Administration of a Next-Generation Probiotic Escherichia coli Nissle 1917-GLP-1 Alleviates Diabetes in Mice With Type 1 and Type 2 Diabetes by Jie Luo, Yilin Fang, Zhanghua Qi, Fengyang Cui, Hong Hu, Shengjie Li, Tingtao Chen, Hongyan Zhang

“…Similarly, EcN-GLP-1 had a pronounced impact on T2DM mice, manifesting increased presence of islet β-cells, decreased inflammatory response and apoptosis, and regulation of lipid metabolism in the liver. In summary, the genetically modified EcN-GLP-1 strain demonstrates the ability to alleviate diabetes by enhancing the islet β-cell population, mitigating inflammatory reactions and apoptosis, optimizing liver lipid metabolism, and reinstating a balanced microbial diversity. …”
Get full text

Lysophosphatidylethanolamine improves diastolic dysfunction by alleviating mitochondrial injury in the aging heart by Guiwen Xu, Wei Xiao, Pengqi Sun, Yuanjun Sun, Xinyu Yang, Xiaomeng Yin, Yang Liu

“…Studies also show that aberrant mitochondrial lipid metabolism impairs mitochondrial function in aging cardiomyocytes. …”
Get full text

FABP4 and I-FABP Levels in Pregnant Women Are Associated with Body Mass Index but Not Gestational Diabetes by Tamara Vorobjova, Aili Tagoma, Ija Talja, Helis Janson, Anne Kirss, Raivo Uibo

“…Fatty acid-binding protein 4 (FABP4) is a regulator of lipid metabolism and is associated with obesity, insulin resistance, and type 2 diabetes. …”
Get full text

Continuous Consumption of Reused Palm Oil Induced Hepatic Injury, Depletion of Glutathione Stores, and Modulation of Cytochrome P450 Profiles in Mice by Waranya Chatuphonprasert, Yollada Sriset, Kanokwan Jarukamjorn

“…The expression of Cyp4a10 and Cyp4a14 , the key enzymes in lipid metabolism, were expectedly up-regulated by both. …”
Get full text

Verbascoside exerts an anti-atherosclerotic effect by regulating liver glycerophospholipid metabolism by Peng Lei, Jialin Lü, Tie Yao, Peng Zhang, Xin Chai, Yuefei Wang, Miaomiao Jiang

“…Atherosclerosis (AS) is a common metabolic disease and abnormal lipid metabolism in liver is inseparable from its formation and development. …”
Get full text

Activated receptors for peroxisomic proliferators. Its role in the atherosclerosis, obesity and high blood pressure. by Mikhail Benet Rodríguez, Yosvel Curbelo Pérez

“…PPAR receptors regulate the expressions of a great variety of genes that codify the proteins that are implied in the lipid metabolism, the energetic homeostasis, the cellular differentiation and the formation of tumours. …”
Get full text

Heart groups in South Africa advocate for tighter LDL-C control and lipoprotein(a) testing to curb atherosclerotic cardiovascular disease by E Q Klug, F J Raal

Get full text

JTT-130, a Novel Intestine-Specific Inhibitor of Microsomal Triglyceride Transfer Protein, Improves Hyperglycemia and Dyslipidemia Independent of Suppression of Food Intake in Diab... by Shohei Sakata, Makoto Ito, Yasuko Mera, Tomohiko Sasase, Hiromi Yamamoto, Makoto Kakutani, Takeshi Ohta

“…We investigated the effects of JTT-130 on glucose and lipid metabolism independent of the suppression of feeding by comparing with pair-fed animals. …”
Get full text

Epithelial-mesenchymal transition in asthma: its role and underlying regulatory mechanisms by Bingxi Zhang, Bingxi Zhang, Xinru Feng, Lincha Tian, Bo Xiao, Lixia Hou, Biwen Mo, Biwen Mo, Biwen Mo, Dong Yao, Dong Yao, Dong Yao

Get full text

Cardiomyocyte-Restricted Deletion of PPARβ/δ in PPARα-Null Mice Causes Impaired Mitochondrial Biogenesis and Defense, but No Further Depression of Myocardial Fatty Acid Oxidation... by Jian Liu, Peiyong Wang, Lan He, Yuquan Li, Jinwen Luo, Lihong Cheng, Qianhong Qin, Lawrence A. Brako, Woo-kuen Lo, William Lewis, Qinglin Yang

“…In the present study, a mouse model with long-term PPARβ/δ deficiency in PPARα-null background showed a comparably reduced cardiac expression of lipid metabolism to those of single PPAR-deficient mouse models. …”
Get full text

RELATIONSHIPS BETWEEN LIPID PROFILE AND COMPLETE BLOOD CELL COUNT PARAMETERS by Yevhen Dzis, Oleksandra Tomashevska, Andriy Petrukh

“…Given that blood cells play an important role in both atherogenesis and lipid metabolism, the research aimed to assess the specifics of the relationship between the parameters of the blood lipid spectrum and the complete blood count (CBC). …”
Get full text

Network Pharmacology Combined With Metabolomics Reveals the Mechanism of Yangxuerongjin Pill Against Type 2 Diabetic Peripheral Neuropathy in Rats by Jin R, Pei H, Yue F, Zhang X, Zhang Z, Xu Y, Li J

“…Metabolomics results showed that the potential metabolic pathways of YXRJP in the treatment of DPN mainly involved amino acid metabolism such as arginine, alanine, aspartic acid, lipid metabolism and nucleotide metabolism.Conclusion: YXRJP can effectively improve the symptoms of DPN rats and reduce nerve damage. …”
Get full text

Augmenter of Liver Regeneration Crotonylation Assists in Mitochondria-ER Contact to Alleviate Hepatic SteatosisSummary by Xiao-lin Wang, Jia-hao He, Ping Xie, Yuan Wu, Ling-yue Dong, Wei An

“…Mitochondrial function and mitochondria-ER interaction (MAM) relevant to ALR-Kcr modification was evaluated for hepatocyte lipid metabolism both in in vivo and in vitro experiments. …”
Get full text

Soluble Receptor for Advanced Glycation End Products: A Protective Molecule against Intramyocardial Lipid Accumulation in Obese Zucker Rats? by Elena Dozio, Elena Vianello, Francesco Bandera, Erika Longhi, Stefano Brizzola, Manuela Nebuloni, Massimiliano M. Corsi Romanelli

“…To this aim, we analyzed whether, in obesity, intramyocardial lipid accumulation and lipid metabolism-related transcriptome are related to RAGE and sRAGE. …”
Get full text

PPARs Mediate Lipid Signaling in Inflammation and Cancer by Liliane Michalik, Walter Wahli

“…PPARs, in turn, control the expression of networks of genes encoding proteins involved in all aspects of lipid metabolism. In addition, PPARs are tumor growth modifiers, via the regulation of cancer cell apoptosis, proliferation, and differentiation, and through their action on the tumor cell environment, namely, angiogenesis, inflammation, and immune cell functions. …”
Get full text

Mitochondrial Dynamics: Functional Link with Apoptosis by Hidenori Otera, Katsuyoshi Mihara

“…Mitochondria participate in a variety of physiologic processes, such as ATP production, lipid metabolism, iron-sulfur cluster biogenesis, and calcium buffering. …”
Get full text

Oxidative Stress and Inflammation in Heart Disease: Do Antioxidants Have a Role in Treatment and/or Prevention? by Fredric J. Pashkow

“…In addition to the formation of atherosclerosis, it involves lipid metabolism, plaque rupture, thrombosis, myocardial injury, apoptosis, fibrosis and failure. …”
Get full text

Citrus Flavonoid Effects on Obesity by Yu Wang, Laura E. Reuss

“…The use of phytochemicals as a safe and natural alternative to treat obesity is under current investigation as citrus flavonoids haven been shown to monitor energy intake versus expenditure, regulate lipid metabolism and adipose tissue, and inhibit amylase function. …”
Get full text

Citrus Flavonoid Effects on Obesity by Yu Wang, Laura E. Reuss

“…The use of phytochemicals as a safe and natural alternative to treat obesity is under current investigation as citrus flavonoids haven been shown to monitor energy intake versus expenditure, regulate lipid metabolism and adipose tissue, and inhibit amylase function. …”
Get full text

Role of PPAR𝛼 in Hepatic Carbohydrate Metabolism by Annelies Peeters, Myriam Baes

“…PPAR𝛼 is the master regulator of lipid metabolism during fasting, but evidence is emerging for a role of PPAR𝛼 in balancing glucose homeostasis as well. …”
Get full text