A truncated pre-F protein mRNA vaccine elicits an enhanced immune response and protection against respiratory syncytial virus by Min Lin, Yifan Yin, Xiaomeng Zhao, Chen Wang, Xueqing Zhu, Letao Zhan, Li Chen, Siling Wang, Xue Lin, Jun Zhang, Ningshao Xia, Zizheng Zheng

“…In this study, we explored an mRNA vaccine based on a modified pre-F protein called LC2DM-lipid nanoparticle (LC2DM-LNP). This vaccine features a truncated version of the pre-F protein that is anchored to the cell membrane. …”
Get full text

Digital Health Solutions for Cardiovascular Disease Prevention: Systematic Review by Yihan Qi, Emma Mohamad, Arina Anis Azlan, Chenglin Zhang, Yilian Ma, Anqi Wu

“…The majority of the study outcomes addressed blood pressure (14/30, 47%), exercise capacity (12/30, 40%), weight (12/30, 40%), and lipid profile (11/30, 37%), while fewer focused on nicotine dependence (9/30, 30%), medication use (8/30, 27%), quality of life (7/30, 23%), dietary habits (5/30, 17%), intervention adherence (4/30, 13%), waist circumference (4/30, 13%), and blood glucose levels (2/30, 7%). …”
Get full text

Mass‐Guided Single‐Cell MALDI Imaging of Low‐Mass Metabolites Reveals Cellular Activation Markers by James L. Cairns, Johanna Huber, Andrea Lewen, Jessica Jung, Stefan J. Maurer, Tobias Bausbacher, Stefan Schmidt, Pavel A. Levkin, Daniel Sevin, Kerstin Göpfrich, Philipp Koch, Oliver Kann, Carsten Hopf

“…Abstract Single‐cell MALDI mass spectrometry imaging (MSI) of lipids and metabolites >200 Da has recently come to the forefront of biomedical research and chemical biology. …”
Get full text

A Study of Correlation of Adiponectin Levels in Metabolic Syndrome by Apurv Singhal, Vedpal Singh Punia, Akash Bharti, Shaavi Mittal, Praveen Raman Mishra, Prem Kuma

“…They also had lower blood pressure, pulse rate, and fasting plasma glucose levels than the people with MetS, and there were statistically significant variations in lipid profiles between those with and without MetS. …”
Get full text

Growth Performance, Serum Biochemical Profile, Oxidative Status, and Fertility Traits in Male Japanese Quail Fed on Ginger (Zingiber officinale, Roscoe) Essential Oil by Tchoffo Herve, Kana Jean Raphaël, Ngoula Ferdinand, Folack Tiwa Laurine Vitrice, Adoum Gaye, Moussa Mahamat Outman, Ngouozeu Moyo Willy Marvel

“…Under the conditions of this study, the ginger rhizomes essential oil can be used in poultry to reduce the lipid peroxidation in reproductive tissues and improve the fertility traits.…”
Get full text

Association between cardiovascular health and osteoporotic fractures: a national population-based study by Jun Ou, Tingting Wang, Ridan Lei, Mengting Sun, Xiaorui Ruan, Jianhui Wei, Jiabi Qin

“…CVH was assessed using the LE8 score, which incorporates eight modifiable cardiovascular health metrics: diet, physical activity, tobacco use, sleep, body mass index (BMI), lipid levels, blood glucose, and blood pressure. …”
Get full text

PTEN Sequence Analysis in Endometrial Hyperplasia and Endometrial Carcinoma in Slovak Women by H. Gbelcová, P. Bakeš, P. Priščáková, V. Šišovský, I. Hojsíková, Ľ. Straka, M. Konečný, J. Markus, C. W. D’Acunto, T. Ruml, D. Böhmer, Ľ. Danihel, V. Repiská

“…Phosphatase and tensin homolog (PTEN) is a protein that acts as a tumor suppressor by dephosphorylating the lipid second messenger phosphatidylinositol 3,4,5-trisphosphate. …”
Get full text

Influence of the A3669G Glucocorticoid Receptor Gene Polymorphism on the Metabolic Profile of Pediatric Patients with Congenital Adrenal Hyperplasia by Ricardo P. P. Moreira, Larissa G. Gomes, Guiomar Madureira, Berenice B. Mendonca, Tânia A. S. S. Bachega

“…Our results suggest that A3669G-polymorphism could be involved with a susceptibility to adverse lipid profile in pediatric CAH patients. This study provides new insight into the GR screening during CAH treatment, which could help to identify the subgroup of at-risk patients who would most benefit from preventive therapeutic action.…”
Get full text

Gastroprotective Value of Berries: Evidences from Methanolic Extracts of Morus nigra and Rubus niveus Fruits by Luciane Angela Nottar Nesello, Maria Luisa Maes Lima Beleza, Marihá Mariot, Luísa Nathália Bolda Mariano, Priscila de Souza, Adriana Campos, Valdir Cechinel-Filho, Sérgio Faloni Andrade, Luísa Mota da Silva

“…The gastroprotective effects of the extracts against 60% ethanol/0.3 M HCl were evaluated in mice. After that, the lipid hydroperoxides and reduced glutathione levels at ulcerated tissue were determined. …”
Get full text

The assessment of marrow adiposity in type 1 diabetic rabbits through magnetic resonance spectroscopy is linked to bone resorption by Wei Li, Wei Wang, Minlan Zhang, Qi Chen, Fengyi Li, Shaojun Li

“…Biochemical analyses covered plasma glucose, enzyme levels, lipid profiles, blood urea nitrogen, creatinine levels, and markers of bone turnover. …”
Get full text

Prevalence of Vitamin K2 Deficiency and Its Association with Coronary Artery Disease: A Case–Control Study by Sameh A. Ahmed, Abdulaziz A. Yar, Anas M. Ghaith, Rayan N. Alahmadi, Faisal A. Almaleki, Hassan S. Alahmadi, Waleed H. Almaramhy, Ahmed M. Alsaedi, Man K. Alraddadi, Hussein M. Ismail

“…Moreover, these outcomes indicate the imperative requirement for an integrative approach that incorporates metabolic, lipid, and vitamin K2-related pathways in the risk stratification and management of CAD.…”
Get full text

Exploring the Role of Salt Supplementation on Milk Composition, Fatty Acids, and Insulin Response in Lactating Camels by Riyadh S. Aljumaah, Ahmed A. K. Salama, Mutassim M. Abdelrahman, Moez Ayadi, Gerardo Caja, Mohammed A. Alshaikh, Mohammed A. Al-Badwi, Abdulkareem M. Matar

“…Milk FA profiles revealed a reduction in unsaturated fatty acids (UFA, <i>p</i> < 0.04), particularly monounsaturated (MUFA, <i>p</i> < 0.05) and odd-chain fatty acids (OCFA, <i>p</i> < 0.05). Furthermore, lipid quality indices such as the atherogenic index (<i>p</i> < 0.01) and the hypocholesterolemic/hypercholesterolemic FA ratio (h/H, <i>p</i> < 0.01) indicated a less favorable milk fat profile in the SAL group. …”
Get full text

MT1G promotes iron autophagy and inhibits the function of gastric cancer cell lines by intervening in GPX4/SQSTM1 by Kaiqiang Meng, Jian Song, Fan Qi, Jiamin Li, Zhichao Fang, Liang Song

“…At high magnification, mitochondrial autophagy, endoplasmic reticulum autophagy, lipid droplet autophagy, and wrinkled mitochondrial cristae are observed, promoting autophagy. …”
Get full text

Comparative Analysis of Meat Quality and Hindgut Microbiota of Cultured and Wild Bighead Carp (<i>Hypophthalmichthys nobilis</i>, Richardson 1845) from the Yangtze River Area by Abdullateef Mukhtar Muhammad, Chang Yang, Bo Liu, Cunxin Sun, Linghong Miao, Xiaochuan Zheng, Liangkun Pan, Dong Xia, Qun-Lan Zhou

“…The results showed that wild bighead carp muscle had significantly higher total saturated fatty acid (∑SFA) and total ω − 3 polyunsaturated fatty acid (∑n − 3 PUFA) content and water-holding capacity and lower lipid, histidine, and total ω − 6 polyunsaturated fatty acid (∑n − 6 PUFA) content than cultured bighead carp, while the muscle texture was not significantly different between the two groups, with the exception of the resilience. …”
Get full text

The effects of diacylglycerol edible oil intervention in patients with chronic metabolic syndrome combined with asymptomatic hyperuricemia: study protocol for a multicenter, prospe... by Gui-yu Li, Cui-feng Zhu, Zhao-qi Huang, Chun-li Piao, Jia-jun Yu, Li Wang, Qiang Zeng, Yu-yu Lei, Yue Li, Xiao-ling Zhu, Zhen-tian Zhang, Tian-hua Huang, Meng-shuang Li, Shu-zhong Lin, Nai-wen Zhang, Fangyingnan Zhang, Yong-hua Wang, Dan-ping Xu

“…Fasting blood glucose, 2 h postprandial blood glucose, fasting insulin, glycated hemoglobin, lipid profile, and average carotid intima-media thickness will be evaluated as the secondary outcomes. …”
Get full text

Fibroblast Growth Factor 21 Deficiency Attenuates Experimental Colitis-Induced Adipose Tissue Lipolysis by Liming Liu, Cuiqing Zhao, Ying Yang, Xiaoxia Kong, Tuo Shao, Li Ren, Xinyu Zhuang, Baishuang Yin, Gerald Dryden, Craig McClain, Weimin Luan, Wenke Feng

“…Fibroblast growth factor 21 (FGF21) is an important endocrine metabolic regulator with emerging beneficial roles in lipid homeostasis. We investigated the impact of FGF21 in experimental colitis-induced epididymal white adipose tissue (eWAT) lipolysis. …”
Get full text

Therapeutic Potential of Combined 5% Lifitegrast and Tocopherol Eye Drops in Managing Inflammation and Oxidative Stress in Murine Dry Eye by Jayoung Moon, Enying Jiang, Jingting Liu, Hui Jin, Hee Su Yoon, Hoon-In Choi, Ji Suk Choi, Hong Qi, Hyeon-Jeong Yoon, Kyung Chul Yoon

“…Clinical parameters (tear volume, tear break-up time (TBUT), corneal fluorescein staining score (CFSS), tear film lipid layer grade (TFLLG)) were assessed on days 7 and 14. …”
Get full text

Wet pulverization combined with temperature cycling strategy for extraction of Stropharia rugosoannulata protein with attenuating hepatic steatosis on obese mice by Peng Liu, Chen Gao, Wen Li, Wanchao Chen, Zhong Zhang, Di Wu, Tingzhao Li, Shuai Sun, Yan Yang

“…SRA alleviated the pathological progression in obese mice induced by high-fat diet via regulating lipid metabolism in liver and adipose tissues. SRA could obviously improve hepatic steatosis, which may be attributed to inhibiting MAPK/PGC-1α pathway. …”
Get full text

Estimation of Apolipoprotein A1, Haptoglobin and Alpha 2macroglobulin with some Biochemical Metabolic Markers in Nonalcoholic Fatty Liver Disease Iraqi Patients by hiba abid Al-hussein hassan, Dawood Salman Dawood, Raghad Jawad Hussein

“… "non-alcoholic fatty liver disease" starts with hepatic lipid accumulation and is a dangerous factor for disease development. …”
Get full text

Serological Evidence of Hepatitis B and E and Dengue Coinfection in Chadian Patients and Impact on Lipidemia Profile by Alexandre Kanga Djasrabe, Borris Rosnay Tietcheu Galani, Moussa Mahamat Ali, Fissou Henry Yandai, Bessimbaye Nadlaou, Mayann Habkreo, Nicolas Yanou Njintang

“…Serum transaminases and biomarkers of lipid profiles were assayed by colorimetry, and atherogenic indexes (AI) and coronary risk (CRI) were calculated. …”
Get full text