (raw milk) and dairy derivatives are established by COVENIN (Venezuelan Commission of Industrial Standards), which determine variables of great importance in milk such as: lipids, proteins, lactose, mineral salts, load microbial, among others. …”
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1389
Longitudinal analysis of lifestyle risk factors, nutrition status and drivers of food choice among urban migrants in Ulaanbaatar, Mongolia, and Almaty, Kazakhstan: a formative stud...
Published 2025-01-01“…Results: Adjusting for age and sex, each month since migration was positively associated with fasting TAG in Almaty (0·55 mg/dl; 95 % CI: 0·13, 0·94) and BMI (0·04 kg/m2; 95 % CI: 0·01, 0·07), body fat (0·14 %; 95 % CI: 0·01, 0·26) and fasting glucose (0·04 mmol/l; 95 % CI: 0·02, 0·05) and lipids in Ulaanbaatar (P < 0·05). In Almaty, nutrition knowledge (measured using an objective 20-point scale) declined despite improvements in diet quality (measured by Prime Diet Quality Score). …”
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1390
Gut microbiome-derived bacterial extracellular vesicles in patients with solid tumours
Published 2025-02-01“…The diverse composition of bEVs, including their proteins, mRNAs, metabolites, and lipids, makes them useful for investigating diseases such as cancer. …”
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1391
Characterisation of pregnancy-induced alterations in apolipoproteins and their associations with maternal metabolic risk factors and offspring birth outcomes: a preconception and l...
Published 2025-02-01“…Summary: Background: Apolipoproteins as an integral part of lipoproteins are crucial for the transport and metabolism of lipids. However, there is a lack of longitudinal studies to quantify the concentrations of maternal apolipoproteins from preconception to postpartum and their associations with maternal metabolic health and offspring birth outcomes. …”
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1392
Clinical Biochemistry /
Published 2017Table of Contents: “…Biochemical investigations and quality control / David Cameron -- Automation / Tim James -- Kidney disease / Edmund Lamb -- Hyperuricaemia and gout / Joanne Marsden -- Fluid and electrolyte disorders / Tim James -- Acid-base disorders / David Tierney -- Clinical enzymology and biomarkers / Paul Collinson, Amy Lloyd -- Liver function tests / Roy Sherwood -- Abnormalities of lipid metabolism / Mike France -- Disorders of calcium, phosphate, and magnesium homeostasis / Nessar Ahmed -- Abnormal pituitary function ; Thyroid disease / Garry McDowell -- Diabetes mellitus and hypoglycaemia / Allen Yates, Ian Laing -- Adrenal disease / John Honour -- Reproductive endocrinology / Ian Laing, Julie Thornton -- Biochemical nutrition / Pat Twomey, William Simpson -- Gastrointestinal disorders and malabsorption / Garry McDowell, Gordon Brydon -- Specific protein markers / Gerald Maguire -- Cancer biochemistry and tumour markers / Joanne Adaway, Gilbert Wieringa -- Inherited metabolic disorders and newborn screening / Mary Anne Preece -- Therapeutic drug monitoring / Robin Whelpton, Nigel Brown, Robert Flanagan -- Chemical toxicology / Gwendolen Ayers.…”
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1393
Clinical Biochemistry ; fundamentals of biomedical science /
Published 2017Table of Contents: “…Biochemical investigations and quality control / David Cameron -- Automation / Tim James -- Kidney disease / Edmund Lamb -- Hyperuricaemia and gout / Joanne Marsden -- Fluid and electrolyte disorders / Tim James -- Acid-base disorders / David Tierney -- Clinical enzymology and biomarkers / Paul Collinson, Amy Lloyd -- Liver function tests / Roy Sherwood -- Abnormalities of lipid metabolism / Mike France -- Disorders of calcium, phosphate, and magnesium homeostasis / Nessar Ahmed -- Abnormal pituitary function ; Thyroid disease / Garry McDowell -- Diabetes mellitus and hypoglycaemia / Allen Yates, Ian Laing -- Adrenal disease / John Honour -- Reproductive endocrinology / Ian Laing, Julie Thornton -- Biochemical nutrition / Pat Twomey, William Simpson -- Gastrointestinal disorders and malabsorption / Garry McDowell, Gordon Brydon -- Specific protein markers / Gerald Maguire -- Cancer biochemistry and tumour markers / Joanne Adaway, Gilbert Wieringa -- Inherited metabolic disorders and newborn screening / Mary Anne Preece -- Therapeutic drug monitoring / Robin Whelpton, Nigel Brown, Robert Flanagan -- Chemical toxicology / Gwendolen Ayers.…”
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1394
Lipoprotein Signal Peptide as Adjuvants: Leveraging Lipobox-Driven TLR2 Activation in Modern Vaccine Design
Published 2025-01-01“…Toll-like receptor 2 (TLR2) signaling is a pivotal component of immune system activation, and it is closely linked to the lipidation of bacterial proteins. This lipidation is guided by bacterial signal peptides (SPs), which ensure the precise targeting and membrane anchoring of these proteins. …”
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1395
Lipidomic Analysis of Endocannabinoid Signaling: Targeted Metabolite Identification and Quantification
Published 2016-01-01“…The endocannabinoids N-arachidonoylethanolamide (or anandamide, AEA) and 2-arachidonoylglycerol (2-AG) belong to the larger groups of N-acylethanolamines (NAEs) and monoacylglycerol (MAG) lipid classes, respectively. They are biologically active lipid molecules that activate G-protein-coupled cannabinoid receptors found in various organisms. …”
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1396
PLIN5 contributes to lipophagy of hepatic stellate cells induced by inorganic arsenic
Published 2025-01-01“…Lipophagy, a specialized form of selective autophagy, is crucial for the degradation of lipid droplets to maintain intracellular lipid metabolism homeostasis. …”
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1397
Options of dyslipidemia treatment at non-alcoholic fatty liver disease
Published 2018-08-01“…These substances play important role in lipid metabolism regulating expression of the genes (including PPARα) involved in lipid and glucose metabolism. …”
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1398
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1399
A Comparative Study of Phase States of the Peribacteroid Membrane from Yellow Lupin and Broad Bean Nodules
Published 2014-01-01“…As a result, it is shown that the lipid bilayer status of the bacteroid outer membrane is mainly determined by microsymbiont, but not the host plant. …”
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Analysis of occupational health examination results among medical radiation workers in Hangzhou City
Published 2025-01-01“…The abnormal rates of thyroid ultrasound and blood lipid were 47.73% and 45.21%, respectively, which were relatively higher than other items. …”
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