Targeting RGMb interactions: Discovery and preclinical characterization of potent anti-RGMb antibodies blocking multiple ligand bindings by Maria Meira, Aurore Frey, Neila Chekkat, Magda Rybczynska, Zaki Sellam, Joon Seok Park, Francesca Smylie Gazzaniga, Alexia Parmentier, Marianne Le Gall, Gordon James Freeman, Dennis Lee Kasper, Arlene Helen Sharpe, Eric Rambeaux, Abdijapar Shamshiev

“…The emergence of Repulsive Guidance Molecule b (RGMb), a ligand for PD-L2, as a novel co-inhibitory pathway in T cells, together with its regulation by the gut microbiome, encouraged the discovery and development of fully human anti-RGMb antibodies. …”
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Agonistic anti-NKG2D antibody structure reveals unique stoichiometry and epitope compared to natural ligands by Daniel Fallon, Ching-Shin Huang, Jingya Ma, Christopher Morgan, Zhaohui Sunny Zhou

“…Despite the variety of NKG2D ligands, they all bind the receptor asymmetrically in a 1:1 ligand to homodimeric NKG2D stoichiometry. …”
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Glucocorticoid-Induced TNFR-Related (GITR) Protein and Its Ligand in Antitumor Immunity: Functional Role and Therapeutic Modulation by Theresa Placke, Hans-Georg Kopp, Helmut Rainer Salih

“…In this paper, we address available data on GITR and its ligand in immune responses and discuss the role and potential therapeutic modulation of this molecule system in antitumor immunity.…”
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Effects of Delta-Like Noncanonical Notch Ligand 1 Expression of Human Fetal Liver Hepatoblasts on Hematopoietic Progenitors by Jörg C. Gerlach, Robert L. Thompson, Bruno Gridelli, Eva Schmelzer

“…Hepatoblasts express delta-like noncanonical Notch ligand 1 (Dlk1), whose cleaved extracellular domain can become a soluble protein. …”
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Corrigendum to “PPARs in Human Neuroepithelial Tumors: PPAR Ligands as Anticancer Therapies for the Most Common Human Neuroepithelial Tumors” by Elisabetta Benedetti, Renato Galzio, Barbara D’Angelo, Maria Paola Cerù, Annamaria Cimini

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Prostanoid Receptor Subtypes and Its Endogenous Ligands with Processing Enzymes within Various Types of Inflammatory Joint Diseases by Mohammed A. Al-Madol, Mohammed Shaqura, Thilo John, Rudolf Likar, Reham Said Ebied, Magdi M. Salih, Sascha Treskatsch, Michael Schäfer, Shaaban A. Mousa

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Micromolar Concentration Affinity Study on a Benchtop NMR Spectrometer with Secondary 13C Labeled Hyperpolarized Ligands by Olivier Cala, Charlotte Bocquelet, Chloé Gioiosa, Felix Torres, Samuel F. Cousin, Sylvie Guibert, Morgan Ceillier, Venita Busse, Frank Decker, James G. Kempf, Stuart J. Elliott, Quentin Stern, Aurélien Bornet, Sami Jannin

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Dye Ligand Epoxide Chitosan/Alginate: A Potential New Stationary Phase for Human IgG Purification by Diego R. Gondim, Luana P. Lima, Maria C. M. de Souza, Igor T. L. Bresolin, Wellington S. Adriano, Diana C. S. Azevedo, Ivanildo J. Silva

“…Cibacron Blue F3GA immobilized as ligand onto epoxide chitosan/alginate composite was prepared and evaluated for the purification of human immunoglobulin G (IgG) isolated from human serum by dye-ligand affinity chromatography. …”
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2-Oxiranyl-pyridines: Synthesis and Regioselective Epoxide Ring Openings with Chiral Amines as a Route to Chiral Ligands by Marzena Wosińska-Hrydczuk, Jacek Skarżewski

“…The obtained enantiomerically pure 2-pyridinyl- and 6-(2,2′-bipyridinyl)-β-amino alcohols were tentatively tested as chiral ligands in the zinc-catalyzed aldol reaction.…”
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Synthesis, In Silico, and Biological Applications of Novel Heteroleptic Copper (II) Complex of Natural Product-Based Semicarbazone Ligands by Fekadu Muleta, Tegene Desalegn

“…Semicarbazone-based moiety holding azomethine (C=N) group become flexible ligands, forming stable complexes. Through a stirring and reflux technique, a novel heteroleptic complex of copper (II) was synthesized by reacting two semicarbazone-based derivative ligands, ortho-phthalaldehyde disemicarbazone (L1) and dehydrozingerone semicarbazone (L2), with copper chloride salt in 1 : 1 : 1 molar ratio. …”
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A proliferation-inducing ligand (APRIL) level among risk factors of ocular involvement in patients with Behçet’s disease by Rasha M. Ghaleb, Hanan S. Gad, Mohamed I. Abdallah, Zaki M. Zaki, Jehan A. Mahmoud

“…Little is known about the expression of a proliferation-inducing ligand (APRIL) in terms of ocular involvement in BD. …”
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Palladium-catalyzed Suzuki–Miyaura cross-coupling with $\alpha $-aminophosphonates based on 1,3,4-oxadiazole as ligands by Hkiri, Shaima, Touil, Soufiane, Samarat, Ali, Sémeril, David

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Synthesis, Crystal Structure, Spectroscopic Properties, and Interaction with Ct-DNA of Zn(II) with 2-Aminoethanethiol Hydrochloride Ligand by Xu-gang Shu, Chun-li Wu, Cui-jin Li, Min Zhang, Ke Wan, Xin Wu

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Differentiation Potential of Pancreatic Fibroblastoid Cells/Stellate Cells: Effects of Peroxisome Proliferator-Activated Receptor Gamma Ligands by M.-L. Kruse, S. Hopf-Jensen, C. Timke, B. Agricola, G. Sparmann, A. Schmid, B. Sipos, A. Arlt, H. Schäfer

“…We tested effects of natural and synthetic ligands of peroxisome proliferator-activated receptor gamma (PPARγ) on human pancreatic fibroblastoid cells (hPFCs) in search for specificity of action. …”
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Synthesis and Evaluation of Cytotoxic Activity of RuCp(II) Complexes Bearing (Iso)nicotinic Acid Based Ligands by Bárbara Marques, Diogo M. Engrácia, João Franco Machado, Jaime A. S. Coelho, Filipa Mendes, Tânia S. Morais

“…Methods: Building on the auspicious results obtained for [Ru(η⁵-C₅H₅)(PPh₃)(bipy)][CF₃SO₃] (TM34), our focus has shifted to examining the effects of incorporating bioactive ligands into the TM34 framework, particularly within the cyclopentadienyl ring. …”
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Synthesis, Characterization, Biological Activity and DNA Binding Studies of Metal Complexes with 4-Aminoantipyrine Schiff Base Ligand by B. Anupama, M. Padmaja, C. Gyana Kumari

“…A new series of transition metal complexes of Cu(II),Ni(II),Co(II), Zn(II) and VO(IV) have been synthesized from the Schiff base ligand (L) derived from 4-amino antipyrine and 5- bromo salicylaldehyde. …”
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Effect of Common Buffers and Heterocyclic Ligands on the Binding of Cu(II) at the Multimetal Binding Site in Human Serum Albumin by Magdalena Sokołowska, Krystyna Pawlas, Wojciech Bal

“…The effects of warfarin and ibuprofen, specific ligands of hydrophobic pockets I and II in HSA on the Cu(II) binding to MBS were also investigated. …”
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Synthesis, Crystal Structure, and DNA-Binding Studies of a Nickel(II) Complex with the Bis(2-benzimidazolymethyl)amine Ligand by Huilu Wu, Tao Sun, Ke Li, Bin Liu, Fan Kou, Fei Jia, Jingkun Yuan, Ying Bai

“…In the complex, the Ni(II) ion is six-coordinated with a N2O4 ligand set, resulting in a distorted octahedron coordination geometry. …”
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Lipopolysaccharide inhibits osteoblast formation and receptor activator of nuclear factor-κB ligand degradation via autophagy inhibition by Huaizhi Zhang, Jianhua Lin, Xu Chen, Jianhui Dai, Haibin Lin

Subjects: “…receptor activator of nuclear factor-κb ligand…”
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Platinum(II) Complexes with Tetradentate Schiff Bases as Ligands: Synthesis, Characterization and Detection of DNA Interaction by Differential Pulse Voltammetry by Lijun Li, Chao Tian, Cheng Wang, Guangyuan Wang, Lianzeng Wang, Jianlong Du

“…The results indicate that ligands with different groups can strongly affect the interaction between [Pt(L)] complexes and ssDNA due to sterical hindrances and complex [Pt(L1)] has the best interaction with DNA among the five complexes.…”
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