Observation of Body‐Centered‐Cubic Cu Nanocluster with Partial Cu(0) Character by Pu Gao, Jing Du, Weijie Hong, Mingzai Wu, Yan Feng, Yanjun Ding, Manzhou Zhu

“…Herein, a Cu(0)‐containing Cu NC is first reported to contain a metallic framework of 23 Cu atoms with a body‐centered‐cubic Cu@Cu8 core, stabilized by 6 triphenylphosphine (TPP) and 18 4‐methylbenzenethiolate ligands, as determined by single‐crystal X‐ray crystallography. …”
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Predicting drug and target interaction with dilated reparameterize convolution by Moping Deng, Jian Wang, Yiming Zhao, Yongjia Zhao, Hao Cao, Zhuo Wang

“…Many existing deep learning methods only learn the high-dimensional representation of ligands and targets on a small scale. However, it is difficult for the model to obtain the potential law of combining pockets or multiple binding sites on a large scale. …”
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An antifouling polydopamine-based fluorescent aptasensor for determination of arginine kinase by Yanbo Wang, Huan Li, Jinru Zhou, Fangting Wang, Yifan Qian, Linglin Fu

“…The aptamer towards AK was firstly selected via systematic evolution of ligands by exponential enrichment method and labeled with fluorescein amidite (FAM) to build a fluorescence resonance energy transfer (FRET) system with PDA particles. …”
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The Angiotensin II Type 2 Receptor in Brain Functions: An Update by Marie-Odile Guimond, Nicole Gallo-Payet

“…The potential utility of novel nonpeptide selective AT2 receptor ligands in clarifying potential roles of this receptor in physiology will also be discussed. …”
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Naphthoxy Bounded Ferrocenium Salts as Cationic Photoinitiators for Epoxy Photopolymerization by Zh. Q. Li, M. Li, G. L. Li, Y. Chen, X. N. Wang, T. Wang

“…To improve the absorption and the bulk of arene ligands, two naphthoxy bounded ferrocenium salts as new cationic photoinitiators, (η6-α-naphthoxybenzene) (η5-cyclopentadienyl) iron hexafluorophosphate (NOFC-1) and (η6-β-naphthoxybenzene) (η5-cyclopentadienyl) iron hexafluorophosphate (NOFC-2), were synthesized, characterized, and studied. …”
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Preparation of a Specific ssDNA Aptamer for Brevetoxin-2 Using SELEX by Rui-Yun Tian, Chao Lin, Shi-Yu Yu, Sheng Gong, Pan Hu, Yan-Song Li, Zong-Cheng Wu, Yang Gao, Yu Zhou, Zeng-Shan Liu, Hong-Lin Ren, Shi-Ying Lu

“…This paper reports the use of aptamers binding to BTX-2 in an analytical assay using the systematic evolution of ligands by exponential enrichment (SELEX). After 12 rounds of selection, the secondary structures of 25 sequences were predicted. …”
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Enantioselective Heck/Tsuji−Trost reaction of flexible vinylic halides with 1,3-dienes by Li-Zhi Zhang, Pei-Chao Zhang, Qian Wang, Min Zhou, Junliang Zhang

“…Engineering the Sadphos bearing androgynous non-C2-symmetric chiral sulfinamide phosphine ligands are vital component in achieving excellent catalytic reactivity and enantioselectivity. …”
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PPAR-γ Agonists and Their Effects on IGF-I Receptor Signaling: Implications for Cancer by A. Belfiore, M. Genua, R. Malaguarnera

“…In this regard, promising drugs have been developed to target the IGF-I receptor or its ligands. These therapies are limited by the development of insulin resistance and compensatory hyperinsulinemia, which in turn, may stimulate cancer growth. …”
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Bioadsorption of Copper(II) Using Halmahera Specific Marine Algae (<i>Sargassum turbinarioides</i>) Encapsulated Calcium Alginate by Dede Ardiansyah Takdir Abubakar Sanawi, Barlah Rumhayati, Qonitah Fardiyah

“…Characterization of the biosorbent using FTIR showed that the biosorbent has active functional groups such as O–H, C–H, S–H, C=O, S=O, and C–O–C, which act as metal ligands, and SEM characterization showed morphological changes in the biosorbent before and after the copper(II) bioadsorption process.…”
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Nuclear receptors in regulation of bile acids transport and metabolism by A. F. Sheptulina, Ye. N. Shirokova, V. T. Ivashkin

“…So, it is supposed, that application of nuclear receptor ligands will help to boost hepatocyte protection mechanisms, and, hence, to slow down or arrest progression of disease.…”
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Fluorescein-based SynNotch adaptors for regulating gene expression responses to diverse extracellular and matrix-based cues by Jeremy C. Tran, Christopher J. Kuffner, Alexander M. Marzilli, Ryan Emily Miller, Zachary E. Silfen, Jeffrey B. McMahan, D. Christopher Sloas, Christopher S. Chen, John T. Ngo

“…Overall, we introduce an optimized fluorescein-binding SynNotch as a versatile tool for regulating transcriptional responses to ligands based on the clinically-approved fluorescein dye.…”
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Bioassays and virtual screening to identify potent natural antifouling compounds from the brown macroalga Dictyota dichotoma by Ba-akdah Mohammad Abdulaziz, Satheesh Sathianeson

“…The secondary metabolite composition of the extract was analyzed by GC-MS and compounds were used as ligands for molecular docking with barnacle cement protein. …”
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Chemokines in Renal Diseases by Stephan Segerer, Peter J. Nelson

“…The therapeutic impact of the blockade of CCR1, CCR2, CCR4, CCR5, or the corresponding ligands has been further studied in various renal disease models. …”
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Early Growth Response Genes Signaling Supports Strong Paracrine Capability of Mesenchymal Stem Cells by Kenichi Tamama, Dominique J. Barbeau

“…Evidence suggests that EGR1 regulates angiogenic and fibrogenic factor production in MSCs, and an EGFR-EGR1-EGFR ligands autocrine loop is one of the underlying mechanisms supporting their strong paracrine machinery through EGR1. …”
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The EGFR-ADAM17 Axis in Chronic Obstructive Pulmonary Disease and Cystic Fibrosis Lung Pathology by Marta Stolarczyk, Bob J. Scholte

“…In airway epithelial cells, ADAM17 sheds multiple soluble signaling proteins by proteolysis, including EGFR ligands such as amphiregulin (AREG), and proinflammatory mediators such as the interleukin 6 coreceptor (IL-6R). …”
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Multiple Factors Determine the Oncolytic or Carcinogenic Effects of TLRs Activation in Cancer by Yingxiang Yang, Chengyue Jin, Anthony Yeo, Bo Jin

“…This mechanism is employed in cancer immunotherapy. Using TLR ligands as adjuvants induces upregulation of costimulatory signals which in turn activates a cytotoxic leukocyte response against cancer cells. …”
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Therapeutic Strategies for Neuropathic Pain: Potential Application of Pharmacosynthetics and Optogenetics by Gum Hwa Lee, Sang Seong Kim

“…Designer Receptors Exclusively Activated by Designer Drugs (DREADDs) facilitate the artificial manipulation of intracellular signaling through excitatory or inhibitory G protein subunits activated by biologically inert synthetic ligands. Expression of excitatory channelrhodopsins and inhibitory halorhodopsins on injured neurons or surrounding cells can attenuate neuropathic pain precisely controlled by light stimulation. …”
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Inflammatory Chemokine Expression via Toll-Like Receptor 3 Signaling in Normal Human Mesangial Cells by Hiroshi Tanaka, Tadaatsu Imaizumi

“…The activation of TLRs and their downstream immune responses can be induced by both infectious pathogens and noninfectious stimuli such as endogenous ligands, and this mechanism may be involved in the pathogenesis of autoimmune renal diseases. …”
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One and Multiple Bonds Interatomic Spin-Spin Coupling in η6-Cymene Ru(II) of 3,5-Dimethyl-, 3,5-Dicarboxylic-, and 5-Phenyl-pyrazole Derivatives by Adebayo A. Adeniyi, Peter A. Ajibade

“…The changes in the interatomic distances and the corresponding spin-spin coupling as a result of the hydrolysis of the ruthenium complexes and the effects of different derivatives of the pyrazole ligands and the substituents methyl, carboxylic, and phenyl on the pyrazole rings were studied. …”
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Theoretical Study on Solubility from Pt Electrocatalyst and Reactivity in Electrolyte Environment of Pt Complex in PEFC by Takayoshi Ishimoto, Michihisa Koyama

“…We theoretically analyzed the formation energy and solvation free energy of Pt(II) and Pt(IV) complexes with three types of ligands (H2O, OH−, and CF3SO3 −) in electrolyte environment under the low- and high-humidity conditions to study the Pt electrocatalyst degradation and dissolution mechanisms for polymer electrolyte fuel cell. …”
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