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2141
Effects of perfluorolauric acid exposure on intestinal microbial community and physiological health indicators in mice
Published 2025-01-01“…In terms of physiological health, exposure to PFLA resulted in increased liver inflammation, lipid abnormalities, and caused histological changes in the colon, such as ulcerative colitis and damage to glandular structures. …”
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2142
Adipokines regulate the development and progression of MASLD through organellar oxidative stress
Published 2025-02-01“…These adipokines intricately orchestrate regulatory pathways that impact glucose and lipid metabolism, oxidative stress, and mitochondrial function, thereby influencing the evolution of hepatic steatosis and progression to metabolic dysfunction–associated steatohepatitis (MASH). …”
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2143
Functional-proteomics-based investigation of the cellular response to farnesyltransferase inhibition in lung cancer
Published 2025-02-01“…Summary: Farnesylation is a lipid post-translational modification of proteins crucial for protein membrane anchoring and cellular signaling. …”
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2144
Salicylic Acid Attenuates Gentamicin-Induced Nephrotoxicity in Rats
Published 2012-01-01“…The results from our study indicate that SA supplement attenuates oxidative-stress associated renal injury by reducing oxygen free radicals and lipid peroxidation in gentamicin-treated rats.…”
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2145
G-quadruplex-forming small RNA inhibits coronavirus and influenza A virus replication
Published 2025-01-01“…The approach has the potential to facilitate the creation of versatile middle-molecule antivirals featuring lipid nanoparticle-free delivery.…”
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2146
Modulatory effects of perindopril on cisplatin-induced nephrotoxicity in mice: Implication of inflammatory cytokines and caspase-3 mediated apoptosis
Published 2020-12-01“…Conversely, perindopril had no significant effect on cisplatin-induced elevations in serum creatinine and urea, microalbuminuria, kidney to body weight ratio, lipid peroxidation marker, superoxide dismutase and catalase activities and reduced glutathione content. …”
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2147
Fasting Upregulates PPAR𝛼 Target Genes in Brain and Influences Pituitary Hormone Expression in a PPAR𝛼 Dependent Manner
Published 2009-01-01“…PPAR𝛼 is a lipid-activable transcription factor that mediates the adaptive response to fasting. …”
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2148
GLP‐1 Receptor Agonists Alleviate Diabetic Kidney Injury via β‐Klotho‐Mediated Ferroptosis Inhibition
Published 2025-01-01“…Subsequently, the adenosine monophosphate‐activated protein kinase (AMPK) signaling pathway is activated, reprograming the key metabolic processes of ferroptosis such as iron metabolism, fatty acid synthesis, and the antioxidant response against lipid peroxidation. Suppression of ferroptosis by Smg further attenuates renal inflammation and fibrosis. …”
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2149
A distant TANGO1 family member promotes vitellogenin export from the ER in C. elegans
Published 2025-02-01“…Summary: Vitellogenin is thought to share a common ancestor with human apolipoprotein B (ApoB) for systemic lipid transport. In Caenorhabditis elegans, although a general route for inter-tissue vitellogenin transport has been described, the full mechanism that underlies its intracellular trafficking within the intestine remains obscure. …”
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2150
Clinical Impact of Sphingosine-1-Phosphate in Breast Cancer
Published 2017-01-01“…Sphingosine-1-phosphate (S1P) is a pleiotropic, bioactive lipid mediator that regulates many cellular functions, including proliferation, migration, survival, angiogenesis/lymphangiogenesis, and immune responses. …”
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2151
PPARγ as a Novel Therapeutic Target in Lung Cancer
Published 2016-01-01“…Its involvement in adipocyte differentiation and glucose and lipid homeostasis is well-recognized, but accumulating evidence now suggests that PPARγ may also function as a tumor suppressor, inhibiting development of primary tumors and metastases in lung cancer and other malignancies. …”
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2152
Multidrug-Resistant Pathogens in Burn Wound, Prevention, Diagnosis, and Therapeutic Approaches (Conventional Antimicrobials and Nanoparticles)
Published 2023-01-01“…Also, some advances in various types of nanomaterials, including metallic nanoparticles, liposomes, hydrogels, carbon quantum dots, and solid lipid nanoparticles in burn wound healing, will be explained.…”
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2153
Immunolocalization of hordein synthesis and transport in developing barley endosperm
Published 2024-09-01“…The pattern seen for hordeins was compared to other abundant grain proteins, such as serpin Z4 and lipid transfer protein 1 (LTP1). Hordein accumulates throughout grain development, from 6 to 37 days post‐anthesis (DPA). …”
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2154
Chemical Feature-Based Molecular Modeling of Urotensin-II Receptor Antagonists: Generation of Predictive Pharmacophore Model for Early Drug Discovery
Published 2014-01-01“…For a series of 35 piperazino-phthalimide and piperazino-isoindolinone based urotensin-II receptor (UT) antagonists, a thoroughly validated 3D pharmacophore model has been developed, consisting of four chemical features: one hydrogen bond acceptor lipid (HBA_L), one hydrophobe (HY), and two ring aromatic (RA). …”
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2155
Protective Effect of Acacia nilotica (L.) against Acetaminophen-Induced Hepatocellular Damage in Wistar Rats
Published 2013-01-01“…The biochemical liver functional tests Alanine transaminase (ALT), Aspartate transaminase (AST), Alkaline phosphatase (ALP), total bilirubin, total protein, oxidative stress test (Lipid peroxidation), antioxidant parameter glutathione (GSH), and histopathological changes were examined. …”
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2156
Is There Really Relationship between Androgenetic Alopecia and Metabolic Syndrome?
Published 2015-01-01“…Age, duration of AGA, AGA onset age, anthropometric measures, body mass index, lipid parameters, fasting blood glucose, blood pressure, and presence of MS were recorded. …”
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2157
Senyawa Fucodiphlorethol Dan Phloroglucinol Alga Coklat Sebagai Inhibitor Lipase Secara In Silico
Published 2022-05-01“…Brown algae improved blood glucose and lipid profile. This study investigated the potential activity of two bioactive compounds from brown algae, as anti-obesity through pancreatic lipase inhibition. …”
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2158
Anti-Inflammation Property of Syzygium cumini (L.) Skeels on Indomethacin-Induced Acute Gastric Ulceration
Published 2015-01-01“…Pretreatment with SCC caused discernible decrease in indomethacin induced gastric lesion and lipid peroxide content. In addition, oxidized glutathione (GSSG), glutathione peroxidase (GPx), nitric oxide (NO) levels, and gastric wall mucus were restored on acute treated mice model. …”
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2159
The Role of TLR2, TLR4, and TLR9 in the Pathogenesis of Atherosclerosis
Published 2016-01-01“…They are associated with the development of CAD through various mechanisms. TLR4 is expressed in lipid-rich and atherosclerotic plaques. In TLR2−/− and TLR4−/− mice, atherosclerosis-associated inflammation was diminished. …”
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2160
Differentiation between some Ulva spp. by morphological, genetic and biochemical analyses
Published 2017-05-01“…The biochemical composition (e.g. protein, carbohydrate, lipid and pigment composition) of the collected Ulva spp. grouped the collected Ulva spp. into two groups (U. fasciata and U. lactuca) and other (U. compressa and U. linzea).…”
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