Efficacy and safety of PCSK9 inhibitors, potent statins, and their combinations for reducing low-density lipoprotein cholesterol in hyperlipidemia patients: a systematic network me... by Yuhua Jiang, Yingying Wang, Sijia Ma, Linlin Qian, Yeteng Jing, Xi Chen, Jinsheng Yang

“…Regarding the efficacy of lipid reduction, four principal medications were evaluated: evolocumab and atorvastatin [mean standard deviation (MD) −3.41, 95% CI −4.81 to −2.00] and evolocumab with rosuvastatin (MD −3.44, 95% CI −5.10 to −1.78) vs. placebo; alirocumab combined with rosuvastatin (MD −2.91, 95% CI −3.95 to −1.88) and alirocumab with atorvastatin (MD −2.90, 95% CI −3.97 to −1.84) vs. placebo. …”
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The Influence of Overnight Orthokeratology on Ocular Surface and Meibomian Gland Dysfunction in Teenagers with Myopia by Xiu Wang, Jing Li, Rui Zhang, Na Li, Yi Pang, Yan Zhang, Ruihua Wei

“…No significant differences of the degree of difficulty of lipid excretions were detected after the initiation of OOK (P>0.05). …”
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Selenomethionine alleviates T-2 toxin-induced articular chondrocyte ferroptosis via the system Xc−/GSH/GPX4 axis by Fang-fang Yu, Juan Zuo, Miao Wang, Shui-yuan Yu, Kang-ting Luo, Tong-tong Sha, Qian Li, Zai-chao Dong, Guo-yu Zhou, Feng Zhang, Xiong Guo, Yue Ba, Yan-jie Wang

“…Mechanistically, T-2 toxin increased ROS, lipid ROS, MDA and Fe2+ contents in chondrocytes, decreased GSH and GPX4 activity, and inhibited the system Xc−/GSH/GPX4 antioxidant axis. …”
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Early Subclinical Atherosclerosis in Gestational Diabetes: The Predictive Role of Routine Biomarkers and Nutrigenetic Variants by Marica Franzago, Federica Fraticelli, Marta Di Nicola, Francesco Bianco, Daniela Marchetti, Claudio Celentano, Marco Liberati, Raffaele De Caterina, Liborio Stuppia, Ester Vitacolonna

“…We aimed to assess the predictive role of 3rd trimester lipid profile during pregnancy for the susceptibility to markers of subclinical atherosclerosis (CVD susceptibility) at 3 years in a cohort of women with history of GDM. …”
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O-GlcNAcylation attenuates ischemia-reperfusion-induced pulmonary epithelial cell ferroptosis via the Nrf2/G6PDH pathway by Liuqing Yang, Hexiao Tang, Jin Wang, Dawei Xu, Rui Xuan, Songping Xie, Pengfei Xu, Xinyi Li

“…Thus, we generated Ogt1-conditional knockout mice and found that Ogt1 deficiency aggravated ferroptosis, as evidenced by lipid reactive oxygen species (lipid ROS), malondialdehyde (MDA), Fe2+, as well as alterations in critical protein expression glutathione peroxidase 4 (GPX4) and solute carrier family 7 member 11 (SLC7A11). …”
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Epithelial–Mesenchymal Transition Suppression by ML210 Enhances Gemcitabine Anti-Tumor Effects on PDAC Cells by Keisuke Takemura, Kyohei Ikeda, Hayato Miyake, Yoshio Sogame, Hiroaki Yasuda, Nobuhiro Okada, Kazumi Iwata, Junichi Sakagami, Kanji Yamaguchi, Yoshito Itoh, Atsushi Umemura

“…Mechanistically, ML210, which was developed as a glutathione peroxidase 4 (GPX4) inhibitor to induce lipid peroxidation, increased the oxidized lipid concentrations in PDAC cells. …”
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Five-Year Predictors of Insulin Initiation in People with Type 2 Diabetes under Real-Life Conditions by Sandro Gentile, Felice Strollo, Francesca Viazzi, Giuseppina Russo, Pamela Piscitelli, Antonio Ceriello, Carlo Giorda, Piero Guida, Paola Fioretto, Roberto Pontremoli, Salvatore De Cosmo, the AMD-Annals Study Group

“…Multivariate analysis identified diabetes duration, HbA1c, triglyceride and low HDL-C values, presence of retinopathy or renal dysfunction, and sulphonylurea utilization (the risk being approximately 3 times greater in the latter case) as independent predictors of insulin treatment initiation. LDL-C, lipid-lowering treatment, and overweight/obese seem to be protective. …”
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Genome-wide identification of the Sec14 gene family and the response to salt and drought stress in soybean (Glycine max) by Jinyu Zhang, Liying Zou, Li Wang, Dongchao Zhang, Ao Shen, Yongqi Lei, Maoni Chao, Xinjuan Xu, Zhiwei Xue, Zhongwen Huang

“…Abstract Background The Sec14 domain is an ancient lipid-binding domain that evolved from yeast Sec14p and performs complex lipid-mediated regulatory functions in subcellular organelles and intracellular traffic. …”
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Evaluation of Six Novel Protein Sources on Apparent Digestibility in Pacific White Shrimp, Litopenaeus vannamei by Xiaoyue Li, Yongkang Chen, Chaozhong Zheng, Shuyan Chi, Shuang Zhang, Beiping Tan, Shiwei Xie

“…The control diet (CD) was formulated to contain 448.8 g/kg crude protein and 71.8 g/kg crude lipid. Then, six experimental diets were formulated to contain 70% CD and 30% test ingredients. …”
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Perbedaan Kadar Malondialdehide dan Tromboksan B2 pada Remaja dengan Dismenore dan Tanpa Dismenore by Berliana Irianti, Ermawati , Arni Amir

“…<p>Abstrak <br />Penyebab dismenore belum semuanya diketahui, ada dugaan peningkatan proses peroksida lipid yang akan mengaktivasi mediator inflamasi pada endometrium yang menimbulkan rasa nyeri haid (dismenore). …”
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Composition, Physicochemical Properties, and Uses of Acorn Starch by Mehdi Taib, Lahboub Bouyazza

“…The amylose content of the acorn starches is reported to vary in the range of 20–39%. Moisture content, lipid, ash, and protein contents of the acorn starches have been reported varying from 2.20 to 15.50%, 0.23 to 2.64%, 0.01 to 1.41%, and 0.01 to 6.7%, respectively. …”
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Roles of Chronic Low-Grade Inflammation in the Development of Ectopic Fat Deposition by Lulu Liu, Mei Mei, Shumin Yang, Qifu Li

“…As a critical biomarker of metabolic complications, chronic low-grade inflammation may have the ability to affect the process of lipid accumulation and further lead to the disorder of fat distribution. …”
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Regulation of Hippo-YAP1/TAZ pathway in metabolic dysfunction-associated steatotic liver disease by Wei Xuan, Dandan Song, Jianghua Hou, Xiuping Meng

“…Metabolic disorders such as iron overload, glycolysis, insulin resistance, lipid dysregulation, and glutaminolysis are found to induce liver senescence and ferroptosis, which are hot topics in the research of MASLD. …”
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Peroxisome Proliferator-Activated Receptor and Retinoic X Receptor in Alcoholic Liver Disease by Tommaso Mello, Simone Polvani, Andrea Galli

“…The increased ethanol metabolism, in turn, leads to alteration of the redox balance of the cells and impairment of RXR/PPAR functions by direct and indirect effects of acetaldehyde, resulting in deranged lipid metabolism, oxidative stress, and release of proinflammatory cytokines. …”
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Breaching Biological Barriers: Protein Translocation Domains as Tools for Molecular Imaging and Therapy by Benjamin L. Franc, Stefanie J. Mandl, Zurab Siprashvili, Paul Wender, Christopher H. Contag

“…The lipid bilayer of a cell presents a significant barrier for the delivery of many molecular imaging reagents into cells at target sites in the body. …”
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Prostaglandin Receptor Signaling in Disease by Toshiyuki Matsuoka, Shuh Narumiya

“…Prostanoids, consisting of the prostaglandins (PGs) and the thromboxanes (TXs), are a group of lipid mediators formed in response to various stimuli. …”
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The Amelioration of Detrimental Biochemical Anomalies by Supplementing B, C, and E Vitamins in Subjects with Type 2 Diabetes Mellitus May Reduce the Rate of Development of Diabetic... by Subhasish Pramanik, Kaustav Banerjee, Lakshmi Kanta Mondal

“…Excessive intracellular glucose in insulin-independent tissues including nerve, nephron, lens, and retina invites mishandling of metabolism of glucose resulting in a background of increased oxidative stress, advanced glycation end products (AGE) formation, lipid peroxidation, and failure of antioxidant defense systems in type 2 diabetes mellitus (T2DM). …”
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Selective Modulators of PPAR-γ Activity: Molecular Aspects Related to Obesity and Side-Effects by Fang Zhang, Brian E. Lavan, Francine M. Gregoire

“…Peroxisome proliferator-activated receptor γ (PPAR-γ) is a key regulator of lipid metabolism and energy balance implicated in the development of insulin resistance and obesity. …”
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The Beneficial Role of Polysaccharide Hydrocolloids in Meat Products: A Review by Hanxiao Bao, Yuxi Wang, Yue Huang, Yuhao Zhang, Hongjie Dai

“…Then, the beneficial roles of polysaccharide hydrocolloids in meat products are comprehensively summarized and highlighted, including retarding lipid and protein oxidation, enhancing nutritional properties, improving texture and color quality, providing antibacterial activity, monitoring freshness, acting as a cryoprotectant, improving printability, and ensuring security. …”
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The Role of Anethum graveolens L. (Dill) in the Management of Diabetes by Mohammad Taghi Goodarzi, Iraj Khodadadi, Heidar Tavilani, Ebrahim Abbasi Oshaghi

“…It acts mainly by affecting antioxidant capacity and change in some genes in glucose and lipid pathways. The aim of the present paper was to summarize pharmacological effects of AG in the management of diabetes. …”
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