Gut Microbiota at the Crossroad of Hepatic Oxidative Stress and MASLD by Fabrizio Termite, Sebastiano Archilei, Francesca D’Ambrosio, Lucrezia Petrucci, Nicholas Viceconti, Roberta Iaccarino, Antonio Liguori, Antonio Gasbarrini, Luca Miele

“…Gut microbiota plays a substantial role in modulating hepatic oxidative stress through multiple pathways: impairing the intestinal barrier, which results in bacterial translocation and chronic hepatic inflammation; modifying bile acid structure, which impacts signaling cascades involved in lipidic metabolism; influencing hepatocytes’ ferroptosis, a form of programmed cell death; regulating trimethylamine N-oxide (TMAO) metabolism; and activating platelet function, both recently identified as pathogenetic factors in MASH progression. …”
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Association between depression and diabetes among American adults using NHANES data from 2005 to 2020 by Chuanjie Zheng, Jianming Yin, Linyue Wu, Zhanhui Hu, Yikai Zhang, Lingyong Cao, Yiqian Qu

“…In conclusion, our study demonstrates that the severity of depression is positively correlated with the risk of diabetes, and this association may be closely linked to various glycemic and lipid metabolic parameters.…”
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Mechanical Activation of cPLA2 Impedes Fatty Acid β‐Oxidation in Vein Grafts by Linwei Fan, Yuanjun Tang, Jian Liu, Yueqi Liu, Yiwei Xu, Jiayu Liu, Han Liu, Wei Pang, Yuxuan Guo, Weijuan Yao, Tao Zhang, Qin Peng, Jing Zhou

“…This study uncovers a novel mechanism in lipid metabolic reprogramming in vein grafts, suggesting a new therapeutic target for vein graft hyperplasia.…”
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Decoding the trajectory of antibiotic resistance genes in saline and alkaline soils: Insights from different fertilization regimes by Dandan Zhang, Jie Li, Guilong Zhang, Yan Xu

“…Meta-genomic and Meta-transcriptomic analysis consistently demonstrated bacterial antibiotic resistance was primarily associated with pyruvate, energy and lipid metabolic pathways. The functional gene related to salinity and alkalinity, like cysH, cysK, plsB and plsC showed negative correlations with MDR. …”
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Expression Profile of Genes Potentially Associated with Adequate Glycemic Control in Patients with Type 2 Diabetes Mellitus by Sâmia Cruz Tfaile Corbi, Alliny Souza Bastos, Rafael Nepomuceno, Thamiris Cirelli, Raquel Alves dos Santos, Catarina Satie Takahashi, Cristiane S. Rocha, Silvana Regina Perez Orrico, Claudia V. Maurer-Morelli, Raquel Mantuaneli Scarel-Caminaga

“…Moreover, genes related to lipid metabolisms and DNA replication/repair were influenced by the glycemic control. …”
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Exploring the effects of Tianma Gouteng granules on L-NAME-induced hypertensive rats based on 16S rDNA gene sequencing and metabolomics by Li Cheng, Zhenyang Huang, Jiawei He, Xinyi Zhang, Jiangxue Di, Hanmei Jiang, Yi Liu

“…TG treatment of hypertension was found to be associated with vitamin B6 metabolic pathway and lipid metabolic pathway. Conclusions: TG can treat hypertension by affecting differential strains and differential metabolites, providing a scientific basis for guiding the rational use of TG.…”
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Duodenal Organoids From Metabolic Dysfunction-Associated Steatohepatitis Patients Exhibit Absorptive and Barrier Alterations by Alia Hadefi, Morgane Leprovots, Gilles Dinsart, Maryam Marefati, Marjorie Vermeersch, Daniel Monteyne, David Pérez-Morga, Anne Lefort, Frédérick Libert, Laurine Verset, Claire Liefferinckx, Christophe Moreno, Jacques Devière, Eric Trépo, Marie-Isabelle Garcia

“…MDEOs displayed altered digestive potential associated with reduced mature absorptive cell fate, but they retained their lipid metabolic capacity, possibly mediated by lipid oxidation in stem/progenitor cells. …”
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Proteomic and Metabolomic Characterization of Metabolically Healthy Obesity: A Descriptive Study from a Swedish Cohort by J. Korduner, P. M. Nilsson, O. Melander, M. J. Gerl, G. Engström, E. Bachus, M. Magnusson, F. Ottosson

“…Compared to MUO individuals, corresponding MHO individuals present with a more favorable lipid metabolic profile, accompanied by a downregulation of potentially harmful proteomic biomarkers. …”
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PEDF Overexpression Ameliorates Cardiac Lipotoxicity in Diabetic Cardiomyopathy via Regulation of Energy Metabolism by Mao T, Wang Y

“…The excessive accumulation of lipid metabolic intermediates within the myocardium can lead to increased production of reactive oxygen species (ROS) and promote apoptosis. …”
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Exploring the role of ELOVLs family in lung adenocarcinoma based on bioinformatic analysis and experimental validation by Zihan Wang, Wenjing Cui, Long Liang, Jingge Qu, Yuqiang Pei, Danyang Li, Ying Luo, Yue Zhang, Yifan Qiu, Yongchang Sun

“…Abstract Background The role of lipid metabolic reprogramming in the development of various types of cancer has already been established. …”
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Associations between Osteocalcin, Calciotropic Hormones, and Energy Metabolism in a Cohort of Chinese Postmenopausal Women: Peking Vertebral Fracture Study by Ruizhi Jiajue, Shuying Liu, Yu Pei, Xuan Qi, Yan Jiang, Qiuping Wang, Wenbo Wang, Xiran Wang, Wei Huang, Xin Zheng, Zhiwei Ning, Ou Wang, Mei Li, Xiaoping Xing, Wei Yu, Ling Xu, Weibo Xia

“…Partial correlation analysis was performed to explore the correlation of OC, parathyroid hormone (PTH), or 25-hydroxyvitamin D (25(OH)D) with glycemic and lipid metabolic parameters. A logistic regression model was used to investigate the association of OC, PTH, or 25(OH)D with the prevalence of diabetes and dyslipidemia. …”
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The association between white blood cell counts and metabolic health obesity among US adults by Zhanbin Li, Zhanbin Li, Zhenyu Yao, Zhenyu Yao, Zhenyu Yao, Qiaoran Liu, Qiaoran Liu

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Comparison of the effects of 3 kinds of oils rich in omega-3 polyunsaturated fatty acids on glycolipid metabolism and lipoprotein subfractions by Hechun Liu, Feng Wang, Hui Xia, Da Pan, Ligang Yang, Shaokang Wang, Feng Zhao, Guiju Sun

“…Both the animal- and plant-derived ω-3 PUFAs have practical value in improving glucose and lipids metabolism in T2DM patients with dyslipidemia.…”
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Fatty acid synthase inhibition improves hypertension-induced erectile dysfunction by suppressing oxidative stress and NLRP3 inflammasome-dependent pyroptosis through activating the... by Jiaochen Luan, Mengchi Yu, Qi Gu, Xuan Zhou, Yunqiang Shao, Tong Chen, Jiayi Zhang, Zheng Zhu, Ninghong Song, Jie Yang

“…Multi-omics analysis revealed significant enrichment in lipid metabolic pathways, with Fasn identified as a hub gene. …”
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Elucidation of the mechanism of berberine against gastric mucosa injury in a rat model with chronic atrophic gastritis based on a combined strategy of multi-omics and molecular bio... by Lisheng Chen, Lisheng Chen, Xin Wang, Xin Wang, Jianyu Li, Lijuan Zhang, Wenbin Wu, Shizhang Wei, Wenjun Zou, Yanling Zhao, Yanling Zhao

“…Furthermore, 234 different expression genes were identified in the gastric tissue transcriptome, which were mainly involved in biological processes such as cell adhesion, angiogenesis, apoptosis, cell migration and lipids metabolism by regulating the MAPK signaling pathway. …”
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Temporal changes in plasma and milk lipids in response to an esophageal bolus of rumen-protected fish oil in lactating Holstein dairy cows by J.E. Rico, V. Sáinz de la Maza-Escolà, N.D. Senevirathne, P. Deme, N.J. Haughey, R. Gervais, J.W. McFadden

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Alchornea cordifolia leaf-extract ameliorates bisphenol A-induced obesity in male Wistar rats by Abdulhakeem Rotimi Agboola, Ako Hogan Itam, Chinedum Martins Ekeleme, Eyuwa Ignatius Agwupuye, Zuwairatu Oyiza Ahmed, Godswill Peter Igiakong, Gideon Bassey Agbor, Asmau Niwoye Abubakar, Zainab Adamu, Esien David-Oku, Item Justin Atangwho

“…., there was observed significant attenuation of the anthropometric indices, serum biochemical indices and lipid metabolizing enzymes studied (p < 0.05). Conclusion Together, the results obtained from this study have scientifically validated the traditional use of Alchornea cordifolia leaves in body weight control, hence suggest that the leaves may possess natural products useful in the management of obesity and its related complications.…”
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