PPARγ as a Potential Target to Treat Airway Mucus Hypersecretion in Chronic Airway Inflammatory Diseases by Yongchun Shen, Lei Chen, Tao Wang, Fuqiang Wen

“…Recent evidence suggests that a key regulator of airway inflammation, hyperresponsiveness, and remodeling is peroxisome proliferator-activated receptor gamma (PPARγ), a ligand-activated transcription factor that regulates adipocyte differentiation and lipid metabolism. PPARγ is expressed in structural, immune, and inflammatory cells in the lung. …”
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Pharmacological Correction of Stress-Induced Gastric Ulceration by Novel Small-Molecule Agents with Antioxidant Profile by Konstantin V. Kudryavtsev, Anna O. Markevich, Oleksandr V. Virchenko, Tetyana M. Falalyeyeva, Tetyana V. Beregova, Lyudmyla I. Ostapchenko, Dmitry V. Zabolotnev, Nikolay S. Zefirov

“…To achieve this goal, four novel organic compounds containing structural fragments with known antioxidant activity were synthesized, characterized by physicochemical methods, and evaluated in vivo at water immersion restraint conditions. The levels of lipid peroxidation products and activities of antioxidative system enzymes were measured in gastric mucosa and correlated with the observed gastroprotective activity of the active compounds. …”
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Mechanical forces pattern endocardial Notch activation via mTORC2-PKC pathway by Yunfei Mu, Shijia Hu, Xiangyang Liu, Xin Tang, Jiayi Lin, Hongjun Shi

“…The strong shear stress altered the membrane lipid microdomain structure of endocardial cells, which activated mTORC2 and PKC and promoted Notch1 cleavage even in the absence of strong ligand stimulation. …”
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Evaluation of Chitosan/Fructose Model as an Antioxidant and Antimicrobial Agent for Shelf Life Extension of Beef Meat During Freezing by Shaheen Mohmed S., Shaaban Hamdy A., Hussein Ahmed M.S., Ahmed Mohamed B.M., El-Massry Khaled, El-Ghorab Ahmed

“…Thus, MRPs derived from chitosan-sugar model system can be promoted as a novel antioxidant to prevent lipid oxidation in minced beef. Chitosan-sugar complex could be a potential alternative natural product for synthetic food additive replacement that would additionally meet consumer safety requirement.…”
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Unique Mode of Lipogenic Activation in Rat Preputial Sebocytes by Dianne Deplewski, Kenan Qin, Nancy Ciletti, Robert L. Rosenfield

“…High-density lipoprotein (HDL) and very low-density lipoprotein (VLDL) markedly enhanced sebocyte differentiation above that found with PPAR agonists and were more potent than explicable by their lipid content. The PPARγ antagonist GW5393 reduced sebocyte differentiation to all PPAR isoform agonists, HDL and VLDL, suggesting that the lipoprotein effect on differentiation occurs partially through activation of PPARγ. …”
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Peroxisome Proliferator-Activated Receptors in Female Reproduction and Fertility by Maurizio Vitti, Giovanna Di Emidio, Michela Di Carlo, Gaspare Carta, Andrea Antonosante, Paolo Giovanni Artini, Annamaria Cimini, Carla Tatone, Elisabetta Benedetti

“…PPARs act as ligand activated transcription factors and regulate metabolic processes such as lipid and glucose metabolism, energy homeostasis, inflammation, and cell proliferation and differentiation. …”
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Wet pulverization combined with temperature cycling strategy for extraction of Stropharia rugosoannulata protein with attenuating hepatic steatosis on obese mice by Peng Liu, Chen Gao, Wen Li, Wanchao Chen, Zhong Zhang, Di Wu, Tingzhao Li, Shuai Sun, Yan Yang

“…SRA alleviated the pathological progression in obese mice induced by high-fat diet via regulating lipid metabolism in liver and adipose tissues. SRA could obviously improve hepatic steatosis, which may be attributed to inhibiting MAPK/PGC-1α pathway. …”
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Inhibitory Effects of Pretreatment with Radon on Acute Alcohol-Induced Hepatopathy in Mice by Teruaki Toyota, Takahiro Kataoka, Yuichi Nishiyama, Takehito Taguchi, Kiyonori Yamaoka

“…Alcohol administration significantly increased the activities of glutamic oxaloacetic transaminase (GOT), glutamic pyruvic transaminase (GPT) in serum, and the levels of triglyceride and lipid peroxide in the liver, suggesting acute alcohol-induced hepatopathy. …”
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Antioxidant Characterization of Oak Extracts Combining Spectrophotometric Assays and Chemometrics by Boris M. Popović, Dubravka Štajner, Ružica Ždero, Saša Orlović, Zoran Galić

“…Beside, mentioned parameters, soluble proteins, lipid peroxidation (LP), pigments and proline contents were also determined. …”
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Non-canonical lysosomal lipolysis drives mobilization of adipose tissue energy stores with fasting by GV Naveen Kumar, Rui-Sheng Wang, Ankit X. Sharma, Natalie L. David, Tânia Amorim, Daniel S. Sinden, Nandini K. Doshi, Martin Wabitsch, Sebastien Gingras, Asim Ejaz, J. Peter Rubin, Bradley A. Maron, Pouneh K. Fazeli, Matthew L. Steinhauser

“…Mobilization of fatty acids and glycerol from adipocyte lipid stores by canonical neutral lipases, including the rate limiting adipose triglyceride lipase (Pnpla2/ATGL), is critical to the adaptive fasting response. …”
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Biological Effects of Weak Electromagnetic Field on Healthy and Infected Lime (Citrus aurantifolia) Trees with Phytoplasma by Fatemeh Abdollahi, Vahid Niknam, Faezeh Ghanati, Faribors Masroor, Seyyed Nasr Noorbakhsh

“…Effects of electromagnetic fields on the changes of lipid peroxidation, content of H2O2, proline, protein, and carbohydrates were investigated in leaves of two-year-old trees of lime (Citrus aurantifolia) infected by the Candidatus Phytoplasma aurantifoliae. …”
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Improvement of non-alcoholic fatty liver disease treatment by P. I. Seliverstov, V. G. Radchenko

“…On a background of «Hepaguard Active» therapy improvement of symptoms was marked, condition of hepatobiliary tract has improved, lipid spectrum was normalized, excessive body weight decreased, quality of life improved.Conclusions. …”
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Effects on Quality Properties of Pork Sausages Enriched with Sea Buckthorn (Hippophae rhamnoides L.) by Anna Marietta Salejda, Agnieszka Nawirska-Olszańska, Urszula Janiewicz, Grażyna Krasnowska

“…The highest inhibition of lipid oxidation was observed in the samples manufactured with 1.5% SBE. …”
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Effect of cerebrolysin on dopaminergic neurodegeneration of rat with oxidative stress induced by 3-nitropropionic acid by Calderón Guzmán David, Brizuela Norma Osnaya, Ortíz Herrera Maribel, Hernández García Ernestina, Barragán Mejía Gerardo, Juárez Olguín Hugo, Valenzuela Peraza Armando, Attilus Jonas, Labra Ruíz Norma

“…Their brains were extracted, and DA, lipid peroxidation (LP), glutathione (GSH), calcium, and H2O2 were measured using validated methods. …”
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Involvement of Nitric Oxide in a Rat Model of Carrageenin-Induced Pleurisy by Masahiro Iwata, Shigeyuki Suzuki, Yuji Asai, Takayuki Inoue, Kenji Takagi

“…We assessed inflammatory cell migration, nitrite/nitrate values, lipid peroxidation and pro-inflammatory mediators. …”
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Peroxisome Proliferator-Activated Receptor Alpha Target Genes by Maryam Rakhshandehroo, Bianca Knoch, Michael Müller, Sander Kersten

“…Here, we present an overview of the involvement of PPARα in lipid metabolism and other pathways through a detailed analysis of the different known or putative PPARα target genes. …”
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The Role of Organelle Stresses in Diabetes Mellitus and Obesity: Implication for Treatment by Yi-Cheng Chang, Siow-Wey Hee, Meng-Lun Hsieh, Yung-Ming Jeng, Lee-Ming Chuang

“…Autophagy is required for clearance of hepatic lipid clearance, alleviation of pancreatic beta-cell stress, and white adipocyte differentiation. …”
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Dietary Supplementation with Omega-3-PUFA-Rich Fish Oil Reduces Signs of Food Allergy in Ovalbumin-Sensitized Mice by Olívia Gonçalves de Matos, Sylvia Stella Amaral, Pedro Elias Marques Pereira da Silva, Denise Alves Perez, Débora Moreira Alvarenga, Adaliene Versiani Matos Ferreira, Jacqueline Alvarez-Leite, Gustavo Batista Menezes, Denise Carmona Cara

“…Mice were fed with regular diet in which 7% of lipid content was provided by soybean (5% of n-3 PUFA) or fish (25% of n-3 PUFA) oil. …”
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PPARG Epigenetic Deregulation and Its Role in Colorectal Tumorigenesis by Lina Sabatino, Alessandra Fucci, Massimo Pancione, Vittorio Colantuoni

“…Peroxisome proliferator-activated receptor gamma (PPARγ) plays critical roles in lipid storage, glucose metabolism, energy homeostasis, adipocyte differentiation, inflammation, and cancer. …”
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GM1 Ganglioside Promotes Osteogenic Differentiation of Human Tendon Stem Cells by Sonia Bergante, Pasquale Creo, Marco Piccoli, Andrea Ghiroldi, Alessandra Menon, Federica Cirillo, Paola Rota, Michelle M. Monasky, Giuseppe Ciconte, Carlo Pappone, Pietro Randelli, Luigi Anastasia

“…Gangliosides, the sialic acid-conjugated glycosphingolipids present in the lipid rafts, have been recognized as important regulators of cell proliferation, migration, and apoptosis. …”
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