CXC Chemokines in the Pathogenesis of Pulmonary Disease and Pharmacological Relevance by Kayode Komolafe, Maricica Pacurari

“…The current review presents the understanding of the roles of CXC ligands (CXCLs) and their cognate receptors (CXCRs) in the pathogenesis of several lung diseases such as allergic rhinitis, COPD, lung fibrosis, lung cancer, pneumonia, and tuberculosis. …”
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Inflammation and Immune Response in COPD: Where Do We Stand? by Nikoletta Rovina, Antonia Koutsoukou, Nikolaos G. Koulouris

“…These signals act as ligands to Toll-like receptors (TLRs), triggering the production of cytokines and inducing innate inflammation. …”
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Synthesis, Spectral, and Biological Properties of Copper(II) Complexes of Thiosemicarbazones of Schiff Bases Derived from 4-Aminoantipyrine and Aromatic Aldehydes by Ram K. Agarwal, Lakshman Singh, Deepak Kumar Sharma

“…These thiosemicarbazones are potential ligands toward transition metal ions. The reaction of copper(II) salts with 4[N-(benzalidene)amino]antipyrinethiosemicarbazone (BAAPTS), 4[N-(4′-methoxybenzalidene) amino] antipyrinethiosemicarbozone (MBAAPTS), 4[N-(4′-dimethylamino benzalidene) amino] antipyrinethiosemicarbazone (DABAAPTS), and 4[N-(cinnamalidene) amino] antipyrinethiosemicarbazone (CAAPTS) resulted in the formation of solid complexes with the general composition CuX2⋅(H2O)(L)(X = Cl, Br, NO3, NCS, or CH3COO; L = BAAPTS, MBAAPTS, DABAAPTS, or CAAPTS). …”
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On the Use of Molecular Weight Cutoff Cassettes to Measure Dynamic Relaxivity of Novel Gadolinium Contrast Agents: Example Using Hyaluronic Acid Polymer Complexes in Phosphate-Buff... by Nima Kasraie, Henry Wayne Oviatt, Geoffrey David Clarke

“…The aims of this study were to determine whether standard extracellular contrast agents of Gd(III) ions in combination with a polymeric entity susceptible to hydrolytic degradation over a finite period of time, such as Hyaluronic Acid (HA), have sufficient vascular residence time to obtain comparable vascular imaging to current conventional compounds and to obtain sufficient data to show proof of concept that HA with Gd-DTPA ligands could be useful as vascular imaging agents. …”
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Biological Activity of Metal Complexes of Sulfamethoxazole and Its Derivatives: A Literature Review by Laith Jumaah Al-Gburi, Taghreed H. Al-Noor, Eid Ahmed Abdalrazaq

“…Many researchers have synthesized organic ligands derived from sulfamethoxazole in the forms of Schiff bases and azo compounds, which exhibited higher biological and industrial properties when compared to sulfamethoxazole alone. …”
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The Role of Cell Surface Architecture of Lactobacilli in Host-Microbe Interactions in the Gastrointestinal Tract by Ranjita Sengupta, Eric Altermann, Rachel C. Anderson, Warren C. McNabb, Paul J. Moughan, Nicole C. Roy

“…Identification of the relevant bacterial ligands and their host receptors is imperative for a better understanding of the mechanisms through which lactobacilli exert their beneficial effects on human health.…”
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Investigation of photophysical properties and potential biological applications of substituted tris(polypyridyl)ruthenium(II) complexes by T. Sumitha Celin, G. Allen Gnana Raj, T. S. Prathima, M. M. Balamurali

“…The physical, electronic, and biological properties of this complex depend on the nature of the ligands and the medium of investigation. Herein, the potential applications of [Ru(bpy)3]2+ in clinical diagnostics as antioxidants and therapeutic agents were evaluated.…”
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Asymmetric synthesis of stereogenic-at-iridium(III) complexes through Pd-catalyzed kinetic resolution by Yun-Peng Chu, Xue-Lin Yue, De-Hai Liu, Chuanyong Wang, Jiajia Ma

“…Abstract Metal-centered chirality has been recognized for over one century, and stereogenic-at-metal complexes where chirality is exclusively attributed to the metal center due to the specific coordination pattern of achiral ligands around the metal ion, has been broadly utilized in diverse areas of natural science. …”
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The Controversial C5a Receptor C5aR2: Its Role in Health and Disease by Ting Zhang, Malgorzata A. Garstka, Ke Li

“…Ramifications and controversies about C5aR2 are under debate since its identification, from putative ligands and cellular localization to intracellular signals and pathological roles in inflammation and immunity. …”
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Regulation of Posttranscriptional Modification as a Possible Therapeutic Approach for Retinal Neuroprotection by Yoko Ozawa, Toshihide Kurihara, Kazuo Tsubota, Hideyuki Okano

“…In innate chorioretinal inflammation, interleukin-6 family ligands induce STAT3 activation in photoreceptors, which causes UPS-mediated excessive degradation of the visual substance, rhodopsin. …”
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A mutation in LXRα uncovers a role for cholesterol sensing in limiting metabolic dysfunction-associated steatohepatitis by Alexis T. Clark, Lillian Russo-Savage, Luke A. Ashton, Niki Haghshenas, Nicolas A. Amselle, Ira G. Schulman

“…We have generated mice with a mutation in LXRα that reduces activity in response to endogenous cholesterol derived LXR ligands while still allowing transcriptional activation by synthetic agonists. …”
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CoMFA and CoMSIA Studies on Inhibitors of HIV-1 Integrase - Bicyclic Pyrimidinones by V. Radhika, S. Sree Kanth, M. Vijjulatha

“…To understand the structural requirements of HIV-1 integrase inhibitors and to design new ligands against human HIV-1 integrase with enhanced inhibitory potency, a 3D QSAR (quantitative structure-activity relationship) study with comparative molecular field analysis (CoMFA) and comparative molecular similarity indices analysis (CoMSIA) for a dataset of 35 bicyclic pyrimidinones which are inhibitors of human HIV-1 integrase was performed. …”
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N-Acetylglucosamine Functions in Cell Signaling by James B. Konopka

“…In addition, the specificity of Notch family receptors for different ligands is altered by GlcNAc attachment to fucose residues in the extracellular domain. …”
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Pattern Recognition via the Toll-Like Receptor System in the Human Female Genital Tract by Kaei Nasu, Hisashi Narahara

“…TLRs recognize conserved pathogen-associated molecular patterns (PAMPs) synthesized by microorganisms including bacteria, fungi, parasites, and viruses as well as endogenous ligands associated with cell damage. Members of the TLR family, which includes 10 human TLRs identified to date, recognize distinct PAMPs produced by various bacterial, fungal, and viral pathogens. …”
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Screening of potential GCMS derived antimigraine compound from the leaves of Abrus precatorius Linn to target “calcitonin gene related peptide” receptor using in silico analysis... by Parthasarathy V., Ajay Kumar T.V

“…Many strategies were employed to design antimigraine drug using various CGRP antagonist/ligands but most of them have failed due to their inability to reach the target “CGRP receptor” as they get metabolized before conferring their pharmacological action and exhibit toxic effect to the liver. …”
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Moroccan natural products for multitarget-based treatment of Alzheimer's disease: A computational study. by Fatima Zahra Guerguer, Amal Bouribab, El Mehdi Karim, Meriem Khedraoui, Fatiha Amegrissi, Yasir S Raouf, Abdelouahid Samadi, Samir Chtita

“…This underscores the necessity of developing multi-target ligands for effective treatment. This study investigates the potential of phytochemical compounds from Moroccan medicinal plants as multi-target agents against Alzheimer's disease, employing computational approaches. …”
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The General Principle of the Warburg Effect as a Possible Approach for Cancer Immunotherapy: The Regulatory Effect of Plant Extracts Could Change the Game by Donika Ivanova, Severina Semkova, Boncho Grigorov, Milena Tzanova, Ana Georgieva, Dancho Danchev, Biliana Nikolova, Zvezdelina Yaneva

“…Because of the reported serious adverse effects of using synthetic ligands for PPARs in combination with chemotherapeutics, searches for less toxic and more active PPAR inhibitors, as well as blocking undesirable cellular PPAR-dependent processes, are in progress. …”
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Targeted Anticancer Immunotoxins and Cytotoxic Agents with Direct Killing Moieties by Koji Kawakami, Oumi Nakajima, Ryuichi Morishita, Ryozo Nagai

“…Among targeted cancer therapeutics, biologicals with targetable antibodies or ligands conjugated or fused to toxins or chemicals for direct cell-killing ability have been developed over the last 2 decades. …”
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Atherogenic ω-6 Lipids Modulate PPAR- EGR-1 Crosstalk in Vascular Cells by Jia Fei, Carla Cook, Miriah Gillespie, Bangning Yu, Khyra Fullen, Nalini Santanam

“…Atherogenic ω-6 lipids are physiological ligands of peroxisome proliferator-activated receptors (PPARs) and elicit pro- and antiatherogenic responses in vascular cells. …”
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EGFR: A Master Piece in G1/S Phase Transition of Liver Regeneration by Alexandra Collin de l'Hortet, Hélène Gilgenkrantz, Jacques-Emmanuel Guidotti

“…Due to the level of complexity surrounding EGFR signaling, involving numerous ligands, highly controlled regulations and multiple downstream pathways, we chose to focus on the EGFR pathway for this paper. …”
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