Preparation and Characterization of an Amphipathic Magnetic Nanosphere by Yongsheng Ji, Ruihong Lv, Zhigang Xu, Chuande Zhao, Haixia Zhang

“…The amphipathic magnetic nanospheres were synthesized using C8 and polyethylene glycol as ligands. Their morphology, structure, and composition were characterized by transmission electron microscope, Fourier transform infrared, and elementary analysis. …”
Get full text

Synthesis, Characterization, and Catalytic Studies of Mn(III)-Schiff Base-Dicyanamide Complexes: Checking the Rhombicity Effect in Peroxidase Studies by Manuel R. Bermejo, Rocío Carballido, M. Isabel Fernández-García, Ana M. González-Noya, Gustavo González-Riopedre, Marcelino Maneiro, Laura Rodríguez-Silva

“…The synthesis of three new manganese(III) complexes 1–3, incorporating these ligands, H2L1–H2L3, and dicyanamide (DCA), is reported. …”
Get full text

Isoxazole-based molecules restore NK cell immune surveillance in hepatocarcinogenesis by targeting TM4SF5 and SLAMF7 linkage by Ji Eon Kim, Hyun Su Kim, Wonsik Kim, Eun Hae Lee, Soyeon Kim, Taewoo Kim, Eun-Ae Shin, Kyung-hee Pyo, Haesong Lee, Seo Hee Jin, Jae-Ho Lee, Soo-Min Byeon, Dong Joo Kim, Jinwook Jeong, Jeongwon Lee, Minjae Ohn, Hyojung Lee, Su Jong Yu, Dongyun Shin, Semi Kim, Jun Yeob Yoo, Seung-Chul Lee, Young-Ger Suh, Jung Weon Lee

“…TM4SF5 expressed by hepatocytes reduced NK cell cytotoxicity by downregulating stimulatory ligands/receptors, including signaling lymphocytic activation molecule family member 7 (SLAMF7). …”
Get full text

“One Ring to Bind Them All”—Part I: The Efficiency of the Macrocyclic Scaffold for G-Quadruplex DNA Recognition by David Monchaud, Anton Granzhan, Nicolas Saettel, Aurore Guédin, Jean-Louis Mergny, Marie-Paule Teulade-Fichou

“…Macrocyclic scaffolds are particularly attractive for designing selective G-quadruplex ligands essentially because, on one hand, they show a poor affinity for the “standard” B-DNA conformation and, on the other hand, they fit nicely with the external G-quartets of quadruplexes. …”
Get full text

Synthesis and Characterization of Oxozirconium(IV), Dioxomolybdenum(VI) and Dioxotungsten(VI) with Ciprofloxacin and Norfloxacin Complexes by Khalaf I. Khallow, Amaal Y. R. Al-Assaf

“…FTIR spectra of both types of complexes suggest that CIP and NOR act as deprotonated bidentate ligands through the ring carbonyl oxygen atom and one of the oxygen atom of carboxylic group.…”
Get full text

Cell-Specific Aptamers as Emerging Therapeutics by Cindy Meyer, Ulrich Hahn, Andrea Rentmeister

“…The first aptamers have been selected about two decades ago by an in vitro process named SELEX (systematic evolution of ligands by exponential enrichment). Since then, numerous aptamers with specificities for a variety of targets from small molecules to proteins or even whole cells have been selected. …”
Get full text

Chemical Biology of G-quadruplex and i-motif DNA: use of topologically constrained DNA by Dejeu, Jérôme, Defrancq, Eric

“…., affine and specific) G4- and i-DNA-interacting ligands, (ii) identify proteins interacting with those structures and determine their cellular relevance and (iii) select specific antibodies for G4 and i-DNA. …”
Get full text

Experimental and Theoretical Studies on the Structure and Photoluminescent Properties of New Mononuclear and Homodinuclear Europium(III) β-Diketonate Complexes by João P. Martins, Pablo Martín-Ramos, Pedro Chamorro-Posada, Pedro S. Pereira Silva, Jesús Martín-Gil, Salvador Hernández-Navarro, Manuela Ramos Silva

“…Two novel europium(III) complexes, a monomer and a homodimer, with 1-(4-chlorophenyl)-4,4,4-trifluoro-1,3-butanedione (Hcbtfa) and 5-chloro-1,10-phenanthroline (cphen) ligands, formulated as [Eu(cbtfa)3(cphen)] and [Eu2(cbtfa)4(cphen)2(CH3O)2], have been synthesized. …”
Get full text

Nanocrystalline Axially Bridged Iron Phthalocyanine Polymeric Conductor: (μ-Thiocyanato)(phthalocyaninato)iron(III) by Eiza Shimizu, Gil Nonato Santos, Derrick Ethelbhert Yu

“…Skewered Iron(III) phthalocyanine conducting polymer can be constructed with the utilization of axial thiocyanato ligands ((μ-thiocyanato)(phthalocyaninato)iron(III)); (FeIII(Pc)(SCN)n) thereby creating additional avenues for electron transport through a linear SCN bridge, apart from the intermolecular π-π orbital overlap between the Pc molecules. …”
Get full text

PPARs: Protectors or Opponents of Myocardial Function? by Christine J. Pol, Melissa Lieu, Konstantinos Drosatos

“…They can be activated by endogenous ligands, such as fatty acids, as well as by pharmacologic agents. …”
Get full text

PPAR Regulation of Inflammatory Signaling in CNS Diseases by John J. Bright, Saravanan Kanakasabai, Wanida Chearwae, Sharmistha Chakraborty

“…Peroxisome proliferator-activated receptors (PPARs) are a family of nuclear hormone receptors that regulate immune and inflammatory responses. Specific ligands for PPAR𝛼, 𝛾, and 𝛿 isoforms have proven effective in the animal models of multiple sclerosis (MS), Alzheimer's disease, Parkinson's disease, and trauma/stroke, suggesting their use in the treatment of neuroinflammatory diseases. …”
Get full text

Spectral Characterization and Antibacterial Activities of Benzyloxybenzaldehydethiosemicarbazone, 3,4-Dihydroxybenzaldehydeisonicotinoylhydrazone and their Transitional Metal Compl... by Lakshmi Narayana Suvarapu, A. Varada Reddy, G. Satheesh Kumar, Sung Ok Baek

“…The synthesis and spectral characterization of benzyloxy-benzaldehydethiosemicarbazone (BBTSC) and the study of antibacterial activity of ligands BBTSC, 3,4-dihydroxybenzaldehydeisoni- cotinoylhydrazone (3,4-DHBINH) and their transition metal complexes was studied. …”
Get full text

A Survey of Strategies to Modulate the Bone Morphogenetic Protein Signaling Pathway: Current and Future Perspectives by Jonathan W. Lowery, Brice Brookshire, Vicki Rosen

“…Bone morphogenetic proteins (BMPs) constitute the largest subdivision of the TGF-β family of ligands and are unequivocally involved in regulating stem cell behavior. …”
Get full text

A novel 2D nickel coordination polymer based on Trimesic acid with glyphosate coordination capabilities by João M. R. Gonçalves, Ademar Wong, Pedro H. O. Santiago, Guilherme Arroyos, Augusto H. Piva, Javier A. Ellena, Benedito S. Lima-Neto, Regina C. G. Frem

“…Additionally, a Co-BTC coordination polymer was synthesized, with an already known structure similar to Ni-BTC, given the coordination modes of the BTC and DMF ligands. The structure of Ni-BTC is also a pseudo-polymorph of the previously published MOF [Ni(HBTC)(DMF)₂·(guest)] (3). …”
Get full text

1,10-Phenanthroline and 4,5-Diazafluorene Ketones and Their Silver(I) and Platinum(II) Complexes: Syntheses and Biological Evaluation as Antiproliferative Agents by Leonardo Sandin-Mazzondo, Jesús M. Martínez-Ilarduya, Jesús A. Miguel, Camino Bartolomé, Concepción Alonso

“…Using non-classical polyfluorophenyl ligands in Pt(II) complexes and other transition metals such as silver is a promising approach in the search for more effective and safer antitumoral drugs. …”
Get full text

Current Views of Toll-Like Receptor Signaling Pathways by Masahiro Yamamoto, Kiyoshi Takeda

“…In this paper, we will describe our current understanding of the relationship between TLRs and their ligands derived from pathogens such as viruses, bacteria, fungi, and parasites. …”
Get full text

A Role for PPARβ/δ in Tumor Stroma and Tumorigenesis by Rolf Müller, Martin Kömhoff, Jeffrey M. Peters, Sabine Müller-Brüsselbach

“…Peroxisome proliferator-activated receptor-β/δ (PPARβ/δ) is a transcription factor that is activated by endogenous fatty acid ligands and by synthetic agonists. Its role in the regulation of skeletal muscle fatty acid catabolism, glucose homeostasis, and cellular differentiation has been established in multiple studies. …”
Get full text

Toll-Like Receptors in Hepatic Ischemia/Reperfusion and Transplantation by John Evankovich, Timothy Billiar, Allan Tsung

“…The family of Toll-like receptors (TLRs) function as pattern-recognition receptors (PRRs) that respond to a myriad of highly conserved ligands. These substrates include pathogen-associated molecular patterns (PAMPs) for the recognition of invading pathogens, as well as damage-associated molecular patterns (DAMPs) for the recognition of endogenous tissue injury. …”
Get full text

Development and Field Application of a New Ultralow Guar Gum Concentration Weighted Fracturing Fluid in HPHT Reservoirs by Yi Liu, Jing Liu, Yunzi Li, Hui Yang, Fei Yan, Jiapeng Zheng, Jun Wu, Jianyi Huang, Zuohao Wu, Cheng Luo, Junkai Lu

“…In this study, a weighting agent was selected, and crosslinking ligands and boric acid were optimized. The crosslinking performance, base fluid viscosity, rheology, and gel-breaking performance of this fracturing fluid were studied. …”
Get full text

PPARs in Alveolar Macrophage Biology by Monica R. Smith, Theodore J. Standiford, Raju C. Reddy

“…We then review the role of PPAR-γ and its ligands in deactivating alveolar macrophages—thus limiting the inflammatory response that, if unchecked, could threaten the essential respiratory function of the alveolus—while upregulating the cell's phagocytotic activity. …”
Get full text