Research and development of Cordyceps in Taiwan by Ching-Peng Chiu, Tsong-Long Hwang, You Chan, Mohamed El-Shazly, Tung-Ying Wu, I-Wen Lo, Yu-Ming Hsu, Kuei-Hung Lai, Ming-Feng Hou, Shyng-Shiou Yuan, Fang-Rong Chang, Yang-Chang Wu

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Immunogenicity of HIV-1 <i>Env</i> mRNA and <i>Env-Gag</i> VLP mRNA Vaccines in Mice by Qi Ma, Jing Yang, Xiaoguang Zhang, Hongxia Li, Yanzhe Hao, Xia Feng

“…BALB/c mice were immunized with env mRNA, env–gag VLP mRNA, env plasmid DNA vaccine, or lipid nanoparticle (LNP) controls. HIV Env-specific binding and neutralizing antibodies in mouse sera were assessed via enzyme-linked immunosorbent assay (ELISA) and pseudovirus-based neutralization assays, respectively. …”
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Non-steroidal anti-inflammatory drugs and oxidative stress biomarkers in fish: a meta-analytic review by Luiz Henrique Zaniolo Justi, Juliana Ferreira Silva, Manuela Santos Santana, Henrique Aparecido Laureano, Meire Ellen Pereira, Cláudia Sirlene Oliveira, Izonete Cristina Guiloski

“…The meta-analysis revealed that (1) chronic and subchronic exposures to NSAIDs decreased catalase (CAT) activity, and acute exposure increased glutathione peroxidase (GPx) activity; (2) hydric exposure increased GPx activity; (3) exposure to low concentrations of NSAIDs increased GPx and superoxide dismutase (SOD) activity; (4) Paracetamol exposure increased GPx and SOD activity and lipid peroxidation levels, but reduced glutathione S-transferase (GST) activity; (5) Diclofenac exposure increased GPx activity. …”
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Wheat flour as carbon source on water quality, growth performance, hemolymph biochemical and immune parameters of Pacific white shrimp (Penaeus vannamei) juveniles in biofloc techn... by Mohammad Hossein Khanjani, Jamshid Eslami, Maurício Gustavo Coelho Emerenciano

“…Adding wheat flour to the rearing system improved the biochemical composition of shrimp bodies, so that the control group had the lowest level of protein (75.31 % DW), lipid (6.81 % DW), and ash (11.48 % DW) (P < 0.05). …”
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Early effects of LT3 + LT4 combination therapy on quality of life in hypothyroid patients: a randomized, double-blind, parallel-group comparison trial by Fatemeh Hajtalebi, Fariba Alaei-Shahmiri, Fatemeh Golgiri, Najmeh Shahini, Hamideh Akbari, Kasra Assadian, Seyedarad Mosalamiaghili

“…While no significant differences emerged between the groups in terms of blood pressure, lipid profiles (except for low-density lipoprotein cholesterol), or body weight, there were notable improvements in physical functioning and bodily pain in the LT4 + LT3 group compared to the LT4 + placebo group. …”
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Adipokines regulate the development and progression of MASLD through organellar oxidative stress by Ke Zhao, Heng Zhang, Wenyu Ding, Xiaoshuai Yu, Yanli Hou, Xihong Liu, Xinhua Li, Xiaolei Wang

“…These adipokines intricately orchestrate regulatory pathways that impact glucose and lipid metabolism, oxidative stress, and mitochondrial function, thereby influencing the evolution of hepatic steatosis and progression to metabolic dysfunction–associated steatohepatitis (MASH). …”
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The Associations of Serum Uric Acid with Obesity-Related Acanthosis nigricans and Related Metabolic Indices by Cuiling Zhu, Ran Cui, Mingming Gao, Sharvan Rampersad, Hui You, Chunjun Sheng, Peng Yang, Hui Sheng, Xiaoyun Cheng, Le Bu, Shen Qu

“…Weight, body mass index (BMI), UA, lipid profile, liver function, and renal function were measured in all participants. …”
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Identification of a binding site for small molecule inhibitors targeting human TRPM4 by Babatunde Ekundayo, Prakash Arullampalam, Christian E. Gerber, Anne-Flore Hämmerli, Sabrina Guichard, Mey Boukenna, Daniela Ross-Kaschitza, Martin Lochner, Jean-Sebastien Rougier, Henning Stahlberg, Hugues Abriel, Dongchun Ni

“…We determine three cryo-EM structures of full-length human TRPM4 embedded in native lipid nanodiscs without inhibitor, bound to NBA, and an anthranilic acid derivative, IBA. …”
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Clerodendrum volubile Ethanol Leaf Extract: A Potential Antidote to Doxorubicin-Induced Cardiotoxicity in Rats by Olufunke Esan Olorundare, Adejuwon Adewale Adeneye, Akinyele Olubiyi Akinsola, Daniel Ayodele Sanni, Mamoru Koketsu, Hasan Mukhtar

“…Thus, cardioprotective potential and mechanism(s) of CVE in DOX-induced cardiotoxicity were investigated using cardiac and oxidative stress markers and histopathological endpoints. 50–400 mg/kg/day CVE in 5% DMSO in distilled water were investigated in Wistar rats intraperitoneally injected with 2.5 mg/kg DOX on alternate days for 14 days, using serum troponin I and LDH, complete lipid profile, cardiac tissue oxidative stress marker assays, and histopathological examination of DOX-treated cardiac tissue. …”
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G-quadruplex-forming small RNA inhibits coronavirus and influenza A virus replication by Ryoya Sekine, Kouki Takeda, Tsukasa Suenaga, Satsuki Tsuno, Takumi Kaiya, Maki Kiso, Seiya Yamayoshi, Yoshihide Takaku, Shiho Ohno, Yoshiki Yamaguchi, Seiichi Nishizawa, Kazuhiro Sumitomo, Kazufumi Ikuta, Teru Kanda, Yoshihiro Kawaoka, Hidekazu Nishimura, Shusuke Kuge

“…The approach has the potential to facilitate the creation of versatile middle-molecule antivirals featuring lipid nanoparticle-free delivery.…”
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Decreased Cardiovascular Risk after Roux-en-Y Gastric Bypass Surgery in Chinese Diabetic Patients with Obesity by Xue Zhao, Wenyan Duan, Chenglin Sun, Zhuo Li, Yujia Liu, Xianchao Xiao, Gang Wang, Xiaokun Gang, Guixia Wang

“…The complete remission rate of diabetes was 90% after RYGB surgery, with significant improvements in blood pressure, BMI, glucose, and lipid metabolism (P<0.05). The 10-year cardiovascular risk of coronary heart disease reduced from 13.05% to 3.81% (P=0.001) and the 10-year risk of stroke reduced from 19.66% to 14.22% (P=0.002). …”
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Free fatty acid receptor 2 promotes cardiomyocyte hypertrophy by activating STAT3 and GATA4 by Hui Gao, Kunming Tian, Xiaojun Feng, Mengqing Yan, Chen Gao, Yisheng Jiang, Chenhao Zhu, Huzhe Zhu, Xueping Liu, Yingfu Peng

“…Free fatty acid receptor 2 (FFA2) can be activated by short-chain FAs and is involved in inflammatory reactions and lipid accumulation. Since the known pathological changes caused by FFA2 are also implicated in cardiac hypertrophy, we hypothesized that FFA2 might be pathogenic in cardiac hypertrophy. …”
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Longitudinal non-targeted metabolomic profiling of urine samples for monitoring of kidney transplantation patients by Ihsan Yozgat, Ulkem Cakır, Muhittin Abdulkadir Serdar, Sevgi Sahin, Osman Ugur Sezerman, Emirhan Nemutlu, Ahmet Tarik Baykal, Mustafa Serteser

“…These distinctive metabolites mainly belonged to lipid, fatty acid, and amino acid categories. Ten models were constructed using a backward conditional approach, with the best performance seen in model 5 for Group 2 at the 1st-week mark (AUC 0.900) and model 3 at the 3rd-month mark (AUC 0.924). …”
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2′-O-Methylperlatolic Acid Enhances Insulin-Regulated Blood Glucose-Lowering Effect through Insulin Receptor Signaling Pathway by Wang Yinghao, Guan Qiaoli, Liu Guanfu, Wu Xiaoyun, Wang Xuanjun, Sheng Jun

“…Next, qRT-PCR was performed to detect the mRNA expression of genes involved in lipid and glucose metabolism in the liver and muscle tissues. …”
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Morphological, Physiological, and Transcriptional Changes in <i>Crocus sativus</i> L. Under In Vitro Polyethylene Glycol-Induced Water Stress by Suman Gusain, Rohit Joshi

“…PEG-induced drought led to decreased plant growth and biomass and lowered relative water content of leaves. Lipid peroxidation, membrane damage, and H₂O₂ content increased, indicating heightened stress levels. …”
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Impact of duration of treatments with metformin and sulfonylureas, individually or in combination, on diabetic retinopathy among newly diagnosed type 2 diabetic patients: a pooled... by Mansour Bahardoust, Yadollah Mehrabi, Farzad Hadaegh, Davood Khalili, Ali Delpisheh

“…Methods The data of 4,068 newly diagnosed DM individuals(mean age, 60.2 ± 0.85 years) from three prospective cohorts of Tehran Sugar and Lipid Study (TLGS), Multi-Ethnic Study of Atherosclerosis (MESA), and Atherosclerosis Risk in Communities (ARIC) with a mean age of 59.6 ± 08 years were pooled. …”
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Tamarind (<i>Tamarindus indica</i> L.) Components as a Sustainable Replacement for Pork Meat in Frankfurter Sausages by Rafael Sepúlveda F. Trevisan Passos, Camila Cristina A. de Sousa, Mauricio C. A. da Silva, Ana M. Herrero, Claudia Ruiz-Capillas, Carlos Pasqualin Cavalheiro

“…No variation in the conformational order of the lipid acyl chains due to the incorporation of tamarind compounds was observed related to physical entrapment of these compounds in the frankfurter matrix. …”
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ACOX1 activates autophagy via the ROS/mTOR pathway to suppress proliferation and migration of colorectal cancer by Bo Shi, Junjie Chen, Haoran Guo, Xinyu Shi, Qingliang Tai, Guoliang Chen, Huihui Yao, Xiuwei Mi, Runze Zhong, Yang Lu, Yiyuan Zhao, Liang Sun, Diyuan Zhou, Yizhou Yao, Songbing He

“…ACOX1 may regulate autophagy by reprogramming lipid metabolism to modulate the ROS/mTOR signaling pathway, consequently inhibiting the proliferation and migration of CRC.…”
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Lipoprotein Particle Predictors of Arterial Stiffness after 17 Years of Follow Up: The Malmö Diet and Cancer Study by Jacob Hartz, Ronald M. Krauss, Mikael Göttsater, Olle Melander, Peter Nilsson, Michele Mietus-Snyder

“…Associations between c-fPWV and lipoprotein particles were determined with multiple linear regression, controlling for sex, presence of diabetes, waist-to-hip circumference, and smoking status at baseline, as well as heart rate (measured at the carotid artery), mean arterial pressure, antihypertensive and lipid-lowering medications, C-reactive protein (CRP), and age at the time of c-fPWV measurement. …”
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ZnO Nanoparticle-Assisted Synthesis of Thiazolo[3,2-α]Pyrimidine Analogs: Antibacterial and Antioxidant Activity, In Silico Molecular Docking, and ADMET Prediction Study by Demis Zelelew, Milkyas Endale, Yadessa Melaku, Taye B. Demissie, Japheth O. Ombito, Rajalakshmanan Eswaramoorthy

“…Compound 19 displayed the highest percent inhibition of DPPH with an IC50 value of 9.48 g/mL using the DPPH free radical scavenging assay compared to ascorbic acid (3.21 g/mL) and promising inhibition of peroxide formation (76.28 ± 0.12%), demonstrating its potential in preventing the formation of lipid peroxides. Thus, according to our findings, both the biological activities and in silico computational results revealed that compounds 14, 16, and 18 are good antibacterial agents against P. aeruginosa and E. coli, whereas compound 19 was found to be a promising antibacterial agent against S. aureus and an antioxidant agent. …”
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