The Role of PPARs in Lung Fibrosis by Heather F. Lakatos, Thomas H. Thatcher, R. Matthew Kottmann, Tatiana M. Garcia, Richard P. Phipps, Patricia J. Sime

“…PPARγ ligands, including the thiazolidinedione class of antidiabetic drugs, effectively inhibit lung fibrosis in vitro and in animal models. …”
Get full text

Synthesis, Characterization, and Cytotoxicity Research of Sulfur-Containing Metal Complexes by Yanting Yang, Danqin Li, Mei Luo

“…In this experiment, the excellent coordination ability of sulfur-containing ligands was utilized. Diphenylacetyl disulfide and 3,3′-diaminodiphenyl sulfone were selected as ligands, and Cu(NO₃)₂·3H₂O, Ni(NO₃)₂·6H₂O and ZnCl₂ were reacted under one-pot conditions to synthesize three mononuclear complexes: [C₄H₁₈CuO₁₂S₂](I), [C₁₂H₁₈N₄NiO₁₁S](II) and [C₂₄H₂₄Cl₂N₄O₄S₂Zn](III). …”
Get full text

Syntheses, Characterization, and Antimicrobial Screening of N-(benzothiazol-2-yl)benzenesulphonamide and its Cu(I), Ni(II), Mn(II), Co(II), and Zn(II) Complexes by N. L. Obasi, Okoye C. O. Benedict, P. O. Ukoha, A. O. Anaga

“…The antimicrobial tests of the ligands and its metal complexes were carried out on both multi-resistant bacterial strains isolated under clinical conditions and cultured species using agar-well diffusion method. …”
Get full text

Bispecific antibody-mediated redirection of NKG2D-CAR natural killer cells facilitates dual targeting and enhances antitumor activity by Congcong Zhang, Anja Waldmann, Winfried S Wels, Jasmin Röder, Anne Scherer, Malena Bodden, Jordi Pfeifer Serrahima, Anita Bhatti, Nina Müller, Pranav Oberoi

“…Background Natural killer group 2D (NKG2D) is an activating receptor of natural killer (NK) cells and other lymphocytes that mediates lysis of malignant cells through recognition of stress-induced ligands such as MICA and MICB. Such ligands are broadly expressed by cancer cells of various origins and serve as targets for adoptive immunotherapy with effector cells endogenously expressing NKG2D or carrying an NKG2D-based chimeric antigen receptor (CAR). …”
Get full text

Speciation of Potentially Carcinogenic Trace Nickel(II) Ion Levels in Human Saliva: A Sequential Metabolomics-Facilitated High-Field ¹H NMR Investigation by Kayleigh Hunwin, Georgina Page, Mark Edgar, Mohammed Bhogadia, Martin Grootveld

“…However, at higher Ni(II) concentrations (140–670 µmol/L), weaker carboxylate O-donor ligands such as lactate, formate, succinate, and acetate were featured as major Ni(II) ligands, a consequence of their much higher WMSS concentrations, which were sufficient for them to compete for these higher Ni(II) availabilities. …”
Get full text

Determination of Acid Dissociation Constants (pKa) of Bicyclic Thiohydantoin-Pyrrolidine Compounds in 20% Ethanol-Water Hydroorganic Solvent by Yahya Nural, H. Ali Döndaş, Hayati Sarı, Hasan Atabey, Samet Belveren, Müge Gemili

“…Proton affinities of potential donor atoms of the ligands were calculated by AM1 and PM3 semiempiric methods. …”
Get full text

Role of PPAR𝛼 in Hepatic Carbohydrate Metabolism by Annelies Peeters, Myriam Baes

“…PPAR𝛼 is the master regulator of lipid metabolism during fasting, but evidence is emerging for a role of PPAR𝛼 in balancing glucose homeostasis as well. By using PPAR𝛼 ligands and PPAR𝛼−/− mice, several crucial genes were shown to be regulated by PPAR𝛼 in a direct or indirect way. …”
Get full text

DEARYLATION IN THE INTERACTIONS BETWEEN (Et3NH)HC2O4 OR (Et3NH)2C2O4 AND SnPh3Cl: INFRARED STUDY by GORGUI AWA SECK, LIBASSE DIOP, ABOUBACARY SENE

“…The anions behave as monochelating ligands, the environments around the metallic centres being octahedral. …”
Get full text

Why is it so difficult to understand why we don’t understand human systemic lupus erythematosus? Contemplating facts, conflicts, and impact of “the causality cascade paradigm”... by Ole Petter Rekvig, Ole Petter Rekvig

“…Likewise, inconclusive dogmatic data indicate that different glomerular ligands are recognized by nephritogenic anti-dsDNA antibodies—exposed chromatin fragments or inherent membrane ligands. …”
Get full text

Wnt/β-catenin signalling underpins juvenile Fasciola hepatica growth and development. by Rebecca Armstrong, Nikki J Marks, Timothy G Geary, John Harrington, Paul M Selzer, Aaron G Maule

“…Here, we identify five putative Wnt ligands and five Frizzled receptors in liver fluke transcriptomic datasets and find that Wnt/β-catenin signalling is most active in juveniles, the most pathogenic life stage. …”
Get full text

Usp11 maintained the survival of marginal zone B cells under ionizing radiation by deubiquitinating DLL1 and JAG2 by Jiaqi Sheng, Depei Wu, Jingzhe Shang, Xiaodan Fu, He Gao, Jianjie Rong, Jun Wang, Jiancheng Hu, Xiaofei Qi

“…Mechanistically, Usp11 sustained the survival of MZ B cells by regulating the ubiquitination of Notch’s ligands, DLL1 and JAG2, thereby promoting immune cell remodeling in the spleen. …”
Get full text

PPARγ in Inflammatory Bowel Disease by Vito Annese, Francesca Rogai, Alessia Settesoldi, Siro Bagnoli

“…Indeed, both natural and synthetic PPARγ ligands have beneficial effects in different models of experimental colitis, with possible implication in the therapy of inflammatory bowel disease (IBD). …”
Get full text

Epoxidation of Alkenes with Molecular Oxygen Catalyzed by Immobilized Co(acac)2 and Co(bpy)2Cl2 Complexes within Nanoreactors of Al-MCM-41 by F. Farzaneh, M. Jalalian, L. Tayebi

“…Cobalt complexes with different ligands such as bipyridine, and acetylacetonate were immobilized within nanoreactors of Al-MCM-41, designated as Co(acac)2/Al-MCM-41 and Co(bipy)22+/Al-MCM41. …”
Get full text

Cation Involvement in Telomestatin Binding to G-Quadruplex DNA by Frédéric Rosu, Valérie Gabelica, Nicolas Smargiasso, Gabriel Mazzucchelli, Kazuo Shin-Ya, Edwin De Pauw

“…This study underlines that monovalent cation coordination capabilities should be integrated in the rational design of G-quadruplex binding ligands.…”
Get full text

New insights into the structure domain and function of NLR family CARD domain containing 5 by Haiqing Zhu, Chengwei Xiao, Jiahua Chen, Bao Guo, Wenyan Wang, Zhenhai Tang, Yunxia Cao, Lei Zhan, Jun-hui Zhang

“…The functional variability of NLRC5 has been attributed to its different domain interactions with specific ligands in different cell types. In this review, we address the molecular mechanisms and their implications in multiple microenvironments based on the different functional domains of NLRC5.…”
Get full text

SEM/EDX and XRD characterization of silver nanocrystalline thin film prepared from organometallic solution precursor by Dimitrijević R., Cvetković O., Miodragović Z., Simić M., Manojlović D., Jović V.

“…The ball-like silver nanoparticles have been synthesized in large quantity by using a modified method of hydrolytic decomposition of silver complexes with amino types ligands formed in ethanol aqueous solution. SEM analysis revealed that Ag nanoparticles are all sphere shaped with bimodal size (40 and 70 nm) distribution. …”
Get full text

Synthesis, Structural, and Antimicrobial Studies of Some New Coordination Compounds of Palladium(II) with Azomethines Derived from Amino Acids by Monika Gupta, Sangeeta Sihag, A. K. Varshney, S. Varshney

“…Pd(II) compounds have been found to be more active than their uncomplexed ligands as both of them were screened for antibacterial, antifungal, and insecticidal activities.…”
Get full text

Synthesis, Characterization and Thermal Analysis of a New Acetic Acid (2-Hydroxy-benzylidene)-hydrazide and its Complexes with Hg(II) and Pd(II) by Hajar Sahebalzamani, Shahriare Ghammamy, Shaghayegh Dexhkam, Alireza Hemati Moghadam, Farhod Siavoshifar

“…The changes observed between the FT-IR, H NMR and UV-Vis spectra of the ligands and of the complexes allowed us to establish the coordination mode of the metal in complexes. …”
Get full text

Fine Tuning Cell Migration by a Disintegrin and Metalloproteinases by D. Dreymueller, K. Theodorou, M. Donners, A. Ludwig

“…The different steps of immune cell, tissue cell, or cancer cell migration are tightly coordinated in time and place by growth factors, cytokines/chemokines, adhesion molecules, and receptors for these ligands. This review describes how a disintegrin and metalloproteinases interfere with several steps of cell migration, either by proteolytic cleavage of such molecules or by functions independent of proteolytic activity.…”
Get full text

Fractalkine and Other Chemokines in Primary Biliary Cirrhosis by Shinji Shimoda, Carlo Selmi, M. Eric Gershwin

“…To address this issue, we challenged BEC using multiple toll-like receptor (TLR) ligands as well as autologous liver infiltrating mononuclear cells (LMNC) with subsequent measurement of BEC phenotype and chemokine production and LMNC chemotaxis by quantifying specific chemokines, specially CX3CL1 (fractalkine). …”
Get full text