Basic Ionic Liquid as Catalyst in Synthesis of Dimethyl 4-(2-(2,6-Bis(methoxycarbonyl)pyridine-4-yl)vinyl)pyridine-2,6-dicarboxylate by Xiaobing Liu, Yulin Hu, Wei Fu

“…In the lanthanide complexes with some organic ligands, the use of pyridine-2,6-dicarboxylic acid derivatives as sensitizers was better than using others. …”
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Probing Cortical Sites of Antipsychotic Drug Action with in vivo Receptor Imaging by P. Shaw, L. S. Pilowsky

“…Imaging receptors using radioactive ligands has allowed direct determination of the sites of action of antipsychotic drugs. …”
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Biological Properties and the Role of IL-25 in Disease Pathogenesis by Yuwan Liu, Zewei Shao, Guoqiang Shangguan, Qingli Bie, Bin Zhang

“…The interleukin- (IL-) 17 superfamily, a T cell-derived cytokine, consists of 6 ligands (IL-17A–IL-17F) and 5 receptors (IL-17RA–IL-17RE). …”
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Perfluorocarbon Nanoparticles: Evolution of a Multimodality and Multifunctional Imaging Agent by Patrick M. Winter

“…The particle surface can be decorated with targeting ligands to direct the agent to a variety of biomarkers that are associated with diseases such as cancer, cardiovascular disease, obesity, and thrombosis. …”
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Toll-Like Receptor 4 Activation in Cancer Progression and Therapy by Alja Oblak, Roman Jerala

“…Nevertheless, TLR4 engagement by endotoxin as well as by endogenous ligands represents notable contribution to the outcome of different cancer treatments, such as radiation or chemotherapy. …”
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Synthesis Characterization and Biological Activity Study of New Schiff and Mannich Bases and Some Metal Complexes Derived from Isatin and Dithiooxamide by Ahlam J. Abdulghani, Nada M. Abbas

“…Metal complexes of the two ligands were synthesized, and their structures were characterized by elemental analyses, atomic absorption, IR and UV-visible spectra, molar conductivity, and magnetic moment determination. …”
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Anticancer Role of PPARγ Agonists in Hematological Malignancies Found in the Vasculature, Marrow, and Eyes by P. J. Simpson-Haidaris, S. J. Pollock, S. Ramon, N. Guo, C. F. Woeller, S. E. Feldon, R. P. Phipps

“…This paper has two objectives: first to highlight the potential uses for PPARγ agonists in anticancer therapy with special emphasis on their role when used as adjuvant or combined therapy in the treatment of hematological malignancies found in the vasculature, marrow, and eyes, and second, to review the potential role PPARγ and/or its ligands may have in modulating cancer-associated angiogenesis and tumor-stromal microenvironment crosstalk in bone marrow.…”
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Immunomodulation by Gut Microbiota: Role of Toll-Like Receptor Expressed by T Cells by Mariagrazia Valentini, Alessia Piermattei, Gabriele Di Sante, Giuseppe Migliara, Giovanni Delogu, Francesco Ria

“…TLRs are able to recognize ligands from commensal or pathogen microbiota to maintain the tolerance or trigger the immune response. …”
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CCN1 promotes APRIL/BAFF signaling in esophageal squamous cell carcinoma but attenuates it in esophageal adenocarcinoma by Lingling Xing, Zhenyu Jiang, Ruize Xu, Tong Dang, Jinbao Wu, Jianyuan Chai, Xianmei Meng

“…Unlike TRAIL, which primarily triggers cell death, APRIL and BAFF promote cell growth via NFκB signaling. They become active ligands by Furin cleavage. This study found that CCN1 upregulated APRIL and BAFF expression in both ESCC and EAC cells but attenuated their signaling in the latter. …”
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The Role of Toll-Like Receptor 4 in Infectious and Noninfectious Inflammation by Monica Molteni, Sabrina Gemma, Carlo Rossetti

“…TLR4-mediated inflammation, triggered by exogenous or endogenous ligands, is also involved in several acute and chronic diseases, having a pivotal role as amplifier of the inflammatory response. …”
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RIPK1 in necroptosis and recent progress in related pharmaceutics by Kunhou Yao, Zhihao Shi, Fengya Zhao, Cong Tan, Yixin Zhang, Hao Fan, Yingzhe Wang, Xingwang Li, Jun Kong, Qun Wang, Dingxi Li

“…Increased expression of death receptor family ligands such as tumor necrosis factor (TNF) increases the susceptibility of cells to apoptosis and necroptosis. …”
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The Role of PPAR Gamma in Systemic Sclerosis by Andréa Tavares Dantas, Michelly Cristiny Pereira, Moacyr Jesus Barreto de Melo Rego, Laurindo Ferreira da Rocha, Ivan da Rocha Pitta, Cláudia Diniz Lopes Marques, Angela Luzia Branco Pinto Duarte, Maira Galdino da Rocha Pitta

“…Recently, antifibrotic effects of PPARγ ligands have been studied in vitro and in vivo and some theories have emerged leading to new insights. …”
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Comparative Studies on the Interaction of Cochinchinenin A and Loureirin B with Bovine Serum Albumin by Tianming Yang, Hao Zhang, Haiyan Fu, Yuanbin She, Can Huang, Yan Hu, Liping Wang

“…The binding distance (rCA, rLB) and the quenching efficiency (KSV), especially for the binding constants value of ligands to BSA, were affected by the methoxyl group at position 4 at different temperatures. …”
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Memory Effects of Benzodiazepines: Memory Stages and Types Versus Binding-Site Subtypes by Miroslav M. Savic, Dragan I. Obradovic, Nenad D. Ugrešic, Dubravko R. Bokonjic

“…Namely, recent genetic studies and standard behavioral tests employing subtype-selective ligands pointed to the predominant involvement of two subtypes of benzodiazepine binding sites in memory modulation. …”
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Purin-6-One Derivatives as Phosphodiesterase-2 Inhibitors by Wei Yuan, Xin-Yun Zhao, Xi Chen, Chang-Guo Zhan

“…The docking results suggested that these ligands bind with hydrophobic pockets of the catalytic active site of PDE2, where a Tyr655 residue was found to be important in binding with compound 2p, the most potent inhibitor identified in this study. …”
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The endocannabinoid system and ophthalmic pathologies: a review of molecular mechanisms and its implications for clinical practice by Tomasz Charytoniuk, Stanisław Półjanowski, Mateusz Michalak, Karolina Kaźmierczak, Bartłomiej Kałużny

“…Therefore, the researchers believe that this biological system, its receptors, pathways, and ligands might be considered as an auxiliary compound to reduce the number of patients suffering from ophthalmic diseases. …”
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The Role of PPARγ in the Transcriptional Control by Agonists and Antagonists by Tamotsu Tsukahara

“…In this paper, we summarize the current knowledge on the mechanism of PPARγ-mediated transcriptional activity and transcriptional repression in response to novel lipid-derived ligands, such as cPA.…”
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On Topological Analysis of Niobium (II) Oxide Network via Curve Fitting and Entropy Measures by Muhammad Kamran Siddiqui, Sana Javed, Sadia Khalid, Mazhar Hussain, Muhammad Shahbaz, Samuel Asefa Fufa

“…Niobium nanoparticles have the ability of easy ligands connection so they are very suitable in treating cancer optothermally. …”
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Research progress on free fatty acid receptors and bronchial asthma by Fangxin Cao, Na Lin, Juntao Lin, Gai Yang, Xintong Wang

“…Free fatty acids are ligands of FFARs. GPR40, GPR41, GPR43, GPR120 and GPR84 have been identified as FFARs. …”
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Cavernous Nerve Injury Resulted Erectile Dysfunction and Regeneration by Nan Jiang, Cheng Wu, Xunrong Zhou, Guanghua Zhai, Jian Wu

“…In addition, such as neuromodulatory proteins, proimmune ligands, gene therapy, stem cell therapy, and the current cutting-edge low-energy shock wave therapy have shown advantages in basic research and limited clinical studies. …”
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