Triterpenoids from Chios Mastiha Resin Against MASLD—A Molecular Docking Survey by Nataša Milošević, Maja Milanović, Milica Medić Stojanoska, Varomyalin Tipmanee, Ilias Smyrnioudis, George V. Dedoussis, Nataša Milić

“…The observed compounds had moderate and high affinity for LXR, GR, MC4R, and PPARγ in comparison to proven ligands, while their affinity for PPARα, AMPK, and VEGFR was less pronounced. …”
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Characterization by Potentiometric Procedures of the Stability Constants of the Binary and Ternary Complexes of Cu(II) and Duloxetine Drug with Amino Acids by Amal M. Al-Mohaimeed, Asma A. Alothman

“…The protonation constants of the ligands and the stability constants of the binary and ternary complexes of Cu(II) with the ligands were calculated from the potentiometric data using the HYPERQUAD program. …”
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Involvement of PPARs in Cell Proliferation and Apoptosis in Human Colon Cancer Specimens and in Normal and Cancer Cell Lines by G. Martinasso, M. Oraldi, A. Trombetta, M. Maggiora, O. Bertetto, R. A. Canuto, G. Muzio

“…Moreover, the results obtained on treating cell lines with PPAR ligands confirm observations in colon cancer: there is an inverse correlation between PPARα and Bcl-2 and between PPARγ and c-Myc.…”
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Separation of Functionalized 5,6-Disubstituted-1,10-Phenanthroline for Dye-Sensitized Solar Cell Applications by Hashem Shahroosvand, Parisa Abbasi, Behrouz Notash, Leyla Najafi

“…5,6-Epoxy-1,10-phenanthroline is used as a convenient starting material for 5-hydroxy-6-Aryl-1,10-phenanthroline ligands containing carboxylic and sulfonic groups useful for further anchoring of the sensitizer on TiO2 for dye-sensitized solar cells (DSCs). …”
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Peroxisome Proliferator-Activated Receptor γ Induces the Expression of Tissue Factor Pathway Inhibitor-1 (TFPI-1) in Human Macrophages by G. Chinetti-Gbaguidi, C. Copin, B. Derudas, N. Marx, J. Eechkoute, B. Staels

“…The induction of TFPI-1 expression by PPARγ ligands, an effect shared by the activation of PPARα and PPARβ/δ, occurs also in proinflammatory M1 and in anti-inflammatory M2 polarized macrophages. …”
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Inhibins Tune the Thymocyte Selection Process by Regulating Thymic Stromal Cell Differentiation by Ebzadrel Carbajal-Franco, Marisol de la Fuente-Granada, Germán R. Alemán-Muench, Eduardo A. García-Zepeda, Gloria Soldevila

“…Inhibins and Activins are members of the TGF-β superfamily that regulate the differentiation of several cell types. These ligands were initially identified as hormones that regulate the hypothalamus-pituitary-gonadal axis; however, increasing evidence has demonstrated that they are key regulators in the immune system. …”
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Effects of Invariant NKT Cells on Parasite Infections and Hygiene Hypothesis by Jun-Qi Yang, Yonghua Zhou, Ram Raj Singh

“…We put particular emphasis as well on the identification of the natural ligands from parasites and the involvement of iNKT cells in the hygiene hypothesis.…”
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NEW ZINC OXALATO AND HYDROGENOXALATO COMPLEXES: SYNTHESIS AND INFRARED STUDY by GORGUI AWA SECK, LIBASSE DIOP, ABOUBACRY SENE

“…The anions behave as monochelating ligands. When the cations and OH group are involved in extra hydrogen bonds, a supramolecular architecture may be obtained. …”
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Data Checking of Asymmetric Catalysis Literature Using a Graph Neural Network Approach by Eduardo Aguilar-Bejarano, Viraj Deorukhkar, Simon Woodward

“…We demonstrate the use of this approach to spot potential literature stereochemical misassignments in the ketone products resulting from catalytic asymmetric 1,4-addition of organoboron nucleophiles to Michael acceptors in two different databases, each one using a different family of chiral ligands (bisphosphine and diene ligands). Our results demonstrate that this methodology is useful for curation of medium-sized databases, speeding this process significantly compared to complete manual curation/checking. …”
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The Determination of Protonation Constants of Peptidomimetic Cyclophanes in Binary Methanol-Water Mixtures by Piotr Seliger, Danuta Tomczyk, Grzegorz Andrijewski, Ewa Tomal

“…The influence of cavity size, location of protonation sites, and attached substituents of the macrocyclic ligands on the protonation constants were discussed on the basis of potentiometric measurement as well as H1-NMR results.…”
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Antihuman Immunodeficiency Virus Type 1 (HIV-1) Activity of Rare Earth Metal Complexes of 4-Hydroxycoumarins in Cell Culture by Ilia Manolov, Sevda Raleva, Petya Genova, Alexey Savov, Liliana Froloshka, Daniela Dundarova, Radka Argirova

“…The spectra of the complexes were interpreted on the basis of comparison with the spectrum of the free ligands. Anti-HIV effect of the complexes/ligands was measured in MT-2 cells by microtiter infection assay. …”
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Epigenetically Mediated Pathogenic Effects of Phenanthrene on Regulatory T Cells by Jing Liu, Luhua Zhang, Lisa C. Winterroth, Marco Garcia, Shannon Weiman, Jillian W. Wong, John B. Sunwoo, Kari C. Nadeau

“…There have been conflicting results regarding the role of other AhR ligands 2,3,7,8- tetrachlorodibenzo-p-dioxin (TCDD) and 6-formylindolo [3,2-b]carbazole (FICZ) in modifying regulatory T cell populations (Treg) or T helper (Th)17 differentiation, and the effects of Phe have been understudied. …”
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New Insights into the PPARγ Agonists for the Treatment of Diabetic Nephropathy by Zhanjun Jia, Ying Sun, Guangrui Yang, Aihua Zhang, Songming Huang, Kristina Marie Heiney, Yue Zhang

“…Thiazolidinediones (TZDs), the synthetic exogenous ligands of nuclear receptor peroxisome proliferator-activated receptor-γ (PPARγ), had been thought to be a promising candidate for strengthening the therapy of DN. …”
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The Notch Pathway in Breast Cancer Progression by Emmanuel N. Kontomanolis, Sofia Kalagasidou, Stamatia Pouliliou, Xanthoula Anthoulaki, Nikolaos Georgiou, Valentinos Papamanolis, Zacharias N. Fasoulakis

“…Inhibition of Notch receptors and ligands provides innovative therapeutic results and could become the therapy of choice in the next few years, even though further research is needed to reach safe conclusions.…”
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Synthesis, Characterization, and BSA-Binding Studies of Novel Sulfonated Zinc-Triazine Complexes by Nalin Abeydeera, Inoka C. Perera, Theshini Perera

“…The IR stretching frequency of N=N and C=N bonds of complexes 1–4 have shifted to lower frequencies in comparison with free ligands, and a bathochromic shift was observed in UV-Vis spectra of all four complexes. …”
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Antihuman Immunodeficiency Virus Type 1 (HIV-1) Activity of Rare Earth Metal Complexes of 4-Hydroxycoumarins in Cell Culture

“…The spectra of the complexes were interpreted on the basis of comparison with the spectrum of the free ligands. Anti-HIV effect of the complexes/ligands was measured in MT-2 cells by microtiter infection assay. …”
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Organophosphate Nerve Agent Detection with Europium Complexes by Jake R. Schwierking, Laird W. Menzel, E. Roland Menzel

“…The detection utilizes europium complexes with 1,10 phenanthroline and thenoyltrifluoroacetone as sensitizing ligands. Both europium luminescence quenching and luminescence enhancement modalities are involved in the detection, which is simple, rapid, and sensitive. …”
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PPARα: A Master Regulator of Bilirubin Homeostasis by Cyril Bigo, Jenny Kaeding, Diala El Husseini, Iwona Rudkowska, Mélanie Verreault, Marie Claude Vohl, Olivier Barbier

“…These observations indicate that PPARα ligands activate bilirubin synthesis in vascular cells and metabolism in liver cells. …”
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Bicyclic peptide-enhanced covalent inhibitor of SARS-CoV-2 3CL protease by Qian Wang, Yanhui Wang, Jian Li, Hong Liu, Shiyu Chen

“…Structural information is also crucial for optimizing the potency of bicyclic peptide ligands.…”
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Fine-Tuning Reception in the Bone: PPARγ and Company by Z. Elizabeth Floyd, Sanjin Zvonic, Mark E. Nuttall, Jeffrey M. Gimble

“…Regulation of PPARγ activity depends on numerous factors ranging from dietary ligands to nuclear hormone coactivators and corepressors to oxygen-sensing mechanisms. …”
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