Peroxisome Proliferator-Activated Receptors and the Heart: Lessons from the Past and Future Directions by Wang-Soo Lee, Jaetaek Kim

“…The main role of PPARs is to regulate the expression of genes involved in lipid and glucose metabolism. Several studies have demonstrated that PPAR agonists improve dyslipidemia and glucose control in animals, supporting their potential as a promising therapeutic option to treat diabetes and dyslipidemia. …”
Get full text

PPARγ and Its Role in Cardiovascular Diseases by Mini Chandra, Sumitra Miriyala, Manikandan Panchatcharam

“…Peroxisome proliferator-activated receptor Gamma (PPARγ), a ligand-activated transcription factor, has a role in various cellular functions as well as glucose homeostasis, lipid metabolism, and prevention of oxidative stress. …”
Get full text

Ursodeoxycholic acid in complex treatment of metabolic syndrome by O. A. Tanchenko, S. V. Naryshkina, O. N. Sivyakova

“…Dynamics of immunoreactive insulin, leptin, lipid spectrum was determined by immunoenzyme test.Results. …”
Get full text

Interaction between PAF and human platelet membranes: a fluorescence study by Ahmad Kantar, Pier Luigi Giorgi, Giovanna Curatola, Rosamaria Fiorini

“…PAF induced a time-limited and significant increase of the lipid order in the exterior part of the membrane and a decrease in membrane heterogeneity. …”
Get full text

Updates in Reproduction Coming from the Endocannabinoid System by Rosaria Meccariello, Natalia Battista, Heather B. Bradshaw, Haibin Wang

“…The endocannabinoid system (ECS) is an evolutionarily conserved master system deeply involved in the central and local control of reproductive functions in both sexes. The tone of these lipid mediators—deeply modulated by the activity of biosynthetic and hydrolyzing machineries—regulates reproductive functions from gonadotropin discharge and steroid biosynthesis to the formation of high quality gametes and successful pregnancy. …”
Get full text

Targeting Polymorphonuclear Leukocytes in Acute Myocardial Infarction by Clara Di Filippo, Francesco Rossi, Michele D'Amico

“…This review, indeed, presents and discusses new data on one of the lipid kinase, the phosphoinositide 3-kinase gamma (PI3Kγ), and its role in neutrophil recruitment during AMI.…”
Get full text

Mitochondrial DNA in atherosclerosis research progress: a mini review by Zheng Liu, Nan Huang, Chan Liu, Can Wu, Ling Zhou, Xiang Liu, Haibo Lei

“…Damage and release of mtDNA are considered central drivers in the development of AS, as they participate in the progression of AS by activating inflammatory pathways and affecting lipid metabolism. Therefore, therapeutic strategies targeting mtDNA and its downstream effects may provide new avenues to address this global health challenge.…”
Get full text

Influence of Free Radicals in the Origin of Atherosclerosis by Yoel Hernández Guerra, Alain Rodríguez Gómez, Janet Villafuerte Reinante, Ignacio Marrero Silva, Carlos Manuel Mora Hernández

“…The increase of oxidative stress favors atherothrombatic phases: platelet adhesion and aggregation, cell proliferation, lipid and protein perioxidation, irreversible damage in DNA and mitochondrial membrane and inestabilzation/desestabilization of the plaque.…”
Get full text

The Role of PPARγ in Helicobacter pylori Infection and Gastric Carcinogenesis by Jong-Min Lee, Sung Soo Kim, Young-Seok Cho

“…Peroxisome proliferator-activated receptor γ (PPARγ) is a nuclear receptor that is important in many physiological and pathological processes, such as lipid metabolism, insulin sensitivity, inflammation, cell proliferation, and carcinogenesis. …”
Get full text

Regulation of Sulfotransferase and UDP-Glucuronosyltransferase Gene Expression by the PPARs by Melissa Runge-Morris, Thomas A. Kocarek

“…In metabolically active tissues, increasing evidence supports a major role for lipid-sensing transcription factors, such as peroxisome proliferator-activated receptors (PPARs), in the regulation of rodent and human SULT and UGT gene expression. …”
Get full text

Successful Treatment of Adenovirus Infection with Brincidofovir in an Immunocompromised Patient after Hematological Stem Cell Transplantation by T. Van Genechten, J. van Heerden, T. Bauters, C. Dhooge

“…Our case describes the successful use of Brincidofovir (CMX001), a lipid-conjugate of the nucleotide analog Cidofovir, in a 9-year-old post-HSCT girl with disseminated adenovirus infection. …”
Get full text

Role of Leukotrienes on Protozoan and Helminth Infections by Alexandre P. Rogerio, Fernanda F. Anibal

“…Leukotrienes (LTs), formed by the 5-lipoxygenase-(5-LO-) catalyzed oxidation of arachidonic acid, are lipid mediators that have potent proinflammatory activities. …”
Get full text

Curcumin as a Supportive Therapy in Type 2 Diabetic Patients by Anand Seth, Sravya Iyyuni, Saurabh Sharma, Ritu Sethi, Suresh Nath, Michael Imeokparia

“…The management of diabetes is a lifelong process that requires diabetic education, attempts to achieve near optimal glycemic control, minimizing cardiovascular and other long-term risk factors, and avoidance of drugs that can exacerbate abnormalities of insulin and lipid metabolism. In the treatment of T2DM, curcumin has demonstrated much potential as an adjunct therapy due to its anti-inflammatory properties and its ability to reduce oxidative stresses within the body. …”
Get full text

The high-density lipoprotein binding protein HDLBP is an unusual RNA-binding protein with multiple roles in cancer and disease by Jonathan Feicht, Ralf-Peter Jansen

“…In this review, we give an overview of some of the functions of the protein as well as introduce its impact on different kinds of cancer, its connection to lipid metabolism and its role in viral infection. …”
Get full text

Lipase and Its Unique Selectivity: A Mini-Review by Jun-Young Park, Kyung-Min Park

“…There are already several commercialized lipases that have become important tools for various lipid-related studies, although there is still a need to discover novel lipases with unique substrate selectivity to facilitate more innovative reactions in human applications such as household care, cosmetics, foods, and pharmaceuticals. …”
Get full text

Pengaruh Pemberian Aspartam terhadap Kadar Low-Density Lipoprotein dan High-Density Lipoprotein pada Tikus Wistar Diabetes Melitus Diinduksi Aloksan by Revivo Rinda Pratama, Eti Yerizel, Rahmatini .

“…Aspartam dapat mempengaruhi metabolisme profil lipid. Tujuan dari penelitian ini adalah mengetahui pengaruh pemberian aspartam terhadap kadar LDL dan HDL tikus diabetes melitus diinduksi aloksan. …”
Get full text

Dietary protein requirement of Chinese hook snout carp (Opsariichthys bidens) and transcriptomic analysis of the liver in response to different protein diets by Yijiang Bei, Linqiang He, Jin Jing, Xiaoming Chen, Fan Yuan, Gaohua Yao, XueYan Ding, Lei Wang, Fan Zhou

“…In contrast, the P35 group presented lower amino acid and lipid metabolism (e.g., stearoyl-CoA desaturase, glutamine synthetase, and bile salt-activated lipase) expression levels. …”
Get full text

Fraxinellone-mediated targeting of cathepsin B leakage from lysosomes induces ferroptosis in fibroblasts to inhibit hypertrophic scar formation by Wei Xu, Hao Lv, Yaxin Xue, Xiaofeng Shi, Shaotian Fu, Xiaojun Li, Chuandong Wang, Danyang Zhao, Dong Han

“…Conclusions This study reveals that FRA ameliorates HS by inducing CTSB leakage from lysosomes, causing SAT1-mediated lipid peroxidation, mitochondrial damage and MAPK signalling pathway activation, thus mediating HSF ferroptosis. …”
Get full text

Apolipoprotein A-V Is a Novel Diagnostic and Prognostic Predictor in Pediatric Patients with Sepsis: A Prospective Pilot Study in PICU by Chunxia Wang, Yun Cui, Huijie Miao, Xi Xiong, Jiaying Dou, Lujing Shao, Xiaomeng Tang, Yucai Zhang

“…Sepsis induces the release of lipid mediators, which control both lipid metabolism and inflammation. …”
Get full text

Incorporation of reduced glutathione to the extender improves frozen-thawed sperm function and fertility potential in mandarin fish (Siniperca chuatsi) by Sen Yang, Wenjie Xu, Yanglin Hua, Qingxin Ruan, Zining Meng

“…Sperm motion parameters, viability, mitochondrial activity, lipid peroxidation, and apoptosis were assessed after thawing. …”
Get full text