Clinical Trials of Immunogene Therapy for Spontaneous Tumors in Companion Animals by Gerardo Claudio Glikin, Liliana María Elena Finocchiaro

“…Both viral and mainly nonviral vectors were used to deliver gene products as cytokines, xenogeneic tumor associated antigens, specific ligands, and proapoptotic regulatory factors. In some cases autologous, allogenic, or xenogeneic transgenic cytokine producing cells were assayed. …”
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Machine learning-powered, high-affinity modification strategies for aptamers by Gubu Amu, Xin Yang, Hang Luo, Sifan Yu, Huarui Zhang, Yuan Tian, Yuanyuan Yu, Shijian Ding, Yufei Pan, Zefeng Chen, Yixin He, Yuan Ma, Baoting Zhang, Ge Zhang

“…Despite diverse post-systematic evolution of ligands by exponential enrichment (post-SELEX) modifications explored in aptamer optimization, accurate prediction of high-affinity modification strategies remains challenging. …”
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The Role of NK Cells in Pig-to-Human Xenotransplantation by Gisella Puga Yung, Mårten K. J. Schneider, Jörg D. Seebach

“…Specific molecular strategies to overcome human anti-pig NK cell responses include (1) blocking of the molecular events leading to recruitment (chemotaxis, adhesion, and transmigration), (2) expression of human MHC class I molecules on pECs that inhibit NK cells, and (3) elimination or blocking of pig ligands for activating human NK receptors. The potential of cell-based strategies including tolerogenic dendritic cells (DC) and regulatory T cells (Treg) and the latest progress using transgenic pigs genetically modified to reduce xenogeneic NK cell responses are discussed. …”
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Catalytic pathways for N-arylation of benzimidazoles: A comprehensive review by Anila Ghulam, Tooba Jabeen, Sana Aslam, Matloob Ahmad, Magdi E.A. Zaki

“…These catalysts, which are frequently supported by a variety of ligands, allow for the selective and efficient production of N-aryl bonds under a wide range of reaction conditions. …”
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Actin Alpha 2 (ACTA2) Downregulation Inhibits Neural Stem Cell Migration through Rho GTPase Activation by Ji Zhang, Xuheng Jiang, Chao Zhang, Jun Zhong, Xuanyu Fang, Huanhuan Li, Fangke Xie, Xiaofei Huang, Xiaojun Zhang, Quan Hu, Hongfei Ge, Anyong Yu

“…Although neural stem cells (NSCs) could migrate towards lesions after central nervous system (CNS) injury, the migration ability always is restricted due to the disturbed composition and density of the adhesion ligands and extracellular matrix (ECM) gradient after CNS injury. …”
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Role of Extracellular Hemoglobin in Thrombosis and Vascular Occlusion in Patients with Sickle Cell Anemia by Zhou Zhou, Molly Behymer, Prasenjit Guchhait

“…ECHb and its degradation product, heme, are known to cause oxidative damage to the vessel wall and stimulate the expression of adhesive protein ligands on vascular endothelium. Our study shows that ECHb binds potently to VWF—largest multimeric glycoprotein in circulation—through the A2-domain, and significantly inhibits its cleavage by the metalloprotease ADAMTS13. …”
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Comprehensive Screening of Cell Surface Markers Expressed by Adult-Derived Human Liver Stem/Progenitor Cells Harvested at Passage 5: Potential Implications for Engraftment by Pierre-Edouard Dollet, Joachim Ravau, Floriane André, Mustapha Najimi, Etienne Sokal, Catherine Lombard

“…Furthermore, study of the adhesion molecule profile of ADHLSCs revealed that they do not express selectin ligands or LFA-1 which are, respectively, involved in the rolling process and the firm adhesion. …”
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Immobilization of NTPDase-1 from Trypanosoma cruzi and Development of an Online Label-Free Assay by Felipe Antunes Calil, Juliana Maria Lima, Arthur Henrique Cavalcante de Oliveira, Christiane Mariotini-Moura, Juliana Lopes Rangel Fietto, Carmen Lucia Cardoso

“…The use of IMERs (Immobilized Enzyme Reactors) as a stationary phase coupled to high performance chromatographic systems is an interesting approach in the screening of new ligands. In addition, IMERs offer many advantages over techniques that employ enzymes in solution. …”
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Molecular Programming Design of Glyconucleic Acid Aptamer with High Stability by Yongqi Han, Rongjun Zhang, Hong‐Liang Bao, Mei Yang, Yuan Gao, Xiaobo Gao, Ruowen Wang, Weihong Tan, Ding‐Kun Ji

“…Through precise molecular design, the accurate modification of four different carbohydrate ligands at specific sites of DNA aptamers is achieved. …”
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Antiemetic activity of Sesamol possibly through serotonergic and dopaminergic receptor interaction pathways: In vivo and in silico studies by Touhidul Islam Tanim, Ayman M. Al-Qaaneh, Raihan Chowdhury, Md. Shimul Bhuia, Tabassum Islam, Md Showkoth Akbor, Md. Tahajul Islam, Md. Mohasin Miah, Ali Raza Ishaq, Mostafa A. Abdel-Maksoud, Mohamed A. El-Tayeb, Mohamed El-Shazly, Muhammad Torequl Islam, Heba A.S. El-Nashar

“…Further, molecular docking was carried out to understand the molecular interaction between selected ligands and different receptors liable for mediating emesis. …”
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Recognition mechanism and sequence optimization of organophosphorus pesticides aptamers for better monitoring contaminations in food by Pengfei Chen, Chaoqiong Hu, Xuan Tao, Zheng Zhou, Lijun Wang, Xiao Yang, Zhenming Che, Xianggui Chen, Yukun Huang

“…However, molecules of OPPs are structurally similar and original aptamers selected by systematic evolution of ligands by exponential enrichment are usually long-chain bases, which hamper the further application under OPPs-aptamer recognition. …”
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Predictive Assessment of the Antiviral Properties of Imperata cylindrica against SARS-CoV-2 by Frank Eric Tatsing Foka, Hazel Tumelo Mufhandu

“…Molecular docking and in silico pharmacokinetic assays were used to assess 72 phytocompounds that are found in I. cylindrica as ligands and Mpro (6LU7) as the target. Only eight phytochemicals (bifendate, cylindrene, tabanone, siderin, 5-hydroxy-2-[2-(2-hydroxyphenyl)ethyl]-4H-1-benzopyran-4-one, maritimin, 5-methoxyflavone, and flavone) displayed high binding affinities with Mpro with docking scores ranging from −5.6 kcal/mol to −9.1 kcal/mol. …”
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Repurposing Lesogaberan to Promote Human Islet Cell Survival and β-Cell Replication by Jide Tian, Hoa Dang, Angela Hu, Willem Xu, Daniel L. Kaufman

“…However, GABA and the most clinically applicable GABA-R ligands may be suboptimal for the long-term treatment of diabetes due to their pharmacological properties or potential side-effects on the central nervous system (CNS). …”
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SAMHD1 shapes deoxynucleotide triphosphate homeostasis by interconnecting the depletion and biosynthesis of different dNTPs by Claudia McCown, Corey H. Yu, Dmitri N. Ivanov

“…The equilibrium between inactive and active tetrameric states regulates dNTPase activity, driven by the binding and dissociation of additional allosteric dNTP ligands to the preassembled tetramer. Furthermore, catalytic efficiency, but not substrate specificity, is modulated by the identity of the dNTPs occupying the allosteric sites. …”
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Novel Biologically Potent Diorganosilicon(IV) Complexes of Indole-2,3-Dione Derivatives by R. V. Singh, Pooja Nagpal

“…The aim of the present study is to synthesize some novel ecofriendly fungicides and bactericides of indole-2,3-dione derivatives, having important pharmacodynamic significance. The ligands used in the present account are derived by the condensation of 1,3-dihydro-3-[2-(phenyl)-2-oxoethylidene]-2H-indol-2- one, 1,3-dihydro-3-[2-(4-nitrophenyl)-2-oxoethylidene]-2H-indol-2-one and 1,3-dihydro-3-[2-(4-nitro-3-methylphenyl)- 2-oxoethylidene]-2H-indol-2-one with hydrazinecarboxamide and hydrazinecarbothioamide. …”
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Theoretical Calculations and Molecular Docking Analysis of 4-(2-(4-Bromophenyl)Hydrazineylidene)-3,5-Diphenyl-4H-Pyrazole Molecule by Ümit Yıldıko, Veysel Tahiroğlu, Mehmet Bağlan, Kenan Gören

“…The highest binding energies and binding conformations between ligands and enzymes were predicted.…”
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Possible Involvement of TLRs and Hemichannels in Stress-Induced CNS Dysfunction via Mastocytes, and Glia Activation by Adam Aguirre, Carola J. Maturana, Paloma A. Harcha, Juan C. Sáez

“…Consequently, activated microglia and astrocytes release ATP and glutamate, affecting myelinization, neuronal development, and survival. Binding of ligands to TLRs induces a cascade of intracellular events leading to activation of several transcription factors that regulate the expression of many genes involved in inflammation. …”
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Rare Earth Elements in Mineral Deposits: Speciation in Hydrothermal Fluids and Partitioning in Calcite by Emily P. Perry, Alexander P. Gysi

“…Results show that, in a high CO2 and low salinity system, bicarbonate/carbonate are the main transporting ligands for the REE, but predominance shifts to chloride complexes in systems with high CO2 and high salinity. …”
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The Aging GABAergic System and Its Nutritional Support by Demetra J. Mills

“…Nutritional support of the GABAergic system with supportive foods, vitamins, and GABA or similar GABA receptor ligands may address some of the GABAergic dysfunction associated with aging.…”
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Computational analysis of the effect of a binding protein (RbpA) on the dynamics of Mycobacterium tuberculosis RNA polymerase assembly. by Sneha Bheemireddy, Ramanathan Sowdhamini, Narayanaswamy Srinivasan

“…<h4>Conclusions</h4>Finally, potential ligands meant for the α1-α2 binding site were identified through virtual screening. …”
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